phrog_6463 is made of 19 protein sequences and is annotated as "HTH DNA binding protein"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
99.26 226 102


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_004683_p47 NP_817724.1 gp47 NC_004683 Mycobacterium virus Che9c Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Chenonavirus.
NC_031097_p42 YP_009289702.1 HTH DNA binding domain protein NC_031097 Gordonia phage Zirinka Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nymbaxtervirinae; Nymphadoravirus.
NC_030921_p37 YP_009274982.1 hypothetical protein NC_030921 Gordonia phage Utz Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_031269_p39 YP_009304369.1 HTH DNA-binding protein NC_031269 Gordonia phage Yeezy Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nymbaxtervirinae; Baxtervirus.
NC_026589_p44 YP_009124698.1 hypothetical protein NC_026589 Mycobacterium phage Sbash Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Chenonavirus.
MG845393_p38 AUV61603.1 helix-turn-helix DNA binding protein MG845393 Gordonia phage Beenie Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
JN020142_p48 AEJ93127.1 XRE family DNA binding domain protein JN020142 Mycobacterium virus Mutaforma13 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus.
NC_026604_p41 YP_009125894.1 CRO protein NC_026604 Mycobacterium phage Cerasum Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_028792_p47 YP_009198151.1 CRO protein NC_028792 Mycobacterium phage Kimberlium Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
KY702574_p41 ARM70635.1 CRO protein KY702574 Mycobacterium phage Kingsley Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_022060_p40 YP_008409577.1 CRO protein NC_022060 Mycobacterium phage Velveteen Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
NC_031251_p40 YP_009303035.1 HTH DNA-binding protein NC_031251 Gordonia phage SoilAssassin Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Attisvirus; unclassified Attisvirus.
NC_031233_p46 YP_009301407.1 HTH DNA-binding protein NC_031233 Gordonia phage Kita Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Nymbaxtervirinae; Nymphadoravirus.
MH020241_p41 AVP42267.1 CRO protein MH020241 Gordonia phage Fenry Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
NC_030943_p44 YP_009276669.1 CRO protein NC_030943 Gordonia phage Blueberry Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
KY348865_p43 APU93045.1 CRO protein KY348865 Mycobacterium phage Bubbles123 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MH020242_p43 AVP42345.1 hypothetical protein MH020242 Mycobacterium phage Misha28 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MF668287_p48 ASZ74422.1 CRO protein MF668287 Mycobacterium phage Wachhund Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Cheoctovirus; unclassified Cheoctovirus.
MG209611_p97 ATW59365.1 transcriptional regulator MG209611 Aphanizomenon phage vB_AphaS-CL131 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_130 726 anti-repressor Ant transcription regulation 7 7.49E-21 11.25
phrog_15107 6 no annotation unknown function 3 1.68E-18 8.9
phrog_16839 5 no annotation unknown function 3 5.60E-19 9.37
phrog_12920 8 no annotation unknown function 2 3.76E-13 3.55

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1373 transcriptional regulator transcription regulation 96.9 5.6E-06 27-84 / 38-87
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 92.6 0.018 20-86 / 7-68
phrog_2328 transcriptional repressor transcription regulation 94.6 0.0027 25-84 / 20-71
phrog_2439 transcriptional regulator transcription regulation 96.5 3.5E-05 24-91 / 10-69
phrog_2967 transcriptional regulator transcription regulation 95.2 0.0011 24-93 / 12-74
phrog_3 transcriptional repressor transcription regulation 95.0 0.0014 24-86 / 7-61
phrog_4836 CII-like regulator transcription regulation 91.9 0.028 24-89 / 86-143
phrog_4 transcriptional repressor transcription regulation 92.5 0.019 31-89 / 12-60
phrog_5823 transcriptional regulator transcription regulation 95.9 0.0002 25-93 / 9-70
phrog_7241 transcriptional regulator transcription regulation 96.8 1E-05 16-87 / 47-120
phrog_7396 no annotation unknown function 90.8 0.047 25-98 / 17-87
phrog_8 transcriptional regulator transcription regulation 96.6 2.5E-05 25-86 / 6-57
phrog_9908 DNA binding protein DNA, RNA and nucleotide metabolism 94.5 0.0029 23-83 / 17-69

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 0.0001 131-167 / 11-47
PF05339.10 Protein of unknown function (DUF739) 0.0011 140-186 / 13-58
PF01381.21 Helix-turn-helix 0.00018 140-186 / 6-51
PF13744.5 Helix-turn-helix domain 0.00069 135-186 / 23-74
PF07022.12 Bacteriophage CI repressor helix-turn-helix domain 0.00055 142-186 / 10-53
PF13413.5 Helix-turn-helix domain 0.00031 139-186 / 5-57
PF13443.5 Cro/C1-type HTH DNA-binding domain 0.00046 141-186 / 8-55
PF14590.5 Domain of unknown function (DUF4447) 0.0031 134-186 / 11-65
PF12844.6 Helix-turn-helix domain 0.0023 141-186 / 10-54
PF13560.5 Helix-turn-helix domain 0.0037 138-186 / 9-57
PF15731.4 Antitoxin component of bacterial toxin-antitoxin system, MqsA 6.3E-05 41-111 / 72-128
PF04645.11 Protein of unknown function, DUF603 0.0046 132-181 / 9-60
PF15943.4 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT 0.0022 145-186 / 10-50
PF08667.9 BetR domain 0.00016 41-113 / 8-71
PF05269.10 Bacteriophage CII protein 0.00024 44-113 / 16-70
PF14549.5 DNA-binding transcriptional regulator Cro 0.00039 44-110 / 3-52
PF13693.5 Winged helix-turn-helix DNA-binding 0.00071 41-112 / 5-60
PF04814.12 Hepatocyte nuclear factor 1 (HNF-1), N terminus 0.002 41-103 / 116-165
PF00356.20 Bacterial regulatory proteins, lacI family 0.0045 53-96 / 1-31
PF08965.9 Domain of unknown function (DUF1870) 0.0066 136-169 / 7-42
PF12116.7 Stage III sporulation protein D 0.0025 49-105 / 17-61
PF04936.11 Protein of unknown function (DUF658) 0.0055 142-169 / 87-114
PF10654.8 Protein of unknown function (DUF2481) 0.0063 48-89 / 77-105
PF04552.12 Sigma-54, DNA binding domain 0.0071 48-90 / 45-74
PF02376.14 CUT domain 0.0079 41-111 / 10-66

Annotations of the NCBI proteins of this PHROG


8:CRO protein 3:HTH DNA-binding protein 3:hypothetical protein 1:transcriptional regulator 1:helix-turn-helix DNA binding protein 1:HTH DNA binding domain protein 1:XRE family DNA binding domain protein 1:protein of an unannotated phage

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0045893 positive regulation of transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0005634 nucleus
GO:0043565 sequence-specific DNA binding
GO:0003677 DNA binding
GO:0045892 negative regulation of transcription, DNA-templated

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