phrog_7545 is made of 16 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
175.69 308 178


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_021471_p19 YP_008083069.1 HNH domain endonuclease NC_021471 Halovirus HSTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_021319_p80 YP_008058442.1 HNH protein NC_021319 Halovirus HCTV-2 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
LC063634_p19 BAS69534.1 putative HNH endonuclease inducing intron mobility LC063634 Pectobacterium phage PPWS1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Corkvirinae; Kotilavirus; Pectobacterium virus PPWS1.
NC_024790_p43 YP_009056172.1 putative HNH endonuclease inducing intron mobility NC_024790 Escherichia phage vB_EcoP_PhAPEC7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Gamaleyavirus.
NC_012742_p45 YP_002922659.1 P45 NC_012742 Xanthomonas virus phil7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Eisenstarkvirus; Xanthomonas virus PhiL7.
NC_024786_p44 YP_009055549.1 putative HNH endonuclease inducing intron mobility NC_024786 Escherichia phage vB_EcoP_PhAPEC5 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Gamaleyavirus.
KT240186_p26 ALA46483.1 putative HNH endonuclease KT240186 Dickeya phage BF25/12 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Autographiviridae; Corkvirinae; Stompvirus; Dickeya virus BF25-12.
NC_009551_p13 YP_001285778.1 probable HNH-type endonuclease NC_009551 Phormidium phage Pf-WMP3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae.
NC_021329_p40 YP_008059529.1 HNH protein NC_021329 Halovirus HRTV-4 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
p57706 no NCBI prot ID no annotation VI_12271 Halobacteria_gi_448728133_100599_153663 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_021319_p84 YP_008058446.1 hypothetical protein NC_021319 Halovirus HCTV-2 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_020158_p77 YP_007378983.1 HNH endonuclease NC_020158 Halovirus HVTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_021327_p76 YP_008059118.1 HNH protein NC_021327 Halovirus HCTV-5 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_021327_p22 YP_008059064.1 HNH protein NC_021327 Halovirus HCTV-5 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_020158_p62 YP_007378968.1 HNH endonuclease NC_020158 Halovirus HVTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
p78611 no NCBI prot ID no annotation VI_04065 unknown_gi_547973622 Viruses.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_2573 56 DNA polymerase DNA, RNA and nucleotide metabolism 4 1.56E-16 6.93
phrog_9556 11 DNA polymerase DNA, RNA and nucleotide metabolism 3 4.34E-16 6.48
phrog_27747 3 no annotation unknown function 2 4.08E-14 4.51

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10730 HNH endonuclease DNA, RNA and nucleotide metabolism 98.0 8.2E-09 61-134 / 14-86
phrog_10822 HNH endonuclease DNA, RNA and nucleotide metabolism 92.4 0.02 15-131 / 16-146
phrog_11376 no annotation unknown function 94.1 0.0051 16-43 / 56-83
phrog_1157 transposase integration and excision 93.7 0.0075 1-42 / 1-41
phrog_1190 RNA polymerase sigma factor transcription regulation 91.9 0.028 7-43 / 142-178
phrog_12058 no annotation unknown function 97.1 2.5E-06 6-69 / 4-67
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 94.2 0.0045 90-136 / 148-202
phrog_1303 DNA binding protein DNA, RNA and nucleotide metabolism 92.2 0.023 6-52 / 34-79
phrog_1337 DNA binding protein DNA, RNA and nucleotide metabolism 90.2 0.059 7-42 / 8-43
phrog_1373 transcriptional regulator transcription regulation 94.8 0.0019 6-40 / 32-66
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 92.1 0.025 6-40 / 10-45
phrog_14913 HNH endonuclease DNA, RNA and nucleotide metabolism 97.3 7.7E-07 64-136 / 14-92
phrog_1492 HNH endonuclease DNA, RNA and nucleotide metabolism 97.4 5.2E-07 61-129 / 51-115
phrog_151 transposase integration and excision 95.3 0.00094 9-46 / 14-51
phrog_1529 no annotation unknown function 95.1 0.0013 6-38 / 4-35
phrog_15357 no annotation unknown function 93.9 0.0062 12-44 / 35-67
phrog_15471 HNH endonuclease DNA, RNA and nucleotide metabolism 98.5 8.3E-11 61-133 / 12-80
phrog_1553 excisionase integration and excision 90.8 0.046 18-38 / 4-24
phrog_1558 no annotation unknown function 93.2 0.011 8-41 / 108-140
phrog_16553 transcriptional repressor transcription regulation 91.3 0.037 17-49 / 21-51
phrog_1740 RNA polymerase sigma factor transcription regulation 90.9 0.044 13-41 / 137-165
phrog_1891 HNH endonuclease DNA, RNA and nucleotide metabolism 97.2 1.5E-06 7-132 / 14-168
phrog_1969 no annotation unknown function 91.1 0.041 16-55 / 52-91
phrog_19902 HNH endonuclease DNA, RNA and nucleotide metabolism 97.9 1.5E-08 56-136 / 61-140
phrog_20467 HNH endonuclease DNA, RNA and nucleotide metabolism 94.0 0.0053 13-45 / 65-97
phrog_20891 HNH endonuclease DNA, RNA and nucleotide metabolism 98.4 2E-10 60-124 / 119-183
phrog_2104 no annotation unknown function 92.4 0.02 5-38 / 45-78
phrog_21964 HNH endonuclease DNA, RNA and nucleotide metabolism 99.0 1.4E-13 79-139 / 3-62
phrog_2328 transcriptional repressor transcription regulation 91.5 0.033 9-46 / 19-56
phrog_2339 HTH DNA binding protein DNA, RNA and nucleotide metabolism 94.9 0.0018 7-75 / 26-88
phrog_25114 no annotation unknown function 98.0 1.2E-08 61-140 / 60-139
phrog_2538 terminase small subunit head and packaging 96.5 3.6E-05 8-42 / 9-43
phrog_25862 HNH endonuclease DNA, RNA and nucleotide metabolism 92.5 0.019 96-136 / 100-140
phrog_2727 no annotation unknown function 90.6 0.051 17-49 / 24-57
phrog_27281 no annotation unknown function 98.6 2.9E-11 61-138 / 28-125
phrog_30377 HNH endonuclease DNA, RNA and nucleotide metabolism 94.3 0.0039 80-144 / 7-67
phrog_309 terminase small subunit head and packaging 94.4 0.0036 10-42 / 16-48
phrog_32138 DNA binding protein DNA, RNA and nucleotide metabolism 92.5 0.018 19-51 / 19-51
phrog_323 transcriptional regulator, D5-like transcription regulation 92.0 0.025 2-46 / 3-43
phrog_32434 no annotation unknown function 95.6 0.00042 19-50 / 1-32
phrog_351 RNA polymerase sigma factor transcription regulation 91.8 0.028 7-41 / 181-217
phrog_357 transcriptional repressor transcription regulation 94.3 0.0039 9-55 / 16-60
phrog_36 transcriptional regulator transcription regulation 91.2 0.039 7-40 / 95-127
phrog_37683 no annotation unknown function 93.6 0.0082 10-130 / 40-181
phrog_3855 HTH DNA binding protein DNA, RNA and nucleotide metabolism 95.2 0.00097 14-42 / 75-103
phrog_3910 transcriptional regulator transcription regulation 94.3 0.0037 12-44 / 73-105
phrog_3 transcriptional repressor transcription regulation 94.6 0.0028 7-40 / 5-38
phrog_4151 DNA binding protein DNA, RNA and nucleotide metabolism 95.9 0.0002 8-49 / 11-52
phrog_4578 HNH endonuclease DNA, RNA and nucleotide metabolism 95.5 0.00054 98-130 / 5-37
phrog_4646 transposase integration and excision 91.0 0.043 15-53 / 19-57
phrog_4779 transcriptional regulator transcription regulation 94.3 0.0037 7-45 / 3-41
phrog_517 HTH DNA binding protein DNA, RNA and nucleotide metabolism 92.7 0.017 6-41 / 68-102
phrog_5229 no annotation unknown function 93.3 0.011 17-49 / 80-112
phrog_5301 transcriptional repressor transcription regulation 91.5 0.033 16-44 / 21-49
phrog_534 DNA binding protein DNA, RNA and nucleotide metabolism 91.8 0.029 10-41 / 21-48
phrog_59 HNH endonuclease DNA, RNA and nucleotide metabolism 98.6 3.9E-11 63-136 / 37-104
phrog_609 RIIB lysis inhibitor lysis 93.4 0.0098 5-46 / 10-51
phrog_6223 transcriptional repressor transcription regulation 91.8 0.028 15-38 / 14-37
phrog_664 DNA binding protein DNA, RNA and nucleotide metabolism 94.6 0.0028 12-49 / 62-99
phrog_66 excisionase and transcriptional regulator integration and excision 94.6 0.0026 18-43 / 9-34
phrog_6831 transcriptional regulator transcription regulation 95.1 0.0013 15-39 / 12-36
phrog_686 HTH DNA binding protein DNA, RNA and nucleotide metabolism 90.3 0.056 8-38 / 27-57
phrog_7061 HTH DNA binding protein DNA, RNA and nucleotide metabolism 94.6 0.0026 13-42 / 39-68
phrog_7344 terminase small subunit head and packaging 95.4 0.00077 6-40 / 15-48
phrog_756 DNA binding protein DNA, RNA and nucleotide metabolism 95.1 0.0011 7-40 / 8-41
phrog_7676 no annotation unknown function 93.7 0.0073 16-67 / 14-66
phrog_803 host nuclease inhibitor moron, auxiliary metabolic gene and host takeover 92.2 0.022 9-39 / 5-39
phrog_826 HNH endonuclease DNA, RNA and nucleotide metabolism 95.0 0.0014 63-133 / 31-97
phrog_8446 HNH endonuclease DNA, RNA and nucleotide metabolism 98.3 4.5E-10 2-46 / 1-45
phrog_867 DNA binding domain DNA, RNA and nucleotide metabolism 94.0 0.0054 11-50 / 21-60
phrog_8794 sigma factor transcription regulation 93.1 0.012 8-46 / 11-49
phrog_8 transcriptional regulator transcription regulation 93.7 0.0076 8-41 / 4-36
phrog_9217 transcriptional regulator transcription regulation 96.9 6.9E-06 4-50 / 38-84
phrog_9366 transposase integration and excision 91.1 0.04 15-42 / 78-105
phrog_959 HNH endonuclease DNA, RNA and nucleotide metabolism 98.2 2.3E-09 62-128 / 38-97
phrog_9759 DNA binding protein DNA, RNA and nucleotide metabolism 98.0 7.4E-09 2-49 / 4-49
phrog_99 HNH endonuclease DNA, RNA and nucleotide metabolism 97.7 6.2E-08 64-133 / 39-98

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF01710.15 Transposase 7.1E-10 4-102 / 2-100
PF04936.11 Protein of unknown function (DUF658) 2.8E-09 13-100 / 2-116
PF08822.10 Protein of unknown function (DUF1804) 5.6E-09 4-101 / 2-109
PF00292.17 'Paired box' domain 2.5E-08 3-46 / 16-58
PF13392.5 HNH endonuclease 4.3E-07 139-183 / 2-44
PF05551.10 Zinc-binding loop region of homing endonuclease 7.7E-07 119-185 / 14-78
PF04552.12 Sigma-54, DNA binding domain 1.1E-06 4-100 / 30-153
PF07750.10 GcrA cell cycle regulator 3.2E-06 4-47 / 2-45
PF09607.9 Brinker DNA-binding domain 9.6E-06 3-46 / 4-50
PF12759.6 InsA C-terminal domain 1.1E-05 4-45 / 5-45
PF10668.8 Phage terminase small subunit 1.5E-05 1-46 / 1-47
PF13011.5 leucine-zipper of insertion element IS481 2.9E-05 4-47 / 7-50
PF07141.10 Putative bacteriophage terminase small subunit 2.8E-05 10-46 / 21-56
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 0.007 202-230 / 12-40
PF05344.10 Domain of Unknown Function (DUF746) 4.4E-05 13-47 / 4-38
PF10654.8 Protein of unknown function (DUF2481) 0.0048 201-228 / 78-105
PF16087.4 Domain of unknown function (DUF4817) 6.2E-05 7-46 / 2-49
PF13309.5 HTH domain 6.5E-05 6-43 / 21-63
PF06627.10 Protein of unknown function (DUF1153) 6.6E-05 4-47 / 29-72
PF15978.4 Tn7-like transposition protein D 8.3E-05 8-46 / 190-228
PF06322.10 Phage NinH protein 9.7E-05 10-46 / 5-41
PF04218.12 CENP-B N-terminal DNA-binding domain 9.9E-05 5-45 / 7-47
PF12824.6 Mitochondrial ribosomal protein subunit L20 9.8E-05 4-44 / 88-130
PF01527.19 Transposase 0.00012 3-46 / 3-46
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 0.00014 6-46 / 4-44
PF13542.5 Helix-turn-helix domain of transposase family ISL3 0.00017 5-45 / 12-50
PF02796.14 Helix-turn-helix domain of resolvase 0.00017 6-44 / 7-44
PF02954.18 Bacterial regulatory protein, Fis family 0.00023 19-44 / 14-39
PF13936.5 Helix-turn-helix domain 0.00026 4-44 / 4-43
PF05225.15 helix-turn-helix, Psq domain 0.00025 10-45 / 5-41
PF03333.12 Adhesin biosynthesis transcription regulatory protein 0.00034 8-46 / 43-80
PF13411.5 MerR HTH family regulatory protein 0.0004 23-47 / 2-26
PF16677.4 DNA-packaging protein gp3 0.00039 4-45 / 5-53
PF11427.7 Tc3 transposase 0.00051 5-46 / 5-45
PF08765.10 Mor transcription activator family 0.0048 203-228 / 72-97
PF13412.5 Winged helix-turn-helix DNA-binding 0.00063 20-46 / 16-42
PF05331.10 Protein of unknown function (DUF742) 0.00068 11-46 / 44-78
PF13404.5 AsnC-type helix-turn-helix domain 0.00076 19-45 / 15-41
PF14493.5 Helix-turn-helix domain 0.00089 13-46 / 5-37
PF01381.21 Helix-turn-helix 0.0009 19-44 / 7-32
PF07900.10 Protein of unknown function (DUF1670) 0.00092 19-97 / 93-177
PF10975.7 Protein of unknown function (DUF2802) 0.00098 7-43 / 30-65
PF17443.1 Uncharacterized protein pXO2-72 0.001 20-45 / 7-32
PF07638.10 ECF sigma factor 0.0011 5-45 / 134-173
PF07453.12 NUMOD1 domain 0.0032 202-224 / 18-40
PF08535.9 KorB domain 0.0014 20-46 / 2-28
PF13384.5 Homeodomain-like domain 0.0016 8-45 / 5-41
PF13518.5 Helix-turn-helix domain 0.0017 20-46 / 10-36
PF07506.10 RepB plasmid partitioning protein 0.0016 4-45 / 4-45
PF13556.5 PucR C-terminal helix-turn-helix domain 0.0017 19-46 / 10-37
PF02042.14 RWP-RK domain 0.0019 19-46 / 10-37
PF12116.7 Stage III sporulation protein D 0.0019 12-44 / 10-42
PF06413.10 Neugrin 0.0041 204-233 / 30-58
PF11112.7 Pyocin activator protein PrtN 0.002 20-46 / 12-39
PF00356.20 Bacterial regulatory proteins, lacI family 0.0067 206-228 / 2-24
PF06806.11 Putative excisionase (DUF1233) 0.0023 21-43 / 9-31
PF00376.22 MerR family regulatory protein 0.0024 23-45 / 1-23
PF13413.5 Helix-turn-helix domain 0.0028 19-44 / 7-32
PF02319.19 E2F/DP family winged-helix DNA-binding domain 0.0028 20-46 / 22-48
PF09862.8 Protein of unknown function (DUF2089) 0.003 19-46 / 47-74
PF01371.18 Trp repressor protein 0.003 13-46 / 41-73
PF11242.7 Protein of unknown function (DUF2774) 0.003 12-46 / 6-39
PF16509.4 TrfB plasmid transcriptional repressor 0.0032 19-46 / 29-56
PF10078.8 Uncharacterized protein conserved in bacteria (DUF2316) 0.003 12-44 / 14-46
PF08281.11 Sigma-70, region 4 0.0033 19-45 / 24-50
PF05930.11 Prophage CP4-57 regulatory protein (AlpA) 0.0036 21-43 / 3-25
PF13022.5 Helix-turn-helix of insertion element transposase 0.004 22-43 / 26-47
PF06970.10 Replication initiator protein A (RepA) N-terminus 0.0042 23-44 / 53-74
PF13551.5 Winged helix-turn helix 0.0047 19-46 / 9-36
PF07825.10 Excisionase-like protein 0.0053 22-47 / 3-30
PF08004.10 Protein of unknown function (DUF1699) 0.0053 6-42 / 90-129
PF07278.10 Protein of unknown function (DUF1441) 0.0055 21-45 / 1-25
PF04545.15 Sigma-70, region 4 0.006 20-44 / 23-47
PF13591.5 MerR HTH family regulatory protein 0.0063 22-45 / 1-24
PF02650.13 WhiA C-terminal HTH domain 0.0063 19-45 / 52-80
PF10743.8 Regulatory phage protein cox 0.0073 19-46 / 9-36
PF09035.9 Excisionase from transposon Tn916 0.0081 20-44 / 14-38
PF00440.22 Bacterial regulatory proteins, tetR family 0.0083 22-44 / 16-38
PF04297.13 Putative helix-turn-helix protein, YlxM / p13 like 0.0083 13-45 / 25-57
PF07037.10 Putative transcription regulator (DUF1323) 0.0088 22-44 / 1-23
PF02001.15 Protein of unknown function DUF134 0.0089 19-45 / 45-71

Annotations of the NCBI proteins of this PHROG


4:HNH protein 4:HNH endonuclease 3:HNH endonuclease inducing intron mobility 1:probable HNH-type endonuclease 1:HNH domain endonuclease 1:hypothetical protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003700 DNA binding transcription factor activity
GO:0005524 ATP binding
GO:0006313 transposition, DNA-mediated
GO:0000150 recombinase activity
GO:0043565 sequence-specific DNA binding
GO:0004803 transposase activity
GO:0003677 DNA binding
GO:0006310 DNA recombination
GO:0005622 intracellular
GO:0006352 DNA-templated transcription, initiation
GO:0006355 regulation of transcription, DNA-templated
GO:0016987 sigma factor activity
GO:0005667 transcription factor complex
GO:0019069 viral capsid assembly

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