phrog_16826 is made of 5 protein sequences and is annotated as "DnaD-like helicase loader"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
332.8 382 341


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KC595514_p77 AGR47210.1 putative prophage replication protein O KC595514 Brevibacillus phage Jimmer2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Jimmervirus; Brevibacillus virus Jimmer.
NC_029104_p77 YP_009226387.1 putative prophage replication protein O NC_029104 Brevibacillus phage Jimmer1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Jimmervirus; unclassified Jimmervirus.
MF595878_p21 ATB52708.1 replication protein O MF595878 Caldibacillus phage CBP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_023612_p45 YP_009010516.1 primase NC_023612 Geobacillus phage GBK2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p58216 no NCBI prot ID no annotation VI_04914 Bacilli_gi_485054371 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_7370 16 HNH endonuclease DNA, RNA and nucleotide metabolism 2 5.53E-13 3.38
phrog_35343 2 no annotation unknown function 1 1.11E-10 1.08

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_186 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 91.1 0.041 217-307 / 154-227
phrog_2365 replication initiation O-like DNA, RNA and nucleotide metabolism 99.2 2.3E-15 6-133 / 23-146
phrog_277 replication initiation O-like DNA, RNA and nucleotide metabolism 99.5 1.2E-17 6-110 / 24-126
phrog_345 replication initiation O-like DNA, RNA and nucleotide metabolism 92.0 0.026 6-86 / 23-108
phrog_5810 replication initiation protein DNA, RNA and nucleotide metabolism 92.6 0.018 7-89 / 9-91
phrog_678 replication initiation O-like DNA, RNA and nucleotide metabolism 98.3 5.5E-10 7-86 / 4-82
phrog_7498 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 99.2 5.5E-15 217-307 / 153-243

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF04492.12 Bacteriophage replication protein O 1.4E-08 8-88 / 4-84
PF16221.4 winged helix-turn-helix 1.1E-05 32-85 / 32-78
PF04358.12 DsrC like protein 1.9E-05 26-87 / 34-95
PF06970.10 Replication initiator protein A (RepA) N-terminus 4.8E-05 13-77 / 2-75
PF08221.10 RNA polymerase III subunit RPC82 helix-turn-helix domain 5.5E-05 29-87 / 11-61
PF10007.8 Uncharacterized protein conserved in archaea (DUF2250) 7E-05 29-87 / 6-56
PF07261.10 Replication initiation and membrane attachment 7.4E-05 239-307 / 9-66
PF09114.9 Transcription factor MotA, activation domain 8.6E-05 27-87 / 12-65
PF02319.19 E2F/DP family winged-helix DNA-binding domain 9.3E-05 53-87 / 23-57
PF08784.10 Replication protein A C terminal 0.00011 28-87 / 37-95
PF05584.10 Sulfolobus plasmid regulatory protein 0.00012 28-87 / 3-52
PF04079.15 Segregation and condensation complex subunit ScpB 0.00014 27-88 / 79-129
PF05732.10 Firmicute plasmid replication protein (RepL) 0.00015 27-88 / 50-110
PF01726.15 LexA DNA binding domain 0.0002 54-87 / 26-60
PF01090.18 Ribosomal protein S19e 0.0002 54-88 / 66-115
PF09012.9 FeoC like transcriptional regulator 0.00022 54-89 / 15-50
PF03965.15 Penicillinase repressor 0.00025 30-88 / 2-58
PF03428.12 Replication protein C N-terminal domain 0.00027 19-88 / 31-106
PF07381.10 Winged helix DNA-binding domain (DUF1495) 0.00034 29-87 / 7-68
PF14557.5 Putative AphA-like transcriptional regulator 0.00037 27-88 / 4-68
PF02295.16 Adenosine deaminase z-alpha domain 0.00038 54-87 / 19-53
PF01978.18 Sugar-specific transcriptional regulator TrmB 0.00043 28-87 / 5-56
PF02002.16 TFIIE alpha subunit 0.00046 32-88 / 13-61
PF13463.5 Winged helix DNA-binding domain 0.00057 54-87 / 18-51
PF06163.10 Bacterial protein of unknown function (DUF977) 0.00064 54-88 / 27-61
PF04182.11 B-block binding subunit of TFIIIC 0.00067 54-88 / 19-53
PF01475.18 Ferric uptake regulator family 0.00067 28-88 / 4-62
PF11313.7 Protein of unknown function (DUF3116) 0.00068 54-88 / 21-62
PF03551.13 Transcriptional regulator PadR-like family 0.00081 54-88 / 15-51
PF08222.10 CodY helix-turn-helix domain 0.00082 54-87 / 5-38
PF13601.5 Winged helix DNA-binding domain 0.00083 54-87 / 15-48
PF01047.21 MarR family 0.00085 54-87 / 18-51
PF05158.11 RNA polymerase Rpc34 subunit 0.00086 27-88 / 88-143
PF14394.5 Domain of unknown function (DUF4423) 0.00095 54-88 / 37-73
PF13730.5 Helix-turn-helix domain 0.001 29-83 / 3-52
PF14277.5 Domain of unknown function (DUF4364) 0.001 53-87 / 15-53
PF12802.6 MarR family 0.0012 54-87 / 22-55
PF12840.6 Helix-turn-helix domain 0.0012 30-87 / 7-54
PF09202.10 Rio2, N-terminal 0.0014 29-87 / 4-58
PF05491.12 Holliday junction DNA helicase ruvB C-terminus 0.0014 28-87 / 5-60
PF13412.5 Winged helix-turn-helix DNA-binding 0.0014 54-83 / 18-47
PF09639.9 YjcQ protein 0.0015 54-87 / 17-52
PF01022.19 Bacterial regulatory protein, arsR family 0.0016 54-83 / 17-46
PF14947.5 Winged helix-turn-helix 0.0017 54-87 / 17-50
PF03444.14 Winged helix-turn-helix transcription repressor, HrcA DNA-binding 0.0019 54-87 / 25-58
PF12793.6 Sugar transport-related sRNA regulator N-term 0.002 54-87 / 19-52
PF09904.8 Winged helix-turn helix 0.002 54-86 / 22-54
PF15977.4 Winged helix-turn-helix DNA binding 0.0026 53-87 / 23-57
PF02334.15 Replication terminator protein 0.0028 54-88 / 32-75
PF10771.8 Winged helix-turn-helix domain (DUF2582) 0.0029 29-89 / 6-58
PF07106.12 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) 0.003 54-89 / 17-54
PF05331.10 Protein of unknown function (DUF742) 0.0031 28-87 / 38-87
PF09339.9 IclR helix-turn-helix domain 0.0035 54-86 / 19-51
PF01638.16 HxlR-like helix-turn-helix 0.0038 54-88 / 20-55
PF16365.4 Ethanolamine utilization protein EutK C-terminus 0.0039 54-86 / 18-50
PF06969.15 HemN C-terminal domain 0.0039 54-86 / 21-54
PF14502.5 Helix-turn-helix domain 0.0039 53-87 / 6-40
PF10711.8 Hypothetical protein (DUF2513) 0.0039 54-88 / 19-57
PF09824.8 ArsR transcriptional regulator 0.0045 31-86 / 17-61
PF01418.16 Helix-turn-helix domain, rpiR family 0.0052 28-87 / 13-68
PF13034.5 Protein of unknown function (DUF3895) 0.0053 54-88 / 20-68
PF01325.18 Iron dependent repressor, N-terminal DNA binding domain 0.0055 54-87 / 22-55
PF08220.11 DeoR-like helix-turn-helix domain 0.0059 54-87 / 15-48
PF00392.20 Bacterial regulatory proteins, gntR family 0.0066 54-87 / 24-58
PF09182.9 Bacterial purine repressor, N-terminal 0.007 54-87 / 21-59
PF02082.19 Transcriptional regulator 0.0071 54-86 / 25-57
PF07848.11 PaaX-like protein 0.0072 54-87 / 21-57
PF13545.5 Crp-like helix-turn-helix domain 0.0072 54-86 / 28-60
PF16864.4 Dimerisation domain 0.0084 54-86 / 33-65
PF04703.11 FaeA-like protein 0.0088 54-87 / 15-48

Annotations of the NCBI proteins of this PHROG


2:prophage replication protein O 1:replication protein O 1:primase

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0005667 transcription factor complex
GO:0045892 negative regulation of transcription, DNA-templated
GO:0007131 reciprocal meiotic recombination
GO:0009378 four-way junction helicase activity
GO:0005622 intracellular
GO:0009289 pilus
GO:0006260 DNA replication
GO:0006383 transcription by RNA polymerase III
GO:0004674 protein serine/threonine kinase activity
GO:0006468 protein phosphorylation
GO:0003726 double-stranded RNA adenosine deaminase activity
GO:0006310 DNA recombination
GO:0003677 DNA binding
GO:0005840 ribosome
GO:0006274 DNA replication termination
GO:0003700 DNA binding transcription factor activity
GO:0004252 serine-type endopeptidase activity
GO:0006281 DNA repair
GO:0006355 regulation of transcription, DNA-templated
GO:0051304 chromosome separation
GO:0006412 translation
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0006508 proteolysis
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005524 ATP binding
GO:0006276 plasmid maintenance

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