Welcome to the news page !

Here you will be informed of every change in PHROGs since its first release !
The annotations of PHROGs are flexible, any noticed problem or suggested change can be reported in the Suggestions page.

Annotation release v4 - June 15 2022

This year 71 PHROG annotations were edited based on the expertized annotation of tranposable prophages and a couple of community suggestions that were retained.
As usual these PHROGs are listed on the table below, and the latest annotation file is available at the end of this news thread.

phrog old_annot old_category new_annot new_category
phrog_3018 unknown function unknown function head decoration protein head and packaging
phrog_6201 unknown function unknown function CI-like repressor transcription regulation
phrog_801 endolysin inhibits RNA polymerase lysis dATP / dGTP pyrophosphohydrolase DNA, RNA and nucleotide metabolism
phrog_1030 unknown function unknown function tail needle knob tail
phrog_4227 unknown function unknown function endonuclease nicking abasic sites generated by host uracil glycosylase Ung moron, auxiliary metabolic gene and host takeover
phrog_1211 adenylosuccinate synthetase moron, auxiliary metabolic gene and host takeover 2-aminooxy adenylosuccinate synthetase DNA, RNA and nucleotide metabolism
phrog_2345 unknown function unknown function transcriptional regulator transcription regulation
phrog_34335 unknown function unknown function GtrB glycosyltransferase for O-antigen conversion moron, auxiliary metabolic gene and host takeover
phrog_10250 unknown function unknown function terminase large subunit head and packaging
phrog_7076 unknown function unknown function dATP triphosphohydrolase DNA, RNA and nucleotide metabolism
phrog_16625 unknown function unknown function Bxa ADP-ribosyl transferase moron, auxiliary metabolic gene and host takeover
phrog_6287 unknown function unknown function BstA abortive infection system, replication inhibitor moron, auxiliary metabolic gene and host takeover
phrog_2414 unknown function unknown function terminase small subunit head and packaging
phrog_5062 unknown function unknown function tail length tape measure protein tail
phrog_32213 unknown function unknown function endolysin lysis
phrog_4529 unknown function unknown function minor head protein and DNA pilot head and packaging
phrog_5857 unknown function unknown function baseplate wedge subunit tail
phrog_14458 unknown function unknown function tail fiber protein tail
phrog_5233 unknown function unknown function baseplate hub tail
phrog_323 endonuclease DNA, RNA and nucleotide metabolism transcriptional regulator, D5-like transcription regulation
phrog_9370 unknown function unknown function tail fiber protein tail
phrog_5445 unknown function unknown function head closure Hc1 head and packaging
phrog_3268 unknown function unknown function spanin lysis
phrog_9907 unknown function unknown function minor head protein and DNA pilot head and packaging
phrog_5857 unknown function unknown function baseplate wedge subunit tail
phrog_46 tail protein tail baseplate hub tail
phrog_8519 unknown function unknown function cysteine protease lysis
phrog_5090 unknown function unknown function baseplate hub tail
phrog_6 baseplate protein tail baseplate wedge subunit tail
phrog_8757 unknown function unknown function virion structural protein head and packaging
phrog_33262 unknown function unknown function phosphoadenosine phosphosulfate reductase moron, auxiliary metabolic gene and host takeover
phrog_2857 unknown function unknown function tail fiber protein tail
phrog_9777 unknown function unknown function tail fiber protein tail
phrog_7764 unknown function unknown function virion structural protein head and packaging
phrog_4930 unknown function unknown function baseplate hub tail
phrog_8797 unknown function unknown function head closure Hc1 connector
phrog_4735 unknown function unknown function head-tail adaptor Ad1 connector
phrog_1232 unknown function unknown function tail terminator connector
phrog_3753 unknown function unknown function portal protein head and packaging
phrog_10340 unknown function unknown function holin/anti-holin lysis
phrog_4588 unknown function unknown function virion structural protein head and packaging
phrog_180 tail protein tail baseplate wedge subunit tail
phrog_5445 unknown function unknown function head closure Hc1 connector
phrog_177 tail protein tail baseplate hub tail
phrog_9521 unknown function unknown function baseplate wedge subunit tail
phrog_1471 minor spike protein tail pilot protein for DNA ejection tail
phrog_220 head morphogenesis head and packaging minor head protein and DNA pilot head and packaging
phrog_11 baseplate protein tail baseplate spike tail
phrog_120 baseplate protein tail baseplate wedge subunit tail
phrog_184 DNA circularization DNA, RNA and nucleotide metabolism baseplate hub tail
phrog_222 tail protein tail tail completion or Neck1 protein connector
phrog_3578 metallo-endopeptidase other endolysin lysis
phrog_5871 unknown function unknown function holin/anti-holin lysis
phrog_203 tail protein tail baseplate wedge subunit tail
phrog_196 virion structural protein head and packaging baseplate hub tail
phrog_8158 unknown function unknown function head maturation protease head and packaging
phrog_7730 unknown function unknown function i-spanin lysis
phrog_205 virion structural protein head and packaging tail sheath tail
phrog_15324 virion structural protein head and packaging tail sheath and receptor binding protein tail
phrog_29955 unknown function unknown function appendage connector
phrog_22232 Abi alpha-like abortive infection mechanism moron, auxiliary metabolic gene and host takeover unknown function unknown function
phrog_107 RNaseH DNA, RNA and nucleotide metabolism exonuclease DNA, RNA and nucleotide metabolism
phrog_1760 anti-termination protein transcription regulation anti-repressor transcription regulation
phrog_31 baseplate hub protein Tal tail central tail fiber J tail
phrog_12003 tail sheath tail internal virion protein head and packaging
phrog_12706 unknown function unknown function tail length tape measure protein tail
phrog_27190 unknown function unknown function tail length tape measure protein tail
phrog_12798 unknown function unknown function tail length tape measure protein tail
phrog_28420 unknown function unknown function tail length tape measure protein tail
phrog_16297 unknown function unknown function tail length tape measure protein tail
phrog_16889 unknown function unknown function tail length tape measure protein tail

   

We thank all users for their suggestions, providing new insight and allowing the growth of PHROGs !




Annotation release v3 - July 7 2021

87 PHROG annotations were edited based on the expertized annotation of phages T4, T5,T7 and M13, while others were found to have no support for their past annotation and were thus modified.
You can check out these PHROGs on the table below, and download the latest annotation file at the end of this news thread.

phrog old_annot new_annot new_category
phrog_33 minor tail protein distal tail protein Dit
phrog_6212 anti-restriction nuclease unknown function unknown function
phrog_1488 endoribonuclease unknown function unknown function
phrog_227 tail sheath tail sheath stabilizer
phrog_1764 single strand DNA binding protein unknown function unknown function
phrog_3725 tail completion or Neck1 protein connector
phrog_2183 outer membrane protein unknown function unknown function
phrog_28042 replication initiation protein DNA, RNA and nucleotide metabolism
phrog_19445 virion structural protein tail tip protein Tal
phrog_202 minor tail protein distal tail protein Dit
phrog_173 dUTPase nucleoside triphosphate pyrophosphohydrolase
phrog_1423 polymerase Reverse transcriptase
phrog_629 excisionase integration and excision
phrog_342 structural protein with endolysin domain internal virion protein with endolysin domain
phrog_1084 L-shaped tail fiber protein assembly unknown function unknown function
phrog_2010 tail fiber protein unknown function unknown function
phrog_2049 endoribonuclease unknown function unknown function
phrog_1644 minor coat protein head and packaging
phrog_464 ribonucleotide reductase NrdA-like unknown function unknown function
phrog_45 tail completion tail tube tail
phrog_31 tail fiber protein baseplate hub protein Tal
phrog_8482 virion structural protein attachment protein
phrog_1302 tail protein distal tail protein
phrog_183 tail protein tail chaperone protein
phrog_622 goF mRNA metabolism modulator unknown function unknown function
phrog_420 5'-3' deoxyribonucleotidase unknown function unknown function
phrog_1043 UvsY-like recombination mediator unknown function unknown function
phrog_3890 tail protein straight fibre tail protein
phrog_1474 NrdC-like thioredoxin unknown function unknown function
phrog_1452 Gp5.5-like host HNS inhibition moron, auxiliary metabolic gene and host takeover
phrog_34807 tail protein collar tail protein for L-shaped tail fibre attachment
phrog_1250 thioredoxin domain unknown function unknown function
phrog_600 endoribonuclease unknown function unknown function
phrog_92 terminase DNA packaging chaperone FI
phrog_1692 membrane protein unknown function unknown function
phrog_2274 NrdC-like thioredoxin unknown function unknown function
phrog_1012 secretin assembly (protein IV of M13) head and packaging
phrog_3889 minor tail protein base plate tail tube protein
phrog_39 tail protein tail assembly protein
phrog_2257 NrdC-like thioredoxin unknown function unknown function
phrog_1646 major head protein major coat protein
phrog_10143 virion structural protein minor coat protein
phrog_626 anaerobic ribonucleoside reductase small subunit anaerobic ribonucleotide reductase small subunit
phrog_2604 membrane protein unknown function unknown function
phrog_1106 MotB-like transcriptional regulator unknown function unknown function
phrog_107 exonuclease RNaseH
phrog_3914 tail assembly chaperone tail
phrog_2052 NrdC-like thioredoxin unknown function unknown function
phrog_1844 anti-restriction nuclease unknown function unknown function
phrog_2333 MotB-like transcriptional regulator unknown function unknown function
phrog_2330 membrane protein unknown function unknown function
phrog_681 endonuclease DNA, RNA and nucleotide metabolism
phrog_646 single strand DNA binding protein unknown function unknown function
phrog_1675 head morphogenesis morphogenesis (protein I of M13)
phrog_35263 membrane protein unknown function unknown function
phrog_1435 thioredoxin domain unknown function unknown function
phrog_253 minor head protein Mu Gam-like end protection DNA, RNA and nucleotide metabolism
phrog_2205 gam-like host nuclease inhibitor Mu Gam-like end protection DNA, RNA and nucleotide metabolism
phrog_491 gam-like host nuclease inhibitor Mu Gam-like end protection DNA, RNA and nucleotide metabolism
phrog_2370 minor head protein neck passage structure connector
phrog_9220 recombination directionality factor unknown function unknown function
phrog_421 transposase unknown function unknown function
phrog_2345 transposase unknown function unknown function
phrog_5 neck protein Ne1 tail completion or Neck1 protein
phrog_26 neck protein Ne1 tail completion or Neck1 protein
phrog_27 neck protein Ne1 tail completion or Neck1 protein
phrog_169 neck protein Ne1 tail completion or Neck1 protein
phrog_321 neck protein Ne1 tail completion or Neck1 protein
phrog_879 neck protein Ne1 tail completion or Neck1 protein
phrog_927 neck protein Ne1 tail completion or Neck1 protein
phrog_17193 neck protein Ne1 tail completion or Neck1 protein
phrog_37 tail completion Tc1 tail terminator
phrog_65 tail completion Tc1 tail terminator
phrog_78 tail completion Tc1 tail terminator
phrog_123 tail completion Tc1 tail terminator
phrog_176 tail completion Tc1 tail terminator
phrog_179 tail completion Tc1 tail terminator
phrog_347 tail completion Tc1 tail terminator
phrog_3907 tail completion Tc1 tail terminator
phrog_4204 tail completion Tc1 tail terminator
phrog_5078 tail completion Tc1 tail terminator
phrog_6485 tail completion Tc1 tail terminator
phrog_7975 tail completion Tc1 tail terminator
phrog_17840 tail completion Tc1 tail terminator
phrog_20428 tail completion Tc1 tail terminator
phrog_4287 DNA injection protein DNA ejection protein
phrog_26400 DNA injection protein DNA ejection protein

   

We thank all contributors that used the suggestions page, PHROGs is getting better and better with your help !




Annotation release v2 - February 15 2021

A couple changes of annotation :
  • phrog_9896 is now annotated as phosphofructokinase
  • phrog_2185 is now annotated as RecT-like ssDNA annealing protein

    • These modifications are both based on PFAMs similar to these PHROGs.

       




    Annotation release v1

  • This is the initial annotation release.

    • You can download the annotation of all PHROGs as a tab separeted file file here :