phrog_4441 is made of 31 protein sequences and is annotated as "HTH DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
100.19 157 101


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p152087 no NCBI prot ID no annotation VI_05530 Betaproteobacteria_gi_149156765_2958_43574 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
NC_009236_p24 YP_001111174.1 gp24, hypothetical protein NC_009236 Burkholderia virus phiE122 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Tigrvirus.
p211373 no NCBI prot ID no annotation VI_01119 Betaproteobacteria_gi_53721039_1426445_1462145 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
p183056 no NCBI prot ID no annotation VI_01091 Betaproteobacteria_gi_339905954_1891604_1929514 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p341560 no NCBI prot ID no annotation VI_01053 Betaproteobacteria_gi_254192738_549538_570582 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
p206813 no NCBI prot ID no annotation VI_01074 Betaproteobacteria_gi_83716035_1578828_1614931 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
p207163 no NCBI prot ID no annotation VI_01062 Betaproteobacteria_gi_254173940_2210684_2246765 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
p184439 no NCBI prot ID no annotation VI_05508 Betaproteobacteria_gi_149132582_8449_46271 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Peduovirus.
NC_021343_p49 YP_008060523.1 helix-turn-helix domain protein NC_021343 Burkholderia phage ST79 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Nampongvirus; Burkholderia virus ST79.
p394805 no NCBI prot ID no annotation VI_05536 Betaproteobacteria_gi_149161195 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Peduovirinae; Tigrvirus; Burkholderia virus phiE122.
p439776 no NCBI prot ID no annotation VI_06945 Gammaproteobacteria_gi_485044143 Viruses.
p6192 no NCBI prot ID no annotation VI_06632 Gammaproteobacteria_gi_260775639_290984_388801 Viruses.
p414235 no NCBI prot ID no annotation VI_11486 Gammaproteobacteria_gi_545084871_1236653_1249102 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p414213 no NCBI prot ID no annotation VI_11482 Gammaproteobacteria_gi_545081878_1452050_1464499 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p441052 no NCBI prot ID no annotation VI_09491 Gammaproteobacteria_gi_484030417 Viruses.
p11742 no NCBI prot ID no annotation VI_06587 Gammaproteobacteria_gi_223044564_334674_422569 Viruses.
p418328 no NCBI prot ID no annotation VI_11492 Gammaproteobacteria_gi_545122446_866549_878573 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p409529 no NCBI prot ID no annotation VI_06598 Gammaproteobacteria_gi_225936441_28485_41472 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p426814 no NCBI prot ID no annotation VI_01086 Betaproteobacteria_gi_241661625_2269330_2280478 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; unclassified Inoviridae; Ralstonia phage 1 NP-2014.
NC_023586_p4 YP_009008122.1 DNA binding protein NC_023586 Ralstonia phage 1 NP-2014 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; unclassified Inoviridae.
AB981170_p15 BAP28165.1 hypothetical protein AB981170 Ralstonia phage RSMSuper Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; Habenivirus; Ralstonia virus RSM3; Ralstonia phage RSM3.
p439389 no NCBI prot ID no annotation VI_05621 Betaproteobacteria_gi_490769071_294376_302519 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae.
NC_008574_p15 YP_863919.2 hypothetical protein NC_008574 Ralstonia phage RSM1 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; Habenivirus.
p439118 no NCBI prot ID no annotation VI_01102 Betaproteobacteria_gi_187927112_2648175_2656505 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae.
p414141 no NCBI prot ID no annotation VI_05565 Betaproteobacteria_gi_485458402_20704_33160 Viruses; Monodnaviria; Loebvirae; Hofneiviricota; Faserviricetes; Tubulavirales; Inoviridae; Inovirus; unclassified Inovirus.
NC_000867_p4 NP_049893.1 hypothetical protein NC_000867 Pseudoalteromonas phage PM2 Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Vinavirales; Corticoviridae; Corticovirus.
p438635 no NCBI prot ID no annotation VI_03638 Gammaproteobacteria_gi_485091576_83543_92247 Viruses.
MG966533_p2 AVJ51866.1 hypothetical protein MG966533 Pseudoalteromonas phage Cr39582 Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Vinavirales; Corticoviridae; Corticovirus; Pseudoalteromonas virus Cr39582.
p434134 no NCBI prot ID no annotation VI_08943 Gammaproteobacteria_gi_484337382_174718_185041 Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Vinavirales; Corticoviridae; Corticovirus; Pseudoalteromonas virus PM2.
p427431 no NCBI prot ID no annotation VI_02643 Gammaproteobacteria_gi_409167409_274568_285664 Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Vinavirales; Corticoviridae; Corticovirus; Pseudoalteromonas virus PM2.
p430139 no NCBI prot ID no annotation VI_11377 Gammaproteobacteria_gi_549963374_770520_781333 Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Vinavirales; Corticoviridae; Corticovirus; Pseudoalteromonas virus PM2.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_33670 2 no annotation unknown function 2 0 1000
phrog_10187 10 no annotation unknown function 2 4.49E-13 3.47

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_11145 DNA binding protein DNA, RNA and nucleotide metabolism 92.9 0.015 22-58 / 5-41
phrog_1124 transcriptional regulator transcription regulation 92.1 0.023 19-56 / 20-59
phrog_1373 transcriptional regulator transcription regulation 96.5 2.8E-05 7-62 / 34-88
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 96.9 6.8E-06 20-59 / 25-64
phrog_1529 no annotation unknown function 97.0 4.4E-06 17-45 / 14-42
phrog_16278 HTH DNA binding protein DNA, RNA and nucleotide metabolism 96.0 0.00015 10-67 / 6-62
phrog_18104 transcriptional regulator transcription regulation 94.5 0.0031 12-60 / 7-55
phrog_18342 transcriptional repressor transcription regulation 91.7 0.029 22-65 / 34-79
phrog_19579 transcriptional regulator transcription regulation 94.1 0.0049 9-70 / 6-67
phrog_2104 no annotation unknown function 91.4 0.034 12-65 / 53-104
phrog_2328 transcriptional repressor transcription regulation 95.4 0.00069 15-68 / 26-78
phrog_2339 HTH DNA binding protein DNA, RNA and nucleotide metabolism 94.5 0.003 20-59 / 39-79
phrog_23446 no annotation unknown function 93.1 0.012 7-84 / 3-93
phrog_2439 transcriptional regulator transcription regulation 95.3 0.00086 7-64 / 9-65
phrog_2538 terminase small subunit head and packaging 93.2 0.012 3-46 / 9-46
phrog_2967 transcriptional regulator transcription regulation 95.9 0.00021 7-71 / 11-75
phrog_3037 transcriptional repressor transcription regulation 93.1 0.013 11-65 / 20-74
phrog_31301 DNA binding protein DNA, RNA and nucleotide metabolism 92.3 0.021 2-82 / 1-77
phrog_34897 no annotation unknown function 98.2 2.1E-09 2-89 / 1-87
phrog_35 transcriptional repressor transcription regulation 95.5 0.00061 17-57 / 12-52
phrog_3642 HTH DNA binding protein DNA, RNA and nucleotide metabolism 97.1 1.9E-06 9-68 / 11-70
phrog_3949 transcriptional repressor transcription regulation 94.9 0.0017 7-81 / 15-88
phrog_3 transcriptional repressor transcription regulation 96.6 1.8E-05 13-65 / 12-63
phrog_409 transcriptional regulator transcription regulation 95.7 0.0004 15-58 / 9-47
phrog_4583 transcriptional repressor transcription regulation 96.5 3.2E-05 19-66 / 24-71
phrog_4836 CII-like regulator transcription regulation 93.9 0.0063 20-68 / 97-145
phrog_4 transcriptional repressor transcription regulation 95.6 0.00042 9-70 / 5-64
phrog_5301 transcriptional repressor transcription regulation 96.4 4.6E-05 14-70 / 19-79
phrog_638 transcriptional regulator transcription regulation 99.7 1.7E-21 4-91 / 2-89
phrog_7126 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.1 0.012 18-62 / 29-74
phrog_7241 transcriptional regulator transcription regulation 94.6 0.0027 20-65 / 76-121
phrog_725 CII-like regulator transcription regulation 96.2 7.9E-05 2-63 / 11-69
phrog_769 transcriptional repressor transcription regulation 90.0 0.065 20-66 / 27-70
phrog_8008 DNA binding protein DNA, RNA and nucleotide metabolism 95.3 0.00091 22-66 / 18-60
phrog_8 transcriptional regulator transcription regulation 97.2 1.4E-06 10-66 / 7-60
phrog_9103 transcriptional repressor transcription regulation 96.9 6.7E-06 5-66 / 7-68

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 8.1E-08 41-105 / 8-77
PF13744.5 Helix-turn-helix domain 1.5E-07 40-104 / 15-79
PF01381.21 Helix-turn-helix 6.3E-07 50-102 / 3-54
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 7.3E-07 48-106 / 3-60
PF14590.5 Domain of unknown function (DUF4447) 8.4E-07 43-105 / 7-71
PF05339.10 Protein of unknown function (DUF739) 1E-06 46-104 / 6-63
PF13413.5 Helix-turn-helix domain 1.4E-06 49-101 / 2-59
PF04645.11 Protein of unknown function, DUF603 2.7E-06 40-104 / 4-67
PF12844.6 Helix-turn-helix domain 2.6E-06 48-105 / 4-60
PF05269.10 Bacteriophage CII protein 6E-06 49-105 / 16-69
PF13560.5 Helix-turn-helix domain 6.7E-06 45-103 / 3-63
PF08667.9 BetR domain 7.7E-06 43-106 / 5-71
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 8.4E-06 44-104 / 70-128
PF13443.5 Cro/C1-type HTH DNA-binding domain 1.7E-05 59-105 / 13-61
PF08965.9 Domain of unknown function (DUF1870) 3.1E-05 45-105 / 3-67
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 6.4E-05 59-105 / 10-56
PF13693.5 Winged helix-turn-helix DNA-binding 0.00011 48-105 / 7-60
PF12116.7 Stage III sporulation protein D 0.00024 54-99 / 17-62
PF04814.12 Hepatocyte nuclear factor 1 (HNF-1), N terminus 0.00027 44-96 / 114-165
PF14549.5 DNA-binding transcriptional regulator Cro 0.00076 50-103 / 4-52
PF02376.14 CUT domain 0.00095 43-105 / 7-67
PF00356.20 Bacterial regulatory proteins, lacI family 0.001 60-86 / 2-28
PF10654.8 Protein of unknown function (DUF2481) 0.0016 53-82 / 77-105

Annotations of the NCBI proteins of this PHROG


5:hypothetical protein 1:helix-turn-helix domain protein 1:DNA binding protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0005634 nucleus
GO:0006355 regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0003677 DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0043565 sequence-specific DNA binding

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