phrog_2323 is made of 64 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
118.84 222 115


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p305521 no NCBI prot ID no annotation VI_07356 Gammaproteobacteria_gi_485453054_0_25173 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_019934_p19 YP_007238136.1 HNH nuclease NC_019934 Cronobacter phage ENT39118 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_019710_p70 YP_007111773.1 hypothetical protein NC_019710 Enterobacteria phage HK140 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus; unclassified Hendrixvirus.
p344255 no NCBI prot ID no annotation VI_09036 Gammaproteobacteria_gi_485060621 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p228592 no NCBI prot ID no annotation VI_10038 Gammaproteobacteria_gi_555249617_778_34694 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_019715_p60 YP_007112073.1 hypothetical protein NC_019715 Enterobacterial phage mEp234 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
p146261 no NCBI prot ID no annotation VI_01106 Betaproteobacteria_gi_332283175 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p333380 no NCBI prot ID no annotation VI_10067 Gammaproteobacteria_gi_555262343 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_016160_p57 YP_004934164.1 hypothetical protein NC_016160 Escherichia phage HK75 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
p226027 no NCBI prot ID no annotation VI_12003 Gammaproteobacteria_gi_327187809 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p49621 no NCBI prot ID no annotation VI_11945 Gammaproteobacteria_gi_565624045 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p347775 no NCBI prot ID no annotation VI_03418 Gammaproteobacteria_gi_556694943_136_20291 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p333264 no NCBI prot ID no annotation VI_11358 Gammaproteobacteria_gi_560997453 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p50268 no NCBI prot ID no annotation VI_07737 Gammaproteobacteria_gi_483979653 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p162488 no NCBI prot ID no annotation VI_03797 Gammaproteobacteria_gi_194733902_4314665_4354412 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p264116 no NCBI prot ID no annotation VI_12128 Gammaproteobacteria_gi_498720545 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p125768 no NCBI prot ID no annotation VI_03649 Gammaproteobacteria_gi_525855729_2971232_3013993 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p397403 no NCBI prot ID no annotation VI_05589 Betaproteobacteria_gi_421485108 Viruses.
NC_019705_p66 YP_007111502.1 hypothetical protein NC_019705 Enterobacteria phage mEpX2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
p300661 no NCBI prot ID no annotation VI_07589 Gammaproteobacteria_gi_378578251_30958_56779 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_002167_p61 NP_037756.1 Gp74 NC_002167 Escherichia virus HK97 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
p350415 no NCBI prot ID no annotation VI_10073 Gammaproteobacteria_gi_555265496 Viruses.
NC_019767_p63 YP_007151670.1 hypothetical protein NC_019767 Enterobacteria phage HK544 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
p187221 no NCBI prot ID no annotation VI_04219 Alphaproteobacteria_gi_459785094 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_019721_p57 YP_007112474.1 hypothetical protein NC_019721 Enterobacterial phage mEp390 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p28729 no NCBI prot ID no annotation VI_09758 Gammaproteobacteria_gi_459800005_21159_89156 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p301695 no NCBI prot ID no annotation VI_11850 Gammaproteobacteria_gi_553841430 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_019719_p67 YP_007112343.1 hypothetical protein NC_019719 Enterobacteria phage HK633 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
p30037 no NCBI prot ID no annotation VI_00108 Alphaproteobacteria_gi_485071565 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae; Rhizobium phage 16-3.
p193697 no NCBI prot ID no annotation VI_07595 Gammaproteobacteria_gi_394743162_165631_202524 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p137414 no NCBI prot ID no annotation VI_03321 Gammaproteobacteria_gi_556495303_2971089_3013109 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p409588 no NCBI prot ID no annotation VI_09776 Gammaproteobacteria_gi_472295859 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p150147 no NCBI prot ID no annotation VI_09932 Gammaproteobacteria_gi_554924806_44998_85823 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p205140 no NCBI prot ID no annotation VI_03461 Gammaproteobacteria_gi_386612163_3168188_3204378 Viruses.
NC_011373_p78 YP_002284412.1 putative endonuclease NC_011373 Pseudomonas phage PAJU2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p24502 no NCBI prot ID no annotation VI_02717 Gammaproteobacteria_gi_425084600_4230163_4302681 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p233621 no NCBI prot ID no annotation VI_02607 Gammaproteobacteria_gi_225594896 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p336668 no NCBI prot ID no annotation VI_09978 Gammaproteobacteria_gi_555228400_0_21515 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
NC_019768_p65 YP_007151735.1 hypothetical protein NC_019768 Enterobacteria phage HK106 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
NC_019769_p57 YP_007151792.1 HNH endonuclease NC_019769 Enterobacteria phage HK542 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
p236336 no NCBI prot ID no annotation VI_03614 Gammaproteobacteria_gi_484027889_0_33167 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_019714_p59 YP_007112012.1 hypothetical protein NC_019714 Enterobacteria phage HK446 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus.
KY979108_p24 ASJ79478.1 hypothetical protein KY979108 Escherichia phage ECP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus; unclassified Hendrixvirus.
p30144 no NCBI prot ID no annotation VI_10214 Gammaproteobacteria_gi_470946471 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p398764 no NCBI prot ID no annotation VI_10078 Gammaproteobacteria_gi_555269585 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p214123 no NCBI prot ID no annotation VI_02162 Gammaproteobacteria_gi_425289286_79329_114624 Viruses.
p400665 no NCBI prot ID no annotation VI_04261 Alphaproteobacteria_gi_483997275 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p181340 no NCBI prot ID no annotation VI_07713 Gammaproteobacteria_gi_402295644 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_010355_p27 YP_001686868.1 HNH endonuclease NC_010355 Azospirillum phage Cd Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p290927 no NCBI prot ID no annotation VI_11476 Gammaproteobacteria_gi_545071081_0_27011 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
MG251388_p39 ATW62292.1 HNH endonuclease MG251388 Pseudomonas phage Psp6 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
p280515 no NCBI prot ID no annotation VI_07320 Gammaproteobacteria_gi_485067335 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p259912 no NCBI prot ID no annotation VI_06606 Gammaproteobacteria_gi_294665708 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p383966 no NCBI prot ID no annotation VI_04306 Alphaproteobacteria_gi_523702149 Viruses.
p191583 no NCBI prot ID no annotation VI_09061 Gammaproteobacteria_gi_483055284 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p304447 no NCBI prot ID no annotation VI_11344 Gammaproteobacteria_gi_544778255 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p34577 no NCBI prot ID no annotation VI_03090 Gammaproteobacteria_gi_553772214_118688_181900 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p49930 no NCBI prot ID no annotation VI_08960 Gammaproteobacteria_gi_421175743_205459_262548 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p34040 no NCBI prot ID no annotation VI_03031 Gammaproteobacteria_gi_553750688_638108_701661 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p233443 no NCBI prot ID no annotation VI_08949 Gammaproteobacteria_gi_421161204 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p341867 no NCBI prot ID no annotation VI_04295 Alphaproteobacteria_gi_513139191 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p394442 no NCBI prot ID no annotation VI_04282 Alphaproteobacteria_gi_484225362_0_14781 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p37640 no NCBI prot ID no annotation VI_04229 Alphaproteobacteria_gi_484349863 Viruses.
p114669 no NCBI prot ID no annotation VI_04236 Alphaproteobacteria_gi_484351531_3486_47539 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_83 1008 terminase small subunit head and packaging 38 6.25E-85 75.33
phrog_10282 10 no annotation unknown function 9 9.28E-40 30.15
phrog_854 169 glucosyltransferase moron, auxiliary metabolic gene and host takeover 7 8.76E-19 9.18
phrog_4676 29 no annotation unknown function 4 4.03E-15 5.52
phrog_5601 23 terminase small subunit head and packaging 4 1.14E-15 6.06
phrog_6225 19 no annotation unknown function 3 1.05E-12 3.1
phrog_9557 11 no annotation unknown function 3 8.94E-14 4.17
phrog_32159 2 no annotation unknown function 2 0 1000
phrog_23132 3 no annotation unknown function 2 2.14E-12 2.79
phrog_11951 8 Rz-like spanin lysis 2 1.20E-10 1.04
phrog_18074 5 no annotation unknown function 2 2.14E-11 1.79

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1035 endonuclease VII DNA, RNA and nucleotide metabolism 94.6 0.0027 23-95 / 100-159
phrog_10822 HNH endonuclease DNA, RNA and nucleotide metabolism 94.0 0.0052 23-87 / 98-147
phrog_11604 HNH endonuclease DNA, RNA and nucleotide metabolism 94.2 0.0046 17-87 / 68-129
phrog_119 HNH endonuclease DNA, RNA and nucleotide metabolism 99.5 9.2E-18 4-94 / 10-87
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 92.4 0.02 9-88 / 131-199
phrog_14314 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 2.6E-05 14-90 / 5-65
phrog_144 HNH endonuclease DNA, RNA and nucleotide metabolism 99.7 1.3E-20 3-94 / 40-118
phrog_16726 HNH endonuclease DNA, RNA and nucleotide metabolism 91.3 0.037 19-92 / 75-133
phrog_1985 HNH endonuclease DNA, RNA and nucleotide metabolism 94.7 0.0024 26-94 / 69-132
phrog_2118 HNH endonuclease DNA, RNA and nucleotide metabolism 95.5 0.00054 24-90 / 16-75
phrog_2214 HNH endonuclease DNA, RNA and nucleotide metabolism 96.3 7.7E-05 24-89 / 35-80
phrog_25184 HNH endonuclease DNA, RNA and nucleotide metabolism 90.8 0.047 40-86 / 127-157
phrog_30443 HNH endonuclease DNA, RNA and nucleotide metabolism 92.3 0.021 7-96 / 42-113
phrog_3106 HNH endonuclease DNA, RNA and nucleotide metabolism 96.3 7.7E-05 7-92 / 24-109
phrog_333 HNH endonuclease DNA, RNA and nucleotide metabolism 98.9 6.4E-13 8-94 / 11-78
phrog_338 HNH endonuclease DNA, RNA and nucleotide metabolism 97.5 3.1E-07 7-92 / 8-86
phrog_4234 HNH endonuclease DNA, RNA and nucleotide metabolism 90.8 0.046 5-91 / 8-85
phrog_4581 terminase small subunit head and packaging 99.0 1E-13 6-95 / 43-114
phrog_5718 HNH endonuclease DNA, RNA and nucleotide metabolism 94.0 0.0053 13-91 / 11-73
phrog_589 HNH endonuclease DNA, RNA and nucleotide metabolism 99.9 1.1E-27 3-96 / 28-106
phrog_5956 HNH endonuclease DNA, RNA and nucleotide metabolism 99.9 1.2E-28 20-113 / 2-79
phrog_6050 HNH endonuclease DNA, RNA and nucleotide metabolism 98.4 2.1E-10 22-89 / 3-54
phrog_7785 HNH endonuclease DNA, RNA and nucleotide metabolism 97.0 3.6E-06 16-98 / 50-120
phrog_8048 HNH endonuclease DNA, RNA and nucleotide metabolism 94.8 0.0019 4-85 / 6-75
phrog_8446 HNH endonuclease DNA, RNA and nucleotide metabolism 95.3 0.00091 8-87 / 112-185
phrog_8660 HNH endonuclease DNA, RNA and nucleotide metabolism 91.0 0.042 22-94 / 108-160
phrog_9545 HNH endonuclease DNA, RNA and nucleotide metabolism 91.1 0.042 15-86 / 101-164
phrog_960 HNH endonuclease DNA, RNA and nucleotide metabolism 92.1 0.024 7-93 / 12-91

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF13395.5 HNH endonuclease 2.7E-08 87-134 / 1-50
PF01844.22 HNH endonuclease 1.6E-07 87-134 / 1-47
PF05315.10 ICEA Protein 2.4E-07 73-134 / 81-149
PF14279.5 HNH endonuclease 7.6E-07 87-135 / 1-45
PF05766.11 Bacteriophage Lambda NinG protein 1.1E-06 71-134 / 72-135
PF13391.5 HNH endonuclease 1.1E-05 87-134 / 1-44
PF09665.9 Type II restriction endonuclease (RE_Alw26IDE) 1.8E-05 84-137 / 253-298
PF06147.10 Protein of unknown function (DUF968) 4.1E-05 84-134 / 127-173
PF16784.4 Putative HNHc nuclease 0.0038 84-134 / 123-170

Annotations of the NCBI proteins of this PHROG


11:hypothetical protein 3:HNH endonuclease 1:endonuclease 1:HNH nuclease

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K07451 mcrA : 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] no pathways 250 6

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0004519 endonuclease activity
GO:0003676 nucleic acid binding

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