phrog_6132 is made of 20 protein sequences and is annotated as "ribonucleotide reductase large subunit"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
257.25 573 248


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
MF001361_p129 ASZ77504.1 ribonucleotide reductase of class Ia (aerobic), alpha subunit MF001361 Enterococcus phage EF5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
MF001358_p21 ASZ76687.1 ribonucleotide reductase of class Ia (aerobic), alpha subunit MF001358 Enterococcus phage EF1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
p167934 no NCBI prot ID no annotation VI_05058 Bacilli_gi_483992947_10153_49378 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Spbetavirus; Bacillus virus SPbeta.
KY554770_p111 ARM66593.1 ribonucleotide diphosphate reductase subunit aplpha KY554770 Lactococcus phage AM3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_015253_p125 YP_004301458.1 gp125 NC_015253 Brochothrix phage A9 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Brochothrix virus A9.
MF422185_p17 AUO79420.1 putative ribonucleotide-diphosphatereductase alpha sudunit N-terminal protein MF422185 Bacillus phage BSP10 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Nitunavirus; unclassified Nitunavirus.
NC_024792_p138 YP_009056407.1 hypothetical protein NC_024792 Bacillus phage Bobb Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Agatevirus.
KX011028_p67 ANH50478.1 ribonucleotide reductase KX011028 Staphylococcus phage pSco-10 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Twortvirinae; Kayvirus; unclassified Kayvirus.
p248696 no NCBI prot ID no annotation VI_00476 Bacilli_gi_397738376 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_020081_p107 YP_007349350.1 putative ribonucleotide reductase of class Ib (aerobic), subunit alpha 1 NC_020081 Bacillus phage phiAGATE Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Agatevirus.
KY554776_p112 ARQ95691.1 ribonucleotide diphosphate reductase subunit aplpha KY554776 Lactococcus phage AM12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_021856_p118 YP_008318377.1 putative ribonucleotide-diphosphatereductase sudunit alpha N-terminal protein NC_021856 Bacillus phage phiNIT1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Bastillevirinae; Nitunavirus.
KY554768_p112 ARM66239.1 ribonucleotide diphosphate reductase subunit aplpha KY554768 Lactococcus phage AM1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KY554769_p111 ARM66416.1 ribonucleotide diphosphate reductase subunit aplpha KY554769 Lactococcus phage AM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KY554773_p111 ARM67146.1 ribonucleotide diphosphate reductase subunit aplpha KY554773 Lactococcus phage AM8 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KY554774_p112 ARM67325.1 ribonucleotide-diphosphate reductase subunit alpha KY554774 Lactococcus phage AM9 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KY554775_p111 ARM67503.1 ribonucleotide diphosphate reductase subunit aplpha KY554775 Lactococcus phage AM11 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_007021_p62 YP_238596.1 ORF045 NC_007021 Staphylococcus phage Twort Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Twortvirinae; Twortvirus.
NC_027335_p126 YP_009147130.1 putative ribonucleotide reductase NC_027335 Enterococcus phage ECP3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Herelleviridae; Brockvirinae; Kochikohdavirus; Enterococcus virus ECP3.
NC_015263_p109 YP_004306269.1 putative ribonucleotide diphosphate reductase alpha subunit NC_015263 Lactococcus phage 949 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_883 163 flavodoxin moron, auxiliary metabolic gene and host takeover 17 1.88E-57 47.85
phrog_1271 117 HNH endonuclease DNA, RNA and nucleotide metabolism 7 4.90E-24 14.43
phrog_30875 2 no annotation unknown function 2 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_12229 ribonucleotide reductase DNA, RNA and nucleotide metabolism 98.0 7E-09 115-247 / 8-148
phrog_30939 ribonucleotide reductase DNA, RNA and nucleotide metabolism 94.8 0.0019 147-237 / 463-550
phrog_3987 ribonucleotide reductase large subunit DNA, RNA and nucleotide metabolism 100.0 1.6E-49 6-248 / 64-292
phrog_84 ribonucleoside-diphosphate reductase large subunit DNA, RNA and nucleotide metabolism 100.0 8.6E-37 12-248 / 71-294

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF08343.9 Ribonucleotide reductase N-terminal 2.1E-23 57-136 / 1-81
PF00743.18 Flavin-binding monooxygenase-like 0.0028 371-403 / 2-34
PF07992.13 Pyridine nucleotide-disulphide oxidoreductase 0.0017 371-459 / 1-111
PF13738.5 Pyridine nucleotide-disulphide oxidoreductase 0.0011 374-454 / 1-122
PF01134.21 Glucose inhibited division protein A 0.0028 372-401 / 1-30
PF13434.5 L-lysine 6-monooxygenase (NADPH-requiring) 0.0019 371-402 / 3-35
PF03486.13 HI0933-like protein 0.0029 372-403 / 2-33
PF01494.18 FAD binding domain 0.0041 371-402 / 2-33
PF01946.16 Thi4 family 6.4E-06 369-403 / 16-52
PF05834.11 Lycopene cyclase protein 9.9E-07 239-270 / 1-32
PF13454.5 FAD-NAD(P)-binding 0.0016 374-401 / 1-32
PF12831.6 FAD dependent oxidoreductase 7.2E-06 239-272 / 1-34
PF00890.23 FAD binding domain 7.8E-06 239-271 / 1-33
PF04820.13 Tryptophan halogenase 1.7E-05 239-270 / 1-35
PF06100.10 MCRA family 8.4E-05 238-274 / 2-42
PF00317.20 Ribonucleotide reductase, all-alpha domain 0.00012 139-196 / 2-65
PF00996.17 GDP dissociation inhibitor 0.00019 236-274 / 3-41
PF00732.18 GMC oxidoreductase 0.00027 238-271 / 1-35
PF01266.23 FAD dependent oxidoreductase 0.00028 239-269 / 1-31
PF06039.14 Malate:quinone oxidoreductase (Mqo) 0.00061 238-272 / 2-38

Annotations of the NCBI proteins of this PHROG


6:ribonucleotide diphosphate reductase subunit aplpha 2:ribonucleotide reductase of class Ia (aerobic), alpha subunit 2:ribonucleotide reductase 1:protein of an unannotated phage 1:ribonucleotide diphosphate reductase alpha subunit 1:ribonucleotide-diphosphatereductase alpha sudunit N-terminal protein 1:ribonucleotide reductase subunit 1:ribonucleotide-diphosphate reductase subunit alpha 1:ribonucleotide reductase of class Ib (aerobic), subunit alpha 1 1:hypothetical protein 1:ribonucleotide-diphosphatereductase sudunit alpha N-terminal protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K00525 E1.17.4.1A, nrdA, nrdE : ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] ko00230 Purine metabolism
ko00240 Pyrimidine metabolism
427 20

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0071949 FAD binding
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0050661 NADP binding
GO:0005092 GDP-dissociation inhibitor activity
GO:0006099 tricarboxylic acid cycle
GO:0050660 flavin adenine dinucleotide binding
GO:0050151 oleate hydratase activity
GO:0007264 small GTPase mediated signal transduction
GO:0008924 malate dehydrogenase (quinone) activity
GO:0005524 ATP binding
GO:0008033 tRNA processing
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0016491 oxidoreductase activity
GO:0006260 DNA replication
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0006631 fatty acid metabolic process
GO:0055114 oxidation-reduction process

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