phrog_6251 is made of 19 protein sequences and is annotated as "replisome organizer DnaA-like"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
297.58 489 288


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_019544_p34 YP_007010955.1 replication protein NC_019544 Deep-sea thermophilic phage D6E Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p228564 no NCBI prot ID no annotation VI_00435 Bacilli_gi_423572779_4730538_4764456 Viruses.
p76716 no NCBI prot ID no annotation VI_04394 Bacilli_gi_126652723_0_48258 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
NC_009552_p44 YP_001285845.1 putative replication protein NC_009552 Geobacillus virus E2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p146817 no NCBI prot ID no annotation VI_00894 Bacilli_gi_336233546_739015_780180 Viruses.
p410141 no NCBI prot ID no annotation VI_05317 Bacilli_gi_513043252 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_029069_p42 YP_009223192.1 HNH nuclease NC_029069 Bacillus phage BM5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p213994 no NCBI prot ID no annotation VI_06128 Clostridia_gi_545044880 Viruses.
p63507 no NCBI prot ID no annotation VI_06090 Clostridia_gi_545036925_220_51237 Viruses.
p75029 no NCBI prot ID no annotation VI_06021 Clostridia_gi_545017943_14335_63007 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p174971 no NCBI prot ID no annotation VI_06119 Clostridia_gi_545043425_97642_136219 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
NC_028764_p58 YP_009195818.1 hypothetical protein NC_028764 Clostridium phage phiCD505 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Lubbockvirus; unclassified Lubbockvirus.
p340974 no NCBI prot ID no annotation VI_05912 Clostridia_gi_544983005_105518_126600 Viruses.
p412523 no NCBI prot ID no annotation VI_05895 Clostridia_gi_544977368 Viruses.
p324906 no NCBI prot ID no annotation VI_06160 Clostridia_gi_545053425_49685_72529 Viruses.
p72551 no NCBI prot ID no annotation VI_05844 Clostridia_gi_544959358_34968_84117 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p71850 no NCBI prot ID no annotation VI_05903 Clostridia_gi_544979865 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p173909 no NCBI prot ID no annotation VI_06198 Clostridia_gi_550130037_95265_133929 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p95435 no NCBI prot ID no annotation VI_06130 Clostridia_gi_545045010_49019_94601 Viruses.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_155 630 Erf-like ssDNA annealing protein DNA, RNA and nucleotide metabolism 10 2.14E-26 16.79
phrog_4601 29 no annotation unknown function 9 9.85E-38 28.13
phrog_7118 17 no annotation unknown function 2 4.72E-11 1.45

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1408 replication initiation protein DNA, RNA and nucleotide metabolism 90.1 0.062 4-97 / 1-105
phrog_1701 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 100.0 1.2E-45 1-129 / 1-133
phrog_186 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 99.2 4.2E-15 4-277 / 7-222
phrog_19120 no annotation unknown function 95.5 0.00057 239-286 / 5-47
phrog_25071 no annotation unknown function 96.1 0.00013 238-277 / 13-47
phrog_2562 replication initiation protein DNA, RNA and nucleotide metabolism 96.3 6.9E-05 184-278 / 184-261
phrog_25711 no annotation unknown function 98.2 1.4E-09 1-107 / 3-108
phrog_270 replication initiation protein DNA, RNA and nucleotide metabolism 92.4 0.02 11-77 / 5-69
phrog_29927 replication initiation protein DNA, RNA and nucleotide metabolism 96.9 7E-06 191-278 / 33-103
phrog_3171 replication initiation protein DNA, RNA and nucleotide metabolism 91.9 0.027 4-118 / 6-135
phrog_4016 replication initiation protein DNA, RNA and nucleotide metabolism 95.8 0.00029 193-277 / 6-74
phrog_6493 DnaD-like helicase loader DNA, RNA and nucleotide metabolism 95.8 0.00032 187-277 / 147-221
phrog_8064 replication initiation protein DNA, RNA and nucleotide metabolism 91.3 0.037 1-117 / 1-132

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF06970.10 Replication initiator protein A (RepA) N-terminus 6.5E-08 15-80 / 2-75
PF07261.10 Replication initiation and membrane attachment 1.9E-06 225-285 / 8-68
PF04492.12 Bacteriophage replication protein O 5.9E-06 12-91 / 6-83
PF09681.9 N-terminal phage replisome organiser (Phage_rep_org_N) 2.3E-05 15-107 / 1-102
PF02319.19 E2F/DP family winged-helix DNA-binding domain 0.00091 55-90 / 22-56
PF01726.15 LexA DNA binding domain 0.001 56-90 / 25-59
PF16221.4 winged helix-turn-helix 0.0015 56-87 / 46-76
PF08222.10 CodY helix-turn-helix domain 0.0027 56-89 / 4-36
PF04358.12 DsrC like protein 0.0028 31-89 / 36-93
PF05732.10 Firmicute plasmid replication protein (RepL) 0.003 31-91 / 51-109
PF03965.15 Penicillinase repressor 0.003 57-91 / 19-57
PF10771.8 Winged helix-turn-helix domain (DUF2582) 0.0034 31-93 / 5-58
PF13730.5 Helix-turn-helix domain 0.0035 31-84 / 2-50
PF08221.10 RNA polymerase III subunit RPC82 helix-turn-helix domain 0.004 56-89 / 27-59
PF07106.12 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) 0.0047 56-90 / 16-52
PF10007.8 Uncharacterized protein conserved in archaea (DUF2250) 0.005 57-89 / 23-55
PF09012.9 FeoC like transcriptional regulator 0.0061 57-91 / 15-48
PF05584.10 Sulfolobus plasmid regulatory protein 0.0063 56-90 / 18-51
PF15977.4 Winged helix-turn-helix DNA binding 0.008 55-90 / 22-56
PF01978.18 Sugar-specific transcriptional regulator TrmB 0.0084 57-91 / 23-56
PF12802.6 MarR family 0.0085 57-90 / 22-54

Annotations of the NCBI proteins of this PHROG


2:replication protein 1:hypothetical protein 1:HNH nuclease

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0005667 transcription factor complex
GO:0004252 serine-type endopeptidase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0006260 DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0007131 reciprocal meiotic recombination
GO:0006508 proteolysis
GO:0003677 DNA binding
GO:0003700 DNA binding transcription factor activity
GO:0006276 plasmid maintenance

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