phrog_11145 is made of 9 protein sequences and is annotated as "DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
342.33 414 338


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p436892 no NCBI prot ID no annotation VI_06394 Gammaproteobacteria_gi_116177078_7188_17197 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; Inovirus.
p437864 no NCBI prot ID no annotation VI_08842 Gammaproteobacteria_gi_420719410 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; Inovirus.
p436905 no NCBI prot ID no annotation VI_08875 Gammaproteobacteria_gi_420768422_170_10179 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; Inovirus.
p436807 no NCBI prot ID no annotation VI_08862 Gammaproteobacteria_gi_420746582_19374_29392 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; Inovirus.
p25635 no NCBI prot ID no annotation VI_05410 Bacilli_gi_560294481 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
EU078592_p1 ACF32351.1 lactose operon repressor EU078592 Enterobacteria phage DE3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Lambdavirus; Escherichia virus DE3.
p6208 no NCBI prot ID no annotation VI_06632 Gammaproteobacteria_gi_260775639_290984_388801 Viruses.
p10672 no NCBI prot ID no annotation VI_04724 Bacilli_gi_418643491 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p32685 no NCBI prot ID no annotation VI_10942 Gammaproteobacteria_gi_487508586 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_33847 2 no annotation unknown function 1 2.47E-11 1.73

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1337 DNA binding protein DNA, RNA and nucleotide metabolism 95.1 0.0012 2-44 / 20-61
phrog_1373 transcriptional regulator transcription regulation 92.5 0.019 3-48 / 46-88
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 96.6 1.8E-05 2-40 / 24-62
phrog_1529 no annotation unknown function 94.9 0.0018 2-43 / 16-60
phrog_18104 transcriptional regulator transcription regulation 92.2 0.022 3-43 / 15-55
phrog_3642 HTH DNA binding protein DNA, RNA and nucleotide metabolism 94.3 0.004 3-39 / 22-58
phrog_3 transcriptional repressor transcription regulation 93.2 0.012 2-48 / 17-60
phrog_4441 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.9 0.0059 5-41 / 22-58
phrog_6223 transcriptional repressor transcription regulation 93.3 0.011 2-26 / 18-42
phrog_6831 transcriptional regulator transcription regulation 92.6 0.018 3-43 / 17-59
phrog_7126 HTH DNA binding protein DNA, RNA and nucleotide metabolism 94.6 0.0026 2-48 / 30-76
phrog_725 CII-like regulator transcription regulation 93.1 0.013 1-46 / 27-66
phrog_7401 no annotation unknown function 91.3 0.036 3-47 / 31-73
phrog_8 transcriptional regulator transcription regulation 91.4 0.035 2-47 / 15-55

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF04392.11 ABC transporter substrate binding protein 3.8E-17 94-385 / 1-291
PF13407.5 Periplasmic binding protein domain 1.3E-16 95-343 / 1-258
PF02608.13 ABC transporter substrate-binding protein PnrA-like 1.8E-14 93-338 / 2-255
PF12683.6 Protein of unknown function (DUF3798) 1.8E-13 93-343 / 1-273
PF00532.20 Periplasmic binding proteins and sugar binding domain of LacI family 2.7E-13 93-346 / 2-269
PF13458.5 Periplasmic binding protein 4.5E-11 92-241 / 1-156
PF13433.5 Periplasmic binding protein domain 9.5E-11 93-306 / 1-233
PF04348.12 LppC putative lipoprotein 7.1E-09 89-241 / 215-370
PF13377.5 Periplasmic binding protein-like domain 2.4E-07 206-345 / 6-156
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 3.2E-07 18-75 / 7-63
PF01094.27 Receptor family ligand binding region 5.7E-06 123-241 / 25-147
PF01381.21 Helix-turn-helix 1.3E-05 28-75 / 3-50
PF13413.5 Helix-turn-helix domain 1.5E-05 27-74 / 2-55
PF04645.11 Protein of unknown function, DUF603 1.8E-05 20-71 / 6-60
PF13744.5 Helix-turn-helix domain 1.8E-05 19-75 / 16-73
PF05339.10 Protein of unknown function (DUF739) 2.4E-05 24-75 / 6-57
PF08965.9 Domain of unknown function (DUF1870) 2.8E-05 23-78 / 3-60
PF14590.5 Domain of unknown function (DUF4447) 2.8E-05 21-62 / 7-48
PF13560.5 Helix-turn-helix domain 4.9E-05 23-75 / 3-56
PF13443.5 Cro/C1-type HTH DNA-binding domain 5.5E-05 26-75 / 2-54
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 6E-05 26-75 / 3-52
PF12844.6 Helix-turn-helix domain 8.5E-05 26-74 / 4-52
PF00356.20 Bacterial regulatory proteins, lacI family 0.00017 36-76 / 1-41
PF04814.12 Hepatocyte nuclear factor 1 (HNF-1), N terminus 0.00018 23-74 / 115-166
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 0.00026 28-75 / 3-49
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 0.00033 22-74 / 70-121
PF00157.16 Pou domain - N-terminal to homeobox domain 0.00034 21-74 / 7-64
PF08667.9 BetR domain 0.00044 21-75 / 5-63
PF12116.7 Stage III sporulation protein D 0.00049 30-75 / 15-61
PF10654.8 Protein of unknown function (DUF2481) 0.00053 30-58 / 76-104
PF14549.5 DNA-binding transcriptional regulator Cro 0.00058 27-75 / 3-47
PF05269.10 Bacteriophage CII protein 0.00063 27-74 / 16-61
PF13693.5 Winged helix-turn-helix DNA-binding 0.0022 25-74 / 6-52

Annotations of the NCBI proteins of this PHROG


1:lactose operon repressor

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K02529 lacI, galR : LacI family transcriptional regulator no pathways 668 5
K03435 fruR1, fruR : LacI family transcriptional regulator, fructose operon transcriptional repressor no pathways 448 1
K03484 scrR : LacI family transcriptional regulator, sucrose operon repressor no pathways 404 1

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0043565 sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 DNA binding transcription factor activity
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

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