phrog_2162 is made of 70 protein sequences and is annotated as "Sir2 (NAD-dependent deacetylase)"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
261.86 381 259


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KY630187_p112 AQW88637.1 Sir2-like protein KY630187 Serratia phage BF Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Eneladusvirus; Serratia virus BF.
KU574722_p120 AMM43685.1 putative Sir2-like protein KU574722 Pectobacterium phage CBB Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Mimasvirus; Pectinobacterium virus CBB.
NC_019401_p121 YP_006987223.1 putative Sir2-like protein NC_019401 Cronobacter phage vB_CsaM_GAP32 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Mimasvirus; Cronobacter virus GAP32.
NC_019526_p502 YP_007007657.1 putative Sir2-like protein NC_019526 Enterobacteria phage vB_KleM-RaK2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Alcyoneusvirus; Klebsiella virus RaK2.
NC_025447_p469 YP_009102063.1 Sir2-like protein NC_025447 Escherichia phage 121Q Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Asteriusvirus; Escherichia virus 121Q.
NC_027364_p95 YP_009150409.1 putative Sir2-like protein NC_027364 Escherichia phage PBECO 4 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Asteriusvirus; Escherichia virus PBECO4.
NC_015938_p56 YP_004782431.1 putative Sir2-like protein NC_015938 Salmonella phage 7-11 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
NC_022323_p78 YP_008530323.1 putative Sir2-like protein (NAD-dependent deacetylase) NC_022323 Escherichia phage JES2013 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Vequintavirus.
KX664695_p55 AOT23255.1 SIR2 family NAD-dependent protein deacetylase KX664695 Escherichia phage ESCO5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Phapecoctavirus; Escherichia virus ESCO5.
MH102285_p45 AVQ09882.1 SIR2 family NAD-dependent protein deacetylase MH102285 Salmonella phage vB_SenS_PHB06 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; unclassified Tequintavirus.
KR422353_p126 AKO61527.1 putative Sir2-like protein KR422353 Escherichia phage APCEc03 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; Escherichia virus phiAPCEc03.
KY787212_p119 ARM69782.1 putative Sir2-like protein KY787212 Salmonella phage BSP22A Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Epseptimavirus; unclassified Epseptimavirus.
KT919973_p288 ALP47418.1 NAD-dependent protein deacetylase of SIR2 family KT919973 Vibrio phage phi-ST2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
NC_031933_p111 YP_009323840.1 hypothetical protein NC_031933 Salmonella phage 118970_sal2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Epseptimavirus.
NC_022968_p107 YP_008857323.1 putative Sir2-like protein NC_022968 Escherichia phage 4MG Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Seunavirus.
MF431736_p105 ASU02468.1 NAD-dependent protein deacetylase of SIR2 family MF431736 Bacteriophage T5-like chee130_1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Epseptimavirus; unclassified Epseptimavirus.
KU522583_p52 AMM43378.1 putative Sir2-like transferase KU522583 Enterobacteria phage ECGD1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_011041_p80 YP_002003582.1 putative Sir2-like protein NC_011041 Escherichia phage V5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Vequintavirus.
MG250486_p137 AUE23363.1 NAD-dependent protein deacetylase MG250486 Raoultella phage Ro1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; unclassified Vequintavirinae.
KR698074_p140 AKO61894.1 hypothetical protein KR698074 Escherichia phage APCEc02 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Vequintavirus; Escherichia virus APECc02.
MF805809_p35 ATI15777.1 NAD-dependent protein deacetylase of SIR2 family MF805809 Escherichia phage vB_EcoM_PHB05 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
MG873442_p94 AVJ48225.1 NAD-dependent protein deacetylase of SIR2 family MG873442 Salmonella phage SE131 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; unclassified Podoviridae.
NC_024134_p77 YP_009030986.1 putative Sir2-like protein NC_024134 Escherichia phage FFH2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Vequintavirus.
KX552041_p57 AOQ27191.1 hypothetical protein KX552041 Escherichia phage ESCO13 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Phapecoctavirus.
NC_024139_p103 YP_009031724.1 putative Sir2-like protein NC_024139 Escherichia phage vB_EcoS_FFH1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
NC_016071_p108 YP_004893915.1 Sir2-like protein NC_016071 Salmonella phage PVP-SE1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Seunavirus; Salmonella virus PVPSE1.
NC_031042_p34 YP_009283375.1 hypothetical protein NC_031042 Salmonella phage NR01 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; Salmonella virus NR01.
MG459987_p115 ATW61952.1 NAD-dependent protein SIR2 family deacetylase MG459987 Klebsiella phage Sugarland Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Sugarlandvirus; Klebsiella virus Sugarland.
NC_019517_p77 YP_007006248.1 putative Sir2-like protein NC_019517 Escherichia phage FV3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Vequintavirus.
NC_017969_p105 YP_006382404.1 Sir2-like protein NC_017969 Escherichia virus AKFV33 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
NC_028840_p100 YP_009202146.1 NAD-dependent protein deacylase NC_028840 Escherichia phage slur09 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
NC_027351_p218 YP_009149014.1 NAD-dependent protein deacetylase of SIR2 family NC_027351 Salmonella phage SSE121 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Seunavirus.
NC_031902_p116 YP_009320840.1 Sir2-like protein NC_031902 Salmonella phage 100268_sal2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Epseptimavirus.
MF979564_p80 ATS94064.1 tail assembly protein MF979564 Pectobacterium phage DU_PP_V Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Mccorquodalevirinae; Hongcheonvirus; Pectobacterium virus DUPPV.
NC_015269_p94 YP_004306577.1 putative Sir2-like protein NC_015269 Salmonella virus SPC35 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
NC_023568_p263 YP_009006337.1 NAD-dependent deacetylase NC_023568 Vibrio phage VH7D Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
KM979355_p79 AJA41732.1 putative Sir2-like protein KM979355 Enterobacteria phage DT571/2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; unclassified Tequintavirus.
AY587007_p96 AAX12033.1 putative transferase AY587007 Escherichia virus T5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
KX845404_p88 APT41131.1 NAD-dependent protein deacetylase of SIR2 family KX845404 Klebsiella phage vB_Kpn_IME260 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Sugarlandvirus; Klebsiella virus IME260.
NC_005859_p102 YP_006930.1 putative Sir2-like protein NC_005859 Escherichia virus T5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
KT001917_p76 AKU44168.1 NAD-dependent deacetylase KT001917 Escherichia phage Murica Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Vequintavirus; Escherichia virus Murica.
NC_028829_p219 YP_009201322.1 NAD-dependent deacetylase NC_028829 Vibrio phage ValKK3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus.
NC_027297_p109 YP_009146050.1 Sir2-like protein NC_027297 Salmonella virus Stitch Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Epseptimavirus.
KT919972_p160 ALP47040.1 NAD-dependent protein deacetylase of SIR2 family KT919972 Vibrio phage phi-Grn1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
NC_021529_p304 YP_008125242.1 Sir2 family NAD-dependent protein deacetylase NC_021529 Vibrio phage nt-1 (nt-1) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus.
KY963424_p123 ASD50296.1 Sir2 family protein KY963424 Shigella phage SSP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; Shigella virus SSP1.
MF001363_p73 ASZ77825.1 NAD-dependent protein deacetylase of SIR2 family MF001363 Salmonella phage SH9 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Epseptimavirus; Salmonella virus SH9.
KY683736_p81 ASJ80437.1 hypothetical protein KY683736 Escherichia phage V18 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Vequintavirus; Escherichia virus V18.
NC_020079_p72 YP_007348440.1 putative Sir2-like protein NC_020079 Escherichia phage phAPEC8 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Phapecoctavirus; Escherichia virus phAPEC8.
NC_018837_p98 YP_006906350.1 Sir2-like protein NC_018837 Pectobacterium phage My1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Mccorquodalevirinae; Myunavirus; Pectobacterium virus My1.
KY677846_p31 ARB06858.1 putative Sir2-like protein KY677846 Escherichia phage phiLLS Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; Escherichia virus phiLLS.
NC_028248_p135 YP_009177525.1 putative Sir2-like protein [Enterobacteria phage vB_EcoM-FV3] NC_028248 Escherichia phage slur16 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Vequintavirus; Escherichia virus slur16.
NC_023693_p38 YP_009012369.1 Phi92_gp038 NC_023693 Enterobacteria phage phi92 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
KY114934_p66 ATI99423.1 SIR2 family NAD-dependent protein deacetylase KY114934 Salmonella phage SP01 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; Salmonella virus SP01.
MF431735_p101 ASU02313.1 NAD-dependent protein deacetylase of SIR2 family MF431735 Bacteriophage T5-like poul124 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; unclassified Tequintavirus.
NC_005083_p43 NP_899291.1 Sir2/CobB protein NC_005083 Vibrio phage KVP40 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus.
KY652726_p88 ARB12592.1 NAD-dependent protein deacetylase KY652726 Klebsiella phage vB_KpnM_BIS47 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; unclassified Vequintavirinae.
MF402939_p52 ASM62912.1 putative Sir2-like protein MF402939 Escherichia phage OSYSP Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; Escherichia virus OSYSP.
NC_028659_p107 YP_009187720.1 putative Sir2-like protein NC_028659 Klebsiella phage vB_KpnM_KB57 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; unclassified Vequintavirinae.
JN849462_p42 AFN37276.1 Sir2/CobB protein JN849462 Vibriophage phi-pp2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; Vibrio virus KVP40.
NC_019919_p99 YP_007237073.1 NAD-dependent protein deacetylase of SIR2 family NC_019919 Yersinia phage phiR201 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Haartmanvirus; Yersinia virus phiR201.
NC_010583_p117 YP_001837040.1 putative Sir2-like protein NC_010583 Escherichia virus EPS7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Epseptimavirus.
NC_028983_p197 YP_009216195.1 NAD dependent deacetylase NC_028983 Bacillus phage Shanette Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Spounavirinae; Siminovitchvirus.
NC_028982_p196 YP_009215976.1 NAD dependent deacetylase NC_028982 Bacillus phage JL Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Spounavirinae; Siminovitchvirus.
p49538 no NCBI prot ID no annotation VI_01135 Clostridia_gi_545639314_6496_63820 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_025423_p129 YP_009099173.1 putative hydrolase NC_025423 Bacillus phage CP-51 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Spounavirinae; Siminovitchvirus.
p14227 no NCBI prot ID no annotation VI_01278 Clostridia_gi_548246196 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p29832 no NCBI prot ID no annotation VI_06311 Epsilonproteobacteria_gi_544659823 Viruses.
p29842 no NCBI prot ID no annotation VI_06311 Epsilonproteobacteria_gi_544659823 Viruses.
p108957 no NCBI prot ID no annotation VI_01216 Clostridia_gi_546486246 Viruses.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_5116 26 no annotation unknown function 20 1.05E-76 67.1
phrog_5827 22 no annotation unknown function 16 1.35E-61 51.99
phrog_671 210 nucleotide pyrophosphohydrolase other 8 6.43E-20 10.31
phrog_13950 7 no annotation unknown function 7 0 1000
phrog_1479 102 no annotation unknown function 7 5.38E-20 10.39
phrog_9509 11 no annotation unknown function 6 5.63E-25 15.37
phrog_15991 6 no annotation unknown function 6 0 1000
phrog_114 788 ATP-dependent DNA ligase DNA, RNA and nucleotide metabolism 6 5.63E-11 1.37
phrog_543 253 DNA topoisomerase II large subunit DNA, RNA and nucleotide metabolism 6 2.00E-14 4.82
phrog_9999 10 nudix hydrolase other 6 2.05E-25 15.81
phrog_5236 25 no annotation unknown function 6 8.19E-22 12.21
phrog_2071 73 ATPase other 4 1.17E-12 3.05
phrog_1818 83 no annotation unknown function 4 2.27E-12 2.77
phrog_15748 6 no annotation unknown function 3 7.93E-15 5.22
phrog_20147 4 no annotation unknown function 2 1.41E-11 1.97

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_18062 Sir2 (NAD-dependent deacetylase) DNA, RNA and nucleotide metabolism 95.1 0.0013 170-208 / 19-51

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF16263.4 Domain of unknown function (DUF4917) 4.4E-17 197-239 / 231-275
PF13289.5 SIR2-like domain 9.4E-15 114-239 / 2-126
PF02146.16 Sir2 family 6.1E-14 93-148 / 59-113

Annotations of the NCBI proteins of this PHROG


27:Sir2-like protein 10:NAD-dependent protein deacetylase of SIR2 family 5:hypothetical protein 3:NAD-dependent deacetylase 3:SIR2 family NAD-dependent protein deacetylase 2:NAD-dependent protein deacetylase 2:Sir2/CobB protein 2:NAD dependent deacetylase 1:protein of an unannotated phage 1:Sir2-like protein (NAD-dependent deacetylase) 1:NAD-dependent protein SIR2 family deacetylase 1:hydrolase 1:Sir2-like protein [Enterobacteria phage vB_EcoM-FV3] 1:tail assembly protein 1:Sir2 family protein 1:NAD-dependent protein deacylase 1:transferase 1:Sir2 family NAD-dependent protein deacetylase 1:Sir2-like transferase

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K12410 npdA : NAD-dependent deacetylase [EC:3.5.1.-] no pathways 312 67

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0070403 NAD+ binding

Loading in process