phrog_14639 is made of 7 protein sequences and is annotated as "cro-like repressor"
Functional category: transcription regulation


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
94.86 116 90


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_005345_p3 NP_958244.1 hypothetical protein NC_005345 Streptomyces phage VWB Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p393836 no NCBI prot ID no annotation VI_04088 Actinobacteria_gi_317512558 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_007967_p8 YP_579180.1 hypothetical protein NC_007967 Streptomyces phage mu1/6 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
KY130461_p38 APD19268.1 helix-turn-helix DNA binding domain protein KY130461 Mycobacterium phage Taptic Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MH001446_p38 AVO21348.1 helix-turn-helix DNA binding domain protein MH001446 Mycobacterium phage Megabear Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
AP018462_p37 BBC28562.1 putative helix-turn-helix DNA binding domain protein AP018462 Mycobacterium phage D12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MH001450_p38 AVO21741.1 helix-turn-helix DNA binding domain protein MH001450 Mycobacterium phage Jeon Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_21783 4 no annotation unknown function 4 0 1000
phrog_526 259 holin lysis 4 8.76E-16 6.18

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1373 transcriptional regulator transcription regulation 95.1 0.0013 8-70 / 33-92
phrog_3949 transcriptional repressor transcription regulation 92.2 0.022 22-76 / 31-81
phrog_3 transcriptional repressor transcription regulation 95.6 0.00047 8-71 / 5-65
phrog_5823 transcriptional regulator transcription regulation 96.0 0.00018 7-80 / 5-76
phrog_7241 transcriptional regulator transcription regulation 92.7 0.016 8-69 / 63-121
phrog_769 transcriptional repressor transcription regulation 95.1 0.0013 7-76 / 13-76
phrog_8 transcriptional regulator transcription regulation 95.1 0.0012 8-73 / 3-63

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 5.6E-10 17-99 / 5-81
PF13744.5 Helix-turn-helix domain 3.6E-08 18-94 / 14-79
PF14590.5 Domain of unknown function (DUF4447) 4E-07 23-96 / 8-72
PF01381.21 Helix-turn-helix 4.2E-07 29-93 / 3-55
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 4.5E-07 28-97 / 4-61
PF05339.10 Protein of unknown function (DUF739) 7.8E-07 25-95 / 6-64
PF13443.5 Cro/C1-type HTH DNA-binding domain 8.8E-07 29-96 / 4-62
PF13413.5 Helix-turn-helix domain 1E-06 29-91 / 3-59
PF12844.6 Helix-turn-helix domain 1.1E-06 27-96 / 4-61
PF04645.11 Protein of unknown function, DUF603 2.5E-06 20-95 / 5-68
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 3.4E-06 23-95 / 70-129
PF08667.9 BetR domain 3.5E-06 23-97 / 6-72
PF05269.10 Bacteriophage CII protein 4.9E-06 28-100 / 16-74
PF13560.5 Helix-turn-helix domain 6.6E-06 24-93 / 3-63
PF08965.9 Domain of unknown function (DUF1870) 2.6E-05 24-97 / 3-69
PF13693.5 Winged helix-turn-helix DNA-binding 5.1E-05 26-96 / 6-61
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 0.00017 31-96 / 5-57
PF12116.7 Stage III sporulation protein D 0.00049 34-90 / 18-63
PF00157.16 Pou domain - N-terminal to homeobox domain 0.00066 22-87 / 7-64
PF04814.12 Hepatocyte nuclear factor 1 (HNF-1), N terminus 0.00068 25-86 / 116-165
PF02376.14 CUT domain 0.00088 23-98 / 8-70
PF10654.8 Protein of unknown function (DUF2481) 0.005 32-69 / 77-105

Annotations of the NCBI proteins of this PHROG


4:helix-turn-helix DNA binding domain protein 2:hypothetical protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0045893 positive regulation of transcription, DNA-templated
GO:0003700 DNA binding transcription factor activity
GO:0006355 regulation of transcription, DNA-templated
GO:0005634 nucleus
GO:0043565 sequence-specific DNA binding
GO:0003677 DNA binding
GO:0045892 negative regulation of transcription, DNA-templated

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