phrog_10371 is made of 10 protein sequences and is annotated as "DNA helicase"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
665 772 686


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_021471_p45 YP_008083095.1 MCM DNA helicase NC_021471 Halovirus HSTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
p89183 no NCBI prot ID no annotation VI_12219 Halobacteria_gi_448349957 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p166387 no NCBI prot ID no annotation VI_12243 Halobacteria_gi_448472989 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p120340 no NCBI prot ID no annotation VI_12480 Thermoprotei_gi_483378806_339141_382559 Viruses; Fuselloviridae; Alphafusellovirus.
p389586 no NCBI prot ID no annotation VI_12496 unknown_gi_506495612_27125_42463 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p389570 no NCBI prot ID no annotation VI_12493 unknown_gi_484235599_6649_21987 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_008695_p35 YP_919062.1 hypothetical protein NC_008695 Archaeal BJ1 virus Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p120283 no NCBI prot ID no annotation VI_12478 Thermoprotei_gi_483377487_338515_381935 Viruses; Fuselloviridae; Alphafusellovirus.
JF917095_p1 AEY69051.1 predicted MCM2/3/5 family helicase JF917095 Thermococcus prieurii virus 1 Viruses; unclassified archaeal viruses.
NC_016899_p2 YP_005271224.1 C-terminal part of the MCM2-like helicase NC_016899 Thermococcus prieurii virus 1 Viruses; unclassified archaeal viruses.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_6819 17 Holliday junction branch migration helicase DNA, RNA and nucleotide metabolism 2 3.81E-12 2.54
phrog_35510 2 no annotation unknown function 2 0 1000
phrog_36679 2 no annotation unknown function 2 0 1000
phrog_37132 2 no annotation unknown function 2 0 1000
phrog_37426 2 no annotation unknown function 2 0 1000
phrog_26506 3 no annotation unknown function 2 5.60E-15 5.37

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10401 ATPase other 93.3 0.011 320-486 / 205-347
phrog_10514 DNA primase DNA, RNA and nucleotide metabolism 96.1 0.00014 259-663 / 319-717
phrog_1297 ATPase other 97.0 3.8E-06 321-467 / 27-170
phrog_14322 no annotation unknown function 93.2 0.012 322-341 / 197-216
phrog_15585 no annotation unknown function 96.7 1.4E-05 322-473 / 350-496
phrog_16448 ATPase other 98.3 6E-10 321-468 / 23-163
phrog_168 clamp loader of DNA polymerase DNA, RNA and nucleotide metabolism 98.0 1.1E-08 321-462 / 40-151
phrog_18685 no annotation unknown function 98.0 5.8E-09 309-565 / 630-882
phrog_2071 ATPase other 91.0 0.043 322-385 / 6-58
phrog_2376 ATPase other 93.5 0.0086 286-398 / 50-139
phrog_249 porphyrin biosynthesis moron, auxiliary metabolic gene and host takeover 97.3 1.1E-06 316-464 / 104-252
phrog_296 DNA transposition protein integration and excision 95.4 0.00068 316-437 / 89-201
phrog_3022 DNA primase DNA, RNA and nucleotide metabolism 95.3 0.00087 292-667 / 360-756
phrog_30773 no annotation unknown function 91.0 0.042 322-396 / 177-246
phrog_3757 no annotation unknown function 97.0 3.9E-06 321-582 / 128-327
phrog_4339 no annotation unknown function 97.9 1.5E-08 381-560 / 311-468
phrog_4871 ATP-dependent protease other 95.4 0.00065 319-534 / 201-407
phrog_5311 helicase DNA, RNA and nucleotide metabolism 96.0 0.00017 297-662 / 334-705
phrog_5846 clamp loader of DNA polymerase DNA, RNA and nucleotide metabolism 96.3 7.7E-05 321-512 / 40-194
phrog_7485 no annotation unknown function 93.4 0.0095 320-402 / 228-295
phrog_7998 no annotation unknown function 96.6 2.3E-05 320-409 / 39-141

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF17207.2 MCM OB domain 1.7E-15 124-245 / 5-128
PF00493.22 MCM2/3/5 family 3.1E-08 301-433 / 16-146
PF14551.5 MCM N-terminal domain 8.8E-08 30-95 / 1-75
PF03215.14 Rad17 cell cycle checkpoint protein 3.7E-07 299-368 / 9-70
PF05496.11 Holliday junction DNA helicase ruvB N-terminus 1E-06 306-367 / 16-69
PF06431.10 Polyomavirus large T antigen C-terminus 1.1E-06 344-367 / 156-179
PF00308.17 Bacterial dnaA protein 1.4E-06 345-368 / 35-58
PF05673.12 Protein of unknown function (DUF815) 1.6E-06 305-368 / 25-79
PF01078.20 Magnesium chelatase, subunit ChlI 3.1E-06 345-368 / 24-47
PF13177.5 DNA polymerase III, delta subunit 9E-06 345-367 / 21-43
PF13337.5 Putative ATP-dependent Lon protease 1E-05 343-367 / 206-230
PF00519.16 Papillomavirus helicase 1.3E-05 343-367 / 262-286
PF13173.5 AAA domain 1.7E-05 345-366 / 4-25
PF12775.6 P-loop containing dynein motor region D3 2E-05 345-368 / 35-58
PF00158.25 Sigma-54 interaction domain 3.1E-05 345-368 / 24-47
PF00004.28 ATPase family associated with various cellular activities (AAA) 3.1E-05 346-367 / 1-22
PF07726.10 ATPase family associated with various cellular activities (AAA) 3.1E-05 345-367 / 1-23
PF06068.12 TIP49 C-terminus 4E-05 307-368 / 22-75
PF13654.5 AAA domain 0.00094 310-369 / 3-50
PF05621.10 Bacterial TniB protein 4.2E-05 344-367 / 39-62
PF03969.15 AFG1-like ATPase 5.8E-05 342-368 / 66-92
PF07728.13 AAA domain (dynein-related subfamily) 7.5E-05 345-367 / 1-23
PF05272.10 Virulence-associated protein E 9.2E-05 342-367 / 58-83
PF12774.6 Hydrolytic ATP binding site of dynein motor region D1 9.4E-05 345-367 / 34-56
PF07693.13 KAP family P-loop domain 0.00013 344-368 / 32-56
PF05729.11 NACHT domain 0.00016 345-368 / 2-25
PF08298.10 PrkA AAA domain 0.00018 406-508 / 236-329
PF01637.17 ATPase domain predominantly from Archaea 0.00031 345-368 / 22-45
PF10443.8 RNA12 protein 0.00039 345-367 / 19-42
PF14532.5 Sigma-54 interaction domain 0.00039 345-431 / 23-91
PF12780.6 P-loop containing dynein motor region D4 0.00062 345-367 / 33-55
PF06144.12 DNA polymerase III, delta subunit 0.00065 346-368 / 1-23
PF02702.16 Osmosensitive K+ channel His kinase sensor domain 0.00083 345-368 / 6-29
PF07724.13 AAA domain (Cdc48 subfamily) 0.00088 345-367 / 5-27
PF05707.11 Zonular occludens toxin (Zot) 0.002 345-363 / 2-20
PF02283.15 Cobinamide kinase / cobinamide phosphate guanyltransferase 0.0022 346-366 / 1-21
PF01695.16 IstB-like ATP binding protein 0.0024 345-367 / 50-72
PF14516.5 AAA-like domain 0.0025 345-368 / 32-55
PF00910.21 RNA helicase 0.0035 346-367 / 1-22
PF07931.11 Chloramphenicol phosphotransferase-like protein 0.0038 345-367 / 3-25
PF00625.20 Guanylate kinase 0.0038 345-367 / 4-26
PF02319.19 E2F/DP family winged-helix DNA-binding domain 0.0059 660-700 / 25-65
PF06414.11 Zeta toxin 0.0059 343-367 / 14-38
PF13671.5 AAA domain 0.0063 346-367 / 2-23
PF03976.13 Polyphosphate kinase 2 (PPK2) 0.0067 345-368 / 30-53
PF13521.5 AAA domain 0.0067 346-367 / 2-23
PF10649.8 Protein of unknown function (DUF2478) 0.007 346-369 / 1-24
PF01745.15 Isopentenyl transferase 0.0073 345-367 / 3-25
PF13238.5 AAA domain 0.0073 346-367 / 1-22
PF04519.12 Polymer-forming cytoskeletal 0.0079 222-263 / 57-103
PF03266.14 NTPase 0.0076 346-367 / 2-23
PF13191.5 AAA ATPase domain 0.008 312-368 / 3-49

Annotations of the NCBI proteins of this PHROG


1:protein of an unannotated phage 1:predicted MCM2/3/5 family helicase 1:MCM DNA helicase 1:C-terminal part of the MCM2-like helicase

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K10726 mcm, cdc21 : replicative DNA helicase Mcm [EC:3.6.4.-] ko03030 DNA replication 379 5
K02212 MCM4, CDC54 : DNA replication licensing factor MCM4 [EC:3.6.4.12] ko03030 DNA replication
ko04110 Cell cycle
ko04111 Cell cycle - yeast
ko04113 Meiosis - yeast
361 2
K02541 MCM3 : DNA replication licensing factor MCM3 [EC:3.6.4.12] ko03030 DNA replication
ko04110 Cell cycle
ko04111 Cell cycle - yeast
ko04113 Meiosis - yeast
306 3

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003887 DNA-directed DNA polymerase activity
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides
GO:0000155 phosphorelay sensor kinase activity
GO:0005667 transcription factor complex
GO:0009058 biosynthetic process
GO:0003678 DNA helicase activity
GO:0006260 DNA replication
GO:0009360 DNA polymerase III complex
GO:0009378 four-way junction helicase activity
GO:0043752 adenosylcobinamide kinase activity
GO:0006310 DNA recombination
GO:0003677 DNA binding
GO:0003700 DNA binding transcription factor activity
GO:0004161 dimethylallyltranstransferase activity
GO:0004673 protein histidine kinase activity
GO:0016301 kinase activity
GO:0006281 DNA repair
GO:0016740 transferase activity
GO:0000166 nucleotide binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0003723 RNA binding
GO:0006355 regulation of transcription, DNA-templated
GO:0003724 RNA helicase activity
GO:0016020 membrane
GO:0051188 cofactor biosynthetic process
GO:0006270 DNA replication initiation
GO:0016887 ATPase activity
GO:0009236 cobalamin biosynthetic process
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0000160 phosphorelay signal transduction system

Loading in process