phrog_5949 is made of 21 protein sequences and is annotated as "GTP cyclohydrolase"
Functional category: other


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
207.33 377 165


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_005083_p123 NP_899371.1 GTP cyclohydrolase I family protein NC_005083 Vibrio phage KVP40 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus.
NC_028829_p137 YP_009201240.1 NADPH-dependent 7-cyano-7-deazaguanine reductase NC_028829 Vibrio phage ValKK3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus.
p62194 no NCBI prot ID no annotation VI_08379 Gammaproteobacteria_gi_389708617 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_023568_p13 YP_009006087.1 NADPH-dependent 7-cyano-7-deazaguanine reductase NC_023568 Vibrio phage VH7D Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
JN849462_p121 AFN37354.1 NADPH-dependent 7-cyano-7-deazaguanine reductase JN849462 Vibriophage phi-pp2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; Vibrio virus KVP40.
KU873925_p78 AND75002.1 hypothetical protein KU873925 Pseudomonas phage pf16 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Chakrabartyvirus; Pseudomonas virus pf16.
KT919973_p373 ALP47403.1 6-pyruvoyl-tetrahydropterin synthase KT919973 Vibrio phage phi-ST2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
KT919972_p238 ALP47024.1 NADPH-dependent 7-cyano-7-deazaguanine reductase KT919972 Vibrio phage phi-Grn1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Schizotequatrovirus; unclassified Schizotequatrovirus.
p399987 no NCBI prot ID no annotation VI_05034 Bacilli_gi_481024207 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p434377 no NCBI prot ID no annotation VI_04640 Bacilli_gi_418278709 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_015274_p1 YP_004306889.1 QueF NC_015274 Streptococcus phage Dp-1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_020860_p55 YP_007675731.1 7-cyano-7-deazaguanine reductase NC_020860 Cellulophaga phage phiSM Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
KC821634_p54 AGO49791.1 Que F, NADPH-dependent 7-cyano-7-deazaguanine reductase KC821634 Cellulophaga phage phi47:1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
KC821616_p54 AGO48249.1 Que F, NADPH-dependent 7-cyano-7-deazaguanine reductase KC821616 Cellulophaga phage phiSM Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
KC821610_p54 AGO47785.1 Que F, NADPH-dependent 7-cyano-7-deazaguanine reductase KC821610 Cellulophaga phage phi3ST:2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
KC821629_p54 AGO49293.1 Que F, NADPH-dependent 7-cyano-7-deazaguanine reductase KC821629 Cellulophaga phage phi38:2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
KC821630_p54 AGO49373.1 Que F, NADPH-dependent 7-cyano-7-deazaguanine reductase KC821630 Cellulophaga phage phi3:1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; unclassified Myoviridae.
NC_021330_p75 YP_008059637.1 QueF NC_021330 Halovirus HCTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_021327_p80 YP_008059122.1 QueF NC_021327 Halovirus HCTV-5 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_020158_p81 YP_007378987.1 7-cyano-7-deazaguanine reductase NC_020158 Halovirus HVTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
KY606587_p84 ARB06138.1 7-cyano-7-deazaguanine reductase KY606587 Dinoroseobacter phage vB_DshS-R5C Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nanhaivirus; Dinoroseobacter virus D5C.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_1550 96 QueC-like queuosine biosynthesis moron, auxiliary metabolic gene and host takeover 8 4.24E-28 18.49
phrog_15829 6 no annotation unknown function 6 0 1000
phrog_16018 6 no annotation unknown function 6 0 1000
phrog_10773 10 no annotation unknown function 6 2.84E-29 19.67
phrog_18638 5 no annotation unknown function 2 8.77E-13 3.18
phrog_31918 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_2197 GTP cyclohydrolase other 93.3 0.011 40-127 / 59-151

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF14819.5 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term 1.2E-17 174-264 / 2-104
PF01227.21 GTP cyclohydrolase I 3.5E-16 61-147 / 62-143
PF14489.5 QueF-like protein 1.4E-11 76-142 / 1-61

Annotations of the NCBI proteins of this PHROG


5:Que F, NADPH-dependent 7-cyano-7-deazaguanine reductase 4:NADPH-dependent 7-cyano-7-deazaguanine reductase 3:7-cyano-7-deazaguanine reductase 3:QueF 1:GTP cyclohydrolase I family protein 1:protein of an unannotated phage 1:6-pyruvoyl-tetrahydropterin synthase

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K09457 queF : 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] ko00790 Folate biosynthesis 303 13
K06879 queF : 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] ko00790 Folate biosynthesis 233 8

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0008616 queuosine biosynthetic process
GO:0033739 preQ1 synthase activity

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