phrog_4578 is made of 30 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
110.9 219 102


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p180900 no NCBI prot ID no annotation VI_03586 Gammaproteobacteria_gi_387615344_996498_1034595 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_024142_p66 YP_009032030.1 hypothetical protein NC_024142 Escherichia phage Bp4 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Gamaleyavirus.
NC_023589_p81 YP_009008482.1 hypothetical protein NC_023589 Shigella phage pSb-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Gamaleyavirus.
MF158039_p66 ATE85793.1 HNH homing endonuclease MF158039 Shigella phage Sf12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Drexlerviridae; Rogunavirinae; Eastlansingvirus; Shigella virus Sf12.
MG250486_p121 AUE23347.1 hypothetical protein MG250486 Raoultella phage Ro1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; unclassified Vequintavirinae.
KY514263_p207 ARB11660.1 hypothetical protein KY514263 Pectobacterium phage vB_PatM_CB7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Certrevirus; unclassified Certrevirus.
NC_031022_p129 YP_009280316.1 homing endonuclease NC_031022 Shigella phage SHSML-45 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; Shigella virus SHSML45.
NC_028754_p115 YP_009194759.1 HNH homing endonuclease NC_028754 Salmonella phage Shivani Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus.
MF431736_p33 ASU02396.1 homing endonuclease MF431736 Bacteriophage T5-like chee130_1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Epseptimavirus; unclassified Epseptimavirus.
NC_031022_p131 YP_009280318.1 homing endonuclease NC_031022 Shigella phage SHSML-45 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Demerecviridae; Markadamsvirinae; Tequintavirus; Shigella virus SHSML45.
NC_031114_p14 YP_009291492.1 hypothetical protein NC_031114 Escherichia phage 64795_ec1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; Escherichia virus 64795ec1.
NC_004665_p14 NP_813760.1 putative NHN endonuclease NC_004665 Pseudomonad phage gh-1 (gh-1) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Ghunavirus.
AY264778_p17 AAP34137.1 gene 3.8 AY264778 Enterobacteria phage T7 (T7) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; Escherichia virus T7.
KU687351_p21 AMR59642.1 HNH endonuclease KU687351 Citrobacter phage SH5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Kayfunavirus; unclassified Kayfunavirus.
JX000007_p16 AGB07339.1 putative HNH endonuclease JX000007 Yersinia phage R Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; unclassified Teseptimavirus.
AY264777_p18 AAP34084.1 gene 3.8 AY264777 Enterobacteria phage T7 (T7) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; Escherichia virus T7.
AY264775_p18 AAP33983.1 gene 3.8 AY264775 Enterobacteria phage T7 (T7) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; Escherichia virus T7.
KU183006_p18 ALT58473.1 homing endonuclease KU183006 Klebsiella phage vB_KpnP_IME205 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Przondovirus; Klebsiella virus IME205.
MG835568_p18 AUV61483.1 hypothetical protein MG835568 Klebsiella phage SH-Kp 152410 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Przondovirus; Klebsiella virus SHKp152410.
NC_001604_p21 NP_041974.1 putative NHN endonuclease NC_001604 Enterobacteria phage T7 (T7) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; Escherichia virus T7.
NC_004777_p16 NP_848278.1 putative NHN endonuclease NC_004777 Yersinia phage phiA1122 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus.
MF979560_p110 ATS93510.1 hypothetical protein MF979560 Pectobacterium phage DU_PP_I Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Certrevirus; unclassified Certrevirus.
MF979563_p111 ATS93827.1 hypothetical protein MF979563 Pectobacterium phage DU_PP_IV Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Vequintavirinae; Certrevirus; unclassified Certrevirus.
KU130131_p147 AMR58217.1 putative HNH endonuclease KU130131 Pseudomonas phage vB_PsyM_KIL3b Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Flaumdravirus; Pseudomonas virus KIL4; Pseudomonas phage vB_PsyM_KIL1.
NC_030934_p145 YP_009276079.1 hypothetical protein NC_030934 Pseudomonas phage vB_PsyM_KIL1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Flaumdravirus; Pseudomonas virus KIL4.
KY883635_p35 ASV41438.1 hypothetical protein KY883635 Vibrio phage JSF6 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
HQ641348_p116 ADX88162.1 hypothetical protein HQ641348 Vibrio phage ICP1_2006_D Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_005833_p16 YP_003882.1 hypothetical protein NC_005833 Escherichia virus T1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Drexlerviridae; Tunavirinae; Tunavirus.
KT070867_p124 AKQ08439.1 hypothetical protein KT070867 Bacillus phage PBC2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_015157_p116 YP_004251057.1 putative HNH endonuclease NC_015157 Vibrio phage ICP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_239 486 DNA primase/helicase DNA, RNA and nucleotide metabolism 10 1.19E-25 16.05
phrog_822 175 amidase lysis 9 1.73E-27 17.88
phrog_28616 2 no annotation unknown function 2 0 1000
phrog_30397 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10730 HNH endonuclease DNA, RNA and nucleotide metabolism 94.6 0.0025 8-35 / 54-80
phrog_10822 HNH endonuclease DNA, RNA and nucleotide metabolism 97.1 2.1E-06 6-32 / 114-140
phrog_12324 intron-like DNA endonuclease DNA, RNA and nucleotide metabolism 92.3 0.021 2-29 / 10-42
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 92.7 0.016 5-37 / 162-196
phrog_13470 HNH endonuclease DNA, RNA and nucleotide metabolism 99.3 4.6E-16 38-97 / 83-142
phrog_14736 HNH endonuclease DNA, RNA and nucleotide metabolism 93.9 0.0061 7-47 / 47-97
phrog_14913 HNH endonuclease DNA, RNA and nucleotide metabolism 95.2 0.0011 6-35 / 55-84
phrog_1492 HNH endonuclease DNA, RNA and nucleotide metabolism 98.1 4.9E-09 1-43 / 80-122
phrog_15471 HNH endonuclease DNA, RNA and nucleotide metabolism 96.1 0.00013 3-59 / 43-93
phrog_1891 HNH endonuclease DNA, RNA and nucleotide metabolism 97.5 1.9E-07 1-37 / 130-166
phrog_24751 HNH endonuclease DNA, RNA and nucleotide metabolism 98.5 1.4E-10 46-94 / 8-56
phrog_25114 no annotation unknown function 92.2 0.023 7-33 / 99-125
phrog_30377 HNH endonuclease DNA, RNA and nucleotide metabolism 96.1 0.00014 10-52 / 26-67
phrog_30933 no annotation unknown function 96.0 0.00015 28-97 / 5-66
phrog_33760 HNH endonuclease DNA, RNA and nucleotide metabolism 98.3 9.1E-10 49-101 / 1-53
phrog_3377 HNH endonuclease DNA, RNA and nucleotide metabolism 96.8 1.1E-05 3-39 / 55-91
phrog_35306 no annotation unknown function 97.4 4.7E-07 44-92 / 21-69
phrog_3593 HNH endonuclease DNA, RNA and nucleotide metabolism 99.8 1.8E-25 1-98 / 82-180
phrog_36769 no annotation unknown function 97.2 1.4E-06 9-89 / 248-330
phrog_37010 no annotation unknown function 96.9 5E-06 2-92 / 158-236
phrog_374 HNH endonuclease DNA, RNA and nucleotide metabolism 99.5 1.1E-17 7-101 / 128-219
phrog_37683 no annotation unknown function 93.0 0.014 10-37 / 154-181
phrog_4590 no annotation unknown function 92.6 0.017 6-38 / 48-82
phrog_4947 no annotation unknown function 90.9 0.044 47-86 / 56-95
phrog_59 HNH endonuclease DNA, RNA and nucleotide metabolism 97.8 3.4E-08 7-42 / 68-103
phrog_6254 HNH endonuclease DNA, RNA and nucleotide metabolism 94.0 0.0055 3-42 / 48-87
phrog_7545 HNH endonuclease DNA, RNA and nucleotide metabolism 95.3 0.00085 6-37 / 99-130
phrog_826 HNH endonuclease DNA, RNA and nucleotide metabolism 97.1 2.1E-06 1-40 / 58-97
phrog_8790 restriction endonuclease DNA, RNA and nucleotide metabolism 95.6 0.00043 3-44 / 63-107
phrog_953 HNH endonuclease DNA, RNA and nucleotide metabolism 98.3 6.7E-10 7-98 / 76-170
phrog_959 HNH endonuclease DNA, RNA and nucleotide metabolism 98.0 7.2E-09 2-39 / 63-101
phrog_99 HNH endonuclease DNA, RNA and nucleotide metabolism 100.0 7.2E-38 1-101 / 60-158

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF13392.5 HNH endonuclease 4.7E-12 14-57 / 2-44
PF05551.10 Zinc-binding loop region of homing endonuclease 1.6E-11 9-62 / 25-81
PF00847.19 AP2 domain 5.9E-07 154-202 / 1-53

Annotations of the NCBI proteins of this PHROG


12:hypothetical protein 4:HNH endonuclease 4:protein of an unannotated phage 4:homing endonuclease 3:NHN endonuclease 2:HNH homing endonuclease

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003700 DNA binding transcription factor activity
GO:0006355 regulation of transcription, DNA-templated

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