phrog_5497 is made of 23 protein sequences and is annotated as "HTH DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
67.87 110 65


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KX610764_p40 AOT26026.1 HTH DNA binding domain protein KX610764 Mycobacterium phage Kersh Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_004686_p48 NP_818021.1 gp48 NC_004686 Mycobacterium virus Che9d Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
NC_021301_p40 YP_008051166.1 HTH DNA binding domain protein NC_021301 Mycobacterium phage SiSi Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_004680_p44 NP_817382.1 gp44 NC_004680 Mycobacterium virus Che8 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
NC_028889_p47 YP_009206765.1 HTH binding domain NC_028889 Mycobacterium phage Florinda Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
JF937098_p41 AEK09137.1 hypothetical protein JF937098 Mycobacterium virus Ibhubesi Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
NC_022056_p40 YP_008409104.1 HTH domain protein NC_022056 Mycobacterium phage Hamulus Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_028813_p41 YP_009199724.1 HTH DNA binding protein NC_028813 Mycobacterium phage Seagreen Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_028654_p43 YP_009187199.1 HTH DNA binding protein NC_028654 Mycobacterium phage Sparkdehlily Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
JF937102_p48 AEK09662.1 hypothetical protein JF937102 Mycobacterium virus Mozy Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
JF704117_p41 AEK06749.1 hypothetical protein JF704117 Mycobacterium virus Rockyhorror Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
MG812488_p46 AUX81972.1 hypothetical protein MG812488 Mycobacterium phage Frankie Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MH001449_p37 AVO21642.1 helix-turn-helix DNA binding protein MH001449 Mycobacterium phage MooMoo Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MF919502_p48 ATN88643.1 helix-turn-helix DNA binding domain protein MF919502 Mycobacterium phage Demsculpinboyz Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_022069_p52 YP_008410724.1 hypothetical protein NC_022069 Mycobacterium phage Jabbawokkie Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
JF704115_p50 AEK07801.1 hypothetical protein JF704115 Mycobacterium virus Yoshi Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
JN020142_p42 AEJ93184.1 hypothetical protein JN020142 Mycobacterium virus Mutaforma13 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
NC_011054_p43 YP_002014259.1 gp43 NC_011054 Mycobacterium virus Boomer Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
NC_026593_p46 YP_009125039.1 HTH DNA binding protein NC_026593 Mycobacterium phage BuzzLyseyear Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
KR997931_p47 AKU45134.1 HTH DNA-binding domain protein KR997931 Mycobacterium phage Girafales Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_028751_p46 YP_009194570.1 HTH binding domain NC_028751 Mycobacterium phage Quico Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MF919501_p43 ATN88535.1 MerR-like HTH DNA binding protein MF919501 Mycobacterium phage DaWorst Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
p69668 no NCBI prot ID no annotation VI_04093 Actinobacteria_gi_440705562 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_14625 7 no annotation unknown function 7 0 1000
phrog_5254 25 no annotation unknown function 7 1.79E-29 19.87
phrog_2437 61 no annotation unknown function 5 5.30E-19 9.4
phrog_7147 16 no annotation unknown function 4 9.64E-19 9.14
phrog_5648 23 no annotation unknown function 3 4.39E-14 4.48
phrog_22001 3 no annotation unknown function 2 1.09E-13 4.08
phrog_32039 2 no annotation unknown function 2 0 1000
phrog_17260 5 no annotation unknown function 2 1.09E-12 3.08

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_11423 no annotation unknown function 91.0 0.043 39-62 / 20-43
phrog_1482 terminase small subunit head and packaging 93.5 0.0093 27-64 / 15-53
phrog_151 transposase integration and excision 95.6 0.00042 27-64 / 8-46
phrog_1558 no annotation unknown function 93.5 0.009 33-65 / 109-141
phrog_2538 terminase small subunit head and packaging 95.9 0.00025 35-64 / 12-42
phrog_3502 no annotation unknown function 94.3 0.0038 36-63 / 20-48
phrog_35 transcriptional repressor transcription regulation 91.4 0.035 39-63 / 11-35
phrog_36978 no annotation unknown function 90.2 0.059 38-65 / 38-70
phrog_3 transcriptional repressor transcription regulation 92.3 0.021 39-63 / 14-38
phrog_4044 terminase small subunit head and packaging 91.7 0.029 31-64 / 20-53
phrog_409 transcriptional regulator transcription regulation 94.5 0.003 39-63 / 9-32
phrog_4102 terminase small subunit head and packaging 94.6 0.0026 27-64 / 12-49
phrog_4494 no annotation unknown function 96.6 2.2E-05 32-63 / 8-39
phrog_4779 transcriptional regulator transcription regulation 93.2 0.012 39-63 / 12-36
phrog_534 DNA binding protein DNA, RNA and nucleotide metabolism 94.7 0.0022 44-64 / 28-48
phrog_5751 terminase large subunit head and packaging 95.3 0.00094 29-63 / 6-40
phrog_575 Cox-like excisionase and repressor integration and excision 91.9 0.028 43-65 / 15-37
phrog_57 terminase small subunit head and packaging 91.9 0.027 43-65 / 4-26
phrog_664 DNA binding protein DNA, RNA and nucleotide metabolism 91.1 0.04 32-62 / 10-40
phrog_66 excisionase and transcriptional regulator integration and excision 95.7 0.00034 43-64 / 11-32
phrog_686 HTH DNA binding protein DNA, RNA and nucleotide metabolism 91.8 0.029 25-60 / 20-56
phrog_7061 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.7 0.00039 14-64 / 17-67
phrog_756 DNA binding protein DNA, RNA and nucleotide metabolism 92.2 0.023 27-64 / 4-42
phrog_836 late transcriptional activator transcription regulation 90.3 0.057 38-64 / 106-132
phrog_8446 HNH endonuclease DNA, RNA and nucleotide metabolism 90.0 0.064 41-65 / 17-41
phrog_8794 sigma factor transcription regulation 94.2 0.0043 43-65 / 23-45
phrog_8 transcriptional regulator transcription regulation 92.6 0.018 40-64 / 13-36
phrog_9366 transposase integration and excision 93.2 0.011 21-64 / 61-104
phrog_9759 DNA binding protein DNA, RNA and nucleotide metabolism 93.7 0.0075 28-64 / 10-41

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF07638.10 ECF sigma factor 2.5E-06 37-78 / 133-174
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 3.7E-06 46-78 / 6-38
PF03333.12 Adhesin biosynthesis transcription regulatory protein 3.7E-06 38-78 / 40-80
PF12759.6 InsA C-terminal domain 4E-06 39-77 / 7-45
PF07750.10 GcrA cell cycle regulator 5.2E-06 39-78 / 4-44
PF05331.10 Protein of unknown function (DUF742) 5.8E-06 36-78 / 37-78
PF08822.10 Protein of unknown function (DUF1804) 7.6E-06 39-78 / 4-44
PF06530.11 Phage antitermination protein Q 7.7E-06 30-78 / 55-104
PF00292.17 'Paired box' domain 7.8E-06 37-78 / 17-58
PF07141.10 Putative bacteriophage terminase small subunit 8.3E-06 43-79 / 21-57
PF01710.15 Transposase 1.1E-05 39-78 / 4-43
PF13011.5 leucine-zipper of insertion element IS481 1.2E-05 40-78 / 10-49
PF04936.11 Protein of unknown function (DUF658) 0.0041 52-78 / 87-113
PF09607.9 Brinker DNA-binding domain 1.3E-05 39-78 / 7-50
PF05344.10 Domain of Unknown Function (DUF746) 3.7E-05 51-78 / 10-37
PF02796.14 Helix-turn-helix domain of resolvase 4.7E-05 48-76 / 16-44
PF16509.4 TrfB plasmid transcriptional repressor 5E-05 39-78 / 17-56
PF07374.10 Protein of unknown function (DUF1492) 5.4E-05 37-77 / 54-95
PF13542.5 Helix-turn-helix domain of transposase family ISL3 5.6E-05 43-77 / 17-50
PF04552.12 Sigma-54, DNA binding domain 6.2E-05 39-78 / 32-73
PF10668.8 Phage terminase small subunit 7.2E-05 42-78 / 8-47
PF13936.5 Helix-turn-helix domain 7.6E-05 45-76 / 12-43
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 8.3E-05 52-78 / 18-44
PF08281.11 Sigma-70, region 4 8.9E-05 39-77 / 12-50
PF04218.12 CENP-B N-terminal DNA-binding domain 0.0001 45-78 / 14-48
PF13411.5 MerR HTH family regulatory protein 0.00011 55-78 / 2-25
PF06322.10 Phage NinH protein 0.00012 52-78 / 15-41
PF13551.5 Winged helix-turn helix 0.00013 51-78 / 9-36
PF08765.10 Mor transcription activator family 0.00018 51-78 / 70-97
PF04545.15 Sigma-70, region 4 0.00018 39-77 / 6-48
PF11427.7 Tc3 transposase 0.00019 48-78 / 15-45
PF04297.13 Putative helix-turn-helix protein, YlxM / p13 like 0.00019 38-78 / 18-58
PF14493.5 Helix-turn-helix domain 0.00022 50-78 / 9-37
PF10654.8 Protein of unknown function (DUF2481) 0.00024 48-77 / 75-104
PF02001.15 Protein of unknown function DUF134 0.00024 38-78 / 32-72
PF13518.5 Helix-turn-helix domain 0.00026 52-78 / 10-36
PF06627.10 Protein of unknown function (DUF1153) 0.00027 39-79 / 31-72
PF13384.5 Homeodomain-like domain 0.00035 48-77 / 12-41
PF01527.19 Transposase 0.00036 42-78 / 9-46
PF05225.15 helix-turn-helix, Psq domain 0.0004 51-77 / 14-41
PF02954.18 Bacterial regulatory protein, Fis family 0.00046 52-76 / 15-39
PF16677.4 DNA-packaging protein gp3 0.00048 52-77 / 28-53
PF01371.18 Trp repressor protein 0.00049 49-78 / 44-73
PF16264.4 SatD family (SatD) 0.00049 38-78 / 151-196
PF16087.4 Domain of unknown function (DUF4817) 0.00051 42-78 / 4-49
PF09035.9 Excisionase from transposon Tn916 0.00051 52-77 / 14-39
PF13309.5 HTH domain 0.00053 54-75 / 42-63
PF12824.6 Mitochondrial ribosomal protein subunit L20 0.00054 38-77 / 89-131
PF17443.1 Uncharacterized protein pXO2-72 0.00057 52-75 / 7-30
PF13412.5 Winged helix-turn-helix DNA-binding 0.00077 52-78 / 16-42
PF05930.11 Prophage CP4-57 regulatory protein (AlpA) 0.00077 54-75 / 4-25
PF10975.7 Protein of unknown function (DUF2802) 0.00076 41-75 / 31-65
PF11242.7 Protein of unknown function (DUF2774) 0.00082 50-78 / 11-39
PF01381.21 Helix-turn-helix 0.0011 51-77 / 7-33
PF11112.7 Pyocin activator protein PrtN 0.0011 52-78 / 12-39
PF08535.9 KorB domain 0.0011 52-78 / 2-28
PF15978.4 Tn7-like transposition protein D 0.0012 43-78 / 192-228
PF13556.5 PucR C-terminal helix-turn-helix domain 0.0013 52-78 / 11-37
PF00376.22 MerR family regulatory protein 0.0015 56-77 / 2-23
PF12964.6 Protein of unknown function (DUF3853) 0.0015 52-78 / 44-70
PF13404.5 AsnC-type helix-turn-helix domain 0.0016 52-77 / 16-41
PF07453.12 NUMOD1 domain 0.0016 54-73 / 20-39
PF13591.5 MerR HTH family regulatory protein 0.0017 55-77 / 2-24
PF06806.11 Putative excisionase (DUF1233) 0.0017 54-75 / 10-31
PF04967.11 HTH DNA binding domain 0.0019 54-78 / 24-48
PF00356.20 Bacterial regulatory proteins, lacI family 0.0018 55-77 / 1-23
PF00126.26 Bacterial regulatory helix-turn-helix protein, lysR family 0.002 52-78 / 10-36
PF06576.10 Protein of unknown function (DUF1133) 0.002 28-77 / 104-164
PF09862.8 Protein of unknown function (DUF2089) 0.0025 39-78 / 35-74
PF07278.10 Protein of unknown function (DUF1441) 0.0028 54-77 / 2-25
PF13413.5 Helix-turn-helix domain 0.003 51-77 / 7-33
PF02042.14 RWP-RK domain 0.0031 51-78 / 10-37
PF07825.10 Excisionase-like protein 0.0035 54-78 / 3-29
PF00196.18 Bacterial regulatory proteins, luxR family 0.0038 50-78 / 14-42
PF10743.8 Regulatory phage protein cox 0.0041 52-78 / 10-36
PF07037.10 Putative transcription regulator (DUF1323) 0.0043 55-76 / 2-23
PF06413.10 Neugrin 0.0043 39-76 / 12-52
PF06970.10 Replication initiator protein A (RepA) N-terminus 0.0048 55-76 / 53-74
PF12728.6 Helix-turn-helix domain 0.0052 54-77 / 2-26
PF01418.16 Helix-turn-helix domain, rpiR family 0.0058 53-78 / 34-59
PF12802.6 MarR family 0.006 54-78 / 22-46
PF13022.5 Helix-turn-helix of insertion element transposase 0.0061 52-76 / 24-48
PF00325.19 Bacterial regulatory proteins, crp family 0.0063 54-77 / 3-26
PF12116.7 Stage III sporulation protein D 0.0068 52-77 / 18-43
PF02319.19 E2F/DP family winged-helix DNA-binding domain 0.0073 52-78 / 22-48
PF07471.11 Phage DNA packaging protein Nu1 0.0086 54-76 / 3-25
PF06971.12 Putative DNA-binding protein N-terminus 0.0087 53-74 / 27-48

Annotations of the NCBI proteins of this PHROG


8:hypothetical protein 3:HTH DNA binding protein 2:protein of an unannotated phage 2:HTH binding domain 2:HTH DNA binding domain protein 1:MerR-like HTH DNA binding protein 1:HTH DNA-binding domain protein 1:HTH domain protein 1:helix-turn-helix DNA binding domain protein 1:helix-turn-helix DNA binding protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0006355 regulation of transcription, DNA-templated
GO:0005737 cytoplasm
GO:0006352 DNA-templated transcription, initiation
GO:0051775 response to redox state
GO:0019069 viral capsid assembly
GO:0060567 negative regulation of DNA-templated transcription, termination
GO:0005524 ATP binding
GO:0043565 sequence-specific DNA binding
GO:0004803 transposase activity
GO:0005622 intracellular
GO:0005667 transcription factor complex
GO:0045892 negative regulation of transcription, DNA-templated
GO:0016987 sigma factor activity
GO:0000150 recombinase activity
GO:0006313 transposition, DNA-mediated
GO:0003700 DNA binding transcription factor activity
GO:0003677 DNA binding
GO:0006310 DNA recombination

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