phrog_4583 is made of 30 protein sequences and is annotated as "transcriptional repressor"
Functional category: transcription regulation


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
82.3 123 80


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_031243_p35 YP_009302349.1 HTH-XRE DNA-binding domain protein NC_031243 Mycobacterium phage Xeno Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Charlievirus.
NC_031281_p34 YP_009304942.1 excise NC_031281 Mycobacterium phage Panchino Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Redivirus.
NC_028779_p38 YP_009197163.1 Xis NC_028779 Mycobacterium phage Carcharodon Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Charlievirus; unclassified Charlievirus.
MG099936_p35 ATW61068.1 excise MG099936 Mycobacterium phage Andies Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Charlievirus; unclassified Charlievirus.
NC_031266_p39 YP_009304231.1 excise NC_031266 Mycobacterium phage Phrann Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Redivirus.
KX756439_p39 AOZ64467.1 excise KX756439 Mycobacterium phage PhancyPhin Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Redivirus; unclassified Redivirus.
KU935729_p33 AMU78463.1 HTH-XRE DNA-binding domain protein KU935729 Mycobacterium phage SkinnyPete Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Redivirus; Mycobacterium virus Skinnyp.
MG099948_p36 ATW60095.1 excise MG099948 Mycobacterium phage Philonius Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Charlievirus; unclassified Charlievirus.
NC_021061_p39 YP_007869850.1 hypothetical protein NC_021061 Mycobacterium phage Butters Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Buttersvirus.
KU935726_p38 AMS01984.1 excise KU935726 Mycobacterium phage Xerxes Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Charlievirus; unclassified Charlievirus.
NC_023730_p39 YP_009017103.1 gp39 NC_023730 Mycobacterium phage Redi Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Redivirus.
NC_023572_p36 YP_009006637.1 Xis NC_023572 Mycobacterium phage MichelleMyBell Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Buttersvirus.
NC_023729_p36 YP_009017032.1 gp36 NC_023729 Mycobacterium phage Charlie Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Charlievirus.
KU935730_p38 AMS02191.1 excise KU935730 Mycobacterium phage Pipsqueaks Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nclasvirinae; Charlievirus; Mycobacterium virus Pipsqueaks.
KX620754_p32 AOT24621.1 DNA binding domain protein KX620754 Propionibacterium phage G4 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Doucettevirus; Propionibacterium virus G4.
p214347 no NCBI prot ID no annotation VI_04154 Actinobacteria_gi_544774031 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KX620750_p32 AOT24384.1 DNA binding domain protein KX620750 Propionibacterium phage B22 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Doucettevirus; Propionibacterium virus B22.
KX620751_p34 AOT24447.1 hypothetical protein KX620751 Propionibacterium phage Doucette Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Doucettevirus; Propionibacterium virus Doucette.
KX620749_p31 AOT24324.1 DNA binding protein KX620749 Propionibacterium phage B3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Anatolevirus; Propionibacterium virus B3.
NC_031076_p28 YP_009287704.1 transcriptional regulator NC_031076 Propionibacterium phage PFR1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Pulverervirus.
NC_031108_p30 YP_009290937.1 transcriptional regulator NC_031108 Propionibacterium phage PFR2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Pulverervirus; unclassified Pulverervirus.
KX620753_p34 AOT24563.1 HTH DNA binding protein KX620753 Propionibacterium phage E6 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Doucettevirus; Propionibacterium virus E6.
NC_031076_p29 YP_009287705.1 hypothetical protein NC_031076 Propionibacterium phage PFR1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Pulverervirus.
NC_031108_p31 YP_009290938.1 hypothetical protein NC_031108 Propionibacterium phage PFR2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Pulverervirus; unclassified Pulverervirus.
KX620753_p35 AOT24564.1 HTH DNA binding protein KX620753 Propionibacterium phage E6 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Doucettevirus; Propionibacterium virus E6.
p101186 no NCBI prot ID no annotation VI_04111 Actinobacteria_gi_484081368 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
p375359 no NCBI prot ID no annotation VI_04156 Actinobacteria_gi_551245205 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_031265_p41 YP_009304155.1 excise NC_031265 Gordonia phage Guacamole Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_026597_p44 YP_009125427.1 CRO protein NC_026597 Mycobacterium phage Sparky Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_011801_p19 YP_002455808.1 hypothetical protein NC_011801 Lactobacillus phage Lv-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_3507 41 no annotation unknown function 14 1.21E-58 49.04
phrog_130 726 anti-repressor Ant transcription regulation 5 1.95E-13 3.83
phrog_4980 27 superinfection exclusion moron, auxiliary metabolic gene and host takeover 2 1.08E-10 1.09
phrog_29861 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_11187 transcriptional regulator transcription regulation 93.1 0.012 7-52 / 4-47
phrog_1124 transcriptional regulator transcription regulation 94.0 0.0057 11-61 / 7-59
phrog_13326 no annotation unknown function 97.8 4.8E-08 24-76 / 18-70
phrog_1337 DNA binding protein DNA, RNA and nucleotide metabolism 95.6 0.00045 9-62 / 5-60
phrog_1373 transcriptional regulator transcription regulation 98.0 6.6E-09 11-70 / 32-91
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 97.8 4.9E-08 8-70 / 7-70
phrog_1468 transcriptional repressor transcription regulation 96.8 9.5E-06 9-68 / 6-64
phrog_147 transcriptional regulator transcription regulation 94.7 0.0023 11-59 / 3-51
phrog_1529 no annotation unknown function 95.4 0.00073 13-49 / 6-41
phrog_16278 HTH DNA binding protein DNA, RNA and nucleotide metabolism 94.0 0.0054 24-70 / 15-60
phrog_1702 transcriptional repressor transcription regulation 97.2 1.8E-06 13-75 / 16-81
phrog_1728 transcriptional regulator transcription regulation 90.8 0.046 12-63 / 5-56
phrog_1746 transcriptional repressor transcription regulation 93.6 0.0078 1-72 / 1-71
phrog_18104 transcriptional regulator transcription regulation 92.4 0.02 13-62 / 5-52
phrog_18342 transcriptional repressor transcription regulation 96.9 7.7E-06 14-73 / 21-82
phrog_18815 no annotation unknown function 92.0 0.026 20-73 / 11-62
phrog_20467 HNH endonuclease DNA, RNA and nucleotide metabolism 94.4 0.0035 17-48 / 64-95
phrog_21705 no annotation unknown function 94.2 0.0044 12-70 / 121-179
phrog_2328 transcriptional repressor transcription regulation 98.4 2.9E-10 7-74 / 12-79
phrog_2339 HTH DNA binding protein DNA, RNA and nucleotide metabolism 97.6 1E-07 10-66 / 24-81
phrog_24325 transcriptional regulator transcription regulation 94.0 0.0053 9-52 / 51-97
phrog_2439 transcriptional regulator transcription regulation 96.4 4.1E-05 12-73 / 8-69
phrog_26445 no annotation unknown function 90.1 0.063 20-48 / 14-42
phrog_268 no annotation unknown function 91.7 0.03 19-47 / 13-40
phrog_2967 transcriptional regulator transcription regulation 98.0 1.2E-08 7-74 / 5-73
phrog_296 DNA transposition protein integration and excision 94.0 0.0056 11-48 / 2-39
phrog_3037 transcriptional repressor transcription regulation 90.6 0.05 23-72 / 27-76
phrog_309 terminase small subunit head and packaging 91.8 0.029 16-52 / 17-53
phrog_323 transcriptional regulator, D5-like transcription regulation 94.1 0.0047 23-70 / 15-82
phrog_3377 HNH endonuclease DNA, RNA and nucleotide metabolism 90.9 0.044 25-56 / 105-134
phrog_34939 no annotation unknown function 93.1 0.012 15-73 / 14-73
phrog_3557 transcriptional regulator transcription regulation 95.8 0.00027 8-70 / 11-72
phrog_35 transcriptional repressor transcription regulation 95.3 0.00081 23-72 / 13-64
phrog_3642 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.3 0.00079 21-65 / 18-62
phrog_38278 no annotation unknown function 95.9 0.00021 14-66 / 1-52
phrog_3855 HTH DNA binding protein DNA, RNA and nucleotide metabolism 90.9 0.044 16-45 / 72-101
phrog_38620 transcriptional regulator transcription regulation 91.6 0.032 15-75 / 6-67
phrog_3949 transcriptional repressor transcription regulation 94.6 0.0025 11-72 / 16-76
phrog_3 transcriptional repressor transcription regulation 98.3 6.9E-10 11-72 / 4-65
phrog_4268 transcriptional repressor transcription regulation 90.8 0.046 10-66 / 35-89
phrog_4441 HTH DNA binding protein DNA, RNA and nucleotide metabolism 96.1 0.00014 25-71 / 20-66
phrog_4779 transcriptional regulator transcription regulation 96.9 5.5E-06 12-49 / 3-40
phrog_4836 CII-like regulator transcription regulation 92.3 0.021 8-76 / 80-148
phrog_4 transcriptional repressor transcription regulation 96.4 4.5E-05 21-75 / 12-64
phrog_517 HTH DNA binding protein DNA, RNA and nucleotide metabolism 90.3 0.057 12-46 / 69-102
phrog_5823 transcriptional regulator transcription regulation 95.5 0.00063 9-75 / 3-70
phrog_6156 endonuclease DNA, RNA and nucleotide metabolism 91.3 0.037 14-48 / 26-59
phrog_6223 transcriptional repressor transcription regulation 95.2 0.0011 20-48 / 14-42
phrog_6288 no annotation unknown function 91.3 0.038 5-57 / 6-60
phrog_638 transcriptional regulator transcription regulation 95.9 0.00021 24-69 / 17-62
phrog_6463 HTH DNA binding protein DNA, RNA and nucleotide metabolism 90.1 0.062 21-71 / 31-89
phrog_664 DNA binding protein DNA, RNA and nucleotide metabolism 94.4 0.0034 17-52 / 62-96
phrog_6831 transcriptional regulator transcription regulation 96.6 2.7E-05 14-48 / 6-40
phrog_686 HTH DNA binding protein DNA, RNA and nucleotide metabolism 91.8 0.029 7-49 / 21-63
phrog_7126 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.5 0.009 19-66 / 26-73
phrog_7241 transcriptional regulator transcription regulation 97.5 2.1E-07 13-70 / 64-121
phrog_725 CII-like regulator transcription regulation 95.4 0.00073 6-66 / 12-67
phrog_769 transcriptional repressor transcription regulation 96.9 5.1E-06 12-73 / 14-72
phrog_8038 no annotation unknown function 94.7 0.0024 14-49 / 6-39
phrog_8 transcriptional regulator transcription regulation 97.6 1.8E-07 12-74 / 3-63
phrog_9103 transcriptional repressor transcription regulation 95.9 0.00021 14-76 / 10-73
phrog_925 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.2 0.0011 12-67 / 6-61
phrog_9425 transcriptional repressor transcription regulation 90.9 0.045 11-63 / 8-61

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 4.9E-09 23-86 / 7-76
PF13744.5 Helix-turn-helix domain 3.1E-08 24-86 / 16-79
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 1E-07 32-89 / 4-61
PF14590.5 Domain of unknown function (DUF4447) 1.5E-07 26-88 / 7-72
PF05339.10 Protein of unknown function (DUF739) 1.5E-07 29-86 / 6-63
PF01381.21 Helix-turn-helix 1.6E-07 34-84 / 4-54
PF12844.6 Helix-turn-helix domain 2.9E-07 32-88 / 5-61
PF04645.11 Protein of unknown function, DUF603 3.4E-07 24-76 / 5-60
PF13443.5 Cro/C1-type HTH DNA-binding domain 4E-07 33-88 / 4-62
PF13413.5 Helix-turn-helix domain 4.5E-07 33-83 / 3-59
PF13560.5 Helix-turn-helix domain 1.5E-06 28-85 / 3-63
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 1.5E-06 27-86 / 70-128
PF08667.9 BetR domain 1.9E-06 27-89 / 6-72
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 2.3E-06 35-88 / 5-57
PF05269.10 Bacteriophage CII protein 2.9E-06 32-88 / 16-70
PF08965.9 Domain of unknown function (DUF1870) 9.2E-06 28-86 / 3-66
PF13693.5 Winged helix-turn-helix DNA-binding 2.8E-05 31-88 / 7-61
PF14549.5 DNA-binding transcriptional regulator Cro 3.3E-05 33-85 / 4-52
PF04814.12 Hepatocyte nuclear factor 1 (HNF-1), N terminus 0.00011 28-78 / 115-165
PF00157.16 Pou domain - N-terminal to homeobox domain 0.00016 26-79 / 7-64
PF12116.7 Stage III sporulation protein D 0.00016 38-81 / 18-62
PF02376.14 CUT domain 0.00026 26-88 / 7-68
PF00356.20 Bacterial regulatory proteins, lacI family 0.00026 41-68 / 1-28
PF10654.8 Protein of unknown function (DUF2481) 0.00066 36-64 / 77-105
PF08535.9 KorB domain 0.0082 38-64 / 2-28

Annotations of the NCBI proteins of this PHROG


8:excise 6:hypothetical protein 2:DNA binding domain protein 2:Xis 2:HTH-XRE DNA-binding domain protein 2:transcriptional regulator 2:HTH DNA binding protein 1:CRO protein 1:protein of an unannotated phage 1:DNA binding protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003677 DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0043565 sequence-specific DNA binding
GO:0006355 regulation of transcription, DNA-templated
GO:0005634 nucleus
GO:0045893 positive regulation of transcription, DNA-templated
GO:0003700 DNA binding transcription factor activity

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