phrog_3106 is made of 47 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
115.02 334 119


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_031274_p35 YP_009304514.1 putative terminase small subunit NC_031274 Pseudomonas phage O4 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
NC_007808_p19 YP_001294612.1 hypothetical protein ORF019 NC_007808 Pseudomonas phage PA11 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
MF788075_p33 ATG86270.1 terminase small subunit MF788075 Pseudomonas phage IME180 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; unclassified Podoviridae.
NC_018859_p26 YP_006908877.1 hypothetical protein NC_018859 Escherichia phage ECBP2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus.
NC_027395_p27 YP_009152878.1 hypothetical protein NC_027395 Escherichia phage vB_EcoP_SU10 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus.
NC_010324_p30 YP_001671775.1 hypothetical protein NC_010324 Escherichia virus phiEco32 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus.
NC_027988_p34 YP_009168417.1 putative HNHc superfamily protein NC_027988 Citrobacter phage CVT22 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
MG676466_p34 AUG88545.1 putative terminase small subunit MG676466 Pseudomonas phage TC6 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; unclassified Podoviridae.
MG673519_p27 AUM57610.1 hypothetical protein MG673519 Escherichia phage LAMP Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus; unclassified Kuravirus.
NC_023593_p27 YP_009008721.1 hypothetical protein NC_023593 Escherichia phage KBNP1711 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus.
MG983840_p18 AVQ10023.1 terminase small subunit MG983840 Escherichia phage myPSH1131 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus; unclassified Kuravirus.
NC_028903_p46 YP_009208194.1 terminase small subunit NC_028903 Escherichia phage 172-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus.
NC_018835_p33 YP_006906104.1 hypothetical protein NC_018835 Escherichia phage NJ01 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus.
NC_011273_p135 YP_002225053.1 gp144 NC_011273 Mycobacterium phage Myrna Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
MF668280_p145 ASZ74720.1 HNH endonuclease MF668280 Mycobacterium phage Phabba Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_013085_p215 YP_003097449.1 conserved phage protein NC_013085 Synechococcus phage S-RSM4 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Cymopoleiavirus; unclassified Cymopoleiavirus.
NC_031242_p14 YP_009302101.1 putative endonuclease NC_031242 Cyanophage S-RIM50 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Neptunevirus; Synechococcus virus SRIM50.
NC_031935_p26 YP_009324189.1 putative endonuclease NC_031935 Synechococcus phage S-WAM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Cymopoleiavirus; Synechococcus virus SWAM2.
KX349314_p115 AOO16676.1 hypothetical protein KX349314 Cyanophage S-RIM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; unclassified Brizovirus.
KX349310_p112 AOO15817.1 hypothetical protein KX349310 Cyanophage S-RIM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; unclassified Brizovirus.
KX349325_p113 AOO19037.1 hypothetical protein KX349325 Cyanophage S-RIM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; unclassified Brizovirus.
KX349320_p115 AOO17968.1 hypothetical protein KX349320 Cyanophage S-RIM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; unclassified Brizovirus.
KX349322_p113 AOO18394.1 hypothetical protein KX349322 Cyanophage S-RIM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; unclassified Brizovirus.
KX349316_p115 AOO17107.1 hypothetical protein KX349316 Cyanophage S-RIM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; unclassified Brizovirus.
KX349309_p114 AOO15604.1 hypothetical protein KX349309 Cyanophage S-RIM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; unclassified Brizovirus.
KX349317_p114 AOO17322.1 hypothetical protein KX349317 Cyanophage S-RIM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; unclassified Brizovirus.
KP027195_p103 AJD82175.1 HNH endonuclease KP027195 Mycobacterium phage Cosmo Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Wildcatvirus; unclassified Wildcatvirus.
KX349293_p155 AOO12102.1 hypothetical protein KX349293 Cyanophage S-RIM44 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vellamovirus; Synechococcus virus SRIM44.
NC_006883_p148 YP_214381.1 hypothetical protein NC_006883 Prochlorococcus phage P-SSM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Salacisavirus; Prochlorococcus virus PSSM2.
KX349274_p22 AOO07814.1 hypothetical protein KX349274 Synechococcus phage S-RIM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Nerrivikvirus; unclassified Nerrivikvirus.
KX349230_p22 AON98397.1 hypothetical protein KX349230 Synechococcus phage S-RIM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Nerrivikvirus; unclassified Nerrivikvirus.
KX349231_p22 AON98612.1 hypothetical protein KX349231 Synechococcus phage S-RIM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Nerrivikvirus; unclassified Nerrivikvirus.
NC_031935_p25 YP_009324188.1 HNH endonuclease NC_031935 Synechococcus phage S-WAM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Cymopoleiavirus; Synechococcus virus SWAM2.
KJ019052_p136 AIX20027.1 hypothetical protein KJ019052 Synechococcus phage ACG-2014f Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Atlauavirus; Synechococcus virus AC2014fSyn7803C8.
NC_031906_p143 YP_009321406.1 hypothetical protein NC_031906 Synechococcus phage S-CAM3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Charybdisvirus; Synechococcus virus SCAM3.
NC_015285_p121 YP_004323732.1 hypothetical protein NC_015285 Prochlorococcus phage Syn33 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Brizovirus; Prochlorococcus virus Syn33.
KU686198_p143 AOV58887.1 hypothetical protein KU686198 Synechococcus phage S-CAM3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Charybdisvirus; Synechococcus virus SCAM3.
JX000007_p9 AGB07332.1 hypothetical protein JX000007 Yersinia phage R Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; unclassified Teseptimavirus.
NC_004777_p9 NP_848271.1 hypothetical protein NC_004777 Yersinia phage phiA1122 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus.
NC_021327_p142 YP_008059184.1 hypothetical protein NC_021327 Halovirus HCTV-5 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_021328_p68 YP_008059276.1 hypothetical protein NC_021328 Halovirus HGTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
MG269973_p10 ATW62213.1 hypothetical protein MG269973 TM7 phage DolZOral124_53_65 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; unclassified Podoviridae.
NC_028955_p174 YP_009213686.1 hypothetical protein NC_028955 Prochlorococcus phage P-TIM68 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p258400 no NCBI prot ID no annotation VI_11918 Gammaproteobacteria_gi_565825697 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_030936_p21 YP_009276140.1 HNH endonuclease NC_030936 Gordonia phage Bachita Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Smoothievirus.
p137974 no NCBI prot ID no annotation VI_04178 Actinobacteria_gi_494002731 Viruses.
KJ019100_p98 AIX31442.1 hypothetical protein KJ019100 Synechococcus phage ACG-2014f Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Atlauavirus; Synechococcus virus AC2014fSyn7803C8.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_138 688 major head protein head and packaging 12 3.62E-26 16.56
phrog_665 211 no annotation unknown function 9 2.02E-24 14.82
phrog_10643 10 no annotation unknown function 7 2.98E-31 21.65
phrog_3715 39 no annotation unknown function 5 2.56E-18 8.71
phrog_17365 5 no annotation unknown function 2 9.35E-12 2.15
phrog_32507 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10212 no annotation unknown function 98.3 8.1E-10 36-109 / 56-127
phrog_10822 HNH endonuclease DNA, RNA and nucleotide metabolism 97.1 2.6E-06 44-102 / 99-145
phrog_11604 HNH endonuclease DNA, RNA and nucleotide metabolism 95.3 0.00084 35-109 / 69-134
phrog_119 HNH endonuclease DNA, RNA and nucleotide metabolism 97.8 4.6E-08 10-110 / 5-86
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 96.3 6.1E-05 43-109 / 145-203
phrog_144 HNH endonuclease DNA, RNA and nucleotide metabolism 97.5 1.9E-07 13-110 / 39-117
phrog_14736 HNH endonuclease DNA, RNA and nucleotide metabolism 95.7 0.00041 37-103 / 25-78
phrog_15103 no annotation unknown function 97.0 3.9E-06 26-112 / 183-260
phrog_16986 no annotation unknown function 92.3 0.021 44-103 / 20-65
phrog_1985 HNH endonuclease DNA, RNA and nucleotide metabolism 97.7 7.3E-08 43-110 / 66-132
phrog_2118 HNH endonuclease DNA, RNA and nucleotide metabolism 95.1 0.0012 36-108 / 9-76
phrog_2214 HNH endonuclease DNA, RNA and nucleotide metabolism 93.8 0.0065 43-107 / 34-81
phrog_22283 no annotation unknown function 91.4 0.036 44-103 / 22-68
phrog_2255 HNH endonuclease DNA, RNA and nucleotide metabolism 99.8 1.3E-25 36-111 / 57-132
phrog_2323 HNH endonuclease DNA, RNA and nucleotide metabolism 95.8 0.00032 25-109 / 8-92
phrog_25862 HNH endonuclease DNA, RNA and nucleotide metabolism 91.1 0.042 44-105 / 89-137
phrog_2914 endonuclease VII DNA, RNA and nucleotide metabolism 94.2 0.0046 31-111 / 27-86
phrog_30726 no annotation unknown function 98.6 3.9E-11 43-108 / 47-113
phrog_32453 HNH endonuclease DNA, RNA and nucleotide metabolism 91.6 0.032 44-110 / 72-121
phrog_333 HNH endonuclease DNA, RNA and nucleotide metabolism 95.8 0.00026 28-111 / 14-78
phrog_338 HNH endonuclease DNA, RNA and nucleotide metabolism 96.1 0.00011 44-109 / 28-86
phrog_3497 no annotation unknown function 95.1 0.0012 34-115 / 16-109
phrog_35854 HNH endonuclease DNA, RNA and nucleotide metabolism 99.1 2.9E-14 43-109 / 5-72
phrog_4234 HNH endonuclease DNA, RNA and nucleotide metabolism 99.6 7.6E-19 23-110 / 9-87
phrog_4581 terminase small subunit head and packaging 96.6 2.3E-05 11-108 / 37-110
phrog_589 HNH endonuclease DNA, RNA and nucleotide metabolism 97.5 3.3E-07 26-110 / 34-103
phrog_5956 HNH endonuclease DNA, RNA and nucleotide metabolism 97.3 8E-07 44-111 / 6-62
phrog_6050 HNH endonuclease DNA, RNA and nucleotide metabolism 96.2 0.0001 44-108 / 5-56
phrog_6544 no annotation unknown function 94.8 0.0021 25-112 / 8-77
phrog_740 HNH endonuclease DNA, RNA and nucleotide metabolism 94.6 0.0027 32-108 / 7-71
phrog_7785 HNH endonuclease DNA, RNA and nucleotide metabolism 94.7 0.0022 34-106 / 59-112
phrog_8048 HNH endonuclease DNA, RNA and nucleotide metabolism 97.3 6.4E-07 28-110 / 13-83
phrog_8446 HNH endonuclease DNA, RNA and nucleotide metabolism 92.5 0.019 29-104 / 116-185

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF05315.10 ICEA Protein 3.1E-08 166-240 / 83-150
PF13395.5 HNH endonuclease 6.5E-08 181-240 / 1-51
PF01844.22 HNH endonuclease 1.6E-07 181-239 / 1-47
PF14279.5 HNH endonuclease 4E-07 181-241 / 1-46
PF00488.20 MutS domain V 1.3E-06 20-127 / 75-172
PF05766.11 Bacteriophage Lambda NinG protein 3.2E-06 178-241 / 87-137
PF09665.9 Type II restriction endonuclease (RE_Alw26IDE) 6E-06 178-241 / 253-297
PF02456.14 Adenovirus IVa2 protein 1E-05 22-77 / 188-239
PF13391.5 HNH endonuclease 1E-05 181-240 / 1-45
PF06147.10 Protein of unknown function (DUF968) 1.4E-05 178-240 / 127-174
PF16813.4 CRISPR-associated protein Csn2 subfamily St 0.00012 22-74 / 183-227
PF11398.7 Protein of unknown function (DUF2813) 0.00065 21-80 / 254-301
PF13304.5 AAA domain, putative AbiEii toxin, Type IV TA system 0.00069 24-75 / 238-278
PF13175.5 AAA ATPase domain 0.00085 22-75 / 356-399
PF09818.8 Predicted ATPase of the ABC class 0.0016 22-61 / 343-397
PF16784.4 Putative HNHc nuclease 0.0021 178-240 / 123-171

Annotations of the NCBI proteins of this PHROG


33:hypothetical protein 5:terminase small subunit 4:HNH endonuclease 2:endonuclease 1:HNHc superfamily protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K07451 mcrA : 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] no pathways 121 1

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0004519 endonuclease activity
GO:0003676 nucleic acid binding
GO:0030983 mismatched DNA binding
GO:0005524 ATP binding
GO:0019073 viral DNA genome packaging
GO:0006298 mismatch repair

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