phrog_5718 is made of 22 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
110.27 408 89


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KU160658_p26 ALY09782.1 HNH endonuclease KU160658 Arthrobacter phage Muttlie Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
MF140417_p26 ASR83586.1 HNH endonuclease MF140417 Arthrobacter phage Link Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
KT355473_p26 ARE89882.1 HNH endonuclease KT355473 Arthrobacter phage Jessica Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
MF140409_p26 ASR83532.1 HNH endonuclease MF140409 Arthrobacter phage Elkhorn Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
NC_028692_p26 YP_009352894.1 HNH endonuclease NC_028692 Arthrobacter phage Decurro Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus.
MF140429_p26 ASR84006.1 HNH endonuclease MF140429 Arthrobacter phage Swenson Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
KU160670_p25 ALY10665.1 HNH endonuclease KU160670 Arthrobacter phage Toulouse Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
NC_016651_p20 YP_005087044.1 HNH endonuclease NC_016651 Rhodococcus phage RRH1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
MF140415_p27 ASR83560.1 HNH endonuclease MF140415 Arthrobacter phage KylieMac Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
KT355475_p26 ARE89883.1 HNH endonuclease KT355475 Arthrobacter phage Sandman Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
MF140431_p26 ASM62394.1 HNH endonuclease MF140431 Arthrobacter phage Taj14 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Decurrovirus; unclassified Decurrovirus.
NC_030907_p27 YP_009273624.1 hypothetical protein NC_030907 Gordonia phage GMA5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
MH045556_p27 AVR56176.1 HNH endonuclease MH045556 Microbacterium phage BonaeVitae Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MH045557_p25 AVR56202.1 HNH endonuclease MH045557 Microbacterium phage BurtonThePup Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MH045561_p25 AVR56417.1 HNH endonuclease MH045561 Microbacterium phage PaoPu Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_027204_p317 YP_009143237.1 HNH endonuclease domain-containing protein NC_027204 Sinorhizobium phage phiM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Emdodecavirus.
NC_028945_p328 YP_009212568.1 HNH endonuclease NC_028945 Sinorhizobium phage phiN3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Emdodecavirus.
KR052480_p323 AKF12868.1 HNH endonuclease KR052480 Sinorhizobium phage phiM7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Emdodecavirus; Sinorhizobium virus M7.
p386859 no NCBI prot ID no annotation VI_04155 Actinobacteria_gi_544775493 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KX925554_p187 APC46449.1 HNH endonuclease KX925554 Streptomyces phage BRock Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_023706_p54 YP_009013844.1 HNH endonuclease NC_023706 Rhodococcus phage ReqiDocB7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p26765 no NCBI prot ID no annotation VI_04091 Actinobacteria_gi_440697762 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_10672 10 no annotation unknown function 10 0 1000
phrog_25871 3 no annotation unknown function 3 0 1000
phrog_21984 4 no annotation unknown function 2 1.08E-13 4.09

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1035 endonuclease VII DNA, RNA and nucleotide metabolism 98.9 1.5E-12 19-79 / 97-161
phrog_10378 HNH endonuclease DNA, RNA and nucleotide metabolism 93.3 0.01 18-69 / 100-151
phrog_11604 HNH endonuclease DNA, RNA and nucleotide metabolism 90.8 0.047 11-81 / 63-141
phrog_119 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 2.5E-05 11-72 / 19-83
phrog_12400 HNH endonuclease DNA, RNA and nucleotide metabolism 98.2 2.2E-09 14-85 / 20-101
phrog_12576 HNH endonuclease DNA, RNA and nucleotide metabolism 97.5 3.3E-07 11-71 / 16-89
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 97.7 5.8E-08 12-72 / 136-201
phrog_14314 HNH endonuclease DNA, RNA and nucleotide metabolism 98.8 1.9E-12 11-74 / 4-67
phrog_144 HNH endonuclease DNA, RNA and nucleotide metabolism 97.9 1.3E-08 11-72 / 50-114
phrog_15103 no annotation unknown function 95.6 0.00048 12-65 / 189-248
phrog_15463 HNH endonuclease DNA, RNA and nucleotide metabolism 97.2 1.5E-06 11-73 / 119-184
phrog_16016 HNH endonuclease DNA, RNA and nucleotide metabolism 92.1 0.024 23-80 / 48-110
phrog_16726 HNH endonuclease DNA, RNA and nucleotide metabolism 99.0 3.6E-13 11-80 / 68-139
phrog_16986 no annotation unknown function 98.3 9.4E-10 11-76 / 8-73
phrog_17283 HNH endonuclease DNA, RNA and nucleotide metabolism 97.4 4.8E-07 38-72 / 9-44
phrog_1808 HNH endonuclease DNA, RNA and nucleotide metabolism 96.0 0.00016 14-78 / 21-96
phrog_2118 HNH endonuclease DNA, RNA and nucleotide metabolism 99.6 1.3E-19 11-82 / 4-85
phrog_22048 HNH endonuclease DNA, RNA and nucleotide metabolism 96.5 3.9E-05 26-81 / 3-58
phrog_2214 HNH endonuclease DNA, RNA and nucleotide metabolism 99.6 7.8E-20 12-81 / 24-90
phrog_22283 no annotation unknown function 95.0 0.0014 25-72 / 24-72
phrog_2323 HNH endonuclease DNA, RNA and nucleotide metabolism 94.3 0.004 11-72 / 13-90
phrog_23251 HNH endonuclease DNA, RNA and nucleotide metabolism 93.3 0.01 18-68 / 27-82
phrog_24252 HNH endonuclease DNA, RNA and nucleotide metabolism 94.2 0.0044 12-82 / 4-86
phrog_25184 HNH endonuclease DNA, RNA and nucleotide metabolism 95.5 0.00056 21-72 / 87-161
phrog_25420 HNH endonuclease DNA, RNA and nucleotide metabolism 95.1 0.0011 17-72 / 38-108
phrog_25983 HNH endonuclease DNA, RNA and nucleotide metabolism 96.4 4.9E-05 25-72 / 12-70
phrog_26098 no annotation unknown function 96.2 9.5E-05 20-73 / 131-188
phrog_29143 HNH endonuclease DNA, RNA and nucleotide metabolism 96.0 0.00017 19-73 / 15-76
phrog_2914 endonuclease VII DNA, RNA and nucleotide metabolism 91.6 0.031 16-73 / 31-83
phrog_29172 no annotation unknown function 92.3 0.021 24-67 / 471-515
phrog_30443 HNH endonuclease DNA, RNA and nucleotide metabolism 92.0 0.025 13-68 / 50-103
phrog_32453 HNH endonuclease DNA, RNA and nucleotide metabolism 97.0 4.2E-06 14-73 / 63-119
phrog_333 HNH endonuclease DNA, RNA and nucleotide metabolism 98.4 2.6E-10 14-72 / 19-74
phrog_33554 HNH endonuclease DNA, RNA and nucleotide metabolism 95.7 0.00036 24-74 / 20-78
phrog_338 HNH endonuclease DNA, RNA and nucleotide metabolism 99.2 2.4E-15 19-74 / 24-86
phrog_4160 no annotation unknown function 90.1 0.061 13-73 / 50-119
phrog_423 endonuclease VII DNA, RNA and nucleotide metabolism 90.4 0.054 11-71 / 9-64
phrog_4581 terminase small subunit head and packaging 98.2 1.8E-09 11-72 / 50-109
phrog_589 HNH endonuclease DNA, RNA and nucleotide metabolism 98.7 1.2E-11 11-73 / 38-101
phrog_5956 HNH endonuclease DNA, RNA and nucleotide metabolism 96.2 8.1E-05 19-72 / 2-58
phrog_6050 HNH endonuclease DNA, RNA and nucleotide metabolism 98.9 5E-13 22-72 / 4-55
phrog_655 homing endonuclease DNA, RNA and nucleotide metabolism 93.1 0.012 36-59 / 21-44
phrog_7030 HNH endonuclease DNA, RNA and nucleotide metabolism 96.7 1.8E-05 25-87 / 28-96
phrog_7370 HNH endonuclease DNA, RNA and nucleotide metabolism 95.2 0.0011 11-66 / 29-81
phrog_740 HNH endonuclease DNA, RNA and nucleotide metabolism 96.7 1.4E-05 10-67 / 5-65
phrog_7785 HNH endonuclease DNA, RNA and nucleotide metabolism 98.9 4.1E-13 16-72 / 61-113
phrog_8446 HNH endonuclease DNA, RNA and nucleotide metabolism 94.7 0.0024 11-68 / 117-184
phrog_8660 HNH endonuclease DNA, RNA and nucleotide metabolism 99.4 1.3E-16 11-80 / 98-164
phrog_9443 HNH endonuclease DNA, RNA and nucleotide metabolism 94.8 0.0021 25-71 / 100-145
phrog_9508 HNH endonuclease DNA, RNA and nucleotide metabolism 98.1 3.3E-09 25-73 / 22-76
phrog_9545 HNH endonuclease DNA, RNA and nucleotide metabolism 98.1 4.4E-09 14-82 / 101-179
phrog_960 HNH endonuclease DNA, RNA and nucleotide metabolism 97.5 2.2E-07 25-75 / 41-91
phrog_9645 HNH endonuclease DNA, RNA and nucleotide metabolism 98.9 6.1E-13 11-73 / 12-77

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF13395.5 HNH endonuclease 2.2E-07 131-185 / 1-53
PF05315.10 ICEA Protein 8.1E-07 114-183 / 79-150
PF09681.9 N-terminal phage replisome organiser (Phage_rep_org_N) 1.2E-06 3-102 / 1-103
PF14279.5 HNH endonuclease 1.4E-06 131-187 / 1-49
PF01844.22 HNH endonuclease 2.6E-06 131-182 / 1-47
PF05766.11 Bacteriophage Lambda NinG protein 9.2E-06 116-184 / 74-137
PF09665.9 Type II restriction endonuclease (RE_Alw26IDE) 2E-05 128-188 / 253-301
PF13391.5 HNH endonuclease 5.3E-05 131-182 / 1-44
PF06147.10 Protein of unknown function (DUF968) 0.00028 127-182 / 126-173
PF14297.5 Domain of unknown function (DUF4373) 0.002 3-80 / 1-81
PF06970.10 Replication initiator protein A (RepA) N-terminus 0.003 3-71 / 2-75

Annotations of the NCBI proteins of this PHROG


18:HNH endonuclease 1:HNH endonuclease domain-containing protein 1:hypothetical protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0004519 endonuclease activity
GO:0003676 nucleic acid binding

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