phrog_4321 is made of 32 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
133.28 161 135


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
MF467949_p2 ASU03998.1 HNH endonuclease MF467949 Streptomyces phage Spectropatronm Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Rimavirus; unclassified Rimavirus.
KX670789_p2 AOZ64868.1 HNH endonuclease KX670789 Streptomyces phage OlympicHelado Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Rimavirus; unclassified Rimavirus.
KX670790_p2 AOZ64956.1 HNH endonuclease KX670790 Streptomyces phage Rima Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Rimavirus; Strepomyces virus Rima.
KU160642_p4 ALY08691.1 HNH endonuclease domain protein KU160642 Arthrobacter phage Circum Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mudcatvirus; Arthrobacter virus Circum.
p18815 no NCBI prot ID no annotation VI_01149 Clostridia_gi_324035751_41009_118330 Viruses.
MF975637_p2 ATN93652.1 HNH endonuclease MF975637 Streptomyces phage Scap1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Scapunavirus; Streptomyces virus Scap1.
p46228 no NCBI prot ID no annotation VI_01226 Clostridia_gi_547240599 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KU160646_p2 ALY08977.1 HNH endonuclease domain protein KU160646 Arthrobacter phage Gordon Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordonvirus; Arthrobacter virus Gordon.
MF140423_p2 ASM62278.1 HNH endonuclease domain protein MF140423 Arthrobacter phage Nightmare Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordonvirus; unclassified Gordonvirus.
NC_024208_p5 YP_009035820.1 homing endonuclease NC_024208 Lactococcus phage P118 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p38914 no NCBI prot ID no annotation VI_01187 Clostridia_gi_355689648_74587_135725 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MF467948_p2 ASU03916.1 HNH endonuclease MF467948 Streptomyces phage DrGrey Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Rimavirus; Strepomyces virus Drgrey.
MF140432_p3 ASR84009.1 HNH endonuclease domain protein MF140432 Arthrobacter phage Teacup Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordonvirus; unclassified Gordonvirus.
NC_010576_p5 YP_001828653.1 hypothetical protein NC_010576 Lactococcus phage 1706 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
MF189175_p4 ASR80455.1 HNH endonuclease domain protein MF189175 Arthrobacter phage Tribby Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mudcatvirus; unclassified Mudcatvirus.
MG711463_p59 AUV56552.1 endonuclease MG711463 Faecalibacterium phage FP_oengus Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Oengusvirus; Faecalibacterium virus Oengus.
MF324906_p4 ASR84584.1 HNH endonuclease MF324906 Arthrobacter phage Cheesy Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mudcatvirus; unclassified Mudcatvirus.
MF189170_p4 ASR79968.1 HNH endonuclease MF189170 Arthrobacter phage Arcadia Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mudcatvirus; unclassified Mudcatvirus.
MF038790_p2 ASD52227.1 HNH endonuclease domain protein MF038790 Arthrobacter phage Niktson Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordonvirus; unclassified Gordonvirus.
NC_023694_p11 YP_009012592.1 gp011 NC_023694 Rhodococcus phage ReqiPoco6 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Pepyhexavirus.
MG757154_p2 AVD99424.1 HNH endonuclease MG757154 Streptomyces phage Bing Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Bingvirus; Streptomyces virus Bing.
NC_031224_p4 YP_009300693.1 HNH endonuclease NC_031224 Arthrobacter phage Mudcat Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mudcatvirus.
MF189173_p4 ASR80258.1 HNH endonuclease MF189173 Arthrobacter phage Heisenberger Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mudcatvirus; unclassified Mudcatvirus.
p46484 no NCBI prot ID no annotation VI_01201 Clostridia_gi_365137247_641329_700297 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_024203_p5 YP_009035066.1 hypothetical protein NC_024203 Lactococcus phage P092 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
KU160641_p3 ALY08603.1 HNH endonuclease domain protein KU160641 Arthrobacter phage CaptnMurica Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordonvirus; Arthrobacter virus Captnmurica.
MF140401_p3 ASR83380.1 HNH endonuclease MF140401 Arthrobacter phage Caterpillar Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Gordonvirus; unclassified Gordonvirus.
MG962369_p8 AVO25342.1 HNH endonuclease MG962369 Gordonia phage Kerry Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_023735_p9 YP_009017623.1 gp009 NC_023735 Rhodococcus phage ReqiPepy6 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Pepyhexavirus.
NC_024215_p5 YP_009036830.1 homing endonuclease NC_024215 Lactococcus phage P078 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
MF189171_p4 ASR80065.1 HNH endonuclease domain protein MF189171 Arthrobacter phage Correa Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mudcatvirus; unclassified Mudcatvirus.
NC_024214_p5 YP_009036748.1 hypothetical protein NC_024214 Lactococcus phage P162 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_4259 32 no annotation unknown function 31 1.41E-137 127.97
phrog_4247 32 virion structural protein head and packaging 7 4.36E-27 17.48
phrog_13392 7 endolysin lysis 7 0 1000
phrog_7698 15 endolysin lysis 5 5.08E-22 12.42
phrog_25585 3 no annotation unknown function 3 0 1000
phrog_15884 6 no annotation unknown function 3 3.49E-16 6.58

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_119 HNH endonuclease DNA, RNA and nucleotide metabolism 99.0 3.1E-13 39-119 / 10-86
phrog_144 HNH endonuclease DNA, RNA and nucleotide metabolism 98.1 4.6E-09 37-117 / 39-115
phrog_4581 terminase small subunit head and packaging 96.5 2.9E-05 30-116 / 28-109
phrog_589 HNH endonuclease DNA, RNA and nucleotide metabolism 96.3 6.1E-05 33-115 / 23-99

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF05766.11 Bacteriophage Lambda NinG protein 8.4E-10 55-129 / 69-138
PF05315.10 ICEA Protein 2.2E-09 59-127 / 80-150
PF13395.5 HNH endonuclease 3.9E-08 75-127 / 1-51
PF01844.22 HNH endonuclease 4.7E-08 75-126 / 1-47
PF14279.5 HNH endonuclease 1E-07 75-131 / 1-49
PF09665.9 Type II restriction endonuclease (RE_Alw26IDE) 8.4E-07 72-132 / 253-301
PF06147.10 Protein of unknown function (DUF968) 5.7E-06 71-127 / 126-174
PF13391.5 HNH endonuclease 7.2E-06 75-128 / 1-46
PF16784.4 Putative HNHc nuclease 0.00011 72-133 / 123-177
PF02945.14 Recombination endonuclease VII 0.00062 66-126 / 21-72

Annotations of the NCBI proteins of this PHROG


12:HNH endonuclease 8:HNH endonuclease domain protein 3:hypothetical protein 2:homing endonuclease 2:protein of an unannotated phage 1:endonuclease

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0004519 endonuclease activity
GO:0003676 nucleic acid binding

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