phrog_10086 is made of 10 protein sequences and is annotated as "HTH DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
91.1 95 91


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p131054 no NCBI prot ID no annotation VI_05755 Clostridia_gi_153883716 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
AY082070_p41 AAL96811.1 Gp41 protein AY082070 Clostridium phage phi3626 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_003524_p41 NP_612870.1 Gp41 protein NC_003524 Clostridium phage phi3626 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_017978_p33 YP_006383537.1 gp33 NC_017978 Clostridium phage PhiS63 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_021325_p42 YP_008058965.1 putative helix-turn-helix domain protein NC_021325 Clostridium phage vB_CpeS-CP51 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_008265_p29 YP_699958.1 putative transcriptional regulator NC_008265 Clostridium phage phiSM101 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p266019 no NCBI prot ID no annotation VI_05752 Clostridia_gi_153883612_29538_60066 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae; Clostridium phage phi3626.
p230930 no NCBI prot ID no annotation VI_05754 Clostridia_gi_153883714_0_33729 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p206847 no NCBI prot ID no annotation VI_01144 Clostridia_gi_422346908_263682_299784 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
p135395 no NCBI prot ID no annotation VI_01157 Clostridia_gi_422348123 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_11726 9 sporulation stage III protein D moron, auxiliary metabolic gene and host takeover 6 2.94E-32 22.65
phrog_7934 14 no annotation unknown function 4 6.31E-21 11.32

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_11961 no annotation unknown function 93.2 0.011 18-64 / 41-90
phrog_2030 transcriptional regulator transcription regulation 93.6 0.0081 27-78 / 29-82
phrog_270 replication initiation protein DNA, RNA and nucleotide metabolism 90.1 0.061 14-66 / 15-74
phrog_3512 sigma factor transcription regulation 90.6 0.05 15-53 / 67-105
phrog_351 RNA polymerase sigma factor transcription regulation 90.4 0.054 12-54 / 173-218
phrog_428 replication initiation protein DNA, RNA and nucleotide metabolism 92.2 0.023 13-75 / 24-96
phrog_5978 no annotation unknown function 93.5 0.0091 17-83 / 306-373
phrog_678 replication initiation O-like DNA, RNA and nucleotide metabolism 95.2 0.0011 2-82 / 12-104
phrog_7882 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 91.8 0.029 20-80 / 39-113

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF02319.19 E2F/DP family winged-helix DNA-binding domain 1E-07 29-63 / 22-56
PF04492.12 Bacteriophage replication protein O 2.6E-07 14-64 / 24-83
PF05331.10 Protein of unknown function (DUF742) 3E-07 13-63 / 37-86
PF16221.4 winged helix-turn-helix 4.4E-07 18-61 / 32-77
PF08222.10 CodY helix-turn-helix domain 5.8E-07 30-64 / 4-38
PF12802.6 MarR family 6.7E-07 31-63 / 22-54
PF00292.17 'Paired box' domain 8.7E-07 14-60 / 17-63
PF05584.10 Sulfolobus plasmid regulatory protein 8.8E-07 15-64 / 4-52
PF14557.5 Putative AphA-like transcriptional regulator 9.5E-07 28-64 / 23-67
PF10007.8 Uncharacterized protein conserved in archaea (DUF2250) 1.1E-06 16-64 / 7-56
PF07381.10 Winged helix DNA-binding domain (DUF1495) 1.2E-06 16-64 / 8-68
PF11313.7 Protein of unknown function (DUF3116) 1.3E-06 29-65 / 19-62
PF03965.15 Penicillinase repressor 1.6E-06 19-65 / 5-58
PF13412.5 Winged helix-turn-helix DNA-binding 1.6E-06 29-60 / 16-47
PF03428.12 Replication protein C N-terminal domain 1.6E-06 31-64 / 71-105
PF08822.10 Protein of unknown function (DUF1804) 2E-06 17-60 / 5-49
PF12793.6 Sugar transport-related sRNA regulator N-term 2.2E-06 29-63 / 17-51
PF09012.9 FeoC like transcriptional regulator 3.6E-06 29-64 / 13-48
PF08221.10 RNA polymerase III subunit RPC82 helix-turn-helix domain 3.9E-06 15-62 / 11-59
PF04079.15 Segregation and condensation complex subunit ScpB 4.1E-06 13-64 / 79-128
PF09114.9 Transcription factor MotA, activation domain 4.4E-06 13-63 / 12-64
PF01978.18 Sugar-specific transcriptional regulator TrmB 4.5E-06 15-64 / 6-56
PF01475.18 Ferric uptake regulator family 4.5E-06 15-64 / 5-61
PF13601.5 Winged helix DNA-binding domain 4.8E-06 29-64 / 13-48
PF14277.5 Domain of unknown function (DUF4364) 4.9E-06 29-63 / 14-52
PF07750.10 GcrA cell cycle regulator 4.8E-06 16-57 / 4-46
PF01726.15 LexA DNA binding domain 5.1E-06 30-64 / 25-60
PF05158.11 RNA polymerase Rpc34 subunit 5.2E-06 14-64 / 89-142
PF01047.21 MarR family 6.8E-06 29-63 / 16-50
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 6.8E-06 28-60 / 11-43
PF13463.5 Winged helix DNA-binding domain 7.2E-06 29-63 / 16-50
PF13518.5 Helix-turn-helix domain 7.9E-06 29-61 / 10-42
PF08784.10 Replication protein A C terminal 7.5E-06 29-63 / 57-94
PF09824.8 ArsR transcriptional regulator 7.6E-06 19-63 / 19-61
PF02002.16 TFIIE alpha subunit 8E-06 21-64 / 16-60
PF02082.19 Transcriptional regulator 8.8E-06 31-63 / 25-57
PF12759.6 InsA C-terminal domain 9.4E-06 26-54 / 17-45
PF13011.5 leucine-zipper of insertion element IS481 1E-05 28-60 / 22-54
PF05344.10 Domain of Unknown Function (DUF746) 1E-05 27-59 / 9-41
PF04182.11 B-block binding subunit of TFIIIC 1E-05 30-64 / 18-52
PF05732.10 Firmicute plasmid replication protein (RepL) 1E-05 30-64 / 75-109
PF11427.7 Tc3 transposase 1.1E-05 27-58 / 17-48
PF02334.15 Replication terminator protein 1.1E-05 29-64 / 30-74
PF07141.10 Putative bacteriophage terminase small subunit 1.1E-05 22-56 / 23-57
PF03333.12 Adhesin biosynthesis transcription regulatory protein 1.1E-05 15-56 / 40-81
PF14947.5 Winged helix-turn-helix 1.3E-05 29-63 / 15-49
PF01710.15 Transposase 1.4E-05 18-58 / 6-46
PF01022.19 Bacterial regulatory protein, arsR family 1.5E-05 29-60 / 15-46
PF06322.10 Phage NinH protein 1.5E-05 28-58 / 14-44
PF06163.10 Bacterial protein of unknown function (DUF977) 1.6E-05 29-64 / 25-60
PF14394.5 Domain of unknown function (DUF4423) 1.6E-05 29-64 / 34-72
PF01090.18 Ribosomal protein S19e 1.8E-05 29-64 / 64-114
PF08535.9 KorB domain 2.1E-05 30-63 / 3-36
PF02295.16 Adenosine deaminase z-alpha domain 2.3E-05 30-63 / 18-52
PF09202.10 Rio2, N-terminal 2.5E-05 29-63 / 23-57
PF10711.8 Hypothetical protein (DUF2513) 2.4E-05 23-64 / 11-56
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 2.6E-05 29-57 / 18-46
PF07638.10 ECF sigma factor 2.6E-05 15-55 / 134-174
PF00325.19 Bacterial regulatory proteins, crp family 2.7E-05 32-59 / 4-31
PF07106.12 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) 2.8E-05 29-64 / 15-52
PF09339.9 IclR helix-turn-helix domain 3.1E-05 31-62 / 19-50
PF16087.4 Domain of unknown function (DUF4817) 3.1E-05 24-60 / 10-54
PF05491.12 Holliday junction DNA helicase ruvB C-terminus 3.4E-05 30-63 / 25-59
PF09607.9 Brinker DNA-binding domain 3.4E-05 31-58 / 26-53
PF03551.13 Transcriptional regulator PadR-like family 3.5E-05 31-64 / 15-50
PF16509.4 TrfB plasmid transcriptional repressor 3.8E-05 15-62 / 16-62
PF04936.11 Protein of unknown function (DUF658) 0.0027 29-54 / 87-112
PF00126.26 Bacterial regulatory helix-turn-helix protein, lysR family 3.9E-05 31-62 / 12-46
PF01638.16 HxlR-like helix-turn-helix 4.1E-05 29-64 / 18-54
PF00392.20 Bacterial regulatory proteins, gntR family 4.3E-05 30-63 / 23-57
PF03444.14 Winged helix-turn-helix transcription repressor, HrcA DNA-binding 4.4E-05 30-63 / 24-57
PF01418.16 Helix-turn-helix domain, rpiR family 4.5E-05 14-62 / 13-66
PF15977.4 Winged helix-turn-helix DNA binding 4.7E-05 30-63 / 23-56
PF13034.5 Protein of unknown function (DUF3895) 5E-05 31-64 / 20-67
PF14493.5 Helix-turn-helix domain 5.6E-05 28-59 / 10-41
PF01325.18 Iron dependent repressor, N-terminal DNA binding domain 6.1E-05 30-63 / 21-54
PF07900.10 Protein of unknown function (DUF1670) 6E-05 29-63 / 94-128
PF06627.10 Protein of unknown function (DUF1153) 6E-05 28-61 / 44-77
PF14502.5 Helix-turn-helix domain 6.5E-05 31-63 / 7-39
PF04218.12 CENP-B N-terminal DNA-binding domain 6.7E-05 29-56 / 22-49
PF10654.8 Protein of unknown function (DUF2481) 6.7E-05 23-53 / 73-103
PF13936.5 Helix-turn-helix domain 8E-05 28-52 / 18-42
PF04552.12 Sigma-54, DNA binding domain 7.6E-05 15-56 / 31-74
PF10668.8 Phage terminase small subunit 8.8E-05 30-60 / 22-52
PF02796.14 Helix-turn-helix domain of resolvase 9.8E-05 29-53 / 20-44
PF16365.4 Ethanolamine utilization protein EutK C-terminus 0.0001 29-63 / 16-50
PF08281.11 Sigma-70, region 4 0.0001 15-55 / 11-51
PF02954.18 Bacterial regulatory protein, Fis family 0.00011 29-53 / 15-39
PF13404.5 AsnC-type helix-turn-helix domain 0.00011 29-54 / 16-41
PF05225.15 helix-turn-helix, Psq domain 0.00011 28-55 / 14-42
PF04545.15 Sigma-70, region 4 0.00011 15-54 / 5-48
PF17443.1 Uncharacterized protein pXO2-72 0.00011 30-52 / 8-30
PF13542.5 Helix-turn-helix domain of transposase family ISL3 0.00013 29-54 / 26-50
PF09904.8 Winged helix-turn helix 0.00015 29-62 / 20-53
PF06970.10 Replication initiator protein A (RepA) N-terminus 0.00015 32-54 / 53-75
PF08279.11 HTH domain 0.00017 29-58 / 14-43
PF06969.15 HemN C-terminal domain 0.00017 29-63 / 19-54
PF04703.11 FaeA-like protein 0.00019 29-63 / 13-47
PF13556.5 PucR C-terminal helix-turn-helix domain 0.00019 29-59 / 11-41
PF07848.11 PaaX-like protein 0.00019 30-63 / 20-56
PF09639.9 YjcQ protein 0.00019 30-64 / 16-52
PF13591.5 MerR HTH family regulatory protein 0.00019 32-62 / 2-28
PF13545.5 Crp-like helix-turn-helix domain 0.0002 30-62 / 27-59
PF08765.10 Mor transcription activator family 0.0002 29-56 / 71-98
PF12824.6 Mitochondrial ribosomal protein subunit L20 0.00019 14-54 / 88-131
PF13551.5 Winged helix-turn helix 0.00022 29-60 / 10-41
PF04967.11 HTH DNA binding domain 0.00022 31-56 / 24-49
PF12840.6 Helix-turn-helix domain 0.00026 29-63 / 22-53
PF13309.5 HTH domain 0.0003 31-52 / 42-63
PF01527.19 Transposase 0.00031 28-59 / 19-49
PF16864.4 Dimerisation domain 0.00031 29-63 / 31-65
PF03297.14 S25 ribosomal protein 0.00031 30-63 / 56-89
PF10771.8 Winged helix-turn-helix domain (DUF2582) 0.00032 17-64 / 8-56
PF09182.9 Bacterial purine repressor, N-terminal 0.00037 29-59 / 19-53
PF07453.12 NUMOD1 domain 0.00038 31-51 / 20-40
PF08220.11 DeoR-like helix-turn-helix domain 0.0004 30-62 / 14-46
PF13730.5 Helix-turn-helix domain 0.0004 41-60 / 33-52
PF01371.18 Trp repressor protein 0.00042 26-56 / 44-74
PF13384.5 Homeodomain-like domain 0.00046 29-54 / 16-41
PF11242.7 Protein of unknown function (DUF2774) 0.00044 27-59 / 11-43
PF13411.5 MerR HTH family regulatory protein 0.00048 32-55 / 2-25
PF10975.7 Protein of unknown function (DUF2802) 0.00049 19-52 / 32-65
PF13022.5 Helix-turn-helix of insertion element transposase 0.00051 30-53 / 25-48
PF02042.14 RWP-RK domain 0.00056 29-59 / 11-41
PF07037.10 Putative transcription regulator (DUF1323) 0.00062 32-60 / 2-27
PF01381.21 Helix-turn-helix 0.00065 28-53 / 7-32
PF00356.20 Bacterial regulatory proteins, lacI family 0.00067 33-53 / 2-22
PF05043.12 Mga helix-turn-helix domain 0.00067 29-57 / 29-57
PF09397.9 Ftsk gamma domain 0.00066 29-64 / 18-53
PF15978.4 Tn7-like transposition protein D 0.0007 29-59 / 202-232
PF06806.11 Putative excisionase (DUF1233) 0.00079 31-52 / 10-31
PF00376.22 MerR family regulatory protein 0.00083 33-53 / 2-22
PF02001.15 Protein of unknown function DUF134 0.00084 15-55 / 32-72
PF07374.10 Protein of unknown function (DUF1492) 0.0009 17-53 / 58-94
PF11972.7 HTH DNA binding domain 0.0009 29-59 / 12-39
PF04297.13 Putative helix-turn-helix protein, YlxM / p13 like 0.00091 15-55 / 18-58
PF16677.4 DNA-packaging protein gp3 0.00094 29-55 / 28-54
PF08461.9 Ribonuclease R winged-helix domain 0.00099 30-63 / 12-50
PF05930.11 Prophage CP4-57 regulatory protein (AlpA) 0.001 31-52 / 4-25
PF09681.9 N-terminal phage replisome organiser (Phage_rep_org_N) 0.0011 32-63 / 55-86
PF07278.10 Protein of unknown function (DUF1441) 0.0012 31-53 / 2-24
PF06530.11 Phage antitermination protein Q 0.0012 17-55 / 66-104
PF12116.7 Stage III sporulation protein D 0.0014 29-54 / 18-43
PF16264.4 SatD family (SatD) 0.0015 15-54 / 151-195
PF07183.10 Protein of unknown function (DUF1403) 0.0015 31-64 / 289-320
PF10743.8 Regulatory phage protein cox 0.0017 30-53 / 11-34
PF13413.5 Helix-turn-helix domain 0.0018 29-53 / 8-32
PF09035.9 Excisionase from transposon Tn916 0.002 30-52 / 15-37
PF08280.10 M protein trans-acting positive regulator (MGA) HTH domain 0.0024 29-56 / 19-46
PF12728.6 Helix-turn-helix domain 0.0025 31-52 / 2-24
PF06413.10 Neugrin 0.0025 14-53 / 10-52
PF07506.10 RepB plasmid partitioning protein 0.003 26-54 / 17-45
PF00196.18 Bacterial regulatory proteins, luxR family 0.0033 29-57 / 16-44
PF06971.12 Putative DNA-binding protein N-terminus 0.0034 30-51 / 27-48
PF09862.8 Protein of unknown function (DUF2089) 0.0034 19-57 / 38-76
PF07471.11 Phage DNA packaging protein Nu1 0.0034 31-53 / 3-25
PF09048.9 Cro 0.0037 30-61 / 13-44
PF09756.8 DDRGK domain 0.0035 31-63 / 116-148
PF08004.10 Protein of unknown function (DUF1699) 0.0035 21-51 / 95-129
PF00440.22 Bacterial regulatory proteins, tetR family 0.0039 31-54 / 16-39
PF12964.6 Protein of unknown function (DUF3853) 0.0038 30-52 / 45-67
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 0.0067 28-52 / 21-45
PF13443.5 Cro/C1-type HTH DNA-binding domain 0.0072 29-53 / 9-34

Annotations of the NCBI proteins of this PHROG


2:hypothetical protein 1:transcriptional regulator 1:transcription regulator 1:helix-turn-helix domain protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0009378 four-way junction helicase activity
GO:0009289 pilus
GO:0006260 DNA replication
GO:0005667 transcription factor complex
GO:0005840 ribosome
GO:0006310 DNA recombination
GO:0003677 DNA binding
GO:0003726 double-stranded RNA adenosine deaminase activity
GO:0005737 cytoplasm
GO:0051304 chromosome separation
GO:0006355 regulation of transcription, DNA-templated
GO:0006412 translation
GO:0004252 serine-type endopeptidase activity
GO:0019069 viral capsid assembly
GO:0060567 negative regulation of DNA-templated transcription, termination
GO:0043565 sequence-specific DNA binding
GO:0004803 transposase activity
GO:0007131 reciprocal meiotic recombination
GO:0005622 intracellular
GO:0006383 transcription by RNA polymerase III
GO:0004674 protein serine/threonine kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0016987 sigma factor activity
GO:0006313 transposition, DNA-mediated
GO:0006274 DNA replication termination
GO:0000150 recombinase activity
GO:0003700 DNA binding transcription factor activity
GO:0006468 protein phosphorylation
GO:0006352 DNA-templated transcription, initiation
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0051775 response to redox state
GO:0006281 DNA repair
GO:0005524 ATP binding
GO:0006276 plasmid maintenance
GO:0006508 proteolysis
GO:0005666 DNA-directed RNA polymerase III complex

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