phrog_10045 is made of 10 protein sequences and is annotated as "HTH DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
73.4 96 79


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KU963258_p53 AMS03446.1 HTH DNA-binding domain protein KU963258 Gordonia phage Katyusha Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Demosthenesvirus; Gordonia virus Katyusha.
NC_030914_p52 YP_009274180.1 HTH DNA binding domain protein NC_030914 Gordonia phage Kvothe Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Demosthenesvirus.
NC_030944_p52 YP_009276763.1 HTH DNA binding domain protein NC_030944 Gordonia phage Demosthenes Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Demosthenesvirus.
NC_029074_p59 YP_009223967.1 DNA binding protein NC_029074 Gordonia phage GordTnk2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordtnkvirus.
NC_031109_p56 YP_009291021.1 helix-turn-helix DNA binding domain protein NC_031109 Gordonia phage Jumbo Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gorjumvirus; Gordonia virus Jumbo.
NC_029060_p58 YP_009222511.1 DNA binding domain protein NC_029060 Gordonia phage GordDuk1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordtnkvirus; unclassified Gordtnkvirus.
NC_028972_p54 YP_009215264.1 DNA binding protein NC_028972 Gordonia phage Gmala1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordtnkvirus; unclassified Gordtnkvirus.
NC_028668_p57 YP_009188625.1 hypothetical protein NC_028668 Gordonia phage GMA3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gamtrevirus; Gordonia virus GMA3.
p278303 no NCBI prot ID no annotation VI_00030 Actinobacteria_gi_548079438 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_030915_p56 YP_009274283.1 DNA binding protein NC_030915 Gordonia phage Orchid Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Orchidvirus; Gordonia virus Orchid.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_192 559 DNA polymerase exonuclease subunit DNA, RNA and nucleotide metabolism 9 1.45E-27 17.96
phrog_62 1174 DNA helicase DNA, RNA and nucleotide metabolism 6 4.82E-16 6.44
phrog_22895 3 no annotation unknown function 3 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_11726 sporulation stage III protein D moron, auxiliary metabolic gene and host takeover 93.0 0.014 11-41 / 20-47
phrog_11967 no annotation unknown function 96.0 0.00017 19-55 / 14-50
phrog_125 DNA invertase DNA, RNA and nucleotide metabolism 91.7 0.03 18-49 / 156-187
phrog_141 terminase small subunit head and packaging 94.3 0.0039 20-42 / 9-31
phrog_151 transposase integration and excision 93.0 0.014 19-43 / 22-46
phrog_15534 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.6 0.00042 17-67 / 36-84
phrog_1553 excisionase integration and excision 94.6 0.0027 18-42 / 2-26
phrog_1558 no annotation unknown function 90.9 0.044 22-44 / 119-141
phrog_16129 excisionase integration and excision 91.8 0.029 17-71 / 10-65
phrog_1668 tail assembly protein tail 90.2 0.058 15-50 / 13-48
phrog_1729 no annotation unknown function 92.4 0.02 19-64 / 83-127
phrog_1840 excisionase integration and excision 96.0 0.00019 18-66 / 4-53
phrog_1864 no annotation unknown function 94.9 0.0017 21-56 / 19-53
phrog_18815 no annotation unknown function 91.4 0.036 21-57 / 15-52
phrog_18890 transcriptional regulator transcription regulation 92.9 0.014 11-50 / 29-71
phrog_1969 no annotation unknown function 96.0 0.00017 16-44 / 50-78
phrog_22141 DNA binding protein DNA, RNA and nucleotide metabolism 96.7 1.4E-05 18-66 / 35-83
phrog_2328 transcriptional repressor transcription regulation 92.0 0.025 20-48 / 28-56
phrog_23834 no annotation unknown function 90.1 0.062 23-51 / 18-46
phrog_24579 terminase small subunit head and packaging 90.1 0.061 6-44 / 18-55
phrog_2474 MerR-like transcriptional regulator transcription regulation 95.5 0.00062 17-47 / 12-42
phrog_2538 terminase small subunit head and packaging 94.9 0.0018 6-45 / 8-44
phrog_25665 excisionase integration and excision 95.2 0.0011 19-60 / 24-64
phrog_2655 excisionase integration and excision 98.1 5.4E-09 16-63 / 3-53
phrog_26674 no annotation unknown function 90.6 0.051 14-43 / 183-211
phrog_268 no annotation unknown function 91.2 0.038 13-43 / 4-39
phrog_2907 excisionase integration and excision 97.4 5.7E-07 18-68 / 3-57
phrog_309 terminase small subunit head and packaging 95.7 0.00033 21-55 / 25-60
phrog_3470 no annotation unknown function 93.5 0.0087 19-43 / 5-29
phrog_35 transcriptional repressor transcription regulation 92.4 0.02 22-63 / 15-61
phrog_409 transcriptional regulator transcription regulation 93.6 0.0084 22-42 / 12-32
phrog_4149 no annotation unknown function 91.4 0.036 22-46 / 93-117
phrog_4370 excisionase integration and excision 92.9 0.014 19-60 / 40-84
phrog_4494 no annotation unknown function 92.8 0.015 20-72 / 17-72
phrog_4745 DNA binding protein DNA, RNA and nucleotide metabolism 95.4 0.0007 17-67 / 1-58
phrog_4779 transcriptional regulator transcription regulation 93.7 0.0073 21-44 / 15-38
phrog_5229 no annotation unknown function 93.0 0.013 19-45 / 80-106
phrog_534 DNA binding protein DNA, RNA and nucleotide metabolism 95.6 0.00046 17-43 / 22-48
phrog_575 Cox-like excisionase and repressor integration and excision 96.5 2.9E-05 14-52 / 7-45
phrog_57 terminase small subunit head and packaging 96.9 6.3E-06 20-65 / 2-48
phrog_597 DNA binding protein DNA, RNA and nucleotide metabolism 96.2 8.8E-05 12-49 / 6-40
phrog_6058 no annotation unknown function 93.2 0.012 17-48 / 2-33
phrog_629 excisionase integration and excision 97.8 3.6E-08 18-60 / 2-49
phrog_6355 no annotation unknown function 94.2 0.0042 12-58 / 10-62
phrog_6401 DNA binding protein DNA, RNA and nucleotide metabolism 99.1 5.5E-14 14-70 / 3-59
phrog_6620 transposase integration and excision 96.1 0.00012 19-57 / 2-40
phrog_664 DNA binding protein DNA, RNA and nucleotide metabolism 94.7 0.0023 17-47 / 65-95
phrog_668 HTH DNA binding protein DNA, RNA and nucleotide metabolism 97.4 4.8E-07 14-69 / 30-84
phrog_66 excisionase and transcriptional regulator integration and excision 98.6 2.5E-11 15-69 / 4-58
phrog_7338 no annotation unknown function 96.4 4.4E-05 16-68 / 26-77
phrog_7344 terminase small subunit head and packaging 91.1 0.041 4-42 / 13-48
phrog_7676 no annotation unknown function 90.9 0.044 21-45 / 17-41
phrog_7950 transcriptional repressor transcription regulation 90.4 0.056 20-44 / 22-46
phrog_8008 DNA binding protein DNA, RNA and nucleotide metabolism 90.8 0.046 23-49 / 17-42
phrog_8446 HNH endonuclease DNA, RNA and nucleotide metabolism 93.8 0.0065 18-48 / 15-45
phrog_8 transcriptional regulator transcription regulation 94.7 0.0023 19-61 / 13-62
phrog_9759 DNA binding protein DNA, RNA and nucleotide metabolism 92.4 0.02 21-46 / 19-44
phrog_9834 excisionase and transcriptional regulator integration and excision 93.3 0.01 21-55 / 29-63
phrog_989 no annotation unknown function 91.4 0.035 18-43 / 3-28

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF13411.5 MerR HTH family regulatory protein 4E-08 30-93 / 2-67
PF13591.5 MerR HTH family regulatory protein 8.5E-08 29-72 / 1-43
PF11112.7 Pyocin activator protein PrtN 9.4E-08 26-76 / 11-67
PF04936.11 Protein of unknown function (DUF658) 0.0003 27-55 / 87-115
PF12964.6 Protein of unknown function (DUF3853) 2.8E-07 25-74 / 42-92
PF09035.9 Excisionase from transposon Tn916 3.1E-07 25-51 / 12-38
PF07825.10 Excisionase-like protein 8E-07 29-67 / 3-44
PF10743.8 Regulatory phage protein cox 9.5E-07 25-56 / 8-39
PF06806.11 Putative excisionase (DUF1233) 1.5E-06 26-53 / 7-33
PF07278.10 Protein of unknown function (DUF1441) 1.8E-06 29-53 / 2-26
PF05930.11 Prophage CP4-57 regulatory protein (AlpA) 1.9E-06 28-55 / 3-31
PF17443.1 Uncharacterized protein pXO2-72 2.4E-06 26-53 / 6-33
PF12728.6 Helix-turn-helix domain 2.9E-06 29-56 / 2-30
PF00292.17 'Paired box' domain 7.6E-06 26-51 / 31-56
PF07471.11 Phage DNA packaging protein Nu1 7.5E-06 28-55 / 2-28
PF01710.15 Transposase 8.2E-06 26-52 / 16-42
PF14493.5 Helix-turn-helix domain 9E-06 26-52 / 10-36
PF07618.10 Protein of unknown function (DUF1580) 9.1E-06 33-74 / 7-52
PF00376.22 MerR family regulatory protein 9.7E-06 31-55 / 2-26
PF08876.10 Domain of unknown function (DUF1836) 1.3E-05 27-73 / 9-61
PF13171.5 Protein of unknown function (DUF4004) 1.2E-05 29-93 / 3-74
PF07141.10 Putative bacteriophage terminase small subunit 1.8E-05 25-51 / 28-54
PF10654.8 Protein of unknown function (DUF2481) 2.5E-05 26-51 / 78-103
PF07750.10 GcrA cell cycle regulator 2.8E-05 25-52 / 15-43
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 5.7E-05 27-52 / 12-37
PF01381.21 Helix-turn-helix 6E-05 26-51 / 7-32
PF08765.10 Mor transcription activator family 6.5E-05 27-52 / 71-96
PF07453.12 NUMOD1 domain 7.1E-05 27-48 / 18-39
PF04552.12 Sigma-54, DNA binding domain 7.1E-05 25-52 / 45-72
PF08535.9 KorB domain 8.4E-05 27-52 / 2-27
PF00356.20 Bacterial regulatory proteins, lacI family 9.4E-05 30-52 / 1-23
PF08822.10 Protein of unknown function (DUF1804) 0.0001 27-51 / 18-42
PF05344.10 Domain of Unknown Function (DUF746) 0.0001 27-52 / 11-36
PF06322.10 Phage NinH protein 0.00012 27-53 / 15-41
PF02954.18 Bacterial regulatory protein, Fis family 0.00014 27-50 / 15-38
PF12759.6 InsA C-terminal domain 0.00014 27-51 / 20-44
PF13413.5 Helix-turn-helix domain 0.00015 26-51 / 7-32
PF13309.5 HTH domain 0.00021 29-49 / 42-62
PF02319.19 E2F/DP family winged-helix DNA-binding domain 0.00023 26-51 / 21-46
PF06970.10 Replication initiator protein A (RepA) N-terminus 0.00023 30-50 / 53-73
PF09607.9 Brinker DNA-binding domain 0.0003 29-52 / 26-49
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 0.00036 27-51 / 18-42
PF13011.5 leucine-zipper of insertion element IS481 0.00036 26-51 / 22-47
PF02796.14 Helix-turn-helix domain of resolvase 0.00037 27-50 / 20-43
PF07037.10 Putative transcription regulator (DUF1323) 0.00037 29-51 / 1-23
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 0.00041 25-52 / 20-47
PF03333.12 Adhesin biosynthesis transcription regulatory protein 0.00043 27-51 / 54-78
PF04218.12 CENP-B N-terminal DNA-binding domain 0.00048 28-51 / 23-46
PF13412.5 Winged helix-turn-helix DNA-binding 0.00053 27-51 / 16-40
PF12824.6 Mitochondrial ribosomal protein subunit L20 0.00056 28-51 / 107-130
PF13542.5 Helix-turn-helix domain of transposase family ISL3 0.00065 30-51 / 28-49
PF13404.5 AsnC-type helix-turn-helix domain 0.00066 27-50 / 16-39
PF02042.14 RWP-RK domain 0.00066 26-52 / 10-36
PF12116.7 Stage III sporulation protein D 0.00065 27-52 / 18-43
PF13936.5 Helix-turn-helix domain 0.00072 26-50 / 18-42
PF07638.10 ECF sigma factor 0.00077 26-51 / 147-172
PF10668.8 Phage terminase small subunit 0.00081 28-52 / 22-46
PF06971.12 Putative DNA-binding protein N-terminus 0.00082 28-49 / 27-48
PF16677.4 DNA-packaging protein gp3 0.00084 27-52 / 28-53
PF08222.10 CodY helix-turn-helix domain 0.00087 27-51 / 3-27
PF05331.10 Protein of unknown function (DUF742) 0.00095 27-51 / 52-76
PF15978.4 Tn7-like transposition protein D 0.001 27-51 / 202-226
PF05225.15 helix-turn-helix, Psq domain 0.0011 27-51 / 15-40
PF00440.22 Bacterial regulatory proteins, tetR family 0.0011 29-51 / 16-38
PF11242.7 Protein of unknown function (DUF2774) 0.0012 26-51 / 12-37
PF01371.18 Trp repressor protein 0.0013 26-52 / 46-72
PF13556.5 PucR C-terminal helix-turn-helix domain 0.0013 27-51 / 11-35
PF06627.10 Protein of unknown function (DUF1153) 0.0014 27-51 / 45-69
PF13022.5 Helix-turn-helix of insertion element transposase 0.0016 27-51 / 24-48
PF13443.5 Cro/C1-type HTH DNA-binding domain 0.0016 27-51 / 9-34
PF10975.7 Protein of unknown function (DUF2802) 0.0016 20-49 / 35-64
PF00325.19 Bacterial regulatory proteins, crp family 0.0019 30-51 / 4-25
PF13518.5 Helix-turn-helix domain 0.002 27-51 / 10-34
PF08281.11 Sigma-70, region 4 0.002 27-51 / 25-49
PF11427.7 Tc3 transposase 0.0021 27-51 / 19-43
PF08279.11 HTH domain 0.0022 27-51 / 14-38
PF04967.11 HTH DNA binding domain 0.0024 28-51 / 23-46
PF16509.4 TrfB plasmid transcriptional repressor 0.0024 27-51 / 30-54
PF05339.10 Protein of unknown function (DUF739) 0.0024 27-51 / 15-39
PF04545.15 Sigma-70, region 4 0.0024 27-51 / 23-47
PF01527.19 Transposase 0.003 26-52 / 19-45
PF09862.8 Protein of unknown function (DUF2089) 0.003 27-51 / 48-72
PF05043.12 Mga helix-turn-helix domain 0.0029 26-51 / 28-53
PF09182.9 Bacterial purine repressor, N-terminal 0.003 26-51 / 18-43
PF09756.8 DDRGK domain 0.003 26-92 / 113-184
PF00126.26 Bacterial regulatory helix-turn-helix protein, lysR family 0.0033 29-51 / 12-34
PF12793.6 Sugar transport-related sRNA regulator N-term 0.0033 25-51 / 15-41
PF07506.10 RepB plasmid partitioning protein 0.0032 26-52 / 19-45
PF16221.4 winged helix-turn-helix 0.0037 27-51 / 45-69
PF14549.5 DNA-binding transcriptional regulator Cro 0.0039 27-48 / 9-29
PF13744.5 Helix-turn-helix domain 0.0042 26-51 / 29-54
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 0.0043 28-52 / 11-36
PF01022.19 Bacterial regulatory protein, arsR family 0.0046 27-51 / 15-39
PF12844.6 Helix-turn-helix domain 0.0046 27-51 / 11-35
PF16701.4 Adenylate cyclase regulatory domain 0.0044 27-55 / 57-86
PF13384.5 Homeodomain-like domain 0.005 27-52 / 16-41
PF09012.9 FeoC like transcriptional regulator 0.0048 27-51 / 13-37
PF12802.6 MarR family 0.0055 29-51 / 22-44
PF13551.5 Winged helix-turn helix 0.0056 27-51 / 10-34
PF08280.10 M protein trans-acting positive regulator (MGA) HTH domain 0.0065 27-51 / 19-43
PF01418.16 Helix-turn-helix domain, rpiR family 0.0065 28-51 / 34-57
PF04492.12 Bacteriophage replication protein O 0.0065 28-51 / 49-72
PF07374.10 Protein of unknown function (DUF1492) 0.0077 27-51 / 70-94
PF00196.18 Bacterial regulatory proteins, luxR family 0.0081 27-51 / 16-40
PF05269.10 Bacteriophage CII protein 0.0081 27-51 / 22-46
PF14590.5 Domain of unknown function (DUF4447) 0.0083 27-51 / 19-43
PF04297.13 Putative helix-turn-helix protein, YlxM / p13 like 0.0085 26-52 / 31-57
PF07381.10 Winged helix DNA-binding domain (DUF1495) 0.0086 26-50 / 22-46
PF09339.9 IclR helix-turn-helix domain 0.0095 28-51 / 18-41
PF04645.11 Protein of unknown function, DUF603 0.0091 27-52 / 18-47

Annotations of the NCBI proteins of this PHROG


3:DNA binding protein 2:HTH DNA binding domain protein 1:helix-turn-helix DNA binding domain protein 1:HTH DNA-binding domain protein 1:hypothetical protein 1:DNA binding domain protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0019069 viral capsid assembly
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006352 DNA-templated transcription, initiation
GO:0051775 response to redox state
GO:0043565 sequence-specific DNA binding
GO:0004803 transposase activity
GO:0005524 ATP binding
GO:0005667 transcription factor complex
GO:0045892 negative regulation of transcription, DNA-templated
GO:0016987 sigma factor activity
GO:0006260 DNA replication
GO:0005622 intracellular
GO:0003677 DNA binding
GO:0006310 DNA recombination
GO:0000150 recombinase activity
GO:0006313 transposition, DNA-mediated
GO:0003700 DNA binding transcription factor activity

Loading in process