phrog_16259 is made of 6 protein sequences and is annotated as "DNA helicase"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
311.17 352 331


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_026607_p174 YP_009126381.2 ATP-dependent DNA helicase NC_026607 Salmonella phage STP4-a Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Gelderlandvirus; Salmonella virus STP4a.
NC_020416_p177 YP_007501216.1 ATP-dependent DNA helicase NC_020416 Salmonella phage vB_SenMS16 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Gelderlandvirus.
MF001355_p166 ASZ76452.1 DNA helicase MF001355 Proteus phage PM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; unclassified Tevenvirinae.
NC_015280_p126 YP_004322551.1 RNA-DNA + DNA-DNA helicase NC_015280 Prochlorococcus phage P-HM1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Eurybiavirus; unclassified Eurybiavirus.
KJ019130_p106 AIX38538.1 RNA-DNA + DNA-DNA helicase KJ019130 Synechococcus phage ACG-2014d Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_023719_p213 YP_009015524.1 gp221 NC_023719 Bacillus virus G Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_22417 3 no annotation unknown function 3 0 1000
phrog_9690 11 DNA helicase DNA, RNA and nucleotide metabolism 2 2.24E-13 3.77

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10417 helicase DNA, RNA and nucleotide metabolism 90.0 0.063 131-273 / 306-430
phrog_13169 DNA polymerase DNA, RNA and nucleotide metabolism 95.4 0.00073 236-322 / 388-459
phrog_14619 DNA helicase DNA, RNA and nucleotide metabolism 98.2 1.1E-09 34-143 / 38-149
phrog_15127 head protein head and packaging 96.1 0.00011 244-322 / 213-291
phrog_16694 no annotation unknown function 97.9 1.9E-08 112-235 / 272-415
phrog_1685 no annotation unknown function 92.2 0.022 111-182 / 830-902
phrog_16 DNA helicase DNA, RNA and nucleotide metabolism 99.8 3.4E-23 112-265 / 1-142
phrog_170 PhoH-like phosphate starvation-inducible other 90.5 0.053 109-238 / 27-178
phrog_1815 guanylate kinase other 90.7 0.048 132-155 / 6-29
phrog_197 Zot-like toxin moron, auxiliary metabolic gene and host takeover 90.8 0.047 132-233 / 5-92
phrog_21587 no annotation unknown function 93.8 0.0069 227-322 / 29-124
phrog_2392 ABC transporter moron, auxiliary metabolic gene and host takeover 95.3 0.00088 128-161 / 369-402
phrog_2467 no annotation unknown function 93.4 0.01 131-231 / 4-110
phrog_2488 DNA helicase DNA, RNA and nucleotide metabolism 98.1 2.7E-09 114-238 / 36-209
phrog_25411 no annotation unknown function 93.0 0.014 117-230 / 218-363
phrog_26785 no annotation unknown function 96.2 9E-05 110-235 / 246-372
phrog_27849 no annotation unknown function 92.1 0.024 121-179 / 27-80
phrog_2 terminase large subunit head and packaging 93.7 0.0075 110-173 / 5-65
phrog_31517 no annotation unknown function 93.3 0.011 112-232 / 301-444
phrog_325 Dda-like helicase DNA, RNA and nucleotide metabolism 95.6 0.00049 113-238 / 5-127
phrog_3830 no annotation unknown function 97.2 1.3E-06 109-259 / 267-441
phrog_4339 no annotation unknown function 92.6 0.018 132-180 / 54-107
phrog_4412 exonuclease V DNA, RNA and nucleotide metabolism 93.9 0.0062 109-235 / 345-450
phrog_50 DnaC-like helicase loader DNA, RNA and nucleotide metabolism 94.4 0.0033 131-264 / 114-221
phrog_62 DNA helicase DNA, RNA and nucleotide metabolism 98.4 2.3E-10 110-255 / 2-159
phrog_6819 Holliday junction branch migration helicase DNA, RNA and nucleotide metabolism 98.0 7.9E-09 112-232 / 19-146
phrog_7485 no annotation unknown function 91.4 0.035 114-172 / 216-264
phrog_9690 DNA helicase DNA, RNA and nucleotide metabolism 98.2 1.2E-09 185-305 / 4-116

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF13086.5 AAA domain 1.8E-08 119-179 / 2-65
PF02562.15 PhoH-like protein 5.4E-08 117-173 / 3-61
PF14890.5 Intein splicing domain 2.6E-07 261-335 / 41-119
PF05970.13 PIF1-like helicase 2.8E-07 119-177 / 2-66
PF04851.14 Type III restriction enzyme, res subunit 4.8E-07 118-172 / 3-62
PF08517.11 Ataxin-1 and HBP1 module (AXH) 1.8E-06 254-332 / 20-114
PF01079.19 Hint module 2.3E-06 253-330 / 31-113
PF07652.13 Flavivirus DEAD domain 4.9E-06 133-178 / 4-50
PF00580.20 UvrD/REP helicase N-terminal domain 5.6E-06 119-177 / 1-61
PF13604.5 AAA domain 9.4E-06 119-153 / 2-36
PF00270.28 DEAD/DEAH box helicase 1.1E-05 121-177 / 2-61
PF06862.11 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 1.9E-05 120-154 / 1-44
PF07517.13 SecA DEAD-like domain 2.3E-05 117-179 / 89-149
PF13872.5 P-loop containing NTP hydrolase pore-1 2.7E-05 117-170 / 34-99
PF13245.5 AAA domain 2.8E-05 125-172 / 3-50
PF09848.8 Uncharacterized conserved protein (DUF2075) 3.6E-05 134-175 / 2-44
PF05127.13 Helicase 7E-05 137-246 / 1-93
PF02399.14 Origin of replication binding protein 0.00018 133-182 / 49-99
PF04466.12 Phage terminase large subunit 0.00021 135-250 / 3-125
PF00176.22 SNF2 family N-terminal domain 0.00067 134-155 / 18-39
PF14617.5 U3-containing 90S pre-ribosomal complex subunit 0.00069 118-181 / 64-138
PF13403.5 Hint domain 0.00075 289-329 / 57-113
PF07591.10 Pretoxin HINT domain 0.00099 254-332 / 14-87
PF03354.14 Phage Terminase 0.0011 134-249 / 24-144
PF01078.20 Magnesium chelatase, subunit ChlI 0.0014 132-157 / 21-46
PF05876.11 Phage terminase large subunit (GpA) 0.003 116-178 / 21-86
PF00158.25 Sigma-54 interaction domain 0.0052 133-157 / 22-46
PF14623.5 Hint-domain 0.0058 253-329 / 22-86
PF05203.15 Hom_end-associated Hint 0.0063 253-326 / 20-110
PF05707.11 Zonular occludens toxin (Zot) 0.0072 136-153 / 3-20

Annotations of the NCBI proteins of this PHROG


2:RNA-DNA + DNA-DNA helicase 2:ATP-dependent DNA helicase 1:hypothetical protein 1:DNA helicase

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K17677 IRC3 : ATP-dependent helicase IRC3 [EC:3.6.4.-] no pathways 58 2

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003678 DNA helicase activity
GO:0006260 DNA replication
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0003688 DNA replication origin binding
GO:0000723 telomere maintenance
GO:0005515 protein binding
GO:0008026 ATP-dependent helicase activity
GO:0003677 DNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0006355 regulation of transcription, DNA-templated
GO:0030908 protein splicing
GO:0006281 DNA repair
GO:0008134 transcription factor binding
GO:0005634 nucleus
GO:0005524 ATP binding
GO:0017038 protein import
GO:0016020 membrane
GO:0006508 proteolysis

Loading in process