phrog_3642 is made of 39 protein sequences and is annotated as "HTH DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
82.23 133 78


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p184909 no NCBI prot ID no annotation VI_05451 Bacilli_gi_519663067_11023_48772 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae; Thermus phage phi OH2.
NC_021784_p54 YP_008240358.1 predicted transcriptional regulator NC_021784 Thermus phage phi OH2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p35222 no NCBI prot ID no annotation VI_00711 Bacilli_gi_507055493_2793767_2856861 Viruses.
JQ300538_p46 AFA45054.1 HTH DNA binding domain protein JQ300538 Mycobacterium phage Spartacus Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; Mycobacterium virus Spartacus.
KX576644_p46 AOQ28500.1 CRO antirepressor KX576644 Mycobacterium phage WillSterrel Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_022069_p58 YP_008410731.1 CRO protein NC_022069 Mycobacterium phage Jabbawokkie Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MG812488_p50 AUX81976.1 CRO protein MG812488 Mycobacterium phage Frankie Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
p68907 no NCBI prot ID no annotation VI_04167 Actinobacteria_gi_343927414 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MG099939_p55 ATW60825.1 Cro protein MG099939 Gordonia phage BENtherdunthat Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Langleyhallvirinae; Getalongvirus; Gordonia virus BENtherdunthat.
NC_031936_p35 YP_009324427.1 hypothetical protein NC_031936 Gordonia phage GAL1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Galunavirus; Gordonia virus GAL1.
MG872834_p43 AVI03673.1 HTH DNA binding protein MG872834 Gordonia phage Confidence Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_023698_p54 YP_009013149.1 gp54 NC_023698 Mycobacterium virus Avani Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
p32132 no NCBI prot ID no annotation VI_04105 Actinobacteria_gi_418422484 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae; Mycobacterium phage Dori.
NC_028953_p93 YP_009213310.1 HTH DNA binding protein NC_028953 Mycobacterium phage MiaZeal Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
NC_023690_p88 YP_009011987.1 gp88 NC_023690 Mycobacterium virus Courthouse Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus.
MF919534_p90 ATS92932.1 helix-turn-helix DNA binding domain protein MF919534 Mycobacterium phage Superphikiman Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
JF937090_p99 AEK08156.1 hypothetical protein JF937090 Mycobacterium virus Baka Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus.
MF919504_p99 ATN88906.1 helix-turn-helix DNA binding domain protein MF919504 Mycobacterium phage DmpstrDiver Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
JF937101_p96 AEK09477.1 hypothetical protein JF937101 Mycobacterium virus Littlee Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus.
MF072690_p91 ASD50721.1 helix-turn-helix DNA binding domain protein MF072690 Mycobacterium phage Porcelain Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
NC_004688_p99 NP_818400.1 gp102 NC_004688 Mycobacterium virus Omega Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus.
NC_023738_p82 YP_009018093.1 gp82 NC_023738 Mycobacterium phage Thibault Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus.
NC_022067_p101 YP_008410490.1 hypothetical protein NC_022067 Mycobacterium phage Wanda Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
MF668284_p91 ASZ74167.1 helix-turn-helix DNA binding domain protein MF668284 Mycobacterium phage Squint Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
MF133445_p90 ASD53483.1 HTH DNA binding domain protein MF133445 Mycobacterium phage Lucky2013 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
NC_026584_p97 YP_009124050.1 hypothetical protein NC_026584 Mycobacterium phage Minerva Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
MF919512_p98 ATN89811.1 hypothetical protein MF919512 Mycobacterium phage Klein Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
JF957059_p91 AEJ92147.1 hypothetical protein JF957059 Mycobacterium virus Optimus Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus.
NC_022066_p89 YP_008410247.1 hypothetical protein NC_022066 Mycobacterium phage Redno2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
NC_028876_p92 YP_009205222.1 hypothetical protein NC_028876 Mycobacterium phage Ariel Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Omegavirus; unclassified Omegavirus.
p166314 no NCBI prot ID no annotation VI_04146 Actinobacteria_gi_550255506 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae; Rhodococcus phage REQ3.
NC_016654_p6 YP_005087198.1 hypothetical protein NC_016654 Rhodococcus phage REQ3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
MF155936_p35 ASJ79116.1 CRO protein MF155936 Mycobacterium phage ZenTime222 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bernalvirus; unclassified Bernalvirus.
NC_024135_p35 YP_009031162.1 Cro (HTH DNA binding) NC_024135 Mycobacterium phage Bernal13 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bernalvirus.
KM591905_p36 AIT13449.1 HTH DNA binding protein KM591905 Mycobacterium phage RonRayGun Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bernalvirus; unclassified Bernalvirus.
MG925349_p34 AVJ50251.1 helix-turn-helix DNA binding domain protein MG925349 Mycobacterium phage Mendokysei Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bernalvirus; unclassified Bernalvirus.
JF704115_p58 AEK07808.1 hypothetical protein JF704115 Mycobacterium virus Yoshi Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
p254388 no NCBI prot ID no annotation VI_04437 Bacilli_gi_196251034_0_31481 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p211921 no NCBI prot ID no annotation VI_00049 Actinobacteria_gi_484032675_42320_77942 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_6903 17 no annotation unknown function 17 0 1000
phrog_130 726 anti-repressor Ant transcription regulation 11 5.36E-28 18.39
phrog_32605 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_11145 DNA binding protein DNA, RNA and nucleotide metabolism 94.7 0.0024 22-50 / 3-31
phrog_1124 transcriptional regulator transcription regulation 91.6 0.031 19-63 / 18-64
phrog_125 DNA invertase DNA, RNA and nucleotide metabolism 90.3 0.058 18-46 / 156-184
phrog_13326 no annotation unknown function 95.6 0.00042 9-67 / 5-64
phrog_1337 DNA binding protein DNA, RNA and nucleotide metabolism 97.2 1.8E-06 3-60 / 3-61
phrog_1373 transcriptional regulator transcription regulation 98.2 1.7E-09 9-62 / 34-86
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 97.1 2.1E-06 20-63 / 23-66
phrog_14131 DNA binding protein DNA, RNA and nucleotide metabolism 92.7 0.017 4-42 / 2-40
phrog_1468 transcriptional repressor transcription regulation 96.1 0.00014 19-63 / 19-62
phrog_147 transcriptional regulator transcription regulation 92.8 0.015 9-61 / 5-58
phrog_15152 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.1 0.0013 11-53 / 37-75
phrog_1529 no annotation unknown function 93.3 0.011 13-49 / 7-44
phrog_1702 transcriptional repressor transcription regulation 97.5 3.2E-07 4-61 / 11-70
phrog_1728 transcriptional regulator transcription regulation 93.8 0.0065 19-63 / 15-59
phrog_18104 transcriptional regulator transcription regulation 94.6 0.0028 23-61 / 16-54
phrog_20467 HNH endonuclease DNA, RNA and nucleotide metabolism 95.1 0.0013 5-47 / 54-97
phrog_2104 no annotation unknown function 94.7 0.0025 5-50 / 44-88
phrog_2119 no annotation unknown function 95.7 0.00034 9-60 / 16-69
phrog_2328 transcriptional repressor transcription regulation 94.6 0.0028 11-72 / 20-79
phrog_2339 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.4 0.00071 11-62 / 29-80
phrog_23446 no annotation unknown function 96.0 0.00017 11-59 / 5-50
phrog_2439 transcriptional regulator transcription regulation 95.9 0.00022 3-62 / 3-61
phrog_2967 transcriptional regulator transcription regulation 96.1 0.00013 11-63 / 13-65
phrog_296 DNA transposition protein integration and excision 95.3 0.00085 10-49 / 5-42
phrog_309 terminase small subunit head and packaging 90.0 0.064 22-42 / 26-46
phrog_3282 sigma factor transcription regulation 90.9 0.045 7-39 / 19-51
phrog_3557 transcriptional regulator transcription regulation 95.8 0.00026 11-69 / 15-74
phrog_35 transcriptional repressor transcription regulation 95.1 0.0013 20-59 / 13-52
phrog_38027 transcriptional repressor transcription regulation 91.2 0.038 19-69 / 69-121
phrog_3949 transcriptional repressor transcription regulation 94.1 0.005 20-64 / 28-71
phrog_3 transcriptional repressor transcription regulation 96.5 3.8E-05 8-70 / 5-65
phrog_4268 transcriptional repressor transcription regulation 95.6 0.00043 23-61 / 49-87
phrog_4441 HTH DNA binding protein DNA, RNA and nucleotide metabolism 97.1 2.2E-06 11-71 / 9-69
phrog_4583 transcriptional repressor transcription regulation 95.6 0.00044 18-62 / 21-65
phrog_4779 transcriptional regulator transcription regulation 97.4 5.5E-07 9-49 / 4-42
phrog_4836 CII-like regulator transcription regulation 91.0 0.043 19-67 / 94-142
phrog_4 transcriptional repressor transcription regulation 94.9 0.0019 17-62 / 12-54
phrog_517 HTH DNA binding protein DNA, RNA and nucleotide metabolism 96.8 8.3E-06 6-43 / 64-102
phrog_5414 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.2 0.012 22-60 / 22-60
phrog_5736 transcriptional regulator transcription regulation 92.6 0.017 5-67 / 5-74
phrog_59 HNH endonuclease DNA, RNA and nucleotide metabolism 92.2 0.023 21-45 / 112-136
phrog_6156 endonuclease DNA, RNA and nucleotide metabolism 95.3 0.0009 5-45 / 18-59
phrog_6223 transcriptional repressor transcription regulation 94.9 0.0018 20-54 / 17-50
phrog_6267 transcriptional repressor transcription regulation 98.6 3.3E-11 4-69 / 26-90
phrog_638 transcriptional regulator transcription regulation 97.1 1.9E-06 11-75 / 7-71
phrog_664 DNA binding protein DNA, RNA and nucleotide metabolism 94.1 0.0047 7-48 / 54-96
phrog_66 excisionase and transcriptional regulator integration and excision 90.9 0.045 19-47 / 8-36
phrog_6831 transcriptional regulator transcription regulation 95.7 0.0004 20-56 / 15-53
phrog_7126 HTH DNA binding protein DNA, RNA and nucleotide metabolism 91.0 0.043 19-45 / 28-54
phrog_7241 transcriptional regulator transcription regulation 92.4 0.02 11-61 / 66-115
phrog_725 CII-like regulator transcription regulation 96.3 6.1E-05 12-60 / 19-64
phrog_8 transcriptional regulator transcription regulation 96.7 1.5E-05 10-60 / 5-52
phrog_9103 transcriptional repressor transcription regulation 98.3 6.1E-10 1-65 / 1-65
phrog_925 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.7 0.00037 9-45 / 7-42

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF14590.5 Domain of unknown function (DUF4447) 1.5E-07 31-96 / 5-71
PF13744.5 Helix-turn-helix domain 4.3E-07 32-95 / 17-79
PF05339.10 Protein of unknown function (DUF739) 4.4E-07 36-94 / 6-62
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 4.9E-07 39-98 / 4-61
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 4.8E-07 32-76 / 9-51
PF01381.21 Helix-turn-helix 6.2E-07 41-92 / 4-53
PF12844.6 Helix-turn-helix domain 1.1E-06 39-96 / 5-60
PF13443.5 Cro/C1-type HTH DNA-binding domain 1.2E-06 40-96 / 4-61
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 2.4E-06 33-95 / 69-128
PF13413.5 Helix-turn-helix domain 3.1E-06 41-87 / 4-55
PF08667.9 BetR domain 4E-06 33-98 / 5-72
PF13560.5 Helix-turn-helix domain 7E-06 35-90 / 3-57
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 9.7E-06 46-97 / 8-57
PF05269.10 Bacteriophage CII protein 1E-05 39-97 / 16-70
PF04645.11 Protein of unknown function, DUF603 1.1E-05 31-84 / 5-60
PF08965.9 Domain of unknown function (DUF1870) 1.5E-05 35-82 / 3-51
PF13693.5 Winged helix-turn-helix DNA-binding 6.4E-05 37-97 / 6-61
PF14549.5 DNA-binding transcriptional regulator Cro 0.00012 40-94 / 4-52
PF04814.12 Hepatocyte nuclear factor 1 (HNF-1), N terminus 0.00013 36-86 / 116-165
PF12116.7 Stage III sporulation protein D 0.00016 46-87 / 18-60
PF00356.20 Bacterial regulatory proteins, lacI family 0.00026 49-84 / 1-36
PF02376.14 CUT domain 0.00049 33-97 / 7-68
PF10654.8 Protein of unknown function (DUF2481) 0.00076 43-71 / 77-104
PF08535.9 KorB domain 0.0087 46-72 / 2-28

Annotations of the NCBI proteins of this PHROG


14:hypothetical protein 5:helix-turn-helix DNA binding domain protein 3:CRO protein 3:HTH DNA binding protein 2:HTH DNA binding domain protein 1:Cro (HTH DNA binding) 1:CRO antirepressor 1:Cro protein 1:HTH DNA binding ( Cro) 1:predicted transcriptional regulator

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0005634 nucleus
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0003677 DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0043565 sequence-specific DNA binding

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