phrog_7229 is made of 16 protein sequences and is annotated as "DNA topoisomerase II"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
149.88 256 158


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_020879_p7 YP_007677724.1 topoisomerase II large subunit NC_020879 Aeromonas phage Aes012 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tulanevirus.
NC_000866_p3 NP_049618.1 gp60 topoisomerase II, large subunit, C-terminal region NC_000866 Enterobacteria phage T4 (T4) Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
NC_031030_p3 YP_009281343.1 topoisomerase II NC_031030 Escherichia phage UFV-AREG1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus; unclassified Tequatrovirus.
KM607003_p4 AIT75188.1 topoisomerase II large subunit KM607003 Enterobacteria phage RB59 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus; Escherichia virus T4.
NC_027349_p3 YP_009148454.1 putative type II DNA topoisomerase NC_027349 Escherichia phage HY01 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
NC_020416_p5 YP_007501044.1 DNA topoisomerase II large subunit C-terminal region NC_020416 Salmonella phage vB_SenMS16 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Gelderlandvirus.
MF001355_p240 ASZ76526.1 DNA topoisomerase MF001355 Proteus phage PM2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; unclassified Tevenvirinae.
NC_028762_p4 YP_009195422.1 topoisomerase II large subunit NC_028762 Proteus phage vB_PmiM_Pm5461 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; unclassified Tevenvirinae.
NC_027997_p176 YP_009169310.1 hypothetical protein NC_027997 Campylobacter virus CP220 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Firehammervirus.
NC_019507_p101 YP_007005171.1 putative DNA topoisomerase II ATP-hydrolyzing DNA gyrase subunit NC_019507 Campylobacter virus CP21 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Firehammervirus.
NC_027996_p181 YP_009169116.1 hypothetical phage protein NC_027996 Campylobacter virus CPt10 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Firehammervirus.
KR233165_p127 AKN44614.1 putative topoisomerase II large subunit KR233165 Escherichia phage PEC04 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus; Escherichia virus HY01.
NC_031047_p193 YP_009284188.1 putative DNA topoisomerase subunit DNA-dependent ATPase NC_031047 Escherichia phage HY03 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus; Escherichia virus HY03.
NC_024125_p3 YP_009030887.1 DNA topoisomerase subunit DNA-dependent ATPase NC_024125 Escherichia phage vB_EcoM_112 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
p30942 no NCBI prot ID no annotation VI_05533 Betaproteobacteria_gi_149158964 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
MG250483_p5 AUE22546.1 topoisomerase II large subunit MG250483 Aeromonas phage Ah1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Tevenvirinae; unclassified Tevenvirinae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_1683 89 no annotation unknown function 7 6.94E-26 16.28
phrog_655 215 homing endonuclease DNA, RNA and nucleotide metabolism 6 1.35E-19 9.99
phrog_19082 4 DNA topoisomerase II DNA, RNA and nucleotide metabolism 3 1.32E-18 9.0
phrog_20888 4 no annotation unknown function 2 1.63E-13 3.91

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_19082 DNA topoisomerase II DNA, RNA and nucleotide metabolism 99.4 2.4E-17 1-44 / 1-45
phrog_28877 DNA topoisomerase II DNA, RNA and nucleotide metabolism 99.0 2.9E-13 25-157 / 491-630
phrog_543 DNA topoisomerase II large subunit DNA, RNA and nucleotide metabolism 100.0 5.2E-49 5-157 / 451-606

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF16898.4 C-terminal associated domain of TOPRIM 3.3E-21 126-220 / 1-100
PF00986.20 DNA gyrase B subunit, carboxyl terminus 9.7E-17 157-213 / 2-63

Annotations of the NCBI proteins of this PHROG


5:topoisomerase II large subunit 2:hypothetical protein 2:DNA topoisomerase subunit DNA-dependent ATPase 1:gp60 topoisomerase II, large subunit, C-terminal region 1:topoisomerase II 1:DNA topoisomerase II large subunit C-terminal region 1:DNA topoisomerase II ATP-hydrolyzing DNA gyrase subunit 1:DNA topoisomerase 1:type II DNA topoisomerase

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K02622 parE : topoisomerase IV subunit B [EC:5.99.1.-] no pathways 492 5

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0006265 DNA topological change
GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity

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