phrog_8446 is made of 13 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
225.69 419 200


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
p57766 no NCBI prot ID no annotation VI_12271 Halobacteria_gi_448728133_100599_153663 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
NC_004084_p22 NP_665939.1 hypothetical protein NC_004084 Natrialba phage PhiCh1 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Myohalovirus; unclassified Myohalovirus.
NC_021335_p50 YP_008060034.1 HNH protein NC_021335 Halovirus HRTV-7 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae.
NC_021327_p107 YP_008059149.1 HNH protein NC_021327 Halovirus HCTV-5 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
NC_021327_p110 YP_008059152.1 HNH protein NC_021327 Halovirus HCTV-5 Viruses; unclassified viruses; unclassified DNA viruses; unclassified archaeal dsDNA viruses; Haloviruses.
p429579 no NCBI prot ID no annotation VI_12230 Halobacteria_gi_448367707 Viruses; unclassified viruses; unclassified DNA viruses; unclassified dsDNA viruses.
p47336 no NCBI prot ID no annotation VI_03977 Halobacteria_gi_289594273 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Myohalovirus; unclassified Myohalovirus; Natrialba phage PhiCh1.
p48127 no NCBI prot ID no annotation VI_12205 Halobacteria_gi_448285003 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Myohalovirus; unclassified Myohalovirus; Natrialba phage PhiCh1.
p68727 no NCBI prot ID no annotation VI_03155 Gammaproteobacteria_gi_553794294 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p424896 no NCBI prot ID no annotation VI_08249 Gammaproteobacteria_gi_484067791 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p72023 no NCBI prot ID no annotation VI_03178 Gammaproteobacteria_gi_553801299_1857978_1907240 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
p55871 no NCBI prot ID no annotation VI_11788 Gammaproteobacteria_gi_550039422_47764_101551 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales.
KT070867_p227 AKQ08542.1 putative HNH endonuclease KT070867 Bacillus phage PBC2 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_9431 11 no annotation unknown function 4 3.16E-21 11.62
phrog_434 299 RecE-like recombination exonuclease DNA, RNA and nucleotide metabolism 4 1.31E-13 4.0
phrog_27001 3 no annotation unknown function 3 0 1000

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_10822 HNH endonuclease DNA, RNA and nucleotide metabolism 96.5 3.9E-05 53-189 / 11-151
phrog_11376 no annotation unknown function 91.9 0.028 59-87 / 56-84
phrog_1157 transposase integration and excision 91.1 0.041 14-41 / 14-41
phrog_119 HNH endonuclease DNA, RNA and nucleotide metabolism 99.4 3.5E-17 112-187 / 14-82
phrog_12058 no annotation unknown function 94.5 0.0031 6-50 / 5-49
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 98.5 8.7E-11 112-186 / 130-199
phrog_12823 no annotation unknown function 94.9 0.0018 14-90 / 25-106
phrog_1303 DNA binding protein DNA, RNA and nucleotide metabolism 96.6 1.8E-05 6-94 / 35-136
phrog_1373 transcriptional regulator transcription regulation 94.7 0.0023 7-90 / 34-88
phrog_1381 plasmid antitoxin with HTH domain moron, auxiliary metabolic gene and host takeover 94.0 0.0052 6-41 / 11-47
phrog_14131 DNA binding protein DNA, RNA and nucleotide metabolism 96.3 7.1E-05 18-94 / 73-157
phrog_141 terminase small subunit head and packaging 95.2 0.00097 17-85 / 9-116
phrog_14314 HNH endonuclease DNA, RNA and nucleotide metabolism 97.2 1.3E-06 119-182 / 6-59
phrog_144 HNH endonuclease DNA, RNA and nucleotide metabolism 99.1 2.3E-14 111-186 / 44-112
phrog_15103 no annotation unknown function 96.6 1.9E-05 122-188 / 193-255
phrog_151 transposase integration and excision 93.3 0.011 49-90 / 11-52
phrog_15357 no annotation unknown function 91.1 0.041 15-41 / 39-65
phrog_1558 no annotation unknown function 95.0 0.0015 7-40 / 108-140
phrog_16568 Ren-like exclusion protein moron, auxiliary metabolic gene and host takeover 92.0 0.026 18-90 / 20-106
phrog_16726 HNH endonuclease DNA, RNA and nucleotide metabolism 97.7 9.5E-08 121-181 / 72-124
phrog_16986 no annotation unknown function 97.9 1.2E-08 121-182 / 12-63
phrog_17821 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.0 0.013 57-143 / 15-88
phrog_1889 terminase small subunit head and packaging 91.0 0.043 7-45 / 10-50
phrog_1969 no annotation unknown function 93.0 0.013 62-114 / 55-100
phrog_2118 HNH endonuclease DNA, RNA and nucleotide metabolism 96.3 6.3E-05 119-183 / 6-70
phrog_2214 HNH endonuclease DNA, RNA and nucleotide metabolism 97.7 8.6E-08 118-182 / 24-75
phrog_2323 HNH endonuclease DNA, RNA and nucleotide metabolism 95.7 0.00034 112-184 / 8-86
phrog_2340 endonuclease DNA, RNA and nucleotide metabolism 91.1 0.041 129-185 / 113-150
phrog_24030 RNA ligase DNA, RNA and nucleotide metabolism 97.7 5.3E-08 119-190 / 8-68
phrog_24252 HNH endonuclease DNA, RNA and nucleotide metabolism 93.7 0.0076 119-184 / 5-69
phrog_24591 no annotation unknown function 91.7 0.031 15-92 / 60-143
phrog_2538 terminase small subunit head and packaging 93.4 0.0094 52-85 / 10-43
phrog_2789 transcriptional regulator transcription regulation 95.5 0.00056 10-90 / 22-101
phrog_30443 HNH endonuclease DNA, RNA and nucleotide metabolism 92.6 0.018 115-183 / 46-102
phrog_309 terminase small subunit head and packaging 94.4 0.0033 10-43 / 17-50
phrog_3106 HNH endonuclease DNA, RNA and nucleotide metabolism 94.9 0.0018 113-185 / 26-104
phrog_32138 DNA binding protein DNA, RNA and nucleotide metabolism 95.2 0.0011 62-91 / 19-48
phrog_323 transcriptional regulator, D5-like transcription regulation 95.0 0.0014 8-71 / 57-120
phrog_333 HNH endonuclease DNA, RNA and nucleotide metabolism 98.1 3.9E-09 105-184 / 3-70
phrog_338 HNH endonuclease DNA, RNA and nucleotide metabolism 95.2 0.00097 125-184 / 24-80
phrog_3497 no annotation unknown function 94.4 0.0037 124-186 / 21-99
phrog_36 transcriptional regulator transcription regulation 91.9 0.028 5-39 / 94-127
phrog_3855 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.8 0.0064 11-40 / 73-102
phrog_3 transcriptional repressor transcription regulation 94.6 0.0028 6-40 / 5-39
phrog_4151 DNA binding protein DNA, RNA and nucleotide metabolism 91.8 0.029 49-95 / 9-54
phrog_4291 RNA-dependent RNA polymerase DNA, RNA and nucleotide metabolism 91.0 0.042 13-90 / 45-120
phrog_4494 no annotation unknown function 93.9 0.006 55-91 / 11-47
phrog_4581 terminase small subunit head and packaging 98.5 9.1E-11 100-184 / 36-105
phrog_4645 endonuclease DNA, RNA and nucleotide metabolism 94.2 0.0045 8-88 / 13-98
phrog_4646 transposase integration and excision 93.3 0.011 12-88 / 17-139
phrog_4779 transcriptional regulator transcription regulation 93.6 0.0082 16-45 / 13-42
phrog_5104 no annotation unknown function 95.3 0.0008 98-183 / 106-205
phrog_5200 HNH endonuclease DNA, RNA and nucleotide metabolism 94.5 0.0032 115-183 / 26-83
phrog_5718 HNH endonuclease DNA, RNA and nucleotide metabolism 94.8 0.002 117-185 / 11-69
phrog_589 HNH endonuclease DNA, RNA and nucleotide metabolism 99.0 1.3E-13 112-183 / 33-95
phrog_5956 HNH endonuclease DNA, RNA and nucleotide metabolism 97.7 5.3E-08 124-184 / 1-54
phrog_6050 HNH endonuclease DNA, RNA and nucleotide metabolism 97.6 1.1E-07 126-184 / 2-51
phrog_6081 no annotation unknown function 94.3 0.0041 15-90 / 17-104
phrog_6223 transcriptional repressor transcription regulation 96.0 0.00016 14-60 / 14-60
phrog_6544 no annotation unknown function 91.0 0.043 122-188 / 19-72
phrog_664 DNA binding protein DNA, RNA and nucleotide metabolism 95.5 0.00062 11-45 / 62-96
phrog_66 excisionase and transcriptional regulator integration and excision 92.4 0.02 61-86 / 9-34
phrog_6831 transcriptional regulator transcription regulation 96.3 6.2E-05 13-59 / 11-58
phrog_7061 HTH DNA binding protein DNA, RNA and nucleotide metabolism 93.1 0.012 12-41 / 39-68
phrog_7168 homing endonuclease DNA, RNA and nucleotide metabolism 92.5 0.019 16-93 / 195-267
phrog_7344 terminase small subunit head and packaging 92.1 0.024 18-40 / 27-49
phrog_7370 HNH endonuclease DNA, RNA and nucleotide metabolism 96.5 3.6E-05 122-188 / 34-87
phrog_740 HNH endonuclease DNA, RNA and nucleotide metabolism 96.6 2.7E-05 120-188 / 9-70
phrog_7545 HNH endonuclease DNA, RNA and nucleotide metabolism 98.4 2.5E-10 1-45 / 2-46
phrog_756 DNA binding protein DNA, RNA and nucleotide metabolism 94.5 0.003 48-81 / 6-39
phrog_7676 no annotation unknown function 91.2 0.039 16-40 / 15-39
phrog_7785 HNH endonuclease DNA, RNA and nucleotide metabolism 97.0 4E-06 122-188 / 61-113
phrog_7950 transcriptional repressor transcription regulation 92.5 0.019 6-45 / 11-50
phrog_8048 HNH endonuclease DNA, RNA and nucleotide metabolism 99.2 1.4E-14 112-185 / 10-77
phrog_8463 transposase integration and excision 93.8 0.0065 9-88 / 17-122
phrog_8660 HNH endonuclease DNA, RNA and nucleotide metabolism 95.5 0.00058 122-188 / 103-157
phrog_8794 sigma factor transcription regulation 91.1 0.041 12-51 / 16-55
phrog_8 transcriptional regulator transcription regulation 94.3 0.004 7-40 / 4-36
phrog_9129 no annotation unknown function 94.9 0.0016 13-90 / 81-177
phrog_9217 transcriptional regulator transcription regulation 96.7 1.2E-05 46-89 / 37-80
phrog_9545 HNH endonuclease DNA, RNA and nucleotide metabolism 93.2 0.011 120-185 / 101-165
phrog_9759 DNA binding protein DNA, RNA and nucleotide metabolism 97.8 2.8E-08 1-45 / 4-46

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF05766.11 Bacteriophage Lambda NinG protein 1E-08 217-339 / 8-137
PF05315.10 ICEA Protein 7.6E-08 270-337 / 82-149
PF13395.5 HNH endonuclease 1.8E-07 284-338 / 1-51
PF01844.22 HNH endonuclease 1.9E-07 284-337 / 1-47
PF04936.11 Protein of unknown function (DUF658) 4E-06 121-203 / 14-117
PF08822.10 Protein of unknown function (DUF1804) 1.2E-05 111-205 / 9-111
PF13391.5 HNH endonuclease 4.7E-07 284-340 / 1-47
PF01710.15 Transposase 1.9E-05 111-206 / 9-102
PF14279.5 HNH endonuclease 9.5E-07 284-338 / 1-45
PF00292.17 'Paired box' domain 0.00011 108-196 / 21-125
PF06147.10 Protein of unknown function (DUF968) 3E-05 280-339 / 126-175
PF09665.9 Type II restriction endonuclease (RE_Alw26IDE) 4.1E-05 281-339 / 253-297
PF04552.12 Sigma-54, DNA binding domain 0.0011 119-204 / 46-155
PF07750.10 GcrA cell cycle regulator 0.00016 46-87 / 3-46
PF07141.10 Putative bacteriophage terminase small subunit 0.00032 50-86 / 21-57
PF06056.11 Putative ATPase subunit of terminase (gpP-like) 0.00041 52-87 / 5-40
PF12759.6 InsA C-terminal domain 0.00045 51-84 / 12-45
PF05344.10 Domain of Unknown Function (DUF746) 0.00053 52-87 / 4-39
PF13411.5 MerR HTH family regulatory protein 0.00075 62-87 / 2-27
PF09862.8 Protein of unknown function (DUF2089) 0.001 13-86 / 10-75
PF10654.8 Protein of unknown function (DUF2481) 0.0015 52-84 / 72-104
PF09607.9 Brinker DNA-binding domain 0.0016 61-86 / 26-51
PF13011.5 leucine-zipper of insertion element IS481 0.0017 54-87 / 18-51
PF06322.10 Phage NinH protein 0.0021 58-87 / 14-43
PF15978.4 Tn7-like transposition protein D 0.0029 119-148 / 201-230
PF02796.14 Helix-turn-helix domain of resolvase 0.0034 55-83 / 16-44
PF16087.4 Domain of unknown function (DUF4817) 0.0037 52-87 / 8-51
PF10668.8 Phage terminase small subunit 0.004 60-87 / 22-49
PF02954.18 Bacterial regulatory protein, Fis family 0.004 58-83 / 14-39
PF13542.5 Helix-turn-helix domain of transposase family ISL3 0.0041 52-84 / 19-50
PF08765.10 Mor transcription activator family 0.0044 53-86 / 66-98
PF14493.5 Helix-turn-helix domain 0.0044 54-87 / 6-39
PF03333.12 Adhesin biosynthesis transcription regulatory protein 0.0047 51-86 / 46-81
PF07900.10 Protein of unknown function (DUF1670) 0.0051 58-145 / 93-176
PF13518.5 Helix-turn-helix domain 0.0057 59-87 / 10-38
PF16784.4 Putative HNHc nuclease 0.0059 280-337 / 122-170
PF13936.5 Helix-turn-helix domain 0.0066 53-83 / 13-43
PF13309.5 HTH domain 0.0066 61-82 / 42-63
PF06627.10 Protein of unknown function (DUF1153) 0.0067 44-87 / 28-73
PF13613.5 Helix-turn-helix of DDE superfamily endonuclease 0.0074 57-86 / 16-45
PF04218.12 CENP-B N-terminal DNA-binding domain 0.0077 60-85 / 23-48
PF17443.1 Uncharacterized protein pXO2-72 0.0087 59-85 / 7-33
PF13556.5 PucR C-terminal helix-turn-helix domain 0.0089 57-87 / 9-39

Annotations of the NCBI proteins of this PHROG


3:HNH protein 1:HNH endonuclease 1:hypothetical protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0019069 viral capsid assembly
GO:0006355 regulation of transcription, DNA-templated
GO:0004519 endonuclease activity
GO:0003676 nucleic acid binding
GO:0006310 DNA recombination
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
GO:0000150 recombinase activity
GO:0005524 ATP binding

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