phrog_8048 is made of 14 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
139.57 417 131


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
NC_021330_p85 YP_008059647.1 hypothetical protein NC_021330 Halovirus HCTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_020158_p91 YP_007378997.1 HNH domain endonuclease NC_020158 Halovirus HVTV-1 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
MF360957_p218 ASU00041.1 HNH endonuclease MF360957 Bacillus virus PBS1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
NC_018264_p12 YP_006546281.1 hypothetical protein NC_018264 Thermoanaerobacterium phage THSA-485A Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
NC_031039_p32 YP_009282937.1 HNH nuclease NC_031039 Bacillus phage AR9 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p197979 no NCBI prot ID no annotation VI_05564 Betaproteobacteria_gi_485458331_0_36835 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p11666 no NCBI prot ID no annotation VI_01067 Betaproteobacteria_gi_134287418 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
p48108 no NCBI prot ID no annotation VI_12205 Halobacteria_gi_448285003 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Myohalovirus; unclassified Myohalovirus; Natrialba phage PhiCh1.
NC_004084_p1 NP_665918.1 putative HNH endonuclease NC_004084 Natrialba phage PhiCh1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Myohalovirus; unclassified Myohalovirus.
p47317 no NCBI prot ID no annotation VI_03977 Halobacteria_gi_289594273 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Myohalovirus; unclassified Myohalovirus; Natrialba phage PhiCh1.
p48352 no NCBI prot ID no annotation VI_12208 Halobacteria_gi_448294712_6476_64495 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p418074 no NCBI prot ID no annotation VI_03976 Halobacteria_gi_161561737 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Myohalovirus; unclassified Myohalovirus; Natrialba phage PhiCh1.
p115373 no NCBI prot ID no annotation VI_09903 Gammaproteobacteria_gi_545908410 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae.
p70757 no NCBI prot ID no annotation VI_05598 Betaproteobacteria_gi_483587362_3686_53282 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_19338 4 no annotation unknown function 4 0 1000
phrog_21336 4 no annotation unknown function 3 3.24E-19 9.61

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10822 HNH endonuclease DNA, RNA and nucleotide metabolism 96.8 8.8E-06 25-78 / 97-148
phrog_119 HNH endonuclease DNA, RNA and nucleotide metabolism 98.5 1.6E-10 11-75 / 15-78
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 97.8 4.2E-08 24-80 / 143-201
phrog_14314 HNH endonuclease DNA, RNA and nucleotide metabolism 96.8 1.2E-05 15-84 / 4-69
phrog_144 HNH endonuclease DNA, RNA and nucleotide metabolism 98.2 1.2E-09 6-78 / 41-112
phrog_14736 HNH endonuclease DNA, RNA and nucleotide metabolism 95.9 0.00022 25-76 / 30-78
phrog_15103 no annotation unknown function 97.0 3.5E-06 17-79 / 190-254
phrog_1571 HNH endonuclease DNA, RNA and nucleotide metabolism 93.5 0.0088 11-75 / 2-85
phrog_16726 HNH endonuclease DNA, RNA and nucleotide metabolism 90.8 0.046 18-79 / 71-130
phrog_16986 no annotation unknown function 94.3 0.0037 15-75 / 8-64
phrog_1985 HNH endonuclease DNA, RNA and nucleotide metabolism 96.2 9.6E-05 24-75 / 64-124
phrog_2118 HNH endonuclease DNA, RNA and nucleotide metabolism 95.0 0.0014 14-93 / 3-84
phrog_2214 HNH endonuclease DNA, RNA and nucleotide metabolism 95.8 0.00027 16-77 / 24-78
phrog_22283 no annotation unknown function 94.0 0.0058 9-75 / 4-67
phrog_22514 HNH endonuclease DNA, RNA and nucleotide metabolism 97.2 1.3E-06 8-75 / 47-107
phrog_2255 HNH endonuclease DNA, RNA and nucleotide metabolism 97.1 2.3E-06 26-82 / 64-130
phrog_2323 HNH endonuclease DNA, RNA and nucleotide metabolism 94.7 0.0025 7-75 / 5-85
phrog_24030 RNA ligase DNA, RNA and nucleotide metabolism 95.6 0.00046 18-80 / 9-66
phrog_24252 HNH endonuclease DNA, RNA and nucleotide metabolism 96.7 1.2E-05 17-75 / 5-68
phrog_25862 HNH endonuclease DNA, RNA and nucleotide metabolism 92.0 0.026 29-75 / 91-134
phrog_2914 endonuclease VII DNA, RNA and nucleotide metabolism 90.7 0.048 16-75 / 27-77
phrog_30443 HNH endonuclease DNA, RNA and nucleotide metabolism 90.7 0.048 12-75 / 45-102
phrog_3106 HNH endonuclease DNA, RNA and nucleotide metabolism 97.6 1E-07 12-83 / 27-110
phrog_32453 HNH endonuclease DNA, RNA and nucleotide metabolism 91.4 0.036 18-81 / 63-119
phrog_333 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 1.8E-05 10-77 / 11-71
phrog_338 HNH endonuclease DNA, RNA and nucleotide metabolism 96.5 2.7E-05 8-82 / 7-86
phrog_3497 no annotation unknown function 96.8 8.4E-06 24-84 / 23-105
phrog_35854 HNH endonuclease DNA, RNA and nucleotide metabolism 95.6 0.00045 25-84 / 4-74
phrog_398 no annotation unknown function 94.6 0.0026 26-75 / 142-188
phrog_4160 no annotation unknown function 95.8 0.0003 6-75 / 37-113
phrog_4234 HNH endonuclease DNA, RNA and nucleotide metabolism 93.9 0.0061 9-75 / 10-79
phrog_4581 terminase small subunit head and packaging 97.6 1.1E-07 11-75 / 46-104
phrog_5200 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 2E-05 13-80 / 26-88
phrog_589 HNH endonuclease DNA, RNA and nucleotide metabolism 98.2 1.3E-09 9-76 / 32-96
phrog_5956 HNH endonuclease DNA, RNA and nucleotide metabolism 96.5 3.3E-05 23-77 / 2-55
phrog_6050 HNH endonuclease DNA, RNA and nucleotide metabolism 94.1 0.0047 25-76 / 3-51
phrog_6544 no annotation unknown function 97.1 2.1E-06 17-83 / 16-75
phrog_7370 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 2.6E-05 10-75 / 24-82
phrog_740 HNH endonuclease DNA, RNA and nucleotide metabolism 97.0 4.7E-06 15-78 / 6-68
phrog_7566 no annotation unknown function 95.5 0.00054 22-83 / 4-60
phrog_7785 HNH endonuclease DNA, RNA and nucleotide metabolism 96.4 5E-05 8-77 / 49-110
phrog_8446 HNH endonuclease DNA, RNA and nucleotide metabolism 99.1 3.7E-14 10-76 / 112-184
phrog_8660 HNH endonuclease DNA, RNA and nucleotide metabolism 94.6 0.0027 16-75 / 99-151
phrog_9443 HNH endonuclease DNA, RNA and nucleotide metabolism 90.1 0.062 18-75 / 89-141

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF13395.5 HNH endonuclease 1.2E-06 179-228 / 1-51
PF05315.10 ICEA Protein 2.7E-06 162-228 / 79-150
PF01844.22 HNH endonuclease 3.1E-06 179-226 / 1-46
PF05766.11 Bacteriophage Lambda NinG protein 2.4E-05 164-228 / 74-136
PF14279.5 HNH endonuclease 3.2E-05 179-228 / 1-45
PF13391.5 HNH endonuclease 3.7E-05 179-228 / 1-45
PF09665.9 Type II restriction endonuclease (RE_Alw26IDE) 0.00017 176-229 / 253-297
PF06147.10 Protein of unknown function (DUF968) 0.00021 175-228 / 126-174

Annotations of the NCBI proteins of this PHROG


2:HNH endonuclease 2:hypothetical protein 1:HNH nuclease 1:HNH domain endonuclease

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
K07453 K07453 : putative restriction endonuclease no pathways 351 1

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0004519 endonuclease activity
GO:0003676 nucleic acid binding

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