phrog_2365 is made of 63 protein sequences and is annotated as "replication initiation O-like"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
182.3 370 199


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p389348 no NCBI prot ID no annotation VI_11574 Gammaproteobacteria_gi_545138111 Viruses.
p389683 no NCBI prot ID no annotation VI_11568 Gammaproteobacteria_gi_545137863 Viruses.
p371633 no NCBI prot ID no annotation VI_02052 Gammaproteobacteria_gi_424543426_69_17416 Viruses.
p279182 no NCBI prot ID no annotation VI_02204 Gammaproteobacteria_gi_425371927_243_28987 Viruses.
p339550 no NCBI prot ID no annotation VI_02277 Gammaproteobacteria_gi_430007049 Viruses.
p285642 no NCBI prot ID no annotation VI_02192 Gammaproteobacteria_gi_425341286_585_28468 Viruses.
p285453 no NCBI prot ID no annotation VI_02913 Gammaproteobacteria_gi_425403535_579_28497 Viruses.
p285608 no NCBI prot ID no annotation VI_02049 Gammaproteobacteria_gi_424537448_575_28471 Viruses.
p272726 no NCBI prot ID no annotation VI_02004 Gammaproteobacteria_gi_424461220_249_29926 Viruses.
p389549 no NCBI prot ID no annotation VI_09713 Gammaproteobacteria_gi_445017384 Viruses.
p279108 no NCBI prot ID no annotation VI_01989 Gammaproteobacteria_gi_424292465_245_28991 Viruses.
p203112 no NCBI prot ID no annotation VI_01928 Gammaproteobacteria_gi_424076549 Viruses.
p278789 no NCBI prot ID no annotation VI_02220 Gammaproteobacteria_gi_425397555_249_29029 Viruses.
p369874 no NCBI prot ID no annotation VI_02068 Gammaproteobacteria_gi_424568381_75_17624 Viruses.
p389196 no NCBI prot ID no annotation VI_11555 Gammaproteobacteria_gi_545137460 Viruses.
p283286 no NCBI prot ID no annotation VI_01964 Gammaproteobacteria_gi_424127174_245_28460 Viruses.
p279071 no NCBI prot ID no annotation VI_02216 Gammaproteobacteria_gi_425391437_247_28995 Viruses.
p334238 no NCBI prot ID no annotation VI_01952 Gammaproteobacteria_gi_424108950_14735_36526 Viruses.
p279294 no NCBI prot ID no annotation VI_02170 Gammaproteobacteria_gi_425310464_466_29204 Viruses.
p277064 no NCBI prot ID no annotation VI_02060 Gammaproteobacteria_gi_424555944_245_29370 Viruses.
p277137 no NCBI prot ID no annotation VI_02093 Gammaproteobacteria_gi_425130908_233_29346 Viruses.
p284223 no NCBI prot ID no annotation VI_02200 Gammaproteobacteria_gi_425365507_577_28692 Viruses.
p374165 no NCBI prot ID no annotation VI_09593 Gammaproteobacteria_gi_433119079 Viruses.
p226015 no NCBI prot ID no annotation VI_12003 Gammaproteobacteria_gi_327187809 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p353475 no NCBI prot ID no annotation VI_08078 Gammaproteobacteria_gi_419273358 Viruses.
p240857 no NCBI prot ID no annotation VI_08045 Gammaproteobacteria_gi_419254143_43973_76735 Viruses.
p332339 no NCBI prot ID no annotation VI_11542 Gammaproteobacteria_gi_545137100 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p60260 no NCBI prot ID no annotation VI_03831 Gammaproteobacteria_gi_387610477_855768_907753 Viruses.
p425222 no NCBI prot ID no annotation VI_07830 Gammaproteobacteria_gi_419074373 Viruses.
p339119 no NCBI prot ID no annotation VI_07783 Gammaproteobacteria_gi_419038489 Viruses.
p402812 no NCBI prot ID no annotation VI_08050 Gammaproteobacteria_gi_419260268 Viruses.
p372241 no NCBI prot ID no annotation VI_08114 Gammaproteobacteria_gi_419303677 Viruses.
p413950 no NCBI prot ID no annotation VI_08041 Gammaproteobacteria_gi_419253454 Viruses.
p366083 no NCBI prot ID no annotation VI_08048 Gammaproteobacteria_gi_419255645 Viruses.
p73175 no NCBI prot ID no annotation VI_08736 Gammaproteobacteria_gi_420390330_156297_205382 Viruses.
p329505 no NCBI prot ID no annotation VI_08122 Gammaproteobacteria_gi_419304746 Viruses.
p90197 no NCBI prot ID no annotation VI_08184 Gammaproteobacteria_gi_419353676_74064_120370 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Lambdavirus; unclassified Lambdavirus.
p165609 no NCBI prot ID no annotation VI_07891 Gammaproteobacteria_gi_419118057_83285_122778 Viruses.
p428811 no NCBI prot ID no annotation VI_07766 Gammaproteobacteria_gi_419022414 Viruses.
p139770 no NCBI prot ID no annotation VI_06364 Gammaproteobacteria_gi_193070463_296_42118 Viruses.
p330022 no NCBI prot ID no annotation VI_08315 Gammaproteobacteria_gi_419872236 Viruses.
p436928 no NCBI prot ID no annotation VI_11540 Gammaproteobacteria_gi_545137088 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p433852 no NCBI prot ID no annotation VI_06792 Gammaproteobacteria_gi_415781566 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p309732 no NCBI prot ID no annotation VI_07208 Gammaproteobacteria_gi_417299571_520434_545128 Viruses.
p384685 no NCBI prot ID no annotation VI_08068 Gammaproteobacteria_gi_419267215 Viruses.
p433215 no NCBI prot ID no annotation VI_07831 Gammaproteobacteria_gi_419074396 Viruses.
p421033 no NCBI prot ID no annotation VI_11530 Gammaproteobacteria_gi_545136879 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p440675 no NCBI prot ID no annotation VI_06515 Gammaproteobacteria_gi_163779984_65597_72817 Viruses.
p408608 no NCBI prot ID no annotation VI_11521 Gammaproteobacteria_gi_545136700 Viruses.
p370619 no NCBI prot ID no annotation VI_11523 Gammaproteobacteria_gi_545136726 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p408365 no NCBI prot ID no annotation VI_07901 Gammaproteobacteria_gi_419127143 Viruses.
p189850 no NCBI prot ID no annotation VI_08194 Gammaproteobacteria_gi_419364337 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Lambdavirus; Escherichia virus HK630; Escherichia phage HK630.
p141032 no NCBI prot ID no annotation VI_07779 Gammaproteobacteria_gi_419033576_272955_314629 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Lambdavirus; unclassified Lambdavirus.
p113124 no NCBI prot ID no annotation VI_03709 Gammaproteobacteria_gi_510918428_1548621_1592864 Viruses.
p281181 no NCBI prot ID no annotation VI_07635 Gammaproteobacteria_gi_418827041 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Lederbergvirus.
p88128 no NCBI prot ID no annotation VI_10103 Gammaproteobacteria_gi_555286310 Viruses.
p152776 no NCBI prot ID no annotation VI_02355 Gammaproteobacteria_gi_476381174_175766_216344 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Lambdavirus; unclassified Lambdavirus.
p426190 no NCBI prot ID no annotation VI_10230 Gammaproteobacteria_gi_490283763 Viruses.
p337993 no NCBI prot ID no annotation VI_03719 Gammaproteobacteria_gi_510921654_180464_201856 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Lambdavirus; unclassified Lambdavirus.
p199950 no NCBI prot ID no annotation VI_01844 Gammaproteobacteria_gi_300934732_0_36650 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Lambdavirus; Escherichia virus HK630; Escherichia phage HK630.
p417939 no NCBI prot ID no annotation VI_09376 Gammaproteobacteria_gi_421825205 Viruses.
p118627 no NCBI prot ID no annotation VI_07347 Gammaproteobacteria_gi_417831737_121144_164762 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Lambdavirus; unclassified Lambdavirus.
p192329 no NCBI prot ID no annotation VI_02401 Gammaproteobacteria_gi_478427068 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_2357 64 no annotation unknown function 37 1.09E-140 131.09
phrog_191 559 CII-like transcriptional activator transcription regulation 27 8.03E-69 59.22
phrog_956 154 transposase integration and excision 4 3.95E-12 2.53
phrog_18589 5 no annotation unknown function 2 7.56E-12 2.24

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1123 no annotation unknown function 91.8 0.028 44-104 / 18-70
phrog_142 Ren-like exclusion protein moron, auxiliary metabolic gene and host takeover 91.4 0.036 67-104 / 15-52
phrog_16826 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 99.3 1.7E-15 24-146 / 7-133
phrog_18020 replication initiation O-like DNA, RNA and nucleotide metabolism 97.7 6.8E-08 29-109 / 9-89
phrog_21732 no annotation unknown function 94.4 0.0034 24-100 / 4-79
phrog_270 replication initiation protein DNA, RNA and nucleotide metabolism 95.5 0.00052 25-106 / 2-76
phrog_277 replication initiation O-like DNA, RNA and nucleotide metabolism 100.0 8.5E-66 1-189 / 2-183
phrog_30562 no annotation unknown function 90.5 0.053 42-99 / 16-82
phrog_345 replication initiation O-like DNA, RNA and nucleotide metabolism 99.6 1.9E-20 1-115 / 1-120
phrog_5810 replication initiation protein DNA, RNA and nucleotide metabolism 99.0 3.2E-13 22-150 / 7-140
phrog_678 replication initiation O-like DNA, RNA and nucleotide metabolism 99.9 1.9E-27 21-120 / 1-101

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF04492.12 Bacteriophage replication protein O 1.7E-08 56-133 / 6-83
PF06970.10 Replication initiator protein A (RepA) N-terminus 2.3E-05 59-123 / 2-75
PF16221.4 winged helix-turn-helix 2.6E-05 78-131 / 32-78
PF08221.10 RNA polymerase III subunit RPC82 helix-turn-helix domain 5.5E-05 75-132 / 11-60
PF04358.12 DsrC like protein 8.4E-05 73-135 / 35-97
PF02319.19 E2F/DP family winged-helix DNA-binding domain 9.8E-05 98-133 / 22-57
PF10007.8 Uncharacterized protein conserved in archaea (DUF2250) 0.00011 75-133 / 6-56
PF09114.9 Transcription factor MotA, activation domain 0.00012 73-134 / 12-66
PF08784.10 Replication protein A C terminal 0.00013 74-133 / 37-95
PF05584.10 Sulfolobus plasmid regulatory protein 0.00014 74-133 / 3-52
PF03965.15 Penicillinase repressor 0.00015 77-134 / 3-58
PF01726.15 LexA DNA binding domain 0.00017 99-133 / 25-60
PF04079.15 Segregation and condensation complex subunit ScpB 0.00019 73-134 / 79-129
PF02295.16 Adenosine deaminase z-alpha domain 0.00028 98-133 / 17-53
PF03428.12 Replication protein C N-terminal domain 0.00028 72-133 / 38-105
PF01090.18 Ribosomal protein S19e 0.00032 80-133 / 54-114
PF01978.18 Sugar-specific transcriptional regulator TrmB 0.00035 74-134 / 5-57
PF02002.16 TFIIE alpha subunit 0.0004 78-134 / 13-61
PF09012.9 FeoC like transcriptional regulator 0.00041 98-134 / 13-49
PF14394.5 Domain of unknown function (DUF4423) 0.00043 78-134 / 22-73
PF07381.10 Winged helix DNA-binding domain (DUF1495) 0.00045 75-133 / 7-68
PF14557.5 Putative AphA-like transcriptional regulator 0.00047 73-133 / 4-67
PF12802.6 MarR family 0.00047 100-133 / 22-55
PF13463.5 Winged helix DNA-binding domain 0.00048 98-132 / 16-50
PF05732.10 Firmicute plasmid replication protein (RepL) 0.00061 73-134 / 50-110
PF03551.13 Transcriptional regulator PadR-like family 0.00068 98-134 / 13-51
PF13601.5 Winged helix DNA-binding domain 0.00073 98-133 / 13-48
PF01047.21 MarR family 0.00079 98-133 / 16-51
PF06163.10 Bacterial protein of unknown function (DUF977) 0.0011 98-134 / 25-61
PF05158.11 RNA polymerase Rpc34 subunit 0.0012 73-134 / 88-143
PF09202.10 Rio2, N-terminal 0.0012 75-133 / 4-58
PF13730.5 Helix-turn-helix domain 0.0012 75-129 / 3-52
PF08222.10 CodY helix-turn-helix domain 0.0012 98-133 / 3-38
PF13412.5 Winged helix-turn-helix DNA-binding 0.0012 98-129 / 16-47
PF03444.14 Winged helix-turn-helix transcription repressor, HrcA DNA-binding 0.0012 98-133 / 23-58
PF11313.7 Protein of unknown function (DUF3116) 0.0015 100-134 / 21-62
PF01022.19 Bacterial regulatory protein, arsR family 0.0015 98-129 / 15-46
PF09904.8 Winged helix-turn helix 0.0015 98-131 / 20-53
PF14947.5 Winged helix-turn-helix 0.0016 98-132 / 15-49
PF12840.6 Helix-turn-helix domain 0.0018 98-133 / 22-54
PF09339.9 IclR helix-turn-helix domain 0.0018 100-132 / 19-51
PF05491.12 Holliday junction DNA helicase ruvB C-terminus 0.0019 74-133 / 5-60
PF10771.8 Winged helix-turn-helix domain (DUF2582) 0.002 75-134 / 6-57
PF12793.6 Sugar transport-related sRNA regulator N-term 0.002 98-133 / 17-52
PF14277.5 Domain of unknown function (DUF4364) 0.0021 98-132 / 14-52
PF02082.19 Transcriptional regulator 0.0022 100-132 / 25-57
PF04182.11 B-block binding subunit of TFIIIC 0.0022 98-133 / 17-52
PF01475.18 Ferric uptake regulator family 0.0025 74-133 / 4-61
PF16365.4 Ethanolamine utilization protein EutK C-terminus 0.0029 98-132 / 16-50
PF15977.4 Winged helix-turn-helix DNA binding 0.0031 98-133 / 22-57
PF06969.15 HemN C-terminal domain 0.004 98-133 / 19-55
PF08220.11 DeoR-like helix-turn-helix domain 0.0041 98-133 / 13-48
PF09681.9 N-terminal phage replisome organiser (Phage_rep_org_N) 0.0047 99-132 / 53-86
PF07106.12 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) 0.0049 98-133 / 15-52
PF01638.16 HxlR-like helix-turn-helix 0.0051 98-133 / 18-54
PF09857.8 Putative toxin of bacterial toxin-antitoxin pair 0.0052 74-133 / 2-63
PF01418.16 Helix-turn-helix domain, rpiR family 0.0058 74-133 / 13-68
PF14502.5 Helix-turn-helix domain 0.006 98-133 / 5-40
PF02334.15 Replication terminator protein 0.0065 99-133 / 31-74
PF13545.5 Crp-like helix-turn-helix domain 0.0066 98-133 / 26-61
PF04703.11 FaeA-like protein 0.0073 98-133 / 13-48
PF16864.4 Dimerisation domain 0.0075 98-132 / 31-65
PF09182.9 Bacterial purine repressor, N-terminal 0.0076 98-132 / 19-58
PF13034.5 Protein of unknown function (DUF3895) 0.0084 110-133 / 40-67

Annotations of the NCBI proteins of this PHROG


no RefSeq proteins in this PHROG (only proteins from VirSorter contigs)

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003735 structural constituent of ribosome
GO:0003723 RNA binding
GO:0006412 translation
GO:0006355 regulation of transcription, DNA-templated
GO:0051304 chromosome separation
GO:0006281 DNA repair
GO:0004252 serine-type endopeptidase activity
GO:0006276 plasmid maintenance
GO:0005524 ATP binding
GO:0005666 DNA-directed RNA polymerase III complex
GO:0006508 proteolysis
GO:0004674 protein serine/threonine kinase activity
GO:0006383 transcription by RNA polymerase III
GO:0009289 pilus
GO:0005622 intracellular
GO:0006260 DNA replication
GO:0009378 four-way junction helicase activity
GO:0007131 reciprocal meiotic recombination
GO:0045892 negative regulation of transcription, DNA-templated
GO:0005667 transcription factor complex
GO:0003700 DNA binding transcription factor activity
GO:0006274 DNA replication termination
GO:0005840 ribosome
GO:0006310 DNA recombination
GO:0003726 double-stranded RNA adenosine deaminase activity
GO:0003677 DNA binding
GO:0006468 protein phosphorylation

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