phrog_21603 is made of 4 protein sequences and is annotated as "unknown function"
Functional category: unknown function


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
73 77 77


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
MH047631_p105 AVR56978.1 MerR-like helix-turn-helix DNA binding protein MH047631 Microbacterium phage Triscuit Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MH047631_p1 AVR56876.1 MerR-like helix-turn-helix DNA binding protein MH047631 Microbacterium phage Triscuit Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MH047631_p8 AVR56883.1 MerR-like helix-turn-helix DNA binding protein MH047631 Microbacterium phage Triscuit Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MH047631_p112 AVR56985.1 MerR-like helix-turn-helix DNA binding protein MH047631 Microbacterium phage Triscuit Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
no colocalized PHROGS                                                                                          

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10045 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.2 0.012 3-53 / 20-69
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 92.9 0.015 3-27 / 23-47
phrog_2538 terminase small subunit head and packaging 90.0 0.065 3-26 / 19-42
phrog_2655 excisionase integration and excision 92.8 0.016 3-51 / 7-57
phrog_2907 excisionase integration and excision 91.3 0.037 1-43 / 3-45
phrog_32138 DNA binding protein DNA, RNA and nucleotide metabolism 96.0 0.00019 3-27 / 18-42
phrog_57 terminase small subunit head and packaging 94.3 0.0041 3-44 / 2-43
phrog_6401 DNA binding protein DNA, RNA and nucleotide metabolism 94.8 0.0021 4-53 / 10-58
phrog_664 DNA binding protein DNA, RNA and nucleotide metabolism 91.7 0.031 4-33 / 69-98
phrog_66 excisionase and transcriptional regulator integration and excision 96.2 0.00011 3-52 / 9-57
phrog_7067 terminase small subunit head and packaging 93.5 0.0089 3-26 / 31-54
phrog_803 host nuclease inhibitor moron, auxiliary metabolic gene and host takeover 93.4 0.01 4-39 / 19-53
phrog_9285 no annotation unknown function 92.0 0.026 5-48 / 36-80
phrog_9759 DNA binding protein DNA, RNA and nucleotide metabolism 93.0 0.013 4-27 / 19-42

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF04936.11 Protein of unknown function (DUF658) 0.00011 5-33 / 87-115
PF10743.8 Regulatory phage protein cox 9.6E-09 5-70 / 10-79
PF11112.7 Pyocin activator protein PrtN 3.9E-08 5-55 / 12-67
PF13411.5 MerR HTH family regulatory protein 1.6E-07 8-35 / 2-29
PF12964.6 Protein of unknown function (DUF3853) 1.6E-07 5-53 / 44-92
PF05930.11 Prophage CP4-57 regulatory protein (AlpA) 3.1E-07 6-33 / 3-31
PF13591.5 MerR HTH family regulatory protein 4.7E-07 7-36 / 1-30
PF09035.9 Excisionase from transposon Tn916 6.9E-07 5-29 / 14-38
PF12728.6 Helix-turn-helix domain 1.6E-06 7-35 / 2-31
PF17443.1 Uncharacterized protein pXO2-72 2.1E-06 4-31 / 6-33
PF07618.10 Protein of unknown function (DUF1580) 3.1E-06 11-54 / 7-53
PF07825.10 Excisionase-like protein 4E-06 7-34 / 3-33
PF00376.22 MerR family regulatory protein 6.6E-06 9-32 / 2-25
PF07141.10 Putative bacteriophage terminase small subunit 6.5E-06 4-29 / 29-54
PF07278.10 Protein of unknown function (DUF1441) 8.4E-06 7-31 / 2-26
PF07471.11 Phage DNA packaging protein Nu1 1.2E-05 6-30 / 2-26
PF01381.21 Helix-turn-helix 1.3E-05 4-29 / 7-32
PF07750.10 GcrA cell cycle regulator 1.4E-05 4-31 / 16-44
PF08765.10 Mor transcription activator family 1.4E-05 6-30 / 72-96
PF00292.17 'Paired box' domain 1.6E-05 5-29 / 32-56
PF06806.11 Putative excisionase (DUF1233) 1.6E-05 4-31 / 7-33
PF10654.8 Protein of unknown function (DUF2481) 1.6E-05 4-29 / 78-103
PF06322.10 Phage NinH protein 1.7E-05 5-30 / 15-40
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 2E-05 5-29 / 12-36
PF07453.12 NUMOD1 domain 2E-05 6-26 / 19-39
PF08535.9 KorB domain 2.1E-05 5-29 / 2-26
PF02954.18 Bacterial regulatory protein, Fis family 2.2E-05 5-28 / 15-38
PF05344.10 Domain of Unknown Function (DUF746) 2.1E-05 4-29 / 10-35
PF04552.12 Sigma-54, DNA binding domain 2.5E-05 4-30 / 46-72
PF02319.19 E2F/DP family winged-helix DNA-binding domain 3.6E-05 5-29 / 22-46
PF00356.20 Bacterial regulatory proteins, lacI family 4.1E-05 8-29 / 1-22
PF12759.6 InsA C-terminal domain 4.3E-05 5-29 / 20-44
PF13309.5 HTH domain 4.3E-05 7-27 / 42-62
PF08822.10 Protein of unknown function (DUF1804) 4.4E-05 5-29 / 18-42
PF13413.5 Helix-turn-helix domain 6.4E-05 4-29 / 7-32
PF09607.9 Brinker DNA-binding domain 8.1E-05 7-29 / 26-48
PF06970.10 Replication initiator protein A (RepA) N-terminus 8.2E-05 8-28 / 53-73
PF04218.12 CENP-B N-terminal DNA-binding domain 9E-05 7-29 / 24-46
PF13404.5 AsnC-type helix-turn-helix domain 0.0001 6-28 / 17-39
PF13011.5 leucine-zipper of insertion element IS481 0.00011 4-29 / 22-47
PF13412.5 Winged helix-turn-helix DNA-binding 0.00011 6-29 / 17-40
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 0.00011 5-29 / 18-42
PF03333.12 Adhesin biosynthesis transcription regulatory protein 0.00011 5-29 / 54-78
PF02796.14 Helix-turn-helix domain of resolvase 0.00012 6-28 / 21-43
PF07037.10 Putative transcription regulator (DUF1323) 0.00013 7-29 / 1-23
PF01710.15 Transposase 0.00014 5-30 / 17-42
PF02042.14 RWP-RK domain 0.00014 4-29 / 10-35
PF08222.10 CodY helix-turn-helix domain 0.00014 5-29 / 3-27
PF06971.12 Putative DNA-binding protein N-terminus 0.00016 6-27 / 27-48
PF12824.6 Mitochondrial ribosomal protein subunit L20 0.00016 6-29 / 107-130
PF12116.7 Stage III sporulation protein D 0.00017 5-30 / 18-43
PF14493.5 Helix-turn-helix domain 0.0002 4-30 / 10-36
PF05225.15 helix-turn-helix, Psq domain 0.00023 5-29 / 15-40
PF07638.10 ECF sigma factor 0.00024 5-29 / 148-172
PF05043.12 Mga helix-turn-helix domain 0.00023 5-29 / 29-53
PF13556.5 PucR C-terminal helix-turn-helix domain 0.00028 5-29 / 11-35
PF13936.5 Helix-turn-helix domain 0.0003 6-27 / 20-41
PF05331.10 Protein of unknown function (DUF742) 0.00027 5-29 / 52-76
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 0.0003 4-30 / 21-47
PF13443.5 Cro/C1-type HTH DNA-binding domain 0.00034 5-29 / 9-34
PF10668.8 Phage terminase small subunit 0.00036 6-29 / 22-45
PF15978.4 Tn7-like transposition protein D 0.00038 5-29 / 202-226
PF07900.10 Protein of unknown function (DUF1670) 0.00041 4-29 / 93-118
PF09012.9 FeoC like transcriptional regulator 0.00041 5-29 / 13-37
PF13542.5 Helix-turn-helix domain of transposase family ISL3 0.00047 8-29 / 28-49
PF06627.10 Protein of unknown function (DUF1153) 0.00045 5-29 / 45-69
PF00440.22 Bacterial regulatory proteins, tetR family 0.00046 7-29 / 16-38
PF10975.7 Protein of unknown function (DUF2802) 0.00044 3-27 / 40-64
PF08876.10 Domain of unknown function (DUF1836) 0.00047 6-35 / 10-49
PF13022.5 Helix-turn-helix of insertion element transposase 0.0005 6-29 / 25-48
PF16677.4 DNA-packaging protein gp3 0.00051 5-29 / 28-52
PF04967.11 HTH DNA binding domain 0.00059 7-29 / 24-46
PF01371.18 Trp repressor protein 0.00057 5-29 / 47-71
PF16221.4 winged helix-turn-helix 0.00056 6-29 / 46-69
PF12793.6 Sugar transport-related sRNA regulator N-term 0.00064 4-29 / 16-41
PF08279.11 HTH domain 0.00066 5-29 / 14-38
PF00325.19 Bacterial regulatory proteins, crp family 0.00072 7-28 / 3-24
PF08281.11 Sigma-70, region 4 0.00074 5-28 / 25-48
PF11242.7 Protein of unknown function (DUF2774) 0.00073 5-29 / 13-37
PF07506.10 RepB plasmid partitioning protein 0.00074 5-29 / 20-44
PF05339.10 Protein of unknown function (DUF739) 0.00077 5-29 / 15-39
PF16509.4 TrfB plasmid transcriptional repressor 0.00078 5-29 / 30-54
PF04545.15 Sigma-70, region 4 0.00081 5-29 / 23-47
PF11427.7 Tc3 transposase 0.00084 6-28 / 20-42
PF09182.9 Bacterial purine repressor, N-terminal 0.00082 5-29 / 19-43
PF13518.5 Helix-turn-helix domain 0.00095 6-29 / 11-34
PF01022.19 Bacterial regulatory protein, arsR family 0.001 6-28 / 16-38
PF14549.5 DNA-binding transcriptional regulator Cro 0.001 4-26 / 8-29
PF04492.12 Bacteriophage replication protein O 0.0011 6-29 / 49-72
PF00126.26 Bacterial regulatory helix-turn-helix protein, lysR family 0.0011 7-29 / 12-34
PF13744.5 Helix-turn-helix domain 0.0012 5-29 / 30-54
PF07381.10 Winged helix DNA-binding domain (DUF1495) 0.0012 4-28 / 22-46
PF16701.4 Adenylate cyclase regulatory domain 0.0013 6-34 / 58-87
PF09904.8 Winged helix-turn helix 0.0013 5-29 / 20-44
PF10007.8 Uncharacterized protein conserved in archaea (DUF2250) 0.0013 6-29 / 22-45
PF01527.19 Transposase 0.0014 5-30 / 20-45
PF08280.10 M protein trans-acting positive regulator (MGA) HTH domain 0.0014 5-29 / 19-43
PF11972.7 HTH DNA binding domain 0.0014 5-29 / 12-36
PF09756.8 DDRGK domain 0.0014 6-57 / 115-170
PF08221.10 RNA polymerase III subunit RPC82 helix-turn-helix domain 0.0015 6-29 / 27-50
PF12844.6 Helix-turn-helix domain 0.0016 5-29 / 11-35
PF01418.16 Helix-turn-helix domain, rpiR family 0.0017 6-29 / 34-57
PF12802.6 MarR family 0.0019 7-29 / 22-44
PF04297.13 Putative helix-turn-helix protein, YlxM / p13 like 0.0019 5-29 / 32-56
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 0.0021 6-29 / 11-35
PF13601.5 Winged helix DNA-binding domain 0.0022 5-29 / 13-37
PF14947.5 Winged helix-turn-helix 0.0024 5-29 / 15-39
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 0.0024 8-27 / 10-29
PF13171.5 Protein of unknown function (DUF4004) 0.0021 7-33 / 3-29
PF13384.5 Homeodomain-like domain 0.0025 6-29 / 17-40
PF14056.5 Domain of unknown function (DUF4250) 0.0024 6-30 / 19-43
PF00196.18 Bacterial regulatory proteins, luxR family 0.0029 6-29 / 17-40
PF02082.19 Transcriptional regulator 0.0028 7-29 / 25-47
PF13551.5 Winged helix-turn helix 0.003 5-29 / 10-34
PF00392.20 Bacterial regulatory proteins, gntR family 0.003 8-29 / 26-47
PF09339.9 IclR helix-turn-helix domain 0.003 7-29 / 19-41
PF16264.4 SatD family (SatD) 0.0029 5-30 / 170-195
PF05584.10 Sulfolobus plasmid regulatory protein 0.003 5-29 / 17-41
PF06413.10 Neugrin 0.0028 6-29 / 29-52
PF06530.11 Phage antitermination protein Q 0.0032 5-29 / 78-102
PF06163.10 Bacterial protein of unknown function (DUF977) 0.0033 5-29 / 25-49
PF07374.10 Protein of unknown function (DUF1492) 0.0035 5-29 / 70-94
PF09048.9 Cro 0.0037 6-29 / 13-36
PF13693.5 Winged helix-turn-helix DNA-binding 0.0038 5-29 / 14-38
PF05269.10 Bacteriophage CII protein 0.0039 5-29 / 22-46
PF13463.5 Winged helix DNA-binding domain 0.0041 5-29 / 16-40
PF13560.5 Helix-turn-helix domain 0.0042 5-29 / 13-37
PF01047.21 MarR family 0.0043 6-29 / 17-40
PF02002.16 TFIIE alpha subunit 0.0043 5-29 / 25-49
PF14590.5 Domain of unknown function (DUF4447) 0.0042 5-29 / 19-43
PF03683.12 Uncharacterised protein family (UPF0175) 0.0053 4-31 / 27-54
PF15977.4 Winged helix-turn-helix DNA binding 0.0057 7-29 / 24-46
PF02001.15 Protein of unknown function DUF134 0.0056 5-29 / 46-70
PF04703.11 FaeA-like protein 0.006 5-29 / 13-37
PF01325.18 Iron dependent repressor, N-terminal DNA binding domain 0.0072 6-29 / 21-44
PF16365.4 Ethanolamine utilization protein EutK C-terminus 0.0077 6-29 / 17-40
PF04182.11 B-block binding subunit of TFIIIC 0.0083 5-29 / 17-41
PF01978.18 Sugar-specific transcriptional regulator TrmB 0.0086 6-29 / 22-45
PF14502.5 Helix-turn-helix domain 0.0086 6-29 / 6-29
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 0.0097 6-29 / 82-105
PF05732.10 Firmicute plasmid replication protein (RepL) 0.0096 5-29 / 74-98
PF06892.10 Phage regulatory protein CII (CP76) 0.0097 8-29 / 21-42

Annotations of the NCBI proteins of this PHROG


4:MerR-like helix-turn-helix DNA binding protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0005524 ATP binding
GO:0006276 plasmid maintenance
GO:0043565 sequence-specific DNA binding
GO:0004803 transposase activity
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006352 DNA-templated transcription, initiation
GO:0051775 response to redox state
GO:0019069 viral capsid assembly
GO:0060567 negative regulation of DNA-templated transcription, termination
GO:0000150 recombinase activity
GO:0006313 transposition, DNA-mediated
GO:0003700 DNA binding transcription factor activity
GO:0006310 DNA recombination
GO:0003677 DNA binding
GO:0009289 pilus
GO:0006260 DNA replication
GO:0005622 intracellular
GO:0005667 transcription factor complex
GO:0045892 negative regulation of transcription, DNA-templated
GO:0016987 sigma factor activity

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