phrog_2197 is made of 69 protein sequences and is annotated as "GTP cyclohydrolase"
Functional category: other


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
213.58 353 196


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_031058_p36 YP_009285847.1 GTP cyclohydrolase NC_031058 Pseudomonas phage NP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nipunavirus.
KX898399_p34 ARB11102.1 putative GTP cyclohydrolase KX898399 Pseudomonas phage JG012 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nipunavirus; unclassified Nipunavirus.
NC_026610_p32 YP_009126590.1 GTP cyclohydrolase NC_026610 Vibrio phage VpKK5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
KX898400_p33 ARB11178.1 putative GTP cyclohydrolase KX898400 Pseudomonas phage JG054 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nipunavirus; unclassified Nipunavirus.
p46153 no NCBI prot ID no annotation VI_01226 Clostridia_gi_547240599 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KT588073_p1 ALJ98956.1 GTP cyclohydrolase I type 1 KT588073 Acinetobacter phage Ab105-3phi Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Vieuvirus; unclassified Vieuvirus.
NC_027296_p54 YP_009145913.1 putative GTP cyclohydrolase I protein NC_027296 Rhizobium phage RHEph06 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Kleczkowskavirus; unclassified Kleczkowskavirus.
NC_024146_p4 YP_009032327.1 GTP cyclohydrolase 1 NC_024146 Enterobacteria phage 9g Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nonagvirus.
p8117 no NCBI prot ID no annotation VI_11181 Gammaproteobacteria_gi_484231890_533788_628137 Viruses.
JQ067084_p37 ALH23793.1 putative GTP cyclohydrolase JQ067084 Pseudomonas phage PaMx25 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nipunavirus; Pseudomonas virus PaMx25.
p68524 no NCBI prot ID no annotation VI_05467 Bacilli_gi_484032490 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_029021_p32 YP_009219312.1 GTP cyclohydrolase I / queuosine biosynthesis protein FolE NC_029021 Enterobacteria phage JenK1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nonagvirus.
KY606587_p83 ARB06137.1 putative GTP cyclohydrolase KY606587 Dinoroseobacter phage vB_DshS-R5C Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nanhaivirus; Dinoroseobacter virus D5C.
NC_028831_p77 YP_009201620.1 GTP cyclohydrolase 1 [Enterobacteria phage 9g] NC_028831 Escherichia phage slur01 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Seuratvirus; unclassified Seuratvirus.
NC_027378_p35 YP_009151979.1 queuosine biosynthesis protein FolE NC_027378 Escherichia phage Seurat Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Seuratvirus.
KY926791_p82 ARM70137.1 GTP cyclohydrolase I type 1 KY926791 Salmonella phage SE1 (in:P22virus) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Lederbergvirus; Salmonella virus SE1Spa.
NC_028997_p33 YP_009216971.1 GTP cyclohydrolase I / queuosine biosynthesis protein FolE NC_028997 Enterobacteria phage JenP2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nonagvirus.
NC_028776_p37 YP_009196831.1 GTP cyclohydrolase I type 1 NC_028776 Escherichia phage CAjan Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Seuratvirus.
NC_029028_p34 YP_009220004.1 GTP cyclohydrolase I / queuosine biosynthesis protein FolE NC_029028 Enterobacteria phage JenP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nonagvirus.
NC_019515_p22 YP_007005873.1 putative GTP cyclohydrolase I NC_019515 Bacillus phage BCD7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
KR560069_p137 AKO61689.1 GTP cyclohydrolase I type 1 KR560069 Stenotrophomonas phage IME-SM1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Ackermannviridae; unclassified Ackermannviridae.
KC821621_p38 AGO48673.1 GTP cyclohydrolase I KC821621 Cellulophaga phage phi19:2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cbastvirus; Cellulophaga virus ST; Cellulophaga phage phiST.
KC821629_p57 AGO49296.1 GTP cyclohydrolase I KC821629 Cellulophaga phage phi38:2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_023568_p11 YP_009006085.1 GTP cyclohydrolase 1 NC_023568 Vibrio phage VH7D Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
NC_021529_p385 YP_008125321.1 GTP cyclohydrolase I NC_021529 Vibrio phage nt-1 (nt-1) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus.
KC821634_p57 AGO49794.1 GTP cyclohydrolase I KC821634 Cellulophaga phage phi47:1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_020842_p68 YP_007673450.1 GTP cyclohydrolase NC_020842 Cellulophaga phage phiST Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cbastvirus; Cellulophaga virus ST.
JN849462_p118 AFN37351.1 GTP cyclohydrolase I type 1 JN849462 Vibriophage phi-pp2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; Vibrio virus KVP40.
KY979132_p121 ASD50401.1 GTP cyclohydrolase I type 1 KY979132 Acidovorax phage ACP17 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Busanvirus; Acidovorax virus ACP17.
KC821610_p57 AGO47788.1 GTP cyclohydrolase I KC821610 Cellulophaga phage phi3ST:2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
KC821604_p38 AGO47177.1 GTP cyclohydrolase I KC821604 Cellulophaga phage phiST Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cbastvirus; Cellulophaga virus ST.
KU873925_p80 AND75004.1 hypothetical protein KU873925 Pseudomonas phage pf16 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Chakrabartyvirus; Pseudomonas virus pf16.
KT919973_p368 ALP47437.1 GTP cyclohydrolase I KT919973 Vibrio phage phi-ST2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
KC821625_p32 AGO49043.1 GTP cyclohydrolase I KC821625 Cellulophaga phage phi13:1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cbastvirus; Cellulophaga virus ST; Cellulophaga phage phiST.
NC_005083_p121 NP_899369.1 GTP cyclohydrolase I NC_005083 Vibrio phage KVP40 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus.
KC821616_p57 AGO48252.1 GTP cyclohydrolase I KC821616 Cellulophaga phage phiSM Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_020860_p58 YP_007675734.1 GTP cyclohydrolase I NC_020860 Cellulophaga phage phiSM Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
KT919972_p236 ALP47057.1 GTP cyclohydrolase I KT919972 Vibrio phage phi-Grn1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
NC_028829_p139 YP_009201242.1 GTP cyclohydrolase 1 NC_028829 Vibrio phage ValKK3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus.
KC821630_p57 AGO49376.1 GTP cyclohydrolase I KC821630 Cellulophaga phage phi3:1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_015274_p5 YP_004306893.1 FolE NC_015274 Streptococcus phage Dp-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_019507_p231 YP_007005301.1 putative GTP cyclohydrolase NC_019507 Campylobacter virus CP21 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Firehammervirus.
NC_027997_p124 YP_009169258.1 hypothetical protein NC_027997 Campylobacter virus CP220 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Firehammervirus.
NC_027996_p129 YP_009169065.1 hypothetical phage protein NC_027996 Campylobacter virus CPt10 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Firehammervirus.
NC_021327_p68 YP_008059110.1 GTP cyclohydrolase I NC_021327 Halovirus HCTV-5 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
KY629621_p4 ARQ32421.1 GTP cyclohydrolase I type 1 KY629621 Streptococcus virus MS1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_021330_p64 YP_008059626.1 GTP cyclohydrolase I NC_021330 Halovirus HCTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_020158_p69 YP_007378975.1 GTP cyclohydrolase NC_020158 Halovirus HVTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
KF024722_p6 AGS81418.1 putative T-Fold protein KF024722 Mycobacterium virus Ta17a Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus.
MG757162_p6 AVE00294.1 GTP cyclohydrolase I MG757162 Mycobacterium phage Opia Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; unclassified Rosebushvirus.
JN699004_p6 AER48628.1 FolE JN699004 Mycobacterium phage Ares Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; Mycobacterium virus Godines.
KM101117_p6 AIK68780.1 GTP cyclohydrolase KM101117 Mycobacterium phage LizLemon Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; Mycobacterium virus Rosebush.
KX443696_p6 ANZ52300.1 FolE-like protein KX443696 Mycobacterium phage Laurie Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; Mycobacterium virus Godines.
JN618996_p6 AEN79510.1 FolE-like protein JN618996 Mycobacterium phage Arbiter Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; unclassified Rosebushvirus.
NC_004684_p6 NP_817767.1 gp6 NC_004684 Mycobacterium phage Rosebush Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus.
NC_008204_p6 YP_655686.1 gp6 NC_008204 Mycobacterium phage Qyrzula Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus.
JN698991_p6 AER47238.1 FolE JN698991 Mycobacterium phage Hedgerow Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; Mycobacterium virus Rosebush.
KR997932_p6 AKU45205.1 FolE KR997932 Mycobacterium phage Godines Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; Mycobacterium virus Godines.
MH051249_p6 AVR76501.1 GTP cyclohydrolase MH051249 Mycobacterium phage Boyle Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; unclassified Rosebushvirus.
MG812490_p6 AUX82174.1 GTP cyclohydrolase I MG812490 Mycobacterium phage Holeinone Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; unclassified Rosebushvirus.
KT880194_p6 AMB17320.1 GTP cyclohydrolase KT880194 Mycobacterium phage Glass Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; unclassified Rosebushvirus.
KT365402_p6 ALF01291.1 GTP cyclohydrolase I KT365402 Mycobacterium phage Tres Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; Mycobacterium virus Rosebush.
MH001452_p6 AVO21853.1 GTP cyclohydrolase I MH001452 Mycobacterium phage Kheth Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; unclassified Rosebushvirus.
MG812491_p6 AUX82216.1 GTP cyclohydrolase I MG812491 Mycobacterium phage ItsyBitsy1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bclasvirinae; Rosebushvirus; unclassified Rosebushvirus.
MG962366_p215 AVO25134.1 GTP cyclohydrolase I MG962366 Rhodococcus phage Finch Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_031253_p7 YP_009303155.1 GTP cyclohydrolase I NC_031253 Mycobacterium phage Bipper Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p18108 no NCBI prot ID no annotation VI_04129 Actinobacteria_gi_421742321 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_009447_p33 YP_001210253.1 BcepGomrgp33 NC_009447 Burkholderia phage BcepGomr Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
MG948468_p35 AVJ51790.1 GTP cyclohydrolase type I MG948468 Pantoea phage vB_PagS_Vid5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Vidquintavirus; Pantoea virus Vid5.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_2076 73 QueE-like radical SAM domain moron, auxiliary metabolic gene and host takeover 26 1.32E-85 76.0
phrog_38 1538 terminase large subunit head and packaging 16 7.40E-27 17.25
phrog_2389 62 QueD-like 6-pyruvoyl-tetrahydropterin synthase moron, auxiliary metabolic gene and host takeover 15 4.84E-48 38.44
phrog_887 163 queuine tRNA-ribosyltransferase moron, auxiliary metabolic gene and host takeover 7 1.76E-18 8.88
phrog_10773 10 no annotation unknown function 6 1.49E-25 15.95
phrog_14221 7 no annotation unknown function 6 1.24E-27 18.03
phrog_8580 13 no annotation unknown function 6 2.13E-24 14.79
phrog_18234 5 no annotation unknown function 5 0 1000
phrog_1035 143 endonuclease VII DNA, RNA and nucleotide metabolism 5 9.32E-14 4.15
phrog_23010 3 no annotation unknown function 3 0 1000
phrog_3636 39 DNA binding protein DNA, RNA and nucleotide metabolism 3 3.62E-11 1.56
phrog_20065 4 no annotation unknown function 2 1.23E-11 2.03
phrog_22165 3 no annotation unknown function 2 3.08E-12 2.63

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_5949 GTP cyclohydrolase other 90.2 0.06 79-151 / 55-127

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF01227.21 GTP cyclohydrolase I 3.6E-51 124-303 / 1-179
PF14489.5 QueF-like protein 7.8E-09 202-262 / 1-61
PF14819.5 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term 1.5E-08 189-253 / 39-104
PF00156.26 Phosphoribosyl transferase domain 6.1E-08 9-85 / 4-99
PF15609.5 Phosphoribosyl transferase 2.4E-07 30-84 / 87-178
PF14572.5 Phosphoribosyl synthetase-associated domain 7.2E-06 59-84 / 82-107
PF15610.5 PRTase ComF-like 0.00044 59-85 / 134-160
PF14681.5 Uracil phosphoribosyltransferase 0.00055 31-85 / 69-136

Annotations of the NCBI proteins of this PHROG


23:GTP cyclohydrolase I 12:GTP cyclohydrolase 7:GTP cyclohydrolase I type 1 4:FolE 3:protein of an unannotated phage 3:GTP cyclohydrolase I / queuosine biosynthesis protein FolE 3:GTP cyclohydrolase 1 2:FolE-like protein 2:hypothetical protein 1:GTP cyclohydrolase type I 1:GTP cyclohydrolase 1 [Enterobacteria phage 9g] 1:T-Fold protein 1:GTP cyclohydrolase I protein 1:queuosine biosynthesis protein FolE 1:COG0302

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K01495 GCH1, folE : GTP cyclohydrolase I [EC:3.5.4.16] ko00790 Folate biosynthesis 290 63

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0004749 ribose phosphate diphosphokinase activity
GO:0000287 magnesium ion binding
GO:0009116 nucleoside metabolic process
GO:0008616 queuosine biosynthetic process
GO:0033739 preQ1 synthase activity
GO:0009165 nucleotide biosynthetic process

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