phrog_35117 is made of 2 protein sequences and is annotated as "HTH DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
51.5 53 53


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KX379668_p25 ANY28814.1 hypothetical protein KX379668 Lactococcus phage 4R16L2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Skunavirus; unclassified Skunavirus.
KP793123_p25 ALM64140.1 HNH endonuclease KP793123 Lactococcus phage 936 group phage Phi4.2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Skunavirus; unclassified Skunavirus.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_30377 2 HNH endonuclease DNA, RNA and nucleotide metabolism 2 0 1000
phrog_3874 36 transglycosylase other 2 2.35E-13 3.75

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
no PHROGs similar                                                                           

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF04645.11 Protein of unknown function, DUF603 3.9E-08 5-48 / 7-53
PF01381.21 Helix-turn-helix 5.3E-08 15-46 / 6-37
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 5.3E-08 6-42 / 11-47
PF05339.10 Protein of unknown function (DUF739) 9.2E-08 12-46 / 10-44
PF00356.20 Bacterial regulatory proteins, lacI family 2.9E-07 20-45 / 1-26
PF14590.5 Domain of unknown function (DUF4447) 3.2E-07 7-46 / 9-48
PF17443.1 Uncharacterized protein pXO2-72 4.7E-07 16-40 / 6-30
PF10654.8 Protein of unknown function (DUF2481) 4.9E-07 16-42 / 78-104
PF09035.9 Excisionase from transposon Tn916 6.1E-07 13-40 / 10-37
PF11112.7 Pyocin activator protein PrtN 6.1E-07 16-44 / 11-40
PF13413.5 Helix-turn-helix domain 9.6E-07 14-43 / 5-34
PF00376.22 MerR family regulatory protein 1E-06 21-45 / 2-26
PF13744.5 Helix-turn-helix domain 1.1E-06 13-42 / 26-55
PF06322.10 Phage NinH protein 1.2E-06 16-43 / 14-41
PF06806.11 Putative excisionase (DUF1233) 1.4E-06 15-40 / 6-31
PF07278.10 Protein of unknown function (DUF1441) 1.7E-06 19-43 / 2-26
PF07453.12 NUMOD1 domain 1.7E-06 16-39 / 17-40
PF08965.9 Domain of unknown function (DUF1870) 1.8E-06 11-45 / 7-43
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 2E-06 17-44 / 10-38
PF12116.7 Stage III sporulation protein D 2.3E-06 17-42 / 18-43
PF13443.5 Cro/C1-type HTH DNA-binding domain 2.4E-06 16-41 / 8-34
PF12844.6 Helix-turn-helix domain 3.1E-06 16-45 / 10-39
PF13560.5 Helix-turn-helix domain 3.1E-06 13-46 / 9-42
PF08535.9 KorB domain 3.2E-06 18-43 / 3-28
PF10743.8 Regulatory phage protein cox 3.5E-06 16-44 / 9-37
PF04814.12 Hepatocyte nuclear factor 1 (HNF-1), N terminus 3.5E-06 14-46 / 122-154
PF07825.10 Excisionase-like protein 3.8E-06 18-44 / 2-30
PF13591.5 MerR HTH family regulatory protein 4.3E-06 20-43 / 2-25
PF05930.11 Prophage CP4-57 regulatory protein (AlpA) 4.6E-06 18-42 / 3-28
PF04936.11 Protein of unknown function (DUF658) 0.00013 17-43 / 87-113
PF08667.9 BetR domain 5.1E-06 6-45 / 6-49
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 5.2E-06 17-43 / 12-38
PF12964.6 Protein of unknown function (DUF3853) 5.8E-06 16-46 / 43-73
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 6.7E-06 20-44 / 10-33
PF07141.10 Putative bacteriophage terminase small subunit 6.5E-06 16-42 / 29-55
PF05269.10 Bacteriophage CII protein 6.9E-06 15-41 / 20-46
PF13411.5 MerR HTH family regulatory protein 8.5E-06 20-42 / 2-24
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 8.6E-06 15-46 / 79-110
PF04552.12 Sigma-54, DNA binding domain 1.1E-05 16-42 / 46-72
PF12728.6 Helix-turn-helix domain 1.1E-05 19-43 / 2-27
PF02042.14 RWP-RK domain 1.6E-05 15-42 / 9-36
PF07471.11 Phage DNA packaging protein Nu1 1.7E-05 18-42 / 2-26
PF08765.10 Mor transcription activator family 1.8E-05 17-43 / 71-97
PF07750.10 GcrA cell cycle regulator 2.1E-05 16-42 / 16-43
PF02954.18 Bacterial regulatory protein, Fis family 2.3E-05 17-40 / 15-38
PF00157.16 Pou domain - N-terminal to homeobox domain 2.6E-05 9-42 / 11-50
PF07037.10 Putative transcription regulator (DUF1323) 2.9E-05 20-41 / 2-23
PF01371.18 Trp repressor protein 3E-05 16-45 / 46-75
PF12759.6 InsA C-terminal domain 3.4E-05 17-41 / 20-44
PF14549.5 DNA-binding transcriptional regulator Cro 3.5E-05 15-38 / 7-29
PF06970.10 Replication initiator protein A (RepA) N-terminus 3.7E-05 20-40 / 53-73
PF12824.6 Mitochondrial ribosomal protein subunit L20 3.9E-05 18-42 / 107-131
PF08822.10 Protein of unknown function (DUF1804) 5.4E-05 16-41 / 17-42
PF02319.19 E2F/DP family winged-helix DNA-binding domain 5.5E-05 17-41 / 22-46
PF13309.5 HTH domain 5.7E-05 19-39 / 42-62
PF05344.10 Domain of Unknown Function (DUF746) 5.7E-05 17-41 / 11-35
PF04218.12 CENP-B N-terminal DNA-binding domain 6.1E-05 18-42 / 23-47
PF13404.5 AsnC-type helix-turn-helix domain 6.9E-05 17-40 / 16-39
PF00292.17 'Paired box' domain 7.7E-05 16-41 / 31-56
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 8.3E-05 17-42 / 18-43
PF03333.12 Adhesin biosynthesis transcription regulatory protein 8.2E-05 17-42 / 54-79
PF02796.14 Helix-turn-helix domain of resolvase 9E-05 17-40 / 20-43
PF05043.12 Mga helix-turn-helix domain 8.7E-05 16-41 / 28-53
PF02376.14 CUT domain 9.3E-05 10-42 / 12-45
PF06971.12 Putative DNA-binding protein N-terminus 9.4E-05 18-39 / 27-48
PF13412.5 Winged helix-turn-helix DNA-binding 9.9E-05 17-42 / 16-41
PF09012.9 FeoC like transcriptional regulator 0.00011 16-41 / 12-37
PF14056.5 Domain of unknown function (DUF4250) 0.00011 16-42 / 17-43
PF09048.9 Cro 0.00012 17-43 / 12-38
PF09607.9 Brinker DNA-binding domain 0.00012 19-42 / 26-49
PF13011.5 leucine-zipper of insertion element IS481 0.00013 16-41 / 22-47
PF00440.22 Bacterial regulatory proteins, tetR family 0.00013 19-42 / 16-39
PF01710.15 Transposase 0.00013 16-41 / 16-41
PF13693.5 Winged helix-turn-helix DNA-binding 0.00016 14-41 / 11-38
PF05225.15 helix-turn-helix, Psq domain 0.00017 16-41 / 14-40
PF08222.10 CodY helix-turn-helix domain 0.00018 18-41 / 4-27
PF07638.10 ECF sigma factor 0.00019 16-42 / 147-173
PF13936.5 Helix-turn-helix domain 0.00021 17-40 / 19-42
PF13542.5 Helix-turn-helix domain of transposase family ISL3 0.00024 20-41 / 28-49
PF07618.10 Protein of unknown function (DUF1580) 0.00023 23-42 / 7-26
PF13556.5 PucR C-terminal helix-turn-helix domain 0.00025 17-41 / 11-35
PF16677.4 DNA-packaging protein gp3 0.00024 17-42 / 28-53
PF14493.5 Helix-turn-helix domain 0.00027 16-41 / 10-35
PF12793.6 Sugar transport-related sRNA regulator N-term 0.00027 15-41 / 15-41
PF13022.5 Helix-turn-helix of insertion element transposase 0.00029 18-41 / 25-48
PF16221.4 winged helix-turn-helix 0.00029 18-41 / 46-69
PF07506.10 RepB plasmid partitioning protein 0.0003 17-42 / 20-45
PF10668.8 Phage terminase small subunit 0.00033 18-41 / 22-45
PF15978.4 Tn7-like transposition protein D 0.00033 17-41 / 202-226
PF04492.12 Bacteriophage replication protein O 0.00033 18-41 / 49-72
PF10007.8 Uncharacterized protein conserved in archaea (DUF2250) 0.00036 17-41 / 21-45
PF01022.19 Bacterial regulatory protein, arsR family 0.00038 17-41 / 15-39
PF04967.11 HTH DNA binding domain 0.00042 19-41 / 24-46
PF08279.11 HTH domain 0.00052 17-41 / 14-38
PF00325.19 Bacterial regulatory proteins, crp family 0.00055 20-41 / 4-25
PF16509.4 TrfB plasmid transcriptional repressor 0.00055 17-41 / 30-54
PF00126.26 Bacterial regulatory helix-turn-helix protein, lysR family 0.00056 19-41 / 12-34
PF08281.11 Sigma-70, region 4 0.00056 17-41 / 25-49
PF05331.10 Protein of unknown function (DUF742) 0.00053 17-41 / 52-76
PF09182.9 Bacterial purine repressor, N-terminal 0.00059 16-41 / 18-43
PF13171.5 Protein of unknown function (DUF4004) 0.00056 19-43 / 3-27
PF11242.7 Protein of unknown function (DUF2774) 0.00061 16-41 / 12-37
PF04545.15 Sigma-70, region 4 0.00062 17-41 / 23-47
PF07381.10 Winged helix DNA-binding domain (DUF1495) 0.00063 16-40 / 22-46
PF11427.7 Tc3 transposase 0.00068 17-41 / 19-43
PF06413.10 Neugrin 0.00063 18-42 / 29-53
PF06627.10 Protein of unknown function (DUF1153) 0.00067 18-41 / 46-69
PF09904.8 Winged helix-turn helix 0.00074 16-41 / 19-44
PF13518.5 Helix-turn-helix domain 0.00078 17-41 / 10-34
PF16264.4 SatD family (SatD) 0.00076 17-42 / 170-195
PF01418.16 Helix-turn-helix domain, rpiR family 0.00077 18-41 / 34-57
PF11972.7 HTH DNA binding domain 0.00081 16-41 / 11-36
PF12802.6 MarR family 0.00089 19-41 / 22-44
PF06892.10 Phage regulatory protein CII (CP76) 0.00095 19-42 / 20-43
PF08221.10 RNA polymerase III subunit RPC82 helix-turn-helix domain 0.0011 16-41 / 25-50
PF08280.10 M protein trans-acting positive regulator (MGA) HTH domain 0.0011 17-42 / 19-44
PF13601.5 Winged helix DNA-binding domain 0.0013 16-41 / 12-37
PF07900.10 Protein of unknown function (DUF1670) 0.0014 16-41 / 93-118
PF01527.19 Transposase 0.0016 16-41 / 19-44
PF02082.19 Transcriptional regulator 0.0016 19-41 / 25-47
PF14947.5 Winged helix-turn-helix 0.0017 16-41 / 14-39
PF09339.9 IclR helix-turn-helix domain 0.0017 19-41 / 19-41
PF15977.4 Winged helix-turn-helix DNA binding 0.0018 17-41 / 22-46
PF00196.18 Bacterial regulatory proteins, luxR family 0.0021 17-41 / 16-40
PF13384.5 Homeodomain-like domain 0.0021 18-41 / 17-40
PF00392.20 Bacterial regulatory proteins, gntR family 0.0021 17-41 / 22-47
PF05584.10 Sulfolobus plasmid regulatory protein 0.0022 16-41 / 16-41
PF13463.5 Winged helix DNA-binding domain 0.0024 16-41 / 15-40
PF01047.21 MarR family 0.0024 17-41 / 16-40
PF04297.13 Putative helix-turn-helix protein, YlxM / p13 like 0.0025 17-42 / 32-57
PF05732.10 Firmicute plasmid replication protein (RepL) 0.0027 17-41 / 74-98
PF13551.5 Winged helix-turn helix 0.0029 18-41 / 11-34
PF06163.10 Bacterial protein of unknown function (DUF977) 0.0031 17-41 / 25-49
PF02002.16 TFIIE alpha subunit 0.0032 16-40 / 24-48
PF04703.11 FaeA-like protein 0.0035 17-40 / 13-36
PF07768.10 PVL ORF-50-like family 0.0033 23-42 / 17-36
PF06530.11 Phage antitermination protein Q 0.0036 17-41 / 78-102
PF10975.7 Protein of unknown function (DUF2802) 0.0037 16-38 / 41-63
PF04182.11 B-block binding subunit of TFIIIC 0.0042 17-41 / 17-41
PF07374.10 Protein of unknown function (DUF1492) 0.0042 17-41 / 70-94
PF01325.18 Iron dependent repressor, N-terminal DNA binding domain 0.0048 17-41 / 20-44
PF13545.5 Crp-like helix-turn-helix domain 0.0053 17-41 / 26-50
PF14502.5 Helix-turn-helix domain 0.0054 18-40 / 6-28
PF01978.18 Sugar-specific transcriptional regulator TrmB 0.0057 17-41 / 21-45
PF02001.15 Protein of unknown function DUF134 0.0056 17-41 / 46-70
PF09824.8 ArsR transcriptional regulator 0.0057 17-42 / 121-146
PF16365.4 Ethanolamine utilization protein EutK C-terminus 0.0067 17-41 / 16-40
PF08220.11 DeoR-like helix-turn-helix domain 0.0078 17-41 / 13-37
PF06969.15 HemN C-terminal domain 0.0083 16-39 / 18-42
PF11994.7 Protein of unknown function (DUF3489) 0.0085 10-41 / 13-44

Annotations of the NCBI proteins of this PHROG


1:hypothetical protein 1:HNH endonuclease

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0009289 pilus
GO:0045893 positive regulation of transcription, DNA-templated
GO:0006260 DNA replication
GO:0005622 intracellular
GO:0005667 transcription factor complex
GO:0045892 negative regulation of transcription, DNA-templated
GO:0016987 sigma factor activity
GO:0000150 recombinase activity
GO:0006313 transposition, DNA-mediated
GO:0003700 DNA binding transcription factor activity
GO:0006310 DNA recombination
GO:0003677 DNA binding
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006352 DNA-templated transcription, initiation
GO:0051775 response to redox state
GO:0019069 viral capsid assembly
GO:0060567 negative regulation of DNA-templated transcription, termination
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0006276 plasmid maintenance
GO:0043565 sequence-specific DNA binding
GO:0004803 transposase activity

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