phrog_4268 is made of 32 protein sequences and is annotated as "transcriptional repressor"
Functional category: transcription regulation


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
100.62 134 98


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p79532 no NCBI prot ID no annotation VI_11488 Gammaproteobacteria_gi_545091524 Viruses.
p164808 no NCBI prot ID no annotation VI_02560 Gammaproteobacteria_gi_490893321 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
p433795 no NCBI prot ID no annotation VI_10206 Gammaproteobacteria_gi_544682987 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p20276 no NCBI prot ID no annotation VI_03506 Gammaproteobacteria_gi_514965089 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p204982 no NCBI prot ID no annotation VI_00022 Actinobacteria_gi_223955933_488_36693 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
p225151 no NCBI prot ID no annotation VI_12183 Gammaproteobacteria_gi_545595213_260_34541 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p259923 no NCBI prot ID no annotation VI_06606 Gammaproteobacteria_gi_294665708 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p192588 no NCBI prot ID no annotation VI_06566 Gammaproteobacteria_gi_538042148 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p43184 no NCBI prot ID no annotation VI_02599 Gammaproteobacteria_gi_425064754_759240_819141 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p413086 no NCBI prot ID no annotation VI_05599 Betaproteobacteria_gi_483606617 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p326174 no NCBI prot ID no annotation VI_10072 Gammaproteobacteria_gi_555264907 Viruses.
NC_031264_p19 YP_009304047.1 addiction module antitoxin/toxin NC_031264 Brucella phage BiPBO1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p70293 no NCBI prot ID no annotation VI_05591 Betaproteobacteria_gi_482909684_27294_76934 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p385796 no NCBI prot ID no annotation VI_07618 Gammaproteobacteria_gi_418801094 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Punavirus; Escherichia virus P1.
p48193 no NCBI prot ID no annotation VI_06444 Gammaproteobacteria_gi_156105548 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Punavirus; Escherichia virus P1.
p262061 no NCBI prot ID no annotation VI_10017 Gammaproteobacteria_gi_555241789 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Punavirus; Escherichia virus P1.
NC_021794_p40 YP_008241233.1 DNA-binding helix-turn-helix protein NC_021794 Cellulophaga phage phi18:3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
NC_021789_p41 YP_008240826.1 DNA-binding helix-turn-helix protein NC_021789 Cellulophaga phage phi19:3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
NC_021803_p42 YP_008242067.1 DNA-binding helix-turn-helix protein NC_021803 Cellulophaga phage phi13:2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
NC_021792_p40 YP_008241083.1 DNA-binding helix-turn-helix protein NC_021792 Cellulophaga phage phi46:3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
p155188 no NCBI prot ID no annotation VI_00067 Alphaproteobacteria_gi_397770539 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
p81555 no NCBI prot ID no annotation VI_04253 Alphaproteobacteria_gi_421760367 Viruses.
p109701 no NCBI prot ID no annotation VI_00077 Alphaproteobacteria_gi_307944653 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p165756 no NCBI prot ID no annotation VI_11886 Gammaproteobacteria_gi_557314302 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p341575 no NCBI prot ID no annotation VI_01053 Betaproteobacteria_gi_254192738_549538_570582 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
p211387 no NCBI prot ID no annotation VI_01119 Betaproteobacteria_gi_53721039_1426445_1462145 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
p169016 no NCBI prot ID no annotation VI_01095 Betaproteobacteria_gi_386860126_133514_172629 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
NC_009236_p6 YP_001111156.1 gp6, putative addiction module antidote protein NC_009236 Burkholderia virus phiE122 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Tigrvirus.
p394822 no NCBI prot ID no annotation VI_05536 Betaproteobacteria_gi_149161195 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Tigrvirus; Burkholderia virus phiE122.
p416191 no NCBI prot ID no annotation VI_05504 Betaproteobacteria_gi_134283347_137806_150093 Viruses.
p152105 no NCBI prot ID no annotation VI_05530 Betaproteobacteria_gi_149156765_2958_43574 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
p341255 no NCBI prot ID no annotation VI_09490 Gammaproteobacteria_gi_484030366 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_3445 42 toxin moron, auxiliary metabolic gene and host takeover 22 1.09E-94 85.09
phrog_23366 3 no annotation unknown function 3 0 1000
phrog_26961 3 no annotation unknown function 3 0 1000
phrog_38014 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_101 CII-like transcriptional activator transcription regulation 92.0 0.026 35-80 / 10-58
phrog_13326 no annotation unknown function 91.5 0.033 51-90 / 22-61
phrog_1373 transcriptional regulator transcription regulation 98.1 3.8E-09 7-93 / 7-91
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 92.4 0.02 49-88 / 26-65
phrog_1702 transcriptional repressor transcription regulation 95.0 0.0015 38-90 / 16-73
phrog_1728 transcriptional regulator transcription regulation 91.9 0.027 40-86 / 8-56
phrog_18104 transcriptional regulator transcription regulation 96.7 1.3E-05 45-89 / 12-56
phrog_2136 no annotation unknown function 95.1 0.0013 36-84 / 29-80
phrog_2328 transcriptional repressor transcription regulation 95.2 0.001 50-90 / 32-72
phrog_2339 HTH DNA binding protein DNA, RNA and nucleotide metabolism 92.5 0.019 35-93 / 24-85
phrog_2439 transcriptional regulator transcription regulation 96.0 0.00015 38-90 / 9-63
phrog_2538 terminase small subunit head and packaging 91.0 0.042 49-76 / 22-46
phrog_268 no annotation unknown function 93.2 0.011 44-68 / 13-38
phrog_2967 transcriptional regulator transcription regulation 95.1 0.0012 33-88 / 6-64
phrog_3557 transcriptional regulator transcription regulation 93.6 0.008 37-89 / 15-68
phrog_35 transcriptional repressor transcription regulation 90.4 0.055 49-92 / 16-59
phrog_3642 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.6 0.0005 49-87 / 23-61
phrog_3 transcriptional repressor transcription regulation 96.3 7.1E-05 40-87 / 8-56
phrog_5823 transcriptional regulator transcription regulation 92.4 0.02 35-90 / 4-62
phrog_6831 transcriptional regulator transcription regulation 94.8 0.0019 45-83 / 12-54
phrog_7241 transcriptional regulator transcription regulation 95.1 0.0013 41-89 / 67-117
phrog_8522 HTH DNA binding protein DNA, RNA and nucleotide metabolism 96.0 0.00016 49-94 / 23-68
phrog_8 transcriptional regulator transcription regulation 95.6 0.00045 40-89 / 6-55
phrog_9103 transcriptional repressor transcription regulation 94.4 0.0037 50-89 / 24-63
phrog_925 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.7 0.00041 46-91 / 15-62
phrog_9425 transcriptional repressor transcription regulation 95.7 0.00039 35-93 / 11-68

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 5.7E-06 60-106 / 17-62
PF13744.5 Helix-turn-helix domain 1.5E-05 45-102 / 19-79
PF14590.5 Domain of unknown function (DUF4447) 1.5E-05 43-105 / 6-73
PF01381.21 Helix-turn-helix 2E-05 58-100 / 12-54
PF05339.10 Protein of unknown function (DUF739) 3.3E-05 49-102 / 8-63
PF12844.6 Helix-turn-helix domain 3.4E-05 58-105 / 15-62
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 5.1E-05 42-102 / 8-76
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 8E-05 58-105 / 11-58
PF08667.9 BetR domain 8.4E-05 46-105 / 7-72
PF04645.11 Protein of unknown function, DUF603 8.7E-05 42-103 / 5-68
PF05269.10 Bacteriophage CII protein 9.1E-05 58-106 / 26-72
PF13413.5 Helix-turn-helix domain 9.8E-05 58-99 / 12-59
PF13443.5 Cro/C1-type HTH DNA-binding domain 0.0002 58-104 / 14-62
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 0.00022 45-102 / 70-128
PF13560.5 Helix-turn-helix domain 0.00026 49-101 / 6-63
PF13693.5 Winged helix-turn-helix DNA-binding 0.001 58-106 / 18-63
PF08965.9 Domain of unknown function (DUF1870) 0.0015 47-102 / 4-66
PF14549.5 DNA-binding transcriptional regulator Cro 0.0057 58-101 / 12-52
PF00356.20 Bacterial regulatory proteins, lacI family 0.0059 59-86 / 3-30
PF12116.7 Stage III sporulation protein D 0.0062 58-97 / 22-62

Annotations of the NCBI proteins of this PHROG


4:DNA-binding helix-turn-helix protein 1:addiction module antitoxin/toxin 1:gp6, addiction module antidote protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0006355 regulation of transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding

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