phrog_12375 is made of 8 protein sequences and is annotated as "DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
111.88 168 113


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p406701 no NCBI prot ID no annotation VI_06565 Gammaproteobacteria_gi_538038770 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Baylorvirus; Mannheimia virus PHL101; Mannheimia phage vB_MhM_1152AP.
p406676 no NCBI prot ID no annotation VI_10198 Gammaproteobacteria_gi_544677275_2739_16098 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Baylorvirus; Mannheimia virus PHL101; Mannheimia phage vB_MhM_1152AP.
p257086 no NCBI prot ID no annotation VI_10204 Gammaproteobacteria_gi_544682955 Viruses.
p378092 no NCBI prot ID no annotation VI_09900 Gammaproteobacteria_gi_498485000_0_16480 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p297319 no NCBI prot ID no annotation VI_09928 Gammaproteobacteria_gi_554922084 Viruses; unclassified bacterial viruses; Phage Gifsy-1.
p387772 no NCBI prot ID no annotation VI_06431 Gammaproteobacteria_gi_149110192 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
KF114877_p3 AGS80568.1 DNA-binding helix-turn-helix protein KF114877 Leptospira phage vB_LnoZ_CZ214-LE1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
p212637 no NCBI prot ID no annotation VI_05731 Betaproteobacteria_gi_565867306 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_956 154 transposase integration and excision 5 3.90E-20 10.53
phrog_14025 7 no annotation unknown function 4 5.49E-24 14.38
phrog_31160 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10408 no annotation unknown function 94.3 0.0041 15-42 / 14-41
phrog_10624 no annotation unknown function 90.7 0.048 22-84 / 26-86
phrog_12527 excisionase integration and excision 92.3 0.022 17-44 / 24-51
phrog_14982 no annotation unknown function 90.0 0.065 24-42 / 31-49
phrog_151 transposase integration and excision 93.4 0.0098 15-51 / 15-52
phrog_157 transposase integration and excision 96.8 9E-06 28-91 / 1-50
phrog_268 no annotation unknown function 94.1 0.0049 18-46 / 12-40
phrog_309 terminase small subunit head and packaging 92.4 0.02 27-83 / 29-77
phrog_310 transposase integration and excision 90.9 0.044 28-63 / 142-177
phrog_37741 no annotation unknown function 92.9 0.014 20-46 / 29-55
phrog_4044 terminase small subunit head and packaging 91.8 0.029 16-45 / 24-53
phrog_409 transcriptional regulator transcription regulation 94.4 0.0036 18-44 / 6-32
phrog_4494 no annotation unknown function 91.9 0.026 15-91 / 10-79
phrog_668 HTH DNA binding protein DNA, RNA and nucleotide metabolism 91.5 0.034 23-40 / 37-54
phrog_66 excisionase and transcriptional regulator integration and excision 94.9 0.0017 21-43 / 8-30
phrog_8463 transposase integration and excision 94.5 0.0029 21-89 / 24-92

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF00292.17 'Paired box' domain 1.3E-09 19-124 / 17-124
PF08822.10 Protein of unknown function (DUF1804) 6.1E-09 23-133 / 6-110
PF04552.12 Sigma-54, DNA binding domain 1.2E-08 32-132 / 45-154
PF01710.15 Transposase 2E-08 23-133 / 6-100
PF04936.11 Protein of unknown function (DUF658) 0.0085 34-60 / 87-113
PF13011.5 leucine-zipper of insertion element IS481 7.4E-07 23-64 / 11-53
PF07141.10 Putative bacteriophage terminase small subunit 1E-05 25-61 / 21-57
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 1.2E-05 26-63 / 4-41
PF15978.4 Tn7-like transposition protein D 1.8E-05 26-63 / 193-231
PF12759.6 InsA C-terminal domain 2.6E-05 25-59 / 11-45
PF09607.9 Brinker DNA-binding domain 2.6E-05 23-61 / 9-51
PF05344.10 Domain of Unknown Function (DUF746) 2.9E-05 32-62 / 9-39
PF07750.10 GcrA cell cycle regulator 2.9E-05 24-61 / 7-45
PF06627.10 Protein of unknown function (DUF1153) 3.1E-05 23-66 / 33-77
PF13518.5 Helix-turn-helix domain 5.4E-05 27-64 / 4-40
PF16087.4 Domain of unknown function (DUF4817) 8.9E-05 24-63 / 4-52
PF10668.8 Phage terminase small subunit 0.00013 24-63 / 8-50
PF14493.5 Helix-turn-helix domain 0.00013 29-63 / 6-40
PF13542.5 Helix-turn-helix domain of transposase family ISL3 0.00014 25-59 / 17-50
PF08765.10 Mor transcription activator family 0.0002 28-60 / 66-97
PF06322.10 Phage NinH protein 0.00027 34-61 / 15-42
PF13309.5 HTH domain 0.00027 36-57 / 42-63
PF02796.14 Helix-turn-helix domain of resolvase 0.00029 31-58 / 17-44
PF13551.5 Winged helix-turn helix 0.0003 31-64 / 7-40
PF04218.12 CENP-B N-terminal DNA-binding domain 0.00039 36-60 / 24-48
PF11427.7 Tc3 transposase 0.0004 30-61 / 15-46
PF13936.5 Helix-turn-helix domain 0.00042 28-58 / 13-43
PF10654.8 Protein of unknown function (DUF2481) 0.00042 32-58 / 77-103
PF03333.12 Adhesin biosynthesis transcription regulatory protein 0.00054 23-60 / 43-80
PF01527.19 Transposase 0.00066 26-60 / 11-46
PF16677.4 DNA-packaging protein gp3 0.0007 34-59 / 28-53
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 0.00082 33-60 / 17-44
PF01371.18 Trp repressor protein 0.00081 25-60 / 38-73
PF02954.18 Bacterial regulatory protein, Fis family 0.00088 34-58 / 15-39
PF17443.1 Uncharacterized protein pXO2-72 0.00089 35-58 / 8-31
PF13411.5 MerR HTH family regulatory protein 0.0011 37-60 / 2-25
PF13384.5 Homeodomain-like domain 0.0013 28-59 / 10-41
PF11242.7 Protein of unknown function (DUF2774) 0.0013 29-61 / 8-40
PF07453.12 NUMOD1 domain 0.0014 36-56 / 20-40
PF13412.5 Winged helix-turn-helix DNA-binding 0.0015 35-62 / 17-44
PF12824.6 Mitochondrial ribosomal protein subunit L20 0.0017 21-58 / 90-130
PF05331.10 Protein of unknown function (DUF742) 0.0018 23-63 / 42-81
PF06806.11 Putative excisionase (DUF1233) 0.0018 36-57 / 10-31
PF11112.7 Pyocin activator protein PrtN 0.0019 35-59 / 13-38
PF01381.21 Helix-turn-helix 0.002 33-58 / 7-32
PF00356.20 Bacterial regulatory proteins, lacI family 0.002 38-58 / 2-22
PF05225.15 helix-turn-helix, Psq domain 0.002 34-59 / 15-41
PF00376.22 MerR family regulatory protein 0.0022 38-58 / 2-22
PF07638.10 ECF sigma factor 0.0024 22-59 / 136-173
PF08535.9 KorB domain 0.0024 35-62 / 3-30
PF13022.5 Helix-turn-helix of insertion element transposase 0.0024 36-57 / 26-47
PF13556.5 PucR C-terminal helix-turn-helix domain 0.0025 34-61 / 11-38
PF09039.10 Mu DNA binding, I gamma subdomain 0.0032 114-131 / 67-84
PF05930.11 Prophage CP4-57 regulatory protein (AlpA) 0.0034 36-57 / 4-25
PF13591.5 MerR HTH family regulatory protein 0.0036 37-58 / 2-23
PF00126.26 Bacterial regulatory helix-turn-helix protein, lysR family 0.0038 33-62 / 9-38
PF07825.10 Excisionase-like protein 0.004 36-59 / 3-28
PF13404.5 AsnC-type helix-turn-helix domain 0.0047 34-59 / 16-41
PF06530.11 Phage antitermination protein Q 0.0048 23-59 / 67-103
PF02042.14 RWP-RK domain 0.0053 34-60 / 11-37
PF10975.7 Protein of unknown function (DUF2802) 0.0052 21-56 / 29-64
PF10743.8 Regulatory phage protein cox 0.0055 34-59 / 10-35
PF07278.10 Protein of unknown function (DUF1441) 0.0055 36-59 / 2-25
PF08281.11 Sigma-70, region 4 0.0059 32-59 / 23-50
PF16509.4 TrfB plasmid transcriptional repressor 0.0058 29-61 / 25-57
PF09035.9 Excisionase from transposon Tn916 0.0058 35-57 / 15-37
PF02319.19 E2F/DP family winged-helix DNA-binding domain 0.0062 34-63 / 22-51
PF00325.19 Bacterial regulatory proteins, crp family 0.0067 37-60 / 4-27
PF13413.5 Helix-turn-helix domain 0.0071 33-58 / 7-32
PF12728.6 Helix-turn-helix domain 0.0087 37-58 / 3-25
PF07037.10 Putative transcription regulator (DUF1323) 0.0095 37-58 / 2-23

Annotations of the NCBI proteins of this PHROG


1:DNA-binding helix-turn-helix protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0006352 DNA-templated transcription, initiation
GO:0005622 intracellular
GO:0006355 regulation of transcription, DNA-templated
GO:0016987 sigma factor activity
GO:0005667 transcription factor complex
GO:0019069 viral capsid assembly
GO:0060567 negative regulation of DNA-templated transcription, termination
GO:0003700 DNA binding transcription factor activity
GO:0005524 ATP binding
GO:0000150 recombinase activity
GO:0006313 transposition, DNA-mediated
GO:0043565 sequence-specific DNA binding
GO:0004803 transposase activity
GO:0006310 DNA recombination
GO:0003677 DNA binding

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