phrog_3593 is made of 40 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
193.28 401 186


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KY348865_p14 APU93018.1 HNH endonuclease KY348865 Mycobacterium phage Bubbles123 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
KX808131_p14 APC43511.1 HNH endonuclease KX808131 Mycobacterium phage SuperGrey Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_021334_p70 YP_008059971.1 putative HNH endonuclease NC_021334 Mycobacterium phage WIVsmall Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_023725_p193 YP_009016654.1 gp223 NC_023725 Mycobacterium phage Nappy Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
NC_028844_p14 YP_009202531.1 HNH homing endonuclease NC_028844 Mycobacterium phage Phatniss Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
JF704116_p189 AEK07034.1 hypothetical protein JF704116 Mycobacterium phage Drazdys Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
NC_004685_p56 NP_817907.1 gp56 NC_004685 Mycobacterium virus Corndog Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Corndogvirus.
NC_019721_p55 YP_007112472.1 hypothetical protein NC_019721 Enterobacterial phage mEp390 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_026593_p15 YP_009125008.1 HNH endonuclease NC_026593 Mycobacterium phage BuzzLyseyear Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
KJ829260_p57 AII28296.1 hypothetical protein KJ829260 Mycobacterium phage YungJamal Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Corndogvirus; unclassified Corndogvirus.
NC_022330_p43 YP_008531119.1 HNH endonuclease NC_022330 Mycobacterium phage Quink Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Kostyavirus; unclassified Kostyavirus.
MF919526_p14 ATN91280.1 HNH endonuclease MF919526 Mycobacterium phage Phasih Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
KY979108_p21 ASJ79475.1 glycosyltransferase KY979108 Escherichia phage ECP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Hendrixvirus; unclassified Hendrixvirus.
NC_023712_p54 YP_009014417.1 gp54 NC_023712 Mycobacterium virus Firecracker Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Corndogvirus.
NC_021538_p15 YP_008126605.1 HNH endonuclease NC_021538 Mycobacterium phage Job42 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_022055_p15 YP_008408972.1 HNH endonuclease NC_022055 Mycobacterium phage Bobi Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MF919501_p15 ATN88507.1 HNH endonuclease MF919501 Mycobacterium phage DaWorst Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_014901_p14 YP_004123836.1 gp14 NC_014901 Mycobacterium phage Wee Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
MG962361_p15 AVO24554.1 HNH endonuclease MG962361 Mycobacterium phage Alexphander Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MH051257_p15 AVR77231.1 HNH endonuclease MH051257 Mycobacterium phage OwlsT2W Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_023725_p87 YP_009016548.1 gp90 NC_023725 Mycobacterium phage Nappy Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
NC_022062_p4 YP_008409736.1 HNH domain protein NC_022062 Mycobacterium phage Trouble Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
NC_023862_p7 YP_009021575.1 hypothetical protein NC_023862 Mycobacterium phage Alsfro Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
p118875 no NCBI prot ID no annotation VI_11329 Gammaproteobacteria_gi_566073850_157357_200954 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p59673 no NCBI prot ID no annotation VI_07031 Gammaproteobacteria_gi_416532884_149707_201891 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p204980 no NCBI prot ID no annotation VI_00022 Actinobacteria_gi_223955933_488_36693 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_011273_p209 YP_002225127.1 gp250 NC_011273 Mycobacterium phage Myrna Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
MH051261_p189 AVR77971.1 HNH endonuclease MH051261 Mycobacterium phage Tyke Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; unclassified Bixzunavirus.
KT365398_p192 ALF51055.1 hypothetical protein KT365398 Mycobacterium phage DTDevon Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
JF704096_p190 AEJ94951.1 hypothetical protein JF704096 Mycobacterium phage Ghost Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
NC_028869_p183 YP_009204748.1 HNH endonuclease NC_028869 Mycobacterium phage HyRo Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
MF919494_p181 ATN87639.1 HNH endonuclease MF919494 Mycobacterium phage BeanWater Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; unclassified Bixzunavirus.
NC_021348_p193 YP_008061451.1 hypothetical protein NC_021348 Mycobacterium phage ArcherS7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
MG872839_p188 AVI04791.1 HNH endonuclease MG872839 Mycobacterium phage LifeSavor Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; unclassified Bixzunavirus.
KX808131_p41 APC43536.1 HNH endonuclease KX808131 Mycobacterium phage SuperGrey Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MH020235_p42 AVP41698.1 HNH endonuclease MH020235 Mycobacterium phage Batiatus Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_022055_p45 YP_008409002.1 HNH endonuclease NC_022055 Mycobacterium phage Bobi Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
JN797798_p216 AEW47722.1 hypothetical protein JN797798 Bacillus phage BCU4 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Tsarbombavirus; Bacillus virus BCP78.
NC_027352_p201 YP_009149239.1 putative HNH homing endonuclease NC_027352 Bacillus phage JBP901 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Caeruleovirus.
NC_024138_p49 YP_009031559.1 HNH homing endonuclease NC_024138 Mycobacterium phage MosMoris Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Marvinvirus.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_1942 79 tail length tape measure protein tail 11 2.26E-36 26.77
phrog_3061 47 no annotation unknown function 9 4.46E-32 22.47
phrog_1362 109 no annotation unknown function 9 3.65E-28 18.56
phrog_621 225 tail assembly chaperone tail 7 2.24E-19 9.77
phrog_978 151 tail assembly chaperone tail 5 4.02E-15 5.52
phrog_1579 95 glycosyltransferase moron, auxiliary metabolic gene and host takeover 4 2.02E-13 3.82
phrog_2337 64 tail length tape measure protein tail 3 2.81E-11 1.67
phrog_25273 3 tail assembly chaperone tail 2 5.56E-13 3.38

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10495 HNH endonuclease DNA, RNA and nucleotide metabolism 96.9 5.2E-06 75-123 / 10-58
phrog_13470 HNH endonuclease DNA, RNA and nucleotide metabolism 97.3 7.3E-07 125-171 / 88-134
phrog_1492 HNH endonuclease DNA, RNA and nucleotide metabolism 97.3 9.1E-07 52-121 / 36-119
phrog_15471 HNH endonuclease DNA, RNA and nucleotide metabolism 91.1 0.04 53-116 / 16-75
phrog_1872 endonuclease DNA, RNA and nucleotide metabolism 99.8 1.5E-24 36-123 / 6-102
phrog_1891 HNH endonuclease DNA, RNA and nucleotide metabolism 92.2 0.023 62-117 / 103-165
phrog_23251 HNH endonuclease DNA, RNA and nucleotide metabolism 97.1 1.9E-06 31-114 / 11-89
phrog_24751 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 2.2E-05 126-173 / 6-53
phrog_30929 no annotation unknown function 90.6 0.05 121-168 / 124-171
phrog_33760 HNH endonuclease DNA, RNA and nucleotide metabolism 97.5 2E-07 132-176 / 2-46
phrog_35306 no annotation unknown function 98.0 8E-09 107-173 / 4-68
phrog_36769 no annotation unknown function 94.0 0.0054 90-175 / 248-334
phrog_374 HNH endonuclease DNA, RNA and nucleotide metabolism 97.4 4.4E-07 86-181 / 126-217
phrog_4160 no annotation unknown function 97.4 5.9E-07 1-112 / 2-120
phrog_4578 HNH endonuclease DNA, RNA and nucleotide metabolism 99.8 7E-25 82-180 / 1-98
phrog_4842 HNH endonuclease DNA, RNA and nucleotide metabolism 99.6 1.3E-19 12-112 / 19-139
phrog_5351 HNH endonuclease DNA, RNA and nucleotide metabolism 94.0 0.0054 1-30 / 3-32
phrog_59 HNH endonuclease DNA, RNA and nucleotide metabolism 97.9 2.3E-08 47-123 / 15-103
phrog_6254 HNH endonuclease DNA, RNA and nucleotide metabolism 99.7 1.5E-20 52-147 / 11-120
phrog_826 HNH endonuclease DNA, RNA and nucleotide metabolism 99.9 2.9E-27 36-121 / 4-97
phrog_953 HNH endonuclease DNA, RNA and nucleotide metabolism 97.1 2.4E-06 79-176 / 69-166
phrog_959 HNH endonuclease DNA, RNA and nucleotide metabolism 92.2 0.023 61-122 / 37-103
phrog_99 HNH endonuclease DNA, RNA and nucleotide metabolism 99.9 4E-27 53-180 / 16-155

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF05551.10 Zinc-binding loop region of homing endonuclease 1E-10 148-218 / 2-80
PF13392.5 HNH endonuclease 8.2E-10 171-214 / 2-44
PF00847.19 AP2 domain 1.1E-05 226-275 / 1-53

Annotations of the NCBI proteins of this PHROG


18:HNH endonuclease 9:hypothetical protein 3:HNH homing endonuclease 2:HNH endonuclease domain 1:HNH domain protein 1:protein of an unannotated phage 1:HNH 1:glycosyltransferase 1:Hnh

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003700 DNA binding transcription factor activity
GO:0006355 regulation of transcription, DNA-templated

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