phrog_4234 is made of 33 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
129.85 186 124


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KT365400_p147 ALF51243.1 HNH endonuclease KT365400 Mycobacterium phage ErnieJ Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
KF024734_p154 AGV99874.1 HNH endonuclease KF024734 Mycobacterium phage Shrimp Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
KP027195_p100 AJD82172.1 HNH endonuclease domain protein KP027195 Mycobacterium phage Cosmo Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Wildcatvirus; unclassified Wildcatvirus.
NC_022071_p110 YP_008410985.1 hypothetical protein NC_022071 Mycobacterium phage Crossroads Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bronvirus; unclassified Bronvirus.
JF704116_p152 AEK06945.1 endonuclease VII JF704116 Mycobacterium phage Drazdys Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
NC_023714_p148 YP_009014742.1 gp169 NC_023714 Mycobacterium phage LinStu Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
KX721255_p149 AOZ63034.1 HNH endonuclease KX721255 Mycobacterium phage Yucca Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; unclassified Bixzunavirus.
NC_023737_p154 YP_009017927.1 gp174 NC_023737 Mycobacterium phage Pleione Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
JF704096_p152 AEJ94854.1 EndoVII JF704096 Mycobacterium phage Ghost Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
JN699625_p150 AER25518.1 hypothetical protein JN699625 Mycobacterium phage Wally Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
MG872839_p150 AVI04753.1 HNH endonuclease MG872839 Mycobacterium phage LifeSavor Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; unclassified Bixzunavirus.
NC_029044_p153 YP_009221283.1 hypothetical protein NC_029044 Mycobacterium phage Breeniome Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
NC_028986_p141 YP_009216405.1 gp148 NC_028986 Mycobacterium phage Alice Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
JN699013_p158 AER49672.1 hypothetical protein JN699013 Mycobacterium phage Pio Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
NC_021349_p149 YP_008061644.1 hypothetical protein NC_021349 Mycobacterium phage Astraea Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
KU234099_p110 ALY07430.1 hypothetical protein KU234099 Mycobacterium phage MkaliMitinis3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bronvirus; unclassified Bronvirus.
KT321476_p151 AKY02445.1 HNH endonuclease KT321476 Mycobacterium phage Zeenon Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
KT591491_p91 ALF00619.1 HNH endonuclease KT591491 Mycobacterium phage Bricole Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mclasvirinae; Bongovirus; unclassified Bongovirus.
KX831080_p74 APD17116.1 HNH endonuclease KX831080 Mycobacterium phage Lukilu Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Lukilu.
NC_004687_p151 NP_818227.1 gp167 NC_004687 Mycobacterium phage Bxz1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
KX369583_p153 ANT41688.1 hypothetical protein KX369583 Mycobacterium phage Littleton Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
NC_021299_p91 YP_008051023.1 HNH domain protein NC_021299 Mycobacterium phage PegLeg Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mclasvirinae; Bongovirus; unclassified Bongovirus.
KT365398_p154 ALF51017.1 HNH endonuclease KT365398 Mycobacterium phage DTDevon Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Bxz1.
NC_021348_p155 YP_008061413.1 Endo VII NC_021348 Mycobacterium phage ArcherS7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
KX781992_p153 AOZ63507.1 HNH endonuclease KX781992 Mycobacterium phage Gabriel Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; unclassified Bixzunavirus.
JN204348_p151 AEK06628.1 hypothetical protein JN204348 Mycobacterium phage Sebata Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus; Mycobacterium virus Sebata.
NC_028869_p144 YP_009204709.1 HNH domain protein NC_028869 Mycobacterium phage HyRo Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
NC_021299_p97 YP_008051029.1 HNH domain protein NC_021299 Mycobacterium phage PegLeg Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mclasvirinae; Bongovirus; unclassified Bongovirus.
NC_023696_p158 YP_009012936.1 gp178 NC_023696 Mycobacterium phage Dandelion Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
NC_008207_p146 YP_656159.1 gp167 NC_008207 Mycobacterium phage Catera Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
NC_011272_p145 YP_002224843.1 gp166 NC_011272 Mycobacterium phage Rizal Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Bixzunavirus.
MF155946_p107 ASR75515.1 HNH endonuclease MF155946 Streptomyces phage Mildred21 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Samistivirus; Streptomyces virus Mildred21.
p101033 no NCBI prot ID no annotation VI_04153 Actinobacteria_gi_506496126_11321_56319 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_382 326 minor tail protein with lysin activity tail 23 6.42E-67 57.31
phrog_1866 81 no annotation unknown function 16 1.47E-55 45.96
phrog_15950 6 no annotation unknown function 4 7.25E-21 11.26
phrog_10206 10 no annotation unknown function 2 3.55E-11 1.57
phrog_37980 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10212 no annotation unknown function 98.8 5.5E-12 29-85 / 66-126
phrog_10822 HNH endonuclease DNA, RNA and nucleotide metabolism 94.1 0.0047 27-78 / 99-144
phrog_11604 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 2.5E-05 27-87 / 75-135
phrog_119 HNH endonuclease DNA, RNA and nucleotide metabolism 96.1 0.00014 6-87 / 8-86
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 96.5 2.9E-05 24-80 / 143-197
phrog_144 HNH endonuclease DNA, RNA and nucleotide metabolism 97.7 7.7E-08 9-86 / 43-116
phrog_14857 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.6 0.0082 89-120 / 89-120
phrog_15673 no annotation unknown function 90.1 0.061 56-113 / 22-81
phrog_16726 HNH endonuclease DNA, RNA and nucleotide metabolism 91.6 0.032 27-47 / 80-105
phrog_1985 HNH endonuclease DNA, RNA and nucleotide metabolism 96.7 1.3E-05 25-98 / 65-142
phrog_2214 HNH endonuclease DNA, RNA and nucleotide metabolism 95.1 0.0012 11-87 / 21-84
phrog_2255 HNH endonuclease DNA, RNA and nucleotide metabolism 99.4 2.2E-16 9-86 / 34-130
phrog_23251 HNH endonuclease DNA, RNA and nucleotide metabolism 92.0 0.025 88-114 / 95-120
phrog_24671 integrase integration and excision 95.5 0.00059 88-114 / 24-50
phrog_30726 no annotation unknown function 96.1 0.00012 27-79 / 49-107
phrog_3106 HNH endonuclease DNA, RNA and nucleotide metabolism 99.6 1.6E-19 9-87 / 23-110
phrog_32453 HNH endonuclease DNA, RNA and nucleotide metabolism 90.7 0.049 15-87 / 62-121
phrog_333 HNH endonuclease DNA, RNA and nucleotide metabolism 97.5 2.5E-07 11-87 / 11-77
phrog_338 HNH endonuclease DNA, RNA and nucleotide metabolism 93.4 0.0096 26-86 / 27-86
phrog_3497 no annotation unknown function 90.6 0.051 24-46 / 23-45
phrog_35854 HNH endonuclease DNA, RNA and nucleotide metabolism 97.4 5.1E-07 26-81 / 5-67
phrog_38041 no annotation unknown function 91.3 0.038 89-113 / 102-126
phrog_4581 terminase small subunit head and packaging 95.3 0.0008 25-114 / 60-137
phrog_589 HNH endonuclease DNA, RNA and nucleotide metabolism 98.0 7.1E-09 9-87 / 30-103
phrog_5956 HNH endonuclease DNA, RNA and nucleotide metabolism 97.0 3.2E-06 27-87 / 6-61
phrog_6050 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 2.3E-05 25-84 / 3-55
phrog_7785 HNH endonuclease DNA, RNA and nucleotide metabolism 95.9 0.0002 27-85 / 68-114
phrog_8048 HNH endonuclease DNA, RNA and nucleotide metabolism 94.3 0.0039 8-79 / 7-75

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF05315.10 ICEA Protein 3.6E-07 33-105 / 78-149
PF05766.11 Bacteriophage Lambda NinG protein 9E-07 39-108 / 77-138
PF13395.5 HNH endonuclease 1.1E-06 51-106 / 1-51
PF01844.22 HNH endonuclease 2.4E-06 51-105 / 1-47
PF14279.5 HNH endonuclease 1.3E-05 51-107 / 1-46
PF13391.5 HNH endonuclease 2.5E-05 51-107 / 1-46
PF06147.10 Protein of unknown function (DUF968) 3.1E-05 46-108 / 125-176
PF09665.9 Type II restriction endonuclease (RE_Alw26IDE) 4.6E-05 48-106 / 253-296
PF16784.4 Putative HNHc nuclease 0.0028 46-106 / 121-171

Annotations of the NCBI proteins of this PHROG


11:hypothetical protein 10:HNH endonuclease 3:HNH domain protein 2:endonuclease VII 2:protein of an unannotated phage 1:Endo VII 1:EndoVII 1:overlaps gene 167 1:HNH endonuclease domain protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0004519 endonuclease activity
GO:0003676 nucleic acid binding

Loading in process