phrog_3377 is made of 42 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
164.14 351 150


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_027355_p168 YP_009149729.1 hypothetical protein NC_027355 Bacillus phage BCP8-2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Caeruleovirus.
KY888882_p255 ARQ95166.1 hypothetical protein KY888882 Bacillus phage Flapjack Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Bequatrovirus; unclassified Bequatrovirus.
NC_000896_p19 NP_050127.1 hypothetical protein NC_000896 Lactobacillus phage phiadh Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
KU708004_p80 AMW64540.1 hypothetical protein KU708004 Pseudomonas phage phiAH14a Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
JQ692107_p1 AFE86328.1 hypothetical protein JQ692107 Vibrio phage SSP002 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mardecavirus; Vibrio virus SSP002.
NC_020081_p170 YP_007349209.1 hypothetical protein NC_020081 Bacillus phage phiAGATE Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Agatevirus.
NC_022763_p251 YP_008770475.1 hypothetical protein NC_022763 Bacillus phage Spock Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Bequatrovirus.
NC_022763_p163 YP_008770387.1 hypothetical protein NC_022763 Bacillus phage Spock Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Bequatrovirus.
NC_027355_p208 YP_009149769.1 hypothetical protein NC_027355 Bacillus phage BCP8-2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Caeruleovirus.
NC_022088_p173 YP_008430957.1 HNH endonuclease domain protein NC_022088 Bacillus phage Troll Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Bequatrovirus.
NC_031100_p166 YP_009290045.1 HNH homing endonuclease NC_031100 Bacillus phage Phrodo Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Bequatrovirus; unclassified Bequatrovirus.
AP017924_p1 BAW18975.1 hypothetical protein AP017924 Ralstonia phage RP12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Ripduovirus; Ralstonia virus RP12.
NC_027352_p42 YP_009149080.1 hypothetical protein NC_027352 Bacillus phage JBP901 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Caeruleovirus.
NC_027355_p73 YP_009149634.1 hypothetical protein NC_027355 Bacillus phage BCP8-2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Caeruleovirus.
MF498901_p265 ASU01112.1 HNH homing endonuclease MF498901 Bacillus phage Anthony Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Bastillevirus; unclassified Bastillevirus.
NC_018863_p90 YP_006908319.1 hypothetical protein NC_018863 Bacillus phage B4 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Bequatrovirus.
NC_018856_p199 YP_006907488.1 deoxyuridine 5'-triphosphate nucleotidohydrolase family protein NC_018856 Bacillus phage Bastille Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Bastillevirus.
NC_023582_p53 YP_009007716.1 hypothetical protein NC_023582 Staphylococcus phage vB_SepS_SEP9 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Sextaecvirus.
p361873 no NCBI prot ID no annotation VI_05424 Bacilli_gi_565851255 Viruses; unclassified bacterial viruses.
NC_028666_p5 YP_009188459.1 hypothetical protein NC_028666 Streptococcus phage Str-PAP-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
KM058087_p36 AIK67540.1 hypothetical protein KM058087 Cronobacter phage vB_CsaP_Ss1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; unclassified Podoviridae.
KJ019086_p189 AIX27830.1 putative HNH endonuclease KJ019086 Synechococcus phage ACG-2014f Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Atlauavirus; Synechococcus virus AC2014fSyn7803C8.
p38141 no NCBI prot ID no annotation VI_05808 Clostridia_gi_484142200 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p314994 no NCBI prot ID no annotation VI_01130 Clostridia_gi_545422032 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_000935_p46 NP_051007.1 P46 NC_000935 Hamiltonella virus APSE1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
NC_019713_p94 YP_007111940.1 hypothetical protein NC_019713 Vibrio phage vB_VpaS_MAR10 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mardecavirus.
NC_007021_p151 YP_238685.1 ORF076 NC_007021 Staphylococcus phage Twort Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Twortvirinae; Twortvirus.
NC_029094_p171 YP_009225605.1 hypothetical protein NC_029094 Pseudoalteromonas phage H101 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
NC_016765_p30 YP_005098233.1 hypothetical protein NC_016765 Pseudomonas virus PMG1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Detrevirus.
NC_016762_p63 YP_005098090.1 hypothetical protein NC_016762 Pseudomonas phage phi297 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_002484_p30 NP_061526.2 hypothetical protein NC_002484 Pseudomonas virus D3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Detrevirus.
p351397 no NCBI prot ID no annotation VI_04804 Bacilli_gi_418973915 Viruses; unclassified bacterial viruses.
p305669 no NCBI prot ID no annotation VI_05427 Bacilli_gi_565854743 Viruses; unclassified bacterial viruses.
p395408 no NCBI prot ID no annotation VI_04399 Bacilli_gi_149004357 Viruses; unclassified bacterial viruses.
p69265 no NCBI prot ID no annotation VI_03262 Gammaproteobacteria_gi_218888746_2690476_2740340 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p69338 no NCBI prot ID no annotation VI_03935 Gammaproteobacteria_gi_568151185_2648273_2698137 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p202809 no NCBI prot ID no annotation VI_11983 Gammaproteobacteria_gi_565901485_0_36402 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; unclassified Podoviridae; Pseudomonas phage vB_PaeP_Tr60_Ab31.
NC_023582_p124 YP_009007787.1 HNH endonuclease NC_023582 Staphylococcus phage vB_SepS_SEP9 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Sextaecvirus.
NC_019713_p1 YP_007111847.1 hypothetical protein NC_019713 Vibrio phage vB_VpaS_MAR10 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mardecavirus.
AB746912_p13 BAN05322.1 hypothetical protein AB746912 Nitratiruptor phage NrS-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_020488_p25 YP_007518367.1 hypothetical protein NC_020488 Vibrio phage VvAW1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
p286989 no NCBI prot ID no annotation VI_08972 Gammaproteobacteria_gi_421264810 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_8418 13 portal protein head and packaging 4 3.16E-18 8.62
phrog_19842 4 polymerase DNA, RNA and nucleotide metabolism 3 3.35E-17 7.6
phrog_9050 12 no annotation unknown function 2 9.91E-11 1.13

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1035 endonuclease VII DNA, RNA and nucleotide metabolism 92.2 0.022 61-91 / 118-151
phrog_1065 no annotation unknown function 96.2 9.7E-05 102-140 / 49-87
phrog_1400 Srd anti-sigma factor moron, auxiliary metabolic gene and host takeover 90.3 0.058 56-91 / 55-86
phrog_2081 HNH endonuclease DNA, RNA and nucleotide metabolism 100.0 2.2E-34 3-125 / 9-148
phrog_26731 no annotation unknown function 95.3 0.00085 95-135 / 5-47
phrog_28742 no annotation unknown function 97.6 1.5E-07 9-125 / 22-140
phrog_3118 HNH endonuclease DNA, RNA and nucleotide metabolism 95.3 0.00084 62-89 / 72-99
phrog_3190 no annotation unknown function 95.4 0.00069 59-140 / 64-152
phrog_3322 endonuclease DNA, RNA and nucleotide metabolism 96.4 4.5E-05 9-91 / 22-108
phrog_374 HNH endonuclease DNA, RNA and nucleotide metabolism 100.0 4.5E-44 5-140 / 74-208
phrog_4578 HNH endonuclease DNA, RNA and nucleotide metabolism 96.5 2.9E-05 55-91 / 3-39
phrog_4583 transcriptional repressor transcription regulation 90.3 0.058 105-134 / 25-56
phrog_59 HNH endonuclease DNA, RNA and nucleotide metabolism 94.8 0.0021 55-123 / 65-131
phrog_8790 restriction endonuclease DNA, RNA and nucleotide metabolism 100.0 1.1E-41 3-99 / 12-110
phrog_953 HNH endonuclease DNA, RNA and nucleotide metabolism 99.6 3.7E-20 4-91 / 23-110

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF04936.11 Protein of unknown function (DUF658) 0.00024 151-229 / 14-114
PF01710.15 Transposase 7.2E-07 199-302 / 13-105
PF08822.10 Protein of unknown function (DUF1804) 1.2E-06 202-299 / 17-112
PF00292.17 'Paired box' domain 1.2E-05 200-289 / 29-125
PF04552.12 Sigma-54, DNA binding domain 8.2E-05 201-298 / 45-156
PF07768.10 PVL ORF-50-like family 0.00069 147-186 / 4-47
PF07750.10 GcrA cell cycle regulator 0.00075 258-295 / 9-47
PF12759.6 InsA C-terminal domain 0.0027 264-291 / 18-45
PF13411.5 MerR HTH family regulatory protein 0.0033 206-226 / 2-22
PF07141.10 Putative bacteriophage terminase small subunit 0.0069 260-291 / 24-55
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 0.0083 265-292 / 11-38

Annotations of the NCBI proteins of this PHROG


24:hypothetical protein 2:HNH homing endonuclease 2:HNH endonuclease 1:protein of an unannotated phage 1:HNH endonuclease domain protein 1:deoxyuridine 5'-triphosphate nucleotidohydrolase family protein 1:P46

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003677 DNA binding
GO:0019069 viral capsid assembly
GO:0006355 regulation of transcription, DNA-templated
GO:0005524 ATP binding

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