PHROGS

Average length of proteins	Number of columns in the MSA	Number of conserved columns in the MSA
144.21	237	152

List of all proteins of this PHROG

PHROG prot ID	NCBI prot ID	NCBI prot annotation	Virus ID (click to view)	Virus name	Virus taxonomy
NC_018859_p49	YP_006908900.1	homing endonuclease	NC_018859	Escherichia phage ECBP2	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Kuravirus.
MG603697_p146	AUG88510.1	hypothetical protein	MG603697	Vibrio phage Vp_R1	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; unclassified Podoviridae.
NC_007808_p14	YP_001294607.1	hypothetical protein ORF014	NC_007808	Pseudomonas phage PA11	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
MG676466_p39	AUG88550.1	putative endonuclease	MG676466	Pseudomonas phage TC6	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; unclassified Podoviridae.
NC_011045_p26	YP_002003959.1	endonuclease	NC_011045	Enterobacteria phage 13a	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus.
NC_007456_p20	YP_338109.1	homing endonuclease	NC_007456	Enterobacteria phage K1F	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Kayfunavirus; Escherichia virus K1F.
NC_031258_p45	YP_009303694.1	hypothetical protein	NC_031258	Salmonella phage BP12A	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Berlinvirus; Salmonella virus BP12A.
MG832642_p5	AUV62629.1	hypothetical protein	MG832642	Escherichia phage HZ2R8	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; Escherichia virus HZ2R8.
NC_027387_p7	YP_009152458.1	hypothetical protein	NC_027387	Escherichia phage CICC 80001	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; Escherichia virus CICC80001.
NC_023715_p44	YP_009014865.1	hypothetical protein	NC_023715	Yersinia phage Yep-phi	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Berlinvirus; Yersinia virus Yepf.
NC_008694_p43	YP_919025.1	Conserved phage & prophage protein	NC_008694	Yersinia phage Berlin	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Berlinvirus; Yersinia virus Berlin.
NC_011038_p46	YP_002003358.1	gp7.7 homolog	NC_011038	Yersinia phage Yepe2	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Berlinvirus; Yersinia virus Yepe2.
NC_015271_p46	YP_004306697.1	predicted endonuclease	NC_015271	Salmonella phage Vi06	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus; Salmonella virus Vi06.
NC_011045_p54	YP_002003987.1	gp19.4	NC_011045	Enterobacteria phage 13a	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Teseptimavirus.
KY084243_p49	APD19661.1	HNH homing endonuclease	KY084243	Pectobacterium phage PP74	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Studiervirinae; Berlinvirus; Pectobacterium virus PP74.
MG972768_p8	AVP40056.1	hypothetical protein	MG972768	Klebsiella phage myPSH1235	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Slopekvirinae; Drulisvirus; Klebsiella virus myPSH1235.
NC_012662_p13	YP_002875637.1	hypothetical protein	NC_012662	Vibrio phage VP93	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Maculvirus; Vibrio virus VP93.
NC_016163_p108	YP_004934341.1	hypothetical protein	NC_016163	Yersinia phage phiR1-37	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
NC_023863_p40	YP_009021706.1	HNH endonuclease	NC_023863	Vibrio phage CHOED	Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.

PHROGs colocalized to this PHROG

PHROG	#Prot	Annotation	Category	#Neighbors	Probability	Score
phrog_17	2050	DNA polymerase	DNA, RNA and nucleotide metabolism	8	1.91E-16	6.84
phrog_38	1538	terminase large subunit	head and packaging	7	2.64E-15	5.7
phrog_2193	69	no annotation	unknown function	4	9.94E-16	6.12
phrog_30163	2	no annotation	unknown function	2	0	1000

PHROGs similar to this PHROG

PHROG	Annotation	Category	Probability	Evalue	posQ/posS
phrog_10495	HNH endonuclease	DNA, RNA and nucleotide metabolism	96.5	2.8E-05	48-85 / 19-56
phrog_1492	HNH endonuclease	DNA, RNA and nucleotide metabolism	98.2	2.2E-09	11-92 / 36-126
phrog_1872	endonuclease	DNA, RNA and nucleotide metabolism	99.9	3.7E-28	9-92 / 22-107
phrog_1891	HNH endonuclease	DNA, RNA and nucleotide metabolism	96.7	1.5E-05	20-82 / 102-166
phrog_3593	HNH endonuclease	DNA, RNA and nucleotide metabolism	99.6	1.9E-20	11-119 / 52-146
phrog_4578	HNH endonuclease	DNA, RNA and nucleotide metabolism	91.5	0.034	48-87 / 3-42
phrog_4842	HNH endonuclease	DNA, RNA and nucleotide metabolism	98.4	2.6E-10	11-74 / 74-137
phrog_59	HNH endonuclease	DNA, RNA and nucleotide metabolism	98.7	9.8E-12	6-148 / 15-134
phrog_826	HNH endonuclease	DNA, RNA and nucleotide metabolism	99.7	5.5E-22	9-85 / 17-97
phrog_959	HNH endonuclease	DNA, RNA and nucleotide metabolism	95.5	0.0006	19-88 / 36-105
phrog_99	HNH endonuclease	DNA, RNA and nucleotide metabolism	98.1	4.3E-09	9-85 / 13-98

PFAMs similar to this PHROG

ID	Definition	Evalue	posQ/posS
PF05551.10	Zinc-binding loop region of homing endonuclease	1.7E-11	21-92 / 1-79
PF13392.5	HNH endonuclease	2.4E-10	46-89 / 2-44
PF07453.12	NUMOD1 domain	0.0021	132-154 / 18-40
PF06413.10	Neugrin	0.0024	113-163 / 11-58

Annotations of the NCBI proteins of this PHROG

8:hypothetical protein 3:homing endonuclease 2:endonuclease 1:HNH endonuclease 1:predicted endonuclease 1:gp19.4 1:HNH homing endonuclease 1:Conserved phage & prophage protein 1:gp7.7 homolog

KEGG orthologous groups similar to this PHROG

ID	Name : Definition	Pathways	BestScore	#Hits
no KEGG group similar to this PHROG

GO terms in Uniprot proteins similar to this PHROG

ID	Definition
no GO term

Loading in process

>NC_018859_p49
-------MAKKTLVL---ETTETGCIIPISHKLNKNGYFRK----VI-DGKWVMYHRHVW
EES---FGSIPDGYEINHKCKNRACSNLEHLEMLEGSEHAIESNTGRNGDRQEAARLYWL
ETECS----GVHLAEKFGVSFGIGCRWIRKWKV---------------------------
---------------------------------------------------------
>MG603697_p146
-------MAKELILA---TCPKTGCITPTSHRLNKDGYFRK----NIGNGVWVMYHRYMW
ETQ---KGPIPDGFEVDHKCKNRACCNVEHLQCIDGTQHAVESNETRYLERLNRAKEFWN
YTSCT----GVELAREFNVTPSCACRWIRGWKV---------------------------
---------------------------------------------------------
>NC_007808_p14
-------------------MTYTDCLDPGFGYENKDGYVRIWDRPKPEGGTLVMRHRWFW
ELQ---KGPIPKGYEINHLCKNRRCCNIEHLECIEGGLHASKSNRERYLEEYLKFKQFYY
LCGEDSFFTQKEWGERFDRSQACISKWVKRYHKEKQN-----------------------
---------------------------------------------------------
>MG676466_p39
-------------------MTYTDCLDPGFGYENKDGYVRIWDRPKPEGGALVMRHRWFW
ELQ---KGPIPKGYEINHLCKNRRCCNIEHLECIEGGLHASKSNRERYLEEYLKFKQFYY
LCGEDSFFTQKEWGERFDRSQACISKWVKRYHKEKQN-----------------------
---------------------------------------------------------
>NC_011045_p26
-------MRGKKLIL---ATTESGCIIPTSHKLNADGYFRK----KT-NGVLEMYHRTVW
KEH---YGDIPEGYEVDHKCRNRACCNVEHLQLLEGSEHTVKTNRERYADRKESAKEYWL
ETGCT----GTHLGEKFGVTFSAACKWIREWKA---------------------------
---------------------------------------------------------
>NC_007456_p20
-------MRGKKLIL---EATETGCIIPTSHKLNQDGYFRK----RT-NGVLEMYHRTVW
IKA---NGPIPEGFEVDHKCRNRACCNVEHLQVLDRDSHLVKTNQERYAARKLEARDYWV
ETGCT----GTKLAEVFNVSFSAACGWIREWKA---------------------------
---------------------------------------------------------
>NC_031258_p45
----------MRVAI----DSITGCHIFQ-GCKTKGGYGRI----RV-DGVHWMAHR--Y
ALTVHLKRPLREGCVVVHSCDNPSCVNPAHLSE--------GTQKENIEDCRAKGRMTRG
G------------ASGKRLSHAERVQQSFDKRLNAVLSANGTD-----AEVAKKLGLNIQ
WVKKARAGKLSMHVK------------------------------------------
>MG832642_p5
------MISKKKYVI----DKETGCWNFR-GCKTKTGYGRI----RV-NGVHWMAHR--Y
SLSCHLGRPIADGMVVMHLCDNPSCVNPEHLKE--------GTQKENIEDCISKGRATKA
TGKRD--------ATKRDPSEERKAIVIRR------YHKGWTA-----TSIARYHKLSVA
WVKRVIEDYLSD---------------------------------------------
>NC_027387_p7
------MINKKKYVV----DKDTGCWNFK-GCKTKTGYGRI----RV-NGVHWMAHR--Y
SLSCHLGRPIADGMVVMHLCDNPSCVNPEHLKE--------GTQKENIEDCISKGRATKA
TGKRD--------ASKRDPSEERKAIVIRR------YHKGWTA-----TSIARYHKLSVA
WVKRAIEEYLSD---------------------------------------------
>NC_023715_p44
----------MRVAI----DSITGCHIFL-GCKTKGGYGRI----RV-NGVHWMAHR--Y
ALHVHLKRPLKEGCVVTHSCDNPSCVNPEHLSE--------GTQKENIEDCRSKGSMVHS
DSSGG--------SSGKHQSHIDKIQKAFNRRLKAVLDADGTD-----SEVAKRLGVNIQ
WVKKARSGRLSMHIK------------------------------------------
>NC_008694_p43
----------MRVAI----DSITGCHIFL-GCKTKGGYGRI----RV-NGVHWMAHR--Y
ALHVHLKRPLKEGCVVTHSCDNPSCVNPEHLSE--------GTQKENIEDCRSKGSMVHS
DSSGG--------SSGKHQSHIDKIQKAFNRRLKAVLDADGTD-----SEVAKRLGVNIQ
WVKKARSGRLSMHIK------------------------------------------
>NC_011038_p46
----------MRVAI----DSITGCHIFL-GCKTKGGYGRI----RV-NGVHWMAHR--Y
ALYVHLQRPLKEGCVVMHSCDNPSCVNPEHLSE--------GTQKENIEDCRSKGSMVRG
GSP------------GKRQSHVDKIQKAFNRRLKAALDAEGTD-----AEVAKRLGLNIQ
WVKKARSGRLNMHIK------------------------------------------
>NC_015271_p46
------MIDREKYVI----DKETGCWNFK-GCKTYTGYGRI----RV-NGVHWMAHR--Y
SLSCHLGRPIADGMVVMHICDNPSCVNPEHLKE--------GTQKENMADCKAKGRMYRP
GRPK-----------VNTSKAAYRSDWREYQVVRYYVHWKWKP-----SRIAKKMRLSIA
WVKRVLEEHVSH---------------------------------------------
>NC_011045_p54
------MISKKKYTV----DKDTGCWNFK-GCKTKTGYGRL----RV-NGVHWMAHR--Y
SLSCHLGRPIADGMVVMHLCDNPSCVNPEHLKE--------GTQKENMDDCKAKGRMYRP
GATGK--------QKTSTAKVAYHDDWRKDQVIRYHVRWKWKP-----SRIAEKMRLSIT
WVKRVLEEYVSL---------------------------------------------
>KY084243_p49
----------MRVAV----DPISGCHNFL-GCKTSGGYGRI----RV-GGVHWMAHR--Y
ALSVHLKRPLEEGCVVMHLCDNPACVNPEHLRE--------GTQKENMQDCKDKGRMHKA
TGP-----------RAPRRPYINKINQRYNERLKAVLEADGSD-----LQVAKKLGLNLQ
WVKKAREGKLVMQEV------------------------------------------
>MG972768_p8
---------------------------------------------------MRLYHRVVY
VRHHGITYADIDGQVIRHSCDNPRCINPAHLLV--------GSMADNVQDKVDRGREARK
ISK-------------------STVEQIRREYVPRSKHANQY-------VLAAKYGVVQS
RVSQIIKGA------------------------------------------------
>NC_012662_p13
------------------------------------------------------------
---MGLKLSEIKHVVVRHTCDNPRCINPDHLIG--------GTIADNNRDRAERGRSAKT
VPS-------------RQKLTLADCCWIREHYVPYCRSFGGG-------AMARKFNVDIA
VIHRVLKGDYPL---------------------------------------------
>NC_016163_p108
------MKDKMQKILDNIKKDENGCWIWQ-RSLTGSGYGQI----FA-EGRNHSVHKYVF
ELI---NGKVPNKYVVRHKCHNRKCCNPDHLLS--------GTNKDNYHDSIEVFKKIHK
SKRL---------------------KWIINDVSYPNSRISSKITKLSQSIICKHMDKETR
IFDYDSYAKACK---IANVEPKKLPTLKTLTKEQKKLIEDNM---------------
>NC_023863_p40
MGRDALMSNSKPIII---NTNSLGCYLVVSHKLNQDGYFRK----MTKEGKAVMWHRKVY
EDT---YGPIPEGFEVDHKCRNRHCINPEHLQLLSIAKHKAKTNIERADDKRIPAKEFWE
STGCS----GAELGRRFGVSFSTGCKWIRNWRNPTVSDLENNMQVKLIGNSPKYIGIPKE
ALGNKVEASLTQEGNLYSIKGDELNRLGCQ----EDCFDDDYYYVFWPEDVEVIHES