phrog_19658 is made of 4 protein sequences and is annotated as "replication initiation protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
268.25 320 300


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KU517658_p15 AMB17427.1 putative replisome organizer KU517658 Clostridium phage HM T Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
p139889 no NCBI prot ID no annotation VI_01356 Fusobacteriia_gi_545623867 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p290269 no NCBI prot ID no annotation VI_01155 Clostridia_gi_490539173 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
KP836356_p17 AJW76972.2 hypothetical protein KP836356 Marinitoga camini virus 2 (MCV2) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_33292 2 no annotation unknown function 1 6.91E-11 1.28
phrog_32487 2 no annotation unknown function 1 6.91E-11 1.28
phrog_35185 2 no annotation unknown function 1 6.91E-11 1.28

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10469 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 99.9 2.2E-33 20-266 / 33-303
phrog_10724 no annotation unknown function 90.4 0.056 43-76 / 35-68
phrog_1163 no annotation unknown function 94.6 0.0027 12-207 / 20-225
phrog_15053 no annotation unknown function 94.3 0.0039 8-79 / 23-95
phrog_151 transposase integration and excision 90.4 0.055 25-68 / 7-52
phrog_16167 replication initiation protein DNA, RNA and nucleotide metabolism 91.5 0.034 8-214 / 9-243
phrog_186 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 98.1 3.1E-09 2-77 / 5-88
phrog_21472 no annotation unknown function 98.2 1.2E-09 139-236 / 164-274
phrog_22134 no annotation unknown function 94.4 0.0033 11-70 / 6-62
phrog_22470 replication protein DNA, RNA and nucleotide metabolism 99.4 1.5E-16 150-237 / 243-339
phrog_22671 replication protein DNA, RNA and nucleotide metabolism 90.2 0.06 16-73 / 51-115
phrog_23776 no annotation unknown function 95.3 0.00083 1-86 / 1-91
phrog_24933 no annotation unknown function 97.1 1.9E-06 145-238 / 14-126
phrog_25487 replication protein DNA, RNA and nucleotide metabolism 94.0 0.0054 16-83 / 13-95
phrog_270 replication initiation protein DNA, RNA and nucleotide metabolism 98.6 4.4E-11 2-77 / 3-76
phrog_2880 replication initiation protein DNA, RNA and nucleotide metabolism 96.7 1.4E-05 15-87 / 19-98
phrog_345 replication initiation O-like DNA, RNA and nucleotide metabolism 99.9 2.5E-27 18-241 / 47-277
phrog_36008 no annotation unknown function 90.7 0.05 6-88 / 28-110
phrog_391 replication initiation O-like DNA, RNA and nucleotide metabolism 93.1 0.013 15-80 / 16-81
phrog_428 replication initiation protein DNA, RNA and nucleotide metabolism 98.9 1.1E-12 2-200 / 11-206
phrog_4617 replication initiation protein DNA, RNA and nucleotide metabolism 94.2 0.0044 16-70 / 12-69
phrog_534 DNA binding protein DNA, RNA and nucleotide metabolism 90.6 0.05 38-83 / 24-75
phrog_5810 replication initiation protein DNA, RNA and nucleotide metabolism 99.8 2.1E-24 24-236 / 33-275
phrog_678 replication initiation O-like DNA, RNA and nucleotide metabolism 96.7 1.4E-05 15-92 / 21-103
phrog_7498 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 94.0 0.0055 16-72 / 19-89
phrog_7882 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 98.9 1.1E-12 4-242 / 22-288
phrog_8102 replication initiation protein DNA, RNA and nucleotide metabolism 93.0 0.013 14-88 / 18-93
phrog_9773 replication initiation O-like DNA, RNA and nucleotide metabolism 96.9 6.7E-06 19-235 / 28-275

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF06970.10 Replication initiator protein A (RepA) N-terminus 2.9E-07 18-66 / 16-75
PF04492.12 Bacteriophage replication protein O 1E-05 19-76 / 24-83
PF05584.10 Sulfolobus plasmid regulatory protein 1.6E-05 20-77 / 4-53
PF01726.15 LexA DNA binding domain 3.7E-05 21-76 / 5-60
PF02319.19 E2F/DP family winged-helix DNA-binding domain 4.1E-05 43-75 / 24-56
PF04079.15 Segregation and condensation complex subunit ScpB 4.3E-05 18-86 / 79-139
PF04358.12 DsrC like protein 4.3E-05 19-76 / 36-95
PF05732.10 Firmicute plasmid replication protein (RepL) 4.4E-05 19-76 / 51-109
PF10007.8 Uncharacterized protein conserved in archaea (DUF2250) 4.6E-05 20-76 / 6-56
PF16221.4 winged helix-turn-helix 5.2E-05 23-74 / 32-78
PF13730.5 Helix-turn-helix domain 6E-05 20-72 / 3-52
PF07381.10 Winged helix DNA-binding domain (DUF1495) 6.6E-05 20-77 / 7-69
PF08221.10 RNA polymerase III subunit RPC82 helix-turn-helix domain 6.9E-05 20-75 / 11-60
PF13463.5 Winged helix DNA-binding domain 8.2E-05 43-76 / 18-51
PF09012.9 FeoC like transcriptional regulator 0.00011 43-78 / 15-50
PF08784.10 Replication protein A C terminal 0.00011 19-76 / 37-95
PF14557.5 Putative AphA-like transcriptional regulator 0.00013 19-77 / 5-68
PF03428.12 Replication protein C N-terminal domain 0.00014 19-77 / 40-106
PF09114.9 Transcription factor MotA, activation domain 0.00014 19-75 / 13-64
PF04182.11 B-block binding subunit of TFIIIC 0.00017 43-77 / 19-53
PF01047.21 MarR family 0.00019 43-77 / 18-52
PF03965.15 Penicillinase repressor 0.00021 22-77 / 3-58
PF01090.18 Ribosomal protein S19e 0.00021 43-77 / 66-115
PF12802.6 MarR family 0.00022 43-76 / 22-55
PF05158.11 RNA polymerase Rpc34 subunit 0.00025 19-77 / 89-143
PF02295.16 Adenosine deaminase z-alpha domain 0.00026 43-76 / 19-53
PF13601.5 Winged helix DNA-binding domain 0.00026 43-77 / 15-49
PF03551.13 Transcriptional regulator PadR-like family 0.00028 43-77 / 15-51
PF02002.16 TFIIE alpha subunit 0.00031 23-77 / 13-61
PF01978.18 Sugar-specific transcriptional regulator TrmB 0.00035 20-76 / 6-56
PF01475.18 Ferric uptake regulator family 0.00036 19-77 / 4-62
PF10771.8 Winged helix-turn-helix domain (DUF2582) 0.00036 20-77 / 6-57
PF12793.6 Sugar transport-related sRNA regulator N-term 0.00042 43-76 / 19-52
PF09681.9 N-terminal phage replisome organiser (Phage_rep_org_N) 0.00043 25-75 / 27-86
PF08222.10 CodY helix-turn-helix domain 0.00047 43-76 / 5-38
PF11313.7 Protein of unknown function (DUF3116) 0.0005 51-78 / 36-63
PF14394.5 Domain of unknown function (DUF4423) 0.00055 43-77 / 37-73
PF03444.14 Winged helix-turn-helix transcription repressor, HrcA DNA-binding 0.00055 22-76 / 4-58
PF13412.5 Winged helix-turn-helix DNA-binding 0.00076 43-72 / 18-47
PF06163.10 Bacterial protein of unknown function (DUF977) 0.00077 43-76 / 27-60
PF15977.4 Winged helix-turn-helix DNA binding 0.00091 41-75 / 22-56
PF01638.16 HxlR-like helix-turn-helix 0.00098 43-77 / 20-55
PF02334.15 Replication terminator protein 0.00097 54-78 / 52-76
PF09202.10 Rio2, N-terminal 0.001 20-76 / 4-58
PF01022.19 Bacterial regulatory protein, arsR family 0.0011 43-72 / 17-46
PF13034.5 Protein of unknown function (DUF3895) 0.0011 53-77 / 40-68
PF13545.5 Crp-like helix-turn-helix domain 0.0011 42-74 / 27-59
PF14277.5 Domain of unknown function (DUF4364) 0.0011 43-75 / 16-52
PF09904.8 Winged helix-turn helix 0.0012 43-74 / 22-53
PF14947.5 Winged helix-turn-helix 0.0013 43-76 / 17-50
PF10711.8 Hypothetical protein (DUF2513) 0.0014 44-77 / 20-57
PF09639.9 YjcQ protein 0.0014 43-77 / 17-53
PF12840.6 Helix-turn-helix domain 0.0015 43-76 / 24-54
PF09824.8 ArsR transcriptional regulator 0.0016 22-75 / 17-61
PF05491.12 Holliday junction DNA helicase ruvB C-terminus 0.0017 20-76 / 6-60
PF07106.12 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) 0.0018 43-77 / 17-53
PF05331.10 Protein of unknown function (DUF742) 0.0019 19-76 / 38-87
PF14502.5 Helix-turn-helix domain 0.0019 42-76 / 6-40
PF02082.19 Transcriptional regulator 0.0022 43-75 / 25-57
PF16365.4 Ethanolamine utilization protein EutK C-terminus 0.0022 43-75 / 18-50
PF09339.9 IclR helix-turn-helix domain 0.0023 43-74 / 19-50
PF07848.11 PaaX-like protein 0.0028 43-76 / 21-57
PF09857.8 Putative toxin of bacterial toxin-antitoxin pair 0.0029 20-76 / 3-63
PF06969.15 HemN C-terminal domain 0.0032 43-75 / 21-54
PF01418.16 Helix-turn-helix domain, rpiR family 0.0032 19-76 / 13-68
PF00392.20 Bacterial regulatory proteins, gntR family 0.0035 44-76 / 26-58
PF01325.18 Iron dependent repressor, N-terminal DNA binding domain 0.0035 43-75 / 22-54
PF03297.14 S25 ribosomal protein 0.0041 43-75 / 57-89
PF08220.11 DeoR-like helix-turn-helix domain 0.0046 43-75 / 15-47
PF04703.11 FaeA-like protein 0.0047 43-76 / 15-48
PF17443.1 Uncharacterized protein pXO2-72 0.0058 43-76 / 9-51
PF08461.9 Ribonuclease R winged-helix domain 0.0069 43-75 / 13-50
PF07900.10 Protein of unknown function (DUF1670) 0.007 42-76 / 95-129
PF00325.19 Bacterial regulatory proteins, crp family 0.0079 44-72 / 4-32
PF09182.9 Bacterial purine repressor, N-terminal 0.0079 43-75 / 21-58
PF02387.14 IncFII RepA protein family 0.0084 39-76 / 88-135
PF16864.4 Dimerisation domain 0.0091 43-75 / 33-65

Annotations of the NCBI proteins of this PHROG


1:replisome organizer 1:hypothetical protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0007131 reciprocal meiotic recombination
GO:0009378 four-way junction helicase activity
GO:0004674 protein serine/threonine kinase activity
GO:0009289 pilus
GO:0005622 intracellular
GO:0006260 DNA replication
GO:0006383 transcription by RNA polymerase III
GO:0045892 negative regulation of transcription, DNA-templated
GO:0005667 transcription factor complex
GO:0006274 DNA replication termination
GO:0005840 ribosome
GO:0003700 DNA binding transcription factor activity
GO:0003726 double-stranded RNA adenosine deaminase activity
GO:0006310 DNA recombination
GO:0003677 DNA binding
GO:0006468 protein phosphorylation
GO:0006412 translation
GO:0051304 chromosome separation
GO:0006355 regulation of transcription, DNA-templated
GO:0003735 structural constituent of ribosome
GO:0003723 RNA binding
GO:0004252 serine-type endopeptidase activity
GO:0006281 DNA repair
GO:0005524 ATP binding
GO:0006276 plasmid maintenance
GO:0006508 proteolysis
GO:0005666 DNA-directed RNA polymerase III complex

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