phrog_37422 is made of 2 protein sequences and is annotated as "unknown function"
Functional category: unknown function


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
56 56 56


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KX581098_p38 ARH11756.1 hypothetical protein KX581098 Vibrio phage VaK Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KY658678_p40 ARB13308.1 hypothetical protein KY658678 Vibrio phage pVa-3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_1032 143 replication initiation protein DNA, RNA and nucleotide metabolism 2 1.57E-11 1.93

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
no PHROGs similar                                                                           

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF02319.19 E2F/DP family winged-helix DNA-binding domain 3.1E-09 5-39 / 21-55
PF08222.10 CodY helix-turn-helix domain 3.9E-08 6-40 / 3-37
PF04492.12 Bacteriophage replication protein O 4.2E-08 7-40 / 49-82
PF16221.4 winged helix-turn-helix 4.2E-08 6-37 / 45-76
PF09012.9 FeoC like transcriptional regulator 4.7E-08 6-40 / 13-47
PF07106.12 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) 1.2E-07 5-41 / 14-52
PF14277.5 Domain of unknown function (DUF4364) 1.9E-07 6-39 / 14-51
PF08221.10 RNA polymerase III subunit RPC82 helix-turn-helix domain 2.3E-07 6-38 / 26-58
PF01726.15 LexA DNA binding domain 2.8E-07 7-39 / 25-58
PF05584.10 Sulfolobus plasmid regulatory protein 3.1E-07 6-40 / 17-51
PF10007.8 Uncharacterized protein conserved in archaea (DUF2250) 3.5E-07 6-40 / 21-55
PF14394.5 Domain of unknown function (DUF4423) 4.6E-07 8-40 / 37-71
PF05732.10 Firmicute plasmid replication protein (RepL) 4.7E-07 6-41 / 74-109
PF11313.7 Protein of unknown function (DUF3116) 4.7E-07 7-40 / 20-60
PF08784.10 Replication protein A C terminal 4.9E-07 5-39 / 56-93
PF12793.6 Sugar transport-related sRNA regulator N-term 5.5E-07 5-39 / 16-50
PF07381.10 Winged helix DNA-binding domain (DUF1495) 6.7E-07 5-39 / 22-66
PF03551.13 Transcriptional regulator PadR-like family 8.2E-07 5-40 / 12-49
PF06163.10 Bacterial protein of unknown function (DUF977) 9.6E-07 6-40 / 25-59
PF03965.15 Penicillinase repressor 1E-06 8-41 / 19-57
PF09904.8 Winged helix-turn helix 1E-06 5-39 / 19-53
PF04358.12 DsrC like protein 1.1E-06 6-37 / 57-91
PF15977.4 Winged helix-turn-helix DNA binding 1.1E-06 7-39 / 23-55
PF02002.16 TFIIE alpha subunit 1.2E-06 6-40 / 25-59
PF07848.11 PaaX-like protein 1.3E-06 6-40 / 19-56
PF02295.16 Adenosine deaminase z-alpha domain 1.3E-06 7-39 / 18-51
PF13601.5 Winged helix DNA-binding domain 1.3E-06 6-40 / 13-47
PF09339.9 IclR helix-turn-helix domain 1.4E-06 8-37 / 19-48
PF04182.11 B-block binding subunit of TFIIIC 1.7E-06 6-39 / 17-50
PF01325.18 Iron dependent repressor, N-terminal DNA binding domain 1.7E-06 6-38 / 20-52
PF12802.6 MarR family 1.8E-06 8-39 / 22-53
PF13545.5 Crp-like helix-turn-helix domain 1.8E-06 6-38 / 26-58
PF00392.20 Bacterial regulatory proteins, gntR family 1.9E-06 6-38 / 22-55
PF01090.18 Ribosomal protein S19e 1.9E-06 6-37 / 64-109
PF05491.12 Holliday junction DNA helicase ruvB C-terminus 2.1E-06 6-39 / 24-58
PF09114.9 Transcription factor MotA, activation domain 2.2E-06 6-39 / 29-63
PF02082.19 Transcriptional regulator 2.2E-06 8-39 / 25-56
PF14557.5 Putative AphA-like transcriptional regulator 2.3E-06 5-40 / 23-66
PF09824.8 ArsR transcriptional regulator 2.6E-06 6-40 / 29-61
PF14502.5 Helix-turn-helix domain 3E-06 6-38 / 5-37
PF12840.6 Helix-turn-helix domain 3.2E-06 5-39 / 21-52
PF07900.10 Protein of unknown function (DUF1670) 3.3E-06 5-38 / 93-126
PF01022.19 Bacterial regulatory protein, arsR family 3.4E-06 6-36 / 15-45
PF13463.5 Winged helix DNA-binding domain 3.4E-06 6-39 / 16-49
PF09639.9 YjcQ protein 3.4E-06 6-39 / 15-50
PF13412.5 Winged helix-turn-helix DNA-binding 3.8E-06 7-36 / 17-46
PF16365.4 Ethanolamine utilization protein EutK C-terminus 3.8E-06 6-38 / 16-48
PF14947.5 Winged helix-turn-helix 4E-06 6-39 / 15-48
PF01978.18 Sugar-specific transcriptional regulator TrmB 4.3E-06 6-39 / 21-54
PF09202.10 Rio2, N-terminal 4.5E-06 6-39 / 23-56
PF01475.18 Ferric uptake regulator family 4.4E-06 6-40 / 21-60
PF03428.12 Replication protein C N-terminal domain 4.5E-06 8-40 / 71-104
PF06970.10 Replication initiator protein A (RepA) N-terminus 5.2E-06 9-31 / 53-75
PF09182.9 Bacterial purine repressor, N-terminal 5.3E-06 5-36 / 18-53
PF10771.8 Winged helix-turn-helix domain (DUF2582) 5.4E-06 5-39 / 20-54
PF06969.15 HemN C-terminal domain 5.7E-06 6-38 / 19-52
PF01047.21 MarR family 6.3E-06 6-39 / 16-49
PF05158.11 RNA polymerase Rpc34 subunit 6.1E-06 5-40 / 106-141
PF08535.9 KorB domain 6.4E-06 7-37 / 3-33
PF05331.10 Protein of unknown function (DUF742) 6.4E-06 6-40 / 52-86
PF08461.9 Ribonuclease R winged-helix domain 6.9E-06 7-38 / 12-48
PF02334.15 Replication terminator protein 7.1E-06 6-39 / 30-72
PF08279.11 HTH domain 7.7E-06 6-35 / 14-43
PF10711.8 Hypothetical protein (DUF2513) 1E-05 7-40 / 18-55
PF01638.16 HxlR-like helix-turn-helix 1.2E-05 6-40 / 18-53
PF03444.14 Winged helix-turn-helix transcription repressor, HrcA DNA-binding 1.4E-05 6-39 / 23-56
PF05043.12 Mga helix-turn-helix domain 1.4E-05 5-34 / 28-57
PF08220.11 DeoR-like helix-turn-helix domain 1.4E-05 6-40 / 13-46
PF16864.4 Dimerisation domain 1.4E-05 6-39 / 31-64
PF00325.19 Bacterial regulatory proteins, crp family 1.8E-05 9-36 / 4-31
PF03297.14 S25 ribosomal protein 1.8E-05 6-40 / 55-89
PF00126.26 Bacterial regulatory helix-turn-helix protein, lysR family 2E-05 9-36 / 13-43
PF04079.15 Segregation and condensation complex subunit ScpB 0.00089 5-35 / 11-41
PF09681.9 N-terminal phage replisome organiser (Phage_rep_org_N) 2.3E-05 8-39 / 54-85
PF17443.1 Uncharacterized protein pXO2-72 2.3E-05 5-36 / 6-46
PF13730.5 Helix-turn-helix domain 2.5E-05 18-36 / 33-51
PF04703.11 FaeA-like protein 3.3E-05 6-37 / 13-44
PF01418.16 Helix-turn-helix domain, rpiR family 4.6E-05 7-36 / 34-63
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 6.8E-05 7-36 / 13-42
PF07453.12 NUMOD1 domain 7.3E-05 7-28 / 19-40
PF11972.7 HTH DNA binding domain 7.8E-05 6-36 / 12-39
PF13404.5 AsnC-type helix-turn-helix domain 9.5E-05 6-31 / 16-41
PF02954.18 Bacterial regulatory protein, Fis family 0.00011 7-30 / 16-39
PF08280.10 M protein trans-acting positive regulator (MGA) HTH domain 0.00014 6-33 / 19-46
PF04967.11 HTH DNA binding domain 0.00014 8-33 / 24-49
PF00356.20 Bacterial regulatory proteins, lacI family 0.00015 9-31 / 1-23
PF13635.5 Domain of unknown function (DUF4143) 0.00015 7-38 / 30-63
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 0.00017 6-34 / 18-46
PF04218.12 CENP-B N-terminal DNA-binding domain 0.0002 8-33 / 24-49
PF11427.7 Tc3 transposase 0.00024 8-34 / 21-47
PF06971.12 Putative DNA-binding protein N-terminus 0.00024 7-28 / 27-48
PF09821.8 C-terminal AAA-associated domain 0.00025 12-38 / 2-28
PF09397.9 Ftsk gamma domain 0.00025 5-37 / 17-49
PF10743.8 Regulatory phage protein cox 0.00028 5-30 / 9-34
PF06806.11 Putative excisionase (DUF1233) 0.00028 5-29 / 7-31
PF05930.11 Prophage CP4-57 regulatory protein (AlpA) 0.0003 7-29 / 3-25
PF07037.10 Putative transcription regulator (DUF1323) 0.0003 8-36 / 1-26
PF08765.10 Mor transcription activator family 0.00032 7-34 / 72-99
PF13518.5 Helix-turn-helix domain 0.00034 8-36 / 12-40
PF08822.10 Protein of unknown function (DUF1804) 0.00037 6-36 / 18-48
PF02042.14 RWP-RK domain 0.0004 6-36 / 11-41
PF13411.5 MerR HTH family regulatory protein 0.00042 9-32 / 2-25
PF09107.10 Elongation factor SelB, winged helix 0.00041 5-40 / 6-40
PF06322.10 Phage NinH protein 0.00044 7-36 / 16-45
PF12759.6 InsA C-terminal domain 0.00045 8-30 / 22-44
PF13591.5 MerR HTH family regulatory protein 0.00044 9-30 / 2-23
PF03333.12 Adhesin biosynthesis transcription regulatory protein 0.00046 6-33 / 54-81
PF04936.11 Protein of unknown function (DUF658) 0.0019 6-31 / 87-112
PF14493.5 Helix-turn-helix domain 0.00048 7-36 / 12-41
PF09035.9 Excisionase from transposon Tn916 0.00051 6-29 / 14-37
PF01381.21 Helix-turn-helix 0.00054 6-30 / 8-32
PF13011.5 leucine-zipper of insertion element IS481 0.00055 7-36 / 24-53
PF00376.22 MerR family regulatory protein 0.00058 10-30 / 2-22
PF00292.17 'Paired box' domain 0.00058 7-36 / 33-62
PF12728.6 Helix-turn-helix domain 0.00073 8-29 / 2-24
PF07278.10 Protein of unknown function (DUF1441) 0.00072 8-31 / 2-25
PF07183.10 Protein of unknown function (DUF1403) 0.00072 7-39 / 288-318
PF08679.10 Dissimilatory sulfite reductase D (DsrD) 0.00074 6-40 / 15-50
PF00440.22 Bacterial regulatory proteins, tetR family 0.00078 8-32 / 16-40
PF04552.12 Sigma-54, DNA binding domain 0.00077 6-32 / 47-73
PF11242.7 Protein of unknown function (DUF2774) 0.00081 7-36 / 14-43
PF13309.5 HTH domain 0.00084 8-28 / 42-62
PF16509.4 TrfB plasmid transcriptional repressor 0.00086 7-36 / 31-59
PF07638.10 ECF sigma factor 0.00087 7-32 / 149-174
PF05344.10 Domain of Unknown Function (DUF746) 0.00087 7-36 / 12-41
PF13556.5 PucR C-terminal helix-turn-helix domain 0.00092 8-35 / 13-40
PF04545.15 Sigma-70, region 4 0.00095 6-32 / 23-49
PF10654.8 Protein of unknown function (DUF2481) 0.00091 6-30 / 79-103
PF08281.11 Sigma-70, region 4 0.001 7-32 / 26-51
PF13413.5 Helix-turn-helix domain 0.0011 6-30 / 8-32
PF07141.10 Putative bacteriophage terminase small subunit 0.0012 7-32 / 31-56
PF02796.14 Helix-turn-helix domain of resolvase 0.0013 8-29 / 22-43
PF05225.15 helix-turn-helix, Psq domain 0.0013 7-31 / 16-41
PF09607.9 Brinker DNA-binding domain 0.0013 8-34 / 26-52
PF12964.6 Protein of unknown function (DUF3853) 0.0014 6-29 / 44-67
PF07471.11 Phage DNA packaging protein Nu1 0.0014 7-30 / 2-25
PF09048.9 Cro 0.0016 7-36 / 13-42
PF12824.6 Mitochondrial ribosomal protein subunit L20 0.0018 7-30 / 107-130
PF15978.4 Tn7-like transposition protein D 0.0022 6-36 / 202-232
PF00196.18 Bacterial regulatory proteins, luxR family 0.0022 8-34 / 18-44
PF13542.5 Helix-turn-helix domain of transposase family ISL3 0.0023 9-30 / 28-49
PF10668.8 Phage terminase small subunit 0.0024 7-36 / 22-51
PF13551.5 Winged helix-turn helix 0.0028 8-36 / 12-40
PF12324.7 Helix-turn-helix domain of alkylmercury lyase 0.0027 4-33 / 32-61
PF13936.5 Helix-turn-helix domain 0.0029 8-29 / 21-42
PF06627.10 Protein of unknown function (DUF1153) 0.0028 7-36 / 46-75
PF14338.5 Mrr N-terminal domain 0.0029 18-52 / 48-83
PF11994.7 Protein of unknown function (DUF3489) 0.0028 5-35 / 19-49
PF13443.5 Cro/C1-type HTH DNA-binding domain 0.0038 7-30 / 10-34
PF12116.7 Stage III sporulation protein D 0.0038 7-31 / 19-43
PF07180.10 CaiF/GrlA transcriptional regulator 0.0037 4-34 / 35-65
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 0.0038 6-29 / 22-45
PF13022.5 Helix-turn-helix of insertion element transposase 0.0041 7-30 / 25-48
PF07506.10 RepB plasmid partitioning protein 0.0048 7-31 / 21-45
PF09756.8 DDRGK domain 0.0049 5-37 / 113-145
PF01371.18 Trp repressor protein 0.0051 7-33 / 48-74
PF01710.15 Transposase 0.0053 7-35 / 18-46
PF04157.15 EAP30/Vps36 family 0.0055 6-37 / 189-220
PF01527.19 Transposase 0.0074 7-36 / 21-49
PF08100.10 Dimerisation domain 0.0079 6-31 / 23-52
PF13384.5 Homeodomain-like domain 0.0092 8-31 / 18-41

Annotations of the NCBI proteins of this PHROG


2:hypothetical protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0005525 GTP binding
GO:0006468 protein phosphorylation
GO:0003700 DNA binding transcription factor activity
GO:0006313 transposition, DNA-mediated
GO:0006274 DNA replication termination
GO:0000150 recombinase activity
GO:0016987 sigma factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0004674 protein serine/threonine kinase activity
GO:0006383 transcription by RNA polymerase III
GO:0005622 intracellular
GO:0007131 reciprocal meiotic recombination
GO:0005666 DNA-directed RNA polymerase III complex
GO:0006508 proteolysis
GO:0006276 plasmid maintenance
GO:0003746 translation elongation factor activity
GO:0005524 ATP binding
GO:0006281 DNA repair
GO:0051775 response to redox state
GO:0003735 structural constituent of ribosome
GO:0006352 DNA-templated transcription, initiation
GO:0003723 RNA binding
GO:0003726 double-stranded RNA adenosine deaminase activity
GO:0006310 DNA recombination
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
GO:0005840 ribosome
GO:0005667 transcription factor complex
GO:0006351 transcription, DNA-templated
GO:0009289 pilus
GO:0006260 DNA replication
GO:0009378 four-way junction helicase activity
GO:0004803 transposase activity
GO:0043565 sequence-specific DNA binding
GO:0001514 selenocysteine incorporation
GO:0004252 serine-type endopeptidase activity
GO:0019069 viral capsid assembly
GO:0006412 translation
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0051304 chromosome separation

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