phrog_5846 is made of 22 protein sequences and is annotated as "clamp loader of DNA polymerase"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
368.5 657 369


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KY606587_p99 ARB06153.1 putative DNA polymerase III, subunit gamma and tau KY606587 Dinoroseobacter phage vB_DshS-R5C Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nanhaivirus; Dinoroseobacter virus D5C.
JQ692107_p69 AFE86396.1 putative DNA polymerase III subunit gamma and tau JQ692107 Vibrio phage SSP002 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mardecavirus; Vibrio virus SSP002.
NC_019713_p72 YP_007111918.1 putative DNA polymerase III NC_019713 Vibrio phage vB_VpaS_MAR10 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Mardecavirus.
KY629621_p14 AQY55377.1 DNA polymerase III subunits gamma and tau KY629621 Streptococcus virus MS1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_015274_p17 YP_004306905.1 DnaX DNA polymerase III clamp loader complex gamma-tau-delta subunit NC_015274 Streptococcus phage Dp-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_014457_p65 YP_003856858.1 putative DNA polymerase III NC_014457 Clostridium phage phiCTP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_017972_p121 YP_006382651.1 putative DNA polymerase III NC_017972 Pseudomonas phage Lu11 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
KY984068_p209 ARW58849.1 putative DNA polymerase III KY984068 Erwinia phage vB_EamM_Y3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Sasquatchvirus; Erwinia virus Y3.
KY448244_p202 AQT28679.1 putative DNA polymerase III KY448244 Erwinia phage vB_EamM_Yoloswag Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Yoloswagvirus; Erwinia virus Yoloswag.
NC_022096_p177 YP_008433508.1 DNA polymerase III subunit gamma NC_022096 Pseudomonas phage PaBG Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Baikalvirus; Pseudomonas virus PaBG.
NC_010811_p166 YP_001950043.1 DNA polymerase III gamma/tau subunit-like protein NC_010811 Ralstonia phage phiRSL1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Mieseafarmvirus.
NC_023719_p70 YP_009015381.1 gp70 NC_023719 Bacillus virus G Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p385485 no NCBI prot ID no annotation VI_01828 Gammaproteobacteria_gi_300915557 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_031245_p221 YP_009302608.1 recombination protein RarA NC_031245 Bacillus phage SP-15 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Thornevirus; Bacillus virus SP15.
p389098 no NCBI prot ID no annotation VI_03407 Gammaproteobacteria_gi_556673882 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
KY629621_p15 AQY55376.1 DNA polymerase III delta prime subunit KY629621 Streptococcus virus MS1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_015274_p18 YP_004306906.1 DNA polymerase III gamma-tau subunit NC_015274 Streptococcus phage Dp-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_014457_p66 YP_003856859.1 putative DNA polymerase III NC_014457 Clostridium phage phiCTP1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_029002_p156 YP_009217840.1 DNA polymerase III subunit gamma and tau NC_029002 Microcystis phage MaMV-DC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
NC_008562_p169 YP_851183.1 holB-like ATPase involved in DNA replication NC_008562 Microcystis aeruginosa phage Ma-LMM01 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
KU230356_p70 ALY07522.1 DNA polymerase III gamma/tau subunits KU230356 Bacteriophage vB_NpeS-2AV2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
p437369 no NCBI prot ID no annotation VI_05501 Betaproteobacteria_gi_83746828_73871_83566 Viruses.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_5846 22 clamp loader of DNA polymerase DNA, RNA and nucleotide metabolism 6 4.85E-26 16.44
phrog_16140 6 no annotation unknown function 3 6.14E-17 7.33
phrog_20214 4 clamp loader of DNA polymerase DNA, RNA and nucleotide metabolism 3 4.09E-18 8.51
phrog_25624 3 no annotation unknown function 2 9.45E-14 4.15
phrog_31277 2 no annotation unknown function 2 0 1000
phrog_6466 19 DNA ligase DNA, RNA and nucleotide metabolism 2 9.15E-11 1.16
phrog_31786 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10255 kinase other 94.3 0.0037 39-67 / 2-30
phrog_10371 DNA helicase DNA, RNA and nucleotide metabolism 92.0 0.026 40-194 / 321-512
phrog_10401 ATPase other 97.9 1.5E-08 32-147 / 199-322
phrog_1139 DNA primase DNA, RNA and nucleotide metabolism 90.9 0.045 41-171 / 546-709
phrog_1156 DNA primase DNA, RNA and nucleotide metabolism 92.2 0.023 37-177 / 514-671
phrog_11838 clamp loader of DNA polymerase DNA, RNA and nucleotide metabolism 99.9 1.9E-27 3-204 / 4-206
phrog_124 Sak4-like ssDNA annealing protein DNA, RNA and nucleotide metabolism 95.8 0.00028 38-118 / 14-101
phrog_1250 unknown function unknown function 97.4 5E-07 29-174 / 94-270
phrog_1297 ATPase other 96.0 0.00018 26-158 / 16-174
phrog_139 deoxynucleoside monophosphate kinase other 92.0 0.025 38-62 / 2-26
phrog_14322 no annotation unknown function 94.2 0.0043 38-166 / 194-331
phrog_14685 no annotation unknown function 94.3 0.0038 39-67 / 3-31
phrog_14719 no annotation unknown function 91.2 0.04 181-272 / 553-657
phrog_15585 no annotation unknown function 97.7 5.7E-08 29-190 / 339-534
phrog_15962 DNA primase DNA, RNA and nucleotide metabolism 90.3 0.056 7-147 / 449-589
phrog_16448 ATPase other 96.2 8E-05 25-159 / 11-168
phrog_168 clamp loader of DNA polymerase DNA, RNA and nucleotide metabolism 99.9 1.5E-32 6-206 / 7-212
phrog_16 DNA helicase DNA, RNA and nucleotide metabolism 92.2 0.023 40-64 / 14-38
phrog_170 PhoH-like phosphate starvation-inducible other 96.0 0.00016 95-132 / 159-195
phrog_1815 guanylate kinase other 93.0 0.013 38-67 / 2-31
phrog_19600 ATPase other 94.1 0.0049 14-122 / 60-175
phrog_197 Zot-like toxin moron, auxiliary metabolic gene and host takeover 91.9 0.027 95-146 / 79-136
phrog_2071 ATPase other 96.4 5.4E-05 38-71 / 3-36
phrog_2107 thymidylate kinase other 93.9 0.0062 40-70 / 5-35
phrog_21086 no annotation unknown function 93.8 0.0066 40-198 / 239-420
phrog_2116 no annotation unknown function 91.3 0.036 24-62 / 16-52
phrog_22983 no annotation unknown function 98.7 1.8E-11 70-165 / 13-110
phrog_2376 ATPase other 96.8 9.1E-06 27-209 / 63-240
phrog_2392 ABC transporter moron, auxiliary metabolic gene and host takeover 95.6 0.00042 22-66 / 356-397
phrog_243 DnaB-like replicative helicase DNA, RNA and nucleotide metabolism 94.5 0.0031 39-112 / 36-156
phrog_249 porphyrin biosynthesis moron, auxiliary metabolic gene and host takeover 95.4 0.00074 27-198 / 97-300
phrog_25411 no annotation unknown function 91.7 0.03 41-135 / 233-342
phrog_25422 no annotation unknown function 90.3 0.057 38-66 / 23-51
phrog_2630 no annotation unknown function 96.4 5.3E-05 27-168 / 23-200
phrog_26606 no annotation unknown function 91.7 0.03 10-77 / 89-173
phrog_2666 terminase large subunit head and packaging 94.3 0.0039 95-163 / 114-186
phrog_2765 PhoH-like phosphate starvation-inducible other 92.3 0.022 78-123 / 347-400
phrog_29395 no annotation unknown function 94.4 0.0035 35-119 / 135-231
phrog_293 ABC transporter moron, auxiliary metabolic gene and host takeover 95.5 0.00053 21-65 / 24-65
phrog_29662 ATP-dependent protease other 95.6 0.00042 12-186 / 321-502
phrog_296 DNA transposition protein integration and excision 98.6 2.2E-11 34-211 / 87-282
phrog_30773 no annotation unknown function 98.0 1.2E-08 11-211 / 136-365
phrog_31701 no annotation unknown function 94.5 0.0031 38-88 / 6-62
phrog_325 Dda-like helicase DNA, RNA and nucleotide metabolism 97.2 1.4E-06 19-130 / 8-141
phrog_34956 no annotation unknown function 91.6 0.031 38-70 / 162-194
phrog_3757 no annotation unknown function 99.0 2.2E-13 38-191 / 126-288
phrog_4339 no annotation unknown function 98.8 2.6E-12 95-207 / 313-468
phrog_4412 exonuclease V DNA, RNA and nucleotide metabolism 94.6 0.0026 27-139 / 357-478
phrog_4581 terminase small subunit head and packaging 97.0 3.2E-06 39-165 / 122-232
phrog_4871 ATP-dependent protease other 97.7 7.8E-08 3-211 / 167-407
phrog_505 polynucleotide kinase other 95.4 0.00077 38-188 / 2-139
phrog_50 DnaC-like helicase loader DNA, RNA and nucleotide metabolism 96.7 1.4E-05 9-147 / 76-234
phrog_5484 DnaA-like replication initiation protein DNA, RNA and nucleotide metabolism 94.9 0.0017 38-165 / 27-148
phrog_5534 no annotation unknown function 96.6 2.1E-05 23-122 / 14-129
phrog_6841 no annotation unknown function 96.1 0.00011 95-196 / 162-269
phrog_6891 ATPase other 96.7 1.2E-05 39-134 / 35-150
phrog_6931 no annotation unknown function 94.0 0.0055 32-59 / 182-208
phrog_7485 no annotation unknown function 98.0 1.1E-08 38-171 / 227-379
phrog_761 thymidylate kinase other 95.7 0.00039 38-149 / 2-139
phrog_7998 no annotation unknown function 98.0 8.7E-09 25-208 / 28-229
phrog_8638 no annotation unknown function 96.5 2.8E-05 10-147 / 276-437
phrog_9172 no annotation unknown function 98.6 3.8E-11 22-200 / 81-284

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF12002.7 MgsA AAA+ ATPase C terminal 2.1E-27 340-465 / 31-166
PF05496.11 Holliday junction DNA helicase ruvB N-terminus 2.6E-11 43-237 / 15-223
PF05673.12 Protein of unknown function (DUF815) 5.2E-10 45-235 / 27-249
PF00308.17 Bacterial dnaA protein 7.3E-10 46-236 / 7-214
PF14516.5 AAA-like domain 1.8E-09 46-236 / 9-244
PF01637.17 ATPase domain predominantly from Archaea 4.5E-09 49-93 / 1-44
PF07693.13 KAP family P-loop domain 1.8E-08 126-236 / 170-302
PF10443.8 RNA12 protein 2.3E-08 126-236 / 147-277
PF09820.8 Predicted AAA-ATPase 4.9E-08 46-93 / 14-55
PF05621.10 Bacterial TniB protein 5.8E-08 48-237 / 15-247
PF00931.21 NB-ARC domain 6.7E-08 53-235 / 2-208
PF06068.12 TIP49 C-terminus 8.3E-08 127-235 / 275-392
PF10923.7 P-loop Domain of unknown function (DUF2791) 3.1E-07 46-93 / 24-73
PF03215.14 Rad17 cell cycle checkpoint protein 6.9E-07 37-94 / 9-70
PF06144.12 DNA polymerase III, delta subunit 1.2E-06 72-235 / 1-179
PF12775.6 P-loop containing dynein motor region D3 2.3E-06 50-94 / 13-58
PF04665.11 Poxvirus A32 protein 3.5E-06 69-93 / 13-37
PF13177.5 DNA polymerase III, delta subunit 4E-06 51-93 / 1-43
PF05729.11 NACHT domain 6.7E-06 71-93 / 2-24
PF13191.5 AAA ATPase domain 1.1E-05 49-93 / 2-48
PF00158.25 Sigma-54 interaction domain 1.7E-05 50-93 / 2-46
PF13173.5 AAA domain 1.8E-05 69-92 / 2-25
PF12774.6 Hydrolytic ATP binding site of dynein motor region D1 2.7E-05 69-141 / 32-99
PF01078.20 Magnesium chelatase, subunit ChlI 2.8E-05 48-93 / 4-46
PF14532.5 Sigma-54 interaction domain 3.3E-05 52-150 / 3-91
PF03266.14 NTPase 3.8E-05 72-93 / 2-23
PF12780.6 P-loop containing dynein motor region D4 5.2E-05 69-94 / 31-56
PF07728.13 AAA domain (dynein-related subfamily) 6.6E-05 72-93 / 2-23
PF00004.28 ATPase family associated with various cellular activities (AAA) 9.8E-05 72-94 / 1-23
PF00519.16 Papillomavirus helicase 0.00012 69-94 / 262-287
PF13401.5 AAA domain 0.00026 69-93 / 5-29
PF03969.15 AFG1-like ATPase 0.00038 69-94 / 67-92
PF06431.10 Polyomavirus large T antigen C-terminus 0.00053 69-139 / 155-215
PF07726.10 ATPase family associated with various cellular activities (AAA) 0.00052 72-94 / 2-24
PF00493.22 MCM2/3/5 family 0.00065 48-94 / 25-82
PF01695.16 IstB-like ATP binding protein 0.00074 69-93 / 48-72
PF07724.13 AAA domain (Cdc48 subfamily) 0.00081 69-93 / 3-27
PF08298.10 PrkA AAA domain 0.00099 46-93 / 57-109
PF05272.10 Virulence-associated protein E 0.0011 69-93 / 59-83
PF00006.24 ATP synthase alpha/beta family, nucleotide-binding domain 0.0012 69-93 / 14-38
PF07931.11 Chloramphenicol phosphotransferase-like protein 0.0032 70-94 / 2-26
PF03976.13 Polyphosphate kinase 2 (PPK2) 0.0034 69-94 / 28-53
PF02283.15 Cobinamide kinase / cobinamide phosphate guanyltransferase 0.0035 72-92 / 1-21
PF00625.20 Guanylate kinase 0.004 69-94 / 2-27
PF13671.5 AAA domain 0.0051 71-93 / 1-23
PF06414.11 Zeta toxin 0.0058 69-93 / 14-38
PF13654.5 AAA domain 0.0065 48-94 / 3-49
PF13521.5 AAA domain 0.007 72-93 / 2-23
PF13238.5 AAA domain 0.0079 72-93 / 1-22

Annotations of the NCBI proteins of this PHROG


6:DNA polymerase III 2:DNA polymerase III subunit gamma and tau 1:DNA polymerase III, subunit gamma and tau 1:DNA polymerase III subunits gamma and tau 1:recombination protein RarA 1:holB-like ATPase involved in DNA replication 1:hypothetical protein 1:DNA polymerase III gamma-tau subunit 1:DnaX DNA polymerase III clamp loader complex gamma-tau-delta subunit 1:DNA polymerase III gamma/tau subunits 1:DNA polymerase III delta prime subunit 1:DNA polymerase III subunit gamma 1:DNA polymerase III gamma/tau subunit-like protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K07478 ycaJ : putative ATPase no pathways 868 7

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0009378 four-way junction helicase activity
GO:0009360 DNA polymerase III complex
GO:0006260 DNA replication
GO:0003678 DNA helicase activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides
GO:0003677 DNA binding
GO:0006310 DNA recombination
GO:0043752 adenosylcobinamide kinase activity
GO:0006355 regulation of transcription, DNA-templated
GO:0004003 ATP-dependent DNA helicase activity
GO:0000166 nucleotide binding
GO:0006281 DNA repair
GO:0016740 transferase activity
GO:0016301 kinase activity
GO:0008134 transcription factor binding
GO:0043531 ADP binding
GO:0009236 cobalamin biosynthetic process
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0006270 DNA replication initiation
GO:0051188 cofactor biosynthetic process

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