phrog_24545 is made of 3 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
283 392 229


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_021330_p48 YP_008059610.1 Hef nuclease NC_021330 Halovirus HCTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_020158_p46 YP_007378952.1 Hef nuclease NC_020158 Halovirus HVTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_021327_p49 YP_008059091.1 Hef and HNH endonuclease NC_021327 Halovirus HCTV-5 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_36117 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_27403 no annotation unknown function 92.4 0.02 173-215 / 4-47
phrog_3490 ERCC4-type nuclease DNA, RNA and nucleotide metabolism 93.4 0.01 4-135 / 16-158
phrog_3869 NAD-dependent DNA ligase DNA, RNA and nucleotide metabolism 93.0 0.013 176-223 / 503-551

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF03834.13 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) 6E-14 6-144 / 1-113
PF05551.10 Zinc-binding loop region of homing endonuclease 2.1E-07 249-308 / 14-79
PF13392.5 HNH endonuclease 5.5E-07 263-305 / 2-44
PF02732.14 ERCC4 domain 1.2E-05 53-143 / 68-186
PF14520.5 Helix-hairpin-helix domain 4.9E-05 172-223 / 3-57
PF12836.6 Helix-hairpin-helix motif 0.00019 165-223 / 8-64
PF14635.5 Helix-hairpin-helix motif 0.00026 169-224 / 48-102
PF12826.6 Helix-hairpin-helix motif 0.00055 175-226 / 7-58
PF04919.11 Protein of unknown function (DUF655) 0.00097 169-226 / 109-165
PF07750.10 GcrA cell cycle regulator 0.0029 327-368 / 3-44
PF02371.15 Transposase IS116/IS110/IS902 family 0.003 171-244 / 2-78
PF12824.6 Mitochondrial ribosomal protein subunit L20 0.003 324-367 / 86-131
PF10391.8 Fingers domain of DNA polymerase lambda 0.0039 173-218 / 3-47
PF07141.10 Putative bacteriophage terminase small subunit 0.0044 332-367 / 21-55
PF12759.6 InsA C-terminal domain 0.0062 331-366 / 10-44
PF10654.8 Protein of unknown function (DUF2481) 0.0076 334-368 / 72-105
PF06413.10 Neugrin 0.0088 325-371 / 9-56

Annotations of the NCBI proteins of this PHROG


2:Hef nuclease 1:Hef and HNH endonuclease

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0004519 endonuclease activity
GO:0006281 DNA repair
GO:0004518 nuclease activity
GO:0034061 DNA polymerase activity
GO:0003684 damaged DNA binding
GO:0005634 nucleus
GO:0006313 transposition, DNA-mediated
GO:0004803 transposase activity
GO:0003677 DNA binding

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