phrog_8660 is made of 13 protein sequences and is annotated as "HNH endonuclease"
Functional category: DNA, RNA and nucleotide metabolism


Average length of proteins Number of columns in the MSA Number of conserved columns in the MSA
174.31 292 172


List of all proteins of this PHROG

PHROG prot ID NCBI prot ID NCBI prot annotation Virus ID (click to view) Virus name Virus taxonomy
KP027203_p12 AJA43493.1 HNH domain protein KP027203 Mycobacterium phage Treddle Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
NC_028810_p11 YP_009199525.1 HNH endonuclease NC_028810 Mycobacterium phage Rufus Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
NC_021297_p12 YP_008050777.1 HNH endonuclease NC_021297 Mycobacterium phage PattyP Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
MH020236_p12 AVP41773.1 HNH endonuclease MH020236 Mycobacterium phage GageAP Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
NC_023687_p9 YP_009011342.1 gp9 NC_023687 Mycobacterium virus Bruns Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus.
JF937103_p12 AEK09732.1 HNH endonuclease JF937103 Mycobacterium virus Museum Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus.
MG812495_p12 AUX82398.1 HNH endonuclease MG812495 Mycobacterium phage Pippin Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
MG812489_p12 AUX82040.1 HNH endonuclease MG812489 Mycobacterium phage Greg Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
MG812486_p12 AUX81757.1 HNH endonuclease MG812486 Mycobacterium phage Acme Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Fromanvirus; unclassified Fromanvirus.
p68862 no NCBI prot ID no annotation VI_04167 Actinobacteria_gi_343927414 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; unclassified Siphoviridae.
KX620748_p2 AOT24294.1 HNH endonuclease KX620748 Propionibacterium phage Anatole Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Anatolevirus; Propionibacterium virus Anatole.
KX620749_p2 AOT24352.1 hypothetical protein KX620749 Propionibacterium phage B3 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Siphoviridae; Anatolevirus; Propionibacterium virus B3.
NC_013697_p141 YP_003358996.1 putative HNH endonuclease NC_013697 Deftia phage phiW-14 Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Myoviridae; Ionavirus; Delftia virus PhiW14.

PHROGs colocalized to this PHROG

PHROG #Prot Annotation Category #Neighbors Probability Score
phrog_9 2977 terminase large subunit head and packaging 11 1.55E-23 13.93
phrog_102 889 endolysin lysis 9 4.40E-24 14.48
phrog_10639 10 DNA binding protein DNA, RNA and nucleotide metabolism 2 2.57E-12 2.71

PHROGs similar to this PHROG

PHROG Annotation Category Probability Evalue posQ/posS
phrog_1035 endonuclease VII DNA, RNA and nucleotide metabolism 99.5 1.2E-17 69-165 / 59-163
phrog_10378 HNH endonuclease DNA, RNA and nucleotide metabolism 93.9 0.0064 105-153 / 100-151
phrog_119 HNH endonuclease DNA, RNA and nucleotide metabolism 95.8 0.0003 101-158 / 22-85
phrog_12400 HNH endonuclease DNA, RNA and nucleotide metabolism 97.1 2.4E-06 100-160 / 19-92
phrog_12576 HNH endonuclease DNA, RNA and nucleotide metabolism 95.8 0.0003 102-157 / 20-91
phrog_1271 HNH endonuclease DNA, RNA and nucleotide metabolism 99.1 7.9E-14 10-157 / 45-202
phrog_14314 HNH endonuclease DNA, RNA and nucleotide metabolism 98.7 8.1E-12 97-154 / 3-63
phrog_144 HNH endonuclease DNA, RNA and nucleotide metabolism 97.7 6.3E-08 104-156 / 56-114
phrog_15463 HNH endonuclease DNA, RNA and nucleotide metabolism 97.8 4.3E-08 105-162 / 126-189
phrog_16016 HNH endonuclease DNA, RNA and nucleotide metabolism 91.7 0.031 106-157 / 44-102
phrog_16726 HNH endonuclease DNA, RNA and nucleotide metabolism 99.2 7.6E-15 98-160 / 68-135
phrog_16986 no annotation unknown function 98.2 2.1E-09 95-156 / 5-69
phrog_17283 HNH endonuclease DNA, RNA and nucleotide metabolism 97.6 1.5E-07 119-155 / 6-43
phrog_2118 HNH endonuclease DNA, RNA and nucleotide metabolism 99.2 1.2E-14 97-167 / 3-86
phrog_22048 HNH endonuclease DNA, RNA and nucleotide metabolism 95.9 0.00021 113-165 / 3-58
phrog_2214 HNH endonuclease DNA, RNA and nucleotide metabolism 99.5 1.9E-18 98-168 / 22-93
phrog_22283 no annotation unknown function 95.9 0.0002 111-164 / 23-80
phrog_22514 HNH endonuclease DNA, RNA and nucleotide metabolism 95.1 0.0012 98-162 / 54-119
phrog_2323 HNH endonuclease DNA, RNA and nucleotide metabolism 91.4 0.034 108-160 / 22-94
phrog_23285 HNH endonuclease DNA, RNA and nucleotide metabolism 94.3 0.0039 119-156 / 88-125
phrog_25184 HNH endonuclease DNA, RNA and nucleotide metabolism 96.1 0.00011 91-154 / 69-159
phrog_25420 HNH endonuclease DNA, RNA and nucleotide metabolism 95.0 0.0015 102-156 / 36-108
phrog_25983 HNH endonuclease DNA, RNA and nucleotide metabolism 96.4 4.9E-05 119-154 / 33-68
phrog_26098 no annotation unknown function 96.3 7.3E-05 75-155 / 99-186
phrog_2633 endonuclease VII DNA, RNA and nucleotide metabolism 90.3 0.058 88-153 / 55-115
phrog_29143 HNH endonuclease DNA, RNA and nucleotide metabolism 95.1 0.0012 106-153 / 15-72
phrog_2914 endonuclease VII DNA, RNA and nucleotide metabolism 92.6 0.018 95-155 / 23-81
phrog_29572 no annotation unknown function 91.1 0.041 103-158 / 13-82
phrog_30443 HNH endonuclease DNA, RNA and nucleotide metabolism 93.1 0.012 102-153 / 52-104
phrog_32453 HNH endonuclease DNA, RNA and nucleotide metabolism 94.3 0.0041 104-156 / 66-118
phrog_333 HNH endonuclease DNA, RNA and nucleotide metabolism 97.4 5.7E-07 101-160 / 19-78
phrog_33554 HNH endonuclease DNA, RNA and nucleotide metabolism 96.3 6.7E-05 99-166 / 8-93
phrog_338 HNH endonuclease DNA, RNA and nucleotide metabolism 99.1 3.8E-14 106-159 / 24-87
phrog_4581 terminase small subunit head and packaging 96.7 1.8E-05 101-156 / 53-109
phrog_5718 HNH endonuclease DNA, RNA and nucleotide metabolism 99.4 5.2E-17 98-165 / 11-81
phrog_589 HNH endonuclease DNA, RNA and nucleotide metabolism 98.3 5.5E-10 99-159 / 39-103
phrog_5956 HNH endonuclease DNA, RNA and nucleotide metabolism 96.8 8.6E-06 106-159 / 2-61
phrog_6050 HNH endonuclease DNA, RNA and nucleotide metabolism 98.9 3.8E-13 109-157 / 4-56
phrog_6975 no annotation unknown function 95.1 0.0013 11-44 / 11-43
phrog_7030 HNH endonuclease DNA, RNA and nucleotide metabolism 93.8 0.0065 110-156 / 26-76
phrog_7370 HNH endonuclease DNA, RNA and nucleotide metabolism 95.3 0.0008 77-150 / 10-81
phrog_740 HNH endonuclease DNA, RNA and nucleotide metabolism 95.1 0.0012 101-150 / 9-64
phrog_7785 HNH endonuclease DNA, RNA and nucleotide metabolism 98.6 3.2E-11 104-155 / 62-112
phrog_8048 HNH endonuclease DNA, RNA and nucleotide metabolism 94.1 0.0049 99-151 / 16-75
phrog_8446 HNH endonuclease DNA, RNA and nucleotide metabolism 95.9 0.00025 103-157 / 122-188
phrog_9508 HNH endonuclease DNA, RNA and nucleotide metabolism 94.7 0.0023 106-164 / 16-85
phrog_9545 HNH endonuclease DNA, RNA and nucleotide metabolism 98.3 5.9E-10 98-161 / 98-173
phrog_960 HNH endonuclease DNA, RNA and nucleotide metabolism 97.3 7E-07 111-165 / 40-97
phrog_9645 HNH endonuclease DNA, RNA and nucleotide metabolism 98.4 2E-10 104-160 / 18-80

PFAMs similar to this PHROG

ID Definition Evalue posQ/posS
PF05766.11 Bacteriophage Lambda NinG protein 2.9E-14 68-263 / 6-186
PF05315.10 ICEA Protein 5.7E-08 133-205 / 79-150
PF13395.5 HNH endonuclease 1E-07 150-206 / 1-52
PF01844.22 HNH endonuclease 6E-07 150-203 / 1-46
PF14279.5 HNH endonuclease 6.5E-07 150-207 / 1-47
PF09665.9 Type II restriction endonuclease (RE_Alw26IDE) 1.2E-05 147-209 / 253-300
PF13391.5 HNH endonuclease 1.5E-05 171-205 / 11-45
PF10013.8 Uncharacterized protein conserved in bacteria (DUF2256) 4.3E-05 11-40 / 5-39
PF06147.10 Protein of unknown function (DUF968) 6.6E-05 146-204 / 126-173
PF12855.6 Life-span regulatory factor 0.00011 12-43 / 4-36
PF16784.4 Putative HNHc nuclease 0.0031 145-205 / 121-171

Annotations of the NCBI proteins of this PHROG


9:HNH endonuclease 1:hypothetical protein 1:HNH-like domain 1:HNH domain protein

KEGG orthologous groups similar to this PHROG

ID Name : Definition Pathways BestScore #Hits
no KEGG group similar to this PHROG                                                            

GO terms in Uniprot proteins similar to this PHROG

ID Definition
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity

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